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Source: Brain Research
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Total 501 results found since Jan 2013.
Silent information regulator 1 ameliorates oxidative stress injury via PGC-1 α/PPARγ-Nrf2 pathway after ischemic stroke in rat
CONCLUSION: Overall, our data indicated that SIRT1 directly mediated the PGC-1α/PPARγ pathway in response to focal cerebral ischemia/reperfusion-induced neurological deficit, providing insights into the treatment of focal cerebral ischemia/reperfusion injury.PMID:34774993 | DOI:10.1016/j.brainresbull.2021.11.001
Source: Brain Research - November 14, 2021 Category: Neurology Authors: Yang Zhou Li Peng Yixin Li Yong Zhao Source Type: research
The neuroprotective effects of Insulin-Like Growth Factor 1 via the Hippo/YAP signaling pathway are mediated by the PI3K/AKT cascade following cerebral ischemia/reperfusion injury
Brain Res Bull. 2021 Oct 27:S0361-9230(21)00309-9. doi: 10.1016/j.brainresbull.2021.10.017. Online ahead of print.ABSTRACTInsulin-like growth factor 1 (IGF-1) has neuroprotective actions, including vasodilatory, anti-inflammatory, and antithrombotic effects, following ischemic stroke. However, the molecular mechanisms underlying the neuroprotective effects of IGF-1 following ischemic stroke remain unknown. Therefore, in the present study, we investigated whether IGF-1 exerted its neuroprotective effects by regulating the Hippo/YAP signaling pathway, potentially via activation of the PI3K/AKT cascade, following ischemic str...
Source: Brain Research - October 31, 2021 Category: Neurology Authors: Pian Gong Yichun Zou Wei Zhang Qi Tian Shoumeng Han Zhou Xu Qianxue Chen Xin Wang Mingchang Li Source Type: research
Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies
Prog Brain Res. 2021;266:301-348. doi: 10.1016/bs.pbr.2021.06.014. Epub 2021 Oct 6.ABSTRACTMilitary personnel are often exposed to high environmental heat associated with industrial or ambient abundance of nanoparticles (NPs) affecting brain function. We have shown that engineered metal NPs Ag and Cu exacerbate hyperthermia induced brain pathology. Thus, exploration of novel drug therapy is needed for effective neuroprotection in heat stroke intoxicated with NPs. In this investigation neuroprotective effects of cerebrolysin, a balanced composition of several neurotrophic factors and active peptides fragments exhibiting pow...
Source: Brain Research - October 25, 2021 Category: Neurology Authors: Hari Shanker Sharma Dafin F Muresanu Asya Ozkizilcik Seaab Sahib Z Ryan Tian Jos é Vicente Lafuente Rudy J Castellani Ala Nozari Lianyuan Feng Anca D Buzoianu Preeti K Menon Ranjana Patnaik Lars Wiklund Aruna Sharma Source Type: research
Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion-symptom mapping study in acute stroke patients
Exp Brain Res. 2021 Oct 15. doi: 10.1007/s00221-021-06224-3. Online ahead of print.ABSTRACTThe anatomical relationship between speech apraxia (SA) and oral apraxia (OA) is still unclear. To shed light on this matter we studied 137 patients with acute ischaemic left-hemisphere stroke and performed support vector regression-based, multivariate lesion-symptom mapping. Thirty-three patients presented with either SA or OA. These two symptoms mostly co-occurred (n = 28), except for few patients with isolated SA (n = 2) or OA (n = 3). All patient with either SA or OA presented with aphasia (p < 0.001) and these symptoms were h...
Source: Brain Research - October 15, 2021 Category: Neurology Authors: Martina Conterno Dorothee K ümmerer Andrea Dressing Volkmar Glauche Horst Urbach Cornelius Weiller Michel Rijntjes Source Type: research
Mirror therapy in upper limb motor recovery and activities of daily living, and its neural correlates in stroke individuals: a systematic review and meta-analysis
Brain Res Bull. 2021 Oct 6:S0361-9230(21)00295-1. doi: 10.1016/j.brainresbull.2021.10.003. Online ahead of print.ABSTRACTAvailable literature indicates that 30% to 66% of stroke survivors present persistent upper limb impairment. Considering the importance of upper limb function for activities of daily living, it is necessary to investigate neurorehabilitation therapies that could improve the upper limb function. Among stroke complementary therapies, mirror therapy has shown promising results. Thus, the aim of this systematic review and meta-analyses was to review and synthesize clinical evidence on the use of mirror thera...
Source: Brain Research - October 9, 2021 Category: Neurology Authors: Nath álya Gardênia de Holanda Marinho Nogueira Juliana Otoni Parma Sara Edith Souza de Assis Le ão Izabella de Souza Sales Lilian Carla Macedo Ana Carolina Daher Ribas Galv ão Dalva Cadeu de Oliveira Tatiane Mois és Murça Lidiane Aparecida Fernandes Source Type: research
Application of neuromuscular electrical stimulation on the support limb during reactive balance control in persons with stroke: a pilot study
Exp Brain Res. 2021 Oct 5. doi: 10.1007/s00221-021-06209-2. Online ahead of print.ABSTRACTThe aim of the present study was to investigate the effect of the application of neuromuscular electrical stimulation to the quadriceps muscle of the paretic limb during externally induced stance perturbations on reactive balance control and on fall outcomes in people with chronic stroke. Ten participants experienced 12 stance treadmill perturbation trails, 6 forward balance perturbation trials and 6 backward balance perturbation trials. For each perturbation condition, three perturbation trials were delivered synchronized with neurom...
Source: Brain Research - October 5, 2021 Category: Neurology Authors: Gonzalo Varas-Diaz Tanvi Bhatt Source Type: research
Spatial attention in children with perinatal stroke
Behav Brain Res. 2021 Oct 1:113614. doi: 10.1016/j.bbr.2021.113614. Online ahead of print.ABSTRACTSpatial neglect is a common feature of right hemisphere damage in adults, but less is known about spatial inattention following early brain damage. We used a Posner-based cueing task to examine hemispatial neglect and aspects of attention in children with perinatal stroke in either left (LH) or right hemisphere (RH) and controls. A visual perception task assessed the speed of visual perception. A spatial attention cueing task (the E-task) measured the ability to discriminate the direction of a target stimulus ("E"), when prese...
Source: Brain Research - October 4, 2021 Category: Neurology Authors: Timothy Adamos Leanne Chukoskie Jeanne Townsend Doris Trauner Source Type: research
Neural correlates of walking post-stroke: neuroimaging insights from the past decade
Exp Brain Res. 2021 Sep 28. doi: 10.1007/s00221-021-06217-2. Online ahead of print.ABSTRACTWalking dysfunction such as slow walking speed and reduced independent mobility are common impairments following stroke. Neural mechanisms of upper limb impairment and motor recovery have been highly studied, while less is known about the neural correlates of walking dysfunction and rehabilitation after stroke. Our objective was to review the literature on neuroimaging correlates of walking and walking recovery post-stroke to provide a more comprehensive picture of neurological regions of interest. We searched the databases PubMed, C...
Source: Brain Research - September 29, 2021 Category: Neurology Authors: McKenna K Perry Denise M Peters Source Type: research
Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke
Prog Brain Res. 2021;265:249-315. doi: 10.1016/bs.pbr.2021.06.007. Epub 2021 Aug 12.ABSTRACTMilitary personnel often exposed to high summer heat are vulnerable to heat stroke (HS) resulting in abnormal brain function and mental anomalies. There are reasons to believe that leakage of the blood-brain barrier (BBB) due to hyperthermia and development of brain edema could result in brain pathology. Thus, exploration of suitable therapeutic strategies is needed to induce neuroprotection in HS. Extracts of Gingko Biloba (EGb-761) is traditionally used in a variety of mental disorders in Chinese traditional medicine since ages. I...
Source: Brain Research - September 25, 2021 Category: Neurology Authors: Seaab Sahib Aruna Sharma Dafin F Muresanu Zhiqiang Zhang Cong Li Z Ryan Tian Anca D Buzoianu Jos é Vicente Lafuente Rudy J Castellani Ala Nozari Ranjana Patnaik Preeti K Menon Lars Wiklund Hari Shanker Sharma Source Type: research
