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Source: Brain Research
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Total 501 results found since Jan 2013.
CircNCOA4 knockdown attenuates OGD-induced neuron injury through miR-338-5p/PDE4B axis
Exp Brain Res. 2023 Sep 16. doi: 10.1007/s00221-023-06702-w. Online ahead of print.ABSTRACTCircular RNAs (circRNAs) have been revealed to be involved in the pathology of acute ischemic stroke (AIS). Herein, we aimed to study the role and mechanism of circNCOA4 in ischemic stroke. The neuron-like cell line SK-N-SH of the experiment group was cultured in oxygen-glucose deprivation (OGD) condition. Cell viability and apoptosis were evaluated by cell counting kit-8 and flow cytometry. The oxidative damage and endoplasmic reticulum stress (ERS) were analyzed by measuring the production of reactive oxygen species (ROS), malondia...
Source: Brain Research - September 16, 2023 Category: Neurology Authors: Danyang Wang Sai Xiao Xiaoming Li Wenbo Qi Source Type: research
A modified murine photothrombotic stroke model: a minimally invasive and reproducible cortical and sub-cortical infarct volume and long-term deficits
In conclusion, this modified model helps to understand stroke pathogenesis and minimize the animals' numbers which help to increase the scientific and statistical potential in pre-clinical studies.PMID:37656197 | DOI:10.1007/s00221-023-06696-5
Source: Brain Research - September 1, 2023 Category: Neurology Authors: Mohd Salman Saifudeen Ismael Tauheed Ishrat Source Type: research
Neuroanatomical Correlates of Cognitive Impairment following Basal Ganglia-Thalamic Post-Hemorrhagic Stroke: Uncovering Network-Wide Alterations in Hemispheric Gray Matter Asymmetry
In conclusion, PhSCI patients exhibited network-wide cortical GM losses, distal to subcortical hemorrhagic lesions, and hemisphere asymmetry changes. These changes appear to predict rTMS-related cognitive improvements, suggesting that even subcortical focal lesions can lead to alterations in distal cortical neuroanatomical architecture. Our preliminary findings provide new insights into the neuroanatomical basis of PhSCI.PMID:37652090 | DOI:10.1016/j.brainres.2023.148559
Source: Brain Research - August 31, 2023 Category: Neurology Authors: Huan Wang Minhua Yu Jinxia Ren Xiaoli Zhong Dan Xu Lei Gao Haibo Xu Source Type: research
A randomized controlled trial of Changes in resting-state functional connectivity associated with short-term motor learning of chopstick use with the non-dominant hand
CONCLUSION]: Offline enhancement of RSFC in these networks was shown to contribute to early chopstick-use motor learning with the left hand. These results serve as a basis for future studies on compensatory networks in individuals with stroke.PMID:37506851 | DOI:10.1016/j.bbr.2023.114599
Source: Brain Research - July 28, 2023 Category: Neurology Authors: Sayori Takeda Reiko Miyamoto Source Type: research
Montelukast Sodium Protects against Focal Cerebral Ischemic Injury by Regulating Inflammatory Reaction via Promoting Microglia Polarization
CONCLUSION: Montelukast sodium can protect against focal cerebral ischemic injury by regulating inflammatory reaction via promoting microglia polarization.PMID:37499731 | DOI:10.1016/j.brainres.2023.148498
Source: Brain Research - July 27, 2023 Category: Neurology Authors: Yanling Wang Ho Jun Yun Yuchuan Ding Huishan Du Xiaokun Geng Source Type: research
Long-term behavioural alterations in mice following transient cerebral ischemia
The objective of this study was to clarify whether and to what extent mouse behaviour was altered during a 6 months period after cerebral stroke. Experimental stroke was induced in mice by intraluminal filament insertion into the middle cerebral artery (fMCAo). Neurological deficits, recovery rate, motor performance, and circadian activity were evaluated following ischemia. We observed severe neurological deficits, motor impairments, and delay in the recovery rate of mice during the first 14 days after fMCAo. Aberrant circadian activity and distorted space map were seen in fMCAo mice starting one month after ischemia, simi...
Source: Brain Research - July 22, 2023 Category: Neurology Authors: Zane Dzirkale Vladimirs Pilipenko Barbara Pijet Linda Klimaviciusa Jolanta Upite Karolina Protokowicz Leszek Kaczmarek Baiba Jansone Source Type: research
Nrf2/HO-1 Blocks TXNIP/NLRP3 interaction via elimination of ROS in Oxygen-glucose Deprivation-induced Neuronal Necroptosis
Brain Res. 2023 Jul 11:148482. doi: 10.1016/j.brainres.2023.148482. Online ahead of print.ABSTRACTAcute ischemic stroke (AIS) is known to trigger a cascade of inflammatory events that induces secondary tissue damages. As a type of regulated inflammatory cell death, necroptosis is associated with AIS, whilst its regulation during neuroinflammation is not well understood. In particular, the actual function of NOD-like-receptor family pyrin domain-containing-3(NLRP3) inflammasome in cortical neuronal necroptosis still not clear. Herein, we explored the function of nuclear factor erythroid-2 related factor-2 (Nrf2)/ heme oxyge...
Source: Brain Research - July 13, 2023 Category: Neurology Authors: Zhihan Liu Ping Cheng Tao Feng Zhiyuan Xie Meifang Yang Zhiren Chen Shuqun Hu Dong Han Weiwei Chen Source Type: research
NLRP3 inflammasome activation after ischemic stroke
Behav Brain Res. 2023 Jul 11;452:114578. doi: 10.1016/j.bbr.2023.114578. Online ahead of print.ABSTRACTCerebral ischemia is a pathological condition resulting from the cessation or reduction of blood supply to the cerebral arteries. Neurological deficits that are clinically relevant can arise as a result of brain damage. The etiology of stroke is multifaceted and intricate, with the inflammatory response being a crucial component that warrants significant attention. Following a cerebrovascular accident, the levels of interleukin-1 beta and interleukin-18 within the central nervous system escalate due to the activation of t...
Source: Brain Research - July 12, 2023 Category: Neurology Authors: Ping-Ping Han Yu Han Xin-Ya Shen Zhen-Kun Gao Xia Bi Source Type: research
"Lifting Yang to Dredging Du Meridian Manipulation" acupuncture alleviates cerebral ischemia-reperfusion injury by mediating the NF- κB pathway
CONCLUSIONS: LYDD acupuncture ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB pathway activity.PMID:37414270 | DOI:10.1016/j.brainres.2023.148477
Source: Brain Research - July 6, 2023 Category: Neurology Authors: Xiahui Zhang Lei Ma Meifang Liu Tao Zhu Zhilin Huang Youlong Xiong Ziyi Wang Jing Shi Source Type: research
