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Source: Brain Research
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Total 501 results found since Jan 2013.
Effects of gait rehabilitation on motor coordination in stroke survivors: an UCM-based approach
Exp Brain Res. 2021 May 6. doi: 10.1007/s00221-021-06117-5. Online ahead of print.ABSTRACTPost-stroke locomotion is usually characterized by asymmetrical gait patterns, compensatory movements of trunk and nonparetic limb, altered motor coordination, and wide inter-stride variability. This pilot study was designed to test a twofold hypothesis: post-stroke survivors can exploit the redundancy of the segmental angles to stabilize the 3D footpath trajectory during the swing phase, in accordance with the Uncontrolled Manifold (UCM) theory; an intense rehabilitative treatment improves both motor performance and outcomes of the U...
Source: Brain Research - May 6, 2021 Category: Neurology Authors: Margherita Lofrumento Peppino Tropea Michela Picardi Paola Antoniotti Silvestro Micera Massimo Corbo Vito Monaco Source Type: research
Neurologic Complications of Poverty: the Associations Between Poverty as a Social Determinant of Health and Adverse Neurologic Outcomes
This study summarizes the recent literature on poverty as it contributes to neurological disease.RECENT FINDINGS: Children growing up in poverty have increased risk for cognitive deficits and behavioral disorders as reported by Noble et al. (Dev Sci. 9(6):642-54, 2006) and Farah et al. (Brain Res. 1110(1):166-74, 2006) as well as worse outcomes when it comes to epilepsy management and disease course as discussed by Camfield et al. (Epilepsia. 57(11):1826-33, 2016). In adulthood, as the number of social determinants of health increases, the incidence of stroke and severe stroke increases significantly as reported by Reshetn...
Source: Brain Research - May 5, 2021 Category: Neurology Authors: Monica Maalouf Maureen Fearon Mary Clare Lipa Hannah Chow-Johnson Linda Tayeh Daniel Lipa Source Type: research
Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3
CONCLUSION: BMSC-EVs carrying miR-221-3p protect against IS by inhibiting ATF3. This study may be helpful for exploring therapeutic strategies of IS.PMID:33932490 | DOI:10.1016/j.brainresbull.2021.04.022
Source: Brain Research - May 1, 2021 Category: Neurology Authors: Zhibing Ai Chaohui Cheng Lan Zhou Songhe Yin Lei Wang Yong Liu Source Type: research
Effect of Hemopexin Treatment on Outcome after Intracerebral Hemorrhage in Mice
Brain Res. 2021 Apr 27:147507. doi: 10.1016/j.brainres.2021.147507. Online ahead of print.ABSTRACTHeme release from hemoglobin may contribute to secondary injury after intracerebral hemorrhage (ICH). The primary endogenous defense against heme toxicity is hemopexin, a 57 kDa glycoprotein that is depleted in the CNS after hemorrhagic stroke. We hypothesized that systemic administration of exogenous hemopexin would reduce perihematomal injury and improve outcome after experimental ICH. Intraperitoneal treatment with purified human plasma hemopexin beginning 2 hours after striatal ICH induction and repeated daily for the foll...
Source: Brain Research - April 30, 2021 Category: Neurology Authors: Jing Chen-Roetling Yang Li Yang Cao Zhe Yan Xiangping Lu Raymond F Regan Source Type: research
Different reorganizations of functional brain networks after first-ever and recurrent ischemic stroke
In this study, we recruited seventeen first-ever stroke patients as well as fourteen recurrent stroke patients, and recorded their resting EEG signals and NIHSS score before and after two weeks of recovery, to compare their neural reorganization from network scale. The clinical improvements were comparable in two groups during the two weeks. However, their brain networks were differently reorganized, especially in the delta band. The recurrent stroke patients showed an increased clustering coefficient and a decreased characteristic path length of the delta network, along with increased ipsilesional intrahemispheric connect...
Source: Brain Research - April 22, 2021 Category: Neurology Authors: Xu Wang Xiaonan Liu Zhuo Wang Shanbao Tong Zheng Jin Xiaoli Guo Source Type: research
Effect of NEUROG3 Polymorphism Rs144643855 on Regional Spontaneous Brain Activity in Major Depressive Disorder
CONCLUSION: These findings suggest a potential relationship between rs144643855 variations and altered frontal brain activity in MDD. NEUROG3 may play an important role in the neuropathophysiology of MDD.PMID:33878431 | DOI:10.1016/j.bbr.2021.113310
Source: Brain Research - April 20, 2021 Category: Neurology Authors: Zhuoliang Hou Xiaoyun Liu Wenhao Jiang Zhenghua Hou Yingying Yin Chunming Xie Haisan Zhang Hongxing Zhang Zhijun Zhang Yonggui Yuan Source Type: research
Protective effects of Astragaloside IV against oxidative injury and apoptosis in cultured astrocytes by regulating Nrf2/JNK signaling
In conclusion, these findings revealed that AS-IV protected against OGD/R-induced astrocytes through inhibiting oxidative stress and apoptotic pathways.PMID:33830313 | DOI:10.1007/s00221-021-06096-7
Source: Brain Research - April 8, 2021 Category: Neurology Authors: Jintao Yang Chongyu Shao Wentao Li Haitong Wan Yu He Jiehong Yang Source Type: research
An Inhibitory and Beneficial Effect of Chlorpromazine and Promethazine (C+P) on Hyperglycolysis through HIF-1 α Regulation in Ischemic Stroke
CONCLUSION: C+P, partially depending on hypothermia, attenuates hyperglycolysis and NOX activation through HIF-1α regulation.PMID:33811844 | DOI:10.1016/j.brainres.2021.147463
Source: Brain Research - April 3, 2021 Category: Neurology Authors: Sichao Guo Eric Cosky Fengwu Li Longfei Guan Yu Ji Wenjing Wei Changya Peng Xiaokun Geng Yuchuan Ding Source Type: research
Gradual adaptation to pelvis perturbation during walking reinforces motor learning of weight shift toward the paretic side in individuals post-stroke
In conclusion, the "gradual adaptation" inducing "small errors" during constraint-induced walking may improve weight shift and enhance forced use of the paretic leg in individuals post-stroke. Applying gradual pelvis assistance force during walking may be used as an intervention strategy to improve walking in individuals post-stroke.PMID:33779790 | DOI:10.1007/s00221-021-06092-x
Source: Brain Research - March 29, 2021 Category: Neurology Authors: Seoung Hoon Park Chao-Jung Hsu Weena Dee Elliot J Roth William Z Rymer Ming Wu Source Type: research
Relation between rich-club organization versus brain functions and functional recovery after acute ischemic stroke
In this study, we aimed to investigate the relation between poststroke brain functions and functional recovery versus the rich-club organization of the structural brain network of patients after first-time acute ischemic stroke. A cohort of 16 acute ischemic stroke patients (11 males) was recruited. Structural brain networks were measured using diffusion tensor imaging within 1 week and at 1, 3 and 6 months after stroke. Motor impairment was assessed using the Upper-Extremity Fugl-Meyer motor scale and activities of daily living using the Barthel Index at the same time points as MRI. The rich-club regions that were stable ...
Source: Brain Research - March 23, 2021 Category: Neurology Authors: Lu Wang Xiaopei Xu Kui Kai Lau Leonard Sw Li Yuen Kwun Wong Christina Yau Henry Kf Mak Edward S Hui Source Type: research
