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Source: Brain Research
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Total 501 results found since Jan 2013.
PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPAR γ in cerebral ischemia-reperfusion injury
Brain Res Bull. 2023 Jan 18:S0361-9230(23)00010-2. doi: 10.1016/j.brainresbull.2023.01.007. Online ahead of print.ABSTRACTMitochondrial dysfunction and endoplasmic reticulum (ER) stress occur in ischemic stroke. The disruption of these two organelles can directly lead to cell death through various signaling pathways. Thus, investigation of the associated molecular mechanisms in cerebral ischemia is a prerequisite for stroke treatment. Pleckstrin homology-like domain family A member 1 (PHLDA1) is a multifunctional protein that can modulate mitochondrial function and ER stress in cardiomyocyte and cancer cells. This work stu...
Source: Brain Research - January 21, 2023 Category: Neurology Authors: Yushuang Liu Hanshu Zhao Nan Chen Yuelong Li Zeyang Zheng Zhiyu Sun Zhongling Zhang Source Type: research
Tongqiao Huoxue decoction alleviates neurological impairment following ischemic stroke via the PTGS2/NF-kappa B axis
Brain Res. 2023 Jan 17:148247. doi: 10.1016/j.brainres.2023.148247. Online ahead of print.ABSTRACTTraditional Chinese medicine has emerged as promising targets for ischemic stroke (IS) therapy, yet the mechanism remains elusive. The current study was performed with an aim to investigate the action and mechanism of Tongqiao Huoxue decoction (TQHXD) affecting the neurological impairment secondary to IS based on network pharmacology. Based on network pharmacology and bioinformatics analysis, target genes and pathways involved in the treatment of TQHXD against IS were predicted. Serum containing TQHXD was prepared through bloo...
Source: Brain Research - January 20, 2023 Category: Neurology Authors: Zheyi Zhou Linglu Dun Qian Yang Jingrui Tao Peishan Yu Hong Xu Na Zhao Na Zheng Hongwei An Ping Yi Source Type: research
Neuroprotective Effects of Pre-Ischemic Exercise are linked to Expression of NT-3/NT-4 and TrkB/TrkC in Rats
CONCLUSION: The findings showed that pre-ischemic exercise can exert neuroprotective effectsvia NT-3 and NT-4 pathways against ischemia in hippocampal CA1 neurons and promote post-injury sensorimotor recovery.PMID:36646145 | DOI:10.1016/j.brainresbull.2023.01.004
Source: Brain Research - January 16, 2023 Category: Neurology Authors: AbdorrezaEghbal Moghanlou Mohtaram Yazdanian Sajad Roshani Abdullah Demirli Mehdi Seydyousefi Gerlinde A S Metz Zeinab Faghfoori Source Type: research
Variation of body weight supported treadmill training parameters during a single session can modulate muscle activity patterns in post-stroke gait
Exp Brain Res. 2023 Jan 13. doi: 10.1007/s00221-023-06551-7. Online ahead of print.ABSTRACTEvidence supporting the benefits of locomotor training (LT) to improve walking ability following stroke are inconclusive and could likely be improved with a better understanding of the effects of individual parameters i.e., body weight support (BWS), speed, and therapist assistance and their interactions with walking ability and specific impairments. We evaluated changes in muscle activity of thirty-seven individuals with chronic stroke (> 6 months), in response to a single session of LT at their self-selected or fastest-comfortab...
Source: Brain Research - January 13, 2023 Category: Neurology Authors: Shraddha Srivastava Bryant A Seamon Carolynn Patten Steven A Kautz Source Type: research
Enhanced cognitive interference during visuomotor tasks may cause eye-hand dyscoordination
Exp Brain Res. 2023 Jan 10. doi: 10.1007/s00221-023-06550-8. Online ahead of print.ABSTRACTIn complex visuomotor tasks, such as cooking, people make many saccades to continuously search for items before and during reaching movements. These tasks require cognitive resources, such as short-term memory and task-switching. Cognitive load may impact limb motor performance by increasing demands on mental processes, but mechanisms remain unclear. The Trail-Making Tests, in which participants sequentially search for and make reaching movements to 25 targets, consist of a simple numeric variant (Trails-A) and a cognitively challeng...
Source: Brain Research - January 10, 2023 Category: Neurology Authors: Tarkeshwar Singh John-Ross Rizzo C édrick Bonnet Jennifer A Semrau Troy M Herter Source Type: research
Electro-acupuncture treatment ameliorates intestinal inflammatory injury in cerebral ischemia-reperfusion rats via regulating the balance of Treg / γδ T cells
Brain Res. 2023 Jan 6:148233. doi: 10.1016/j.brainres.2023.148233. Online ahead of print.ABSTRACTElectro-acupuncture (EA) has an anti-inflammatory role in ischemic stroke, but whether the protective effect of EA involves the regulation of the intestine barrier and Treg/ γδ T cells is unclear. Cerebral ischemia-reperfusion (I/R) injury was induced by middle cerebral artery occlusion(MCAO) for 2 hours followed by reperfusion for 24 hours. The rats have treated with EA at the "Baihui" acupoint(GV20). Triphenyl tetrazolium chloride (TTC) staining and Longa neurologic score were performed to evaluate the outcomes after ischem...
Source: Brain Research - January 9, 2023 Category: Neurology Authors: Ya-Ling Wang Ling-Ling Meng Yong-Lin Chen Ling OuYang Bu-Fan Wu Rou Peng Sheng-Feng Lu Qing Liu Tao Zhang Xiao-Xiao Li Xin-Yue Jing Bin Xu Shu-Ping Fu Source Type: research
Metformin enhances neural precursor cells migration and functional recovery after ischemic stroke in mice
Exp Brain Res. 2023 Jan 8. doi: 10.1007/s00221-023-06547-3. Online ahead of print.ABSTRACTResident neural precursor cells (NPCs) activation is a promising therapeutic strategy for brain repair. This strategy involves stimulating multiple stages of NPCs development, including proliferation, self-renewal, migration, and differentiation. Metformin, an FDA-approved diabetes drug, has been shown to promote the proliferation and differentiation of NPCs. However, it is still unclear whether metformin promotes the migration of NPCs. EVOS living cell imaging system was used for observing the migration for primary NPCs dynamically i...
Source: Brain Research - January 7, 2023 Category: Neurology Authors: Liang Zhang Jing Zhang Xiaoming Zhu Wei Jiao Yang Yang Youping Wu Likun Yang Yuhai Wang Source Type: research
TUK9Ferrostatin-1 alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3 β signaling pathway
In conclusion, Fer-1 has protective effects on cerebral I/R injury by activating the AKT/GSK3β pathway, indicating that ferroptosis may become a novel target in the treatment of ischemic stroke.PMID:36596364 | DOI:10.1016/j.brainresbull.2022.12.009
Source: Brain Research - January 3, 2023 Category: Neurology Authors: Xinyao Liu Yue Du Jian Liu Linggang Cheng Wen He Wei Zhang Source Type: research
Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Brain Research - January 2, 2023 Category: Neurology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research
