Filtered By:
Source: Brain Research
This page shows you your search results in order of date. This is page number 10.
Order by Relevance | Date
Total 501 results found since Jan 2013.
Adipose-derived mesenchymal stem cells reduced transient cerebral ischemia injury by modulation of inflammatory factors and AMPK signaling
In this study, by releasing the clips, the reperfusion period was extended to 96hours, and two hours after cerebral ischemia, animals received adipose-derived MSCs. MSCs were isolated from the inguinal fat pads of rats and injected into two-vessel occlusion (2VO) rats 1hour after ischemia induction. Ninety-six hours after 2VO induction, behavioral and molecular tests were assessed. Adipose-derived MSCs treatment improves neurological scores, passive avoidance memory, and novel object recognition tests in the 2VO model compared to 2VO rats (P<0.001). MSCs treatment decreased TNF-α (P<0.01) and IL-6 (P<0.01) and ap...
Source: Brain Research - July 9, 2022 Category: Neurology Authors: Mina Ranjbaran Reyhaneh Vaali Zahra Yaghoobi Fardin Sehati Vida Jashn Sevda Mahdipour Kolur Fariba Akhondzadeh Ghorbangol Ashabi Source Type: research
Effects of wheel-running on anxiety and depression-relevant behaviours in the MCAO mouse model of stroke: moderation of brain-derived neurotrophic factor and serotonin receptor gene expression
We report that MCAO induced hypo-locomotion and anhedonia-related behaviours, with some improvements conferred by wheel-running. Serotonin transporter gene expression was increased in the MCAO hippocampus and frontal cortex, but this increase remained despite wheel-running. Wheel-running associated up-regulation of BDNF gene expression was unaffected in MCAO mice, reflecting conservation of key neuroplasticity molecular pathways. Taken together, our results highlight the need for further research into serotonergic modulation of the affective symptoms of stroke.PMID:35777551 | DOI:10.1016/j.bbr.2022.113983
Source: Brain Research - July 1, 2022 Category: Neurology Authors: Vanessa H Brait Katherine A Jackman Terence Y Pang Source Type: research
TSPO knockdown attenuates OGD/R-induced neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPAR γ pathway
In conclusion, TSPO knockdown attenuates neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPARγ pathway.PMID:35738501 | DOI:10.1016/j.brainresbull.2022.06.009
Source: Brain Research - June 23, 2022 Category: Neurology Authors: Kai Wang Gang Wang Botao Zhou Source Type: research
Exploring biomarkers for ischemic stroke through integrated microarray data analysis
This study aimed to explore high-confidence candidate genes associated with ischemic stroke (IS) through bioinformatics analysis and identify potential diagnostic biomarkers and gene-drug interactions. Weighted gene coexpression network analysis (WGCNA) and differentially expressed genes (DEGs) were integrated to identify overlapping genes. Then, high-confidence candidate genes were screened by least absolute shrinkage and selection operator (LASSO) regression. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value of high-confidence candidate genes as biomarkers for IS. The NetworkAnalys...
Source: Brain Research - June 12, 2022 Category: Neurology Authors: Miao Lv Wanting He Tian Liang Jialei Yang Xiaolan Huang Shengying Liu Xueying Liang Jianxiong Long Li Su Source Type: research
The effect of coupled inhibitory-facilitatory repetitive transcranial magnetic stimulation on shaping early reorganization of the motor network after stroke
This study aimed to evaluate functional connectivity (FC) changes in the cortical motor network after coupled inhibitory-facilitatory repetitive transcranial magnetic stimulation (rTMS) treatment and to assess the correlation between FC changes and functional recovery, further characterizing the neural mechanisms underlying the beneficial effects of rTMS. We randomly divided 63 patients with acute stroke into four groups: (1) Group A received coupled inhibitory-facilitatory rTMS [1 Hz over the contralesional primary motor cortex (M1) and 10 Hz over ipsilesional M1]; (2) Group B received a contralesional sham stimulation an...
Source: Brain Research - June 2, 2022 Category: Neurology Authors: Qingmei Chen Wenjun Shen Haiwei Sun Hanjun Zhang Chuandao Liu Zhiguo Chen Liqiang Yu Xiuying Cai Jun Ke Li Li Lichi Zhang Qi Fang Source Type: research
Predicting the prognosis of unilateral spatial neglect using magnetic resonance imaging in patients with stroke: A systematic review
Brain Res. 2022 May 26;1789:147954. doi: 10.1016/j.brainres.2022.147954. Online ahead of print.ABSTRACTAccurate prognosis prediction of unilateral spatial neglect (USN) is clinically important for identifying patients with potentially poor recovery who require more intensive rehabilitation and early interdisciplinary support for residual disabilities. Magnetic resonance imaging (MRI)-based neuroimaging can provide clinicians with high-quality and high-resolution neuroanatomical information from the aspects of neuroanatomy, integrity of the neural tract, and neural functional connectivity. Although the application of MRI is...
Source: Brain Research - June 1, 2022 Category: Neurology Authors: Takeshi Imura Tsubasa Mitsutake Tomonari Hori Ryo Tanaka Source Type: research
Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats
Brain Res Bull. 2022 May 16;185:162-173. doi: 10.1016/j.brainresbull.2022.05.008. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH), a type of hemorrhagic stroke, is a neurological emergency with high morbidity and mortality. Early brain injury (EBI) after SAH is the leading cause of poor prognosis in SAH patients. TRX system is a NADPH-dependent antioxidant system which is composed of thioredoxin reductase (TRXR), thioredoxin (TRX). The pentose phosphate pathway (PPP), a pathway through which glucose can be metabolized, is a major source of NADPH. Thioredoxin 1 (TRX1) is a member of thioredoxin system mainly loc...
Source: Brain Research - May 19, 2022 Category: Neurology Authors: Xiaodong Wang Zongqi Wang Jie Wu Lingling Wang Xiang Li Haitao Shen Haiying Li Jianguo Xu Wen Li Gang Chen Source Type: research
Cortical mapping of active and passive upper limb training in stroke patients and healthy people: A functional near-infrared spectroscopy study
Brain Res. 2022 Apr 29:147935. doi: 10.1016/j.brainres.2022.147935. Online ahead of print.ABSTRACTActive exercise for upper limb training has been widely used to improve hemiplegic upper limb function, and its effect may be boosted by extrinsic visual feedback. The passive movement of the hemiplegic upper limb is also commonly used. We conducted a functional near-infrared spectroscopy experiment to compare cortical activation during the following three conditions: active left upper limb movement (on the hemiplegic sides in stroke patients), with or without extrinsic motor performance visual feedback (LAV, LAnV), and passiv...
Source: Brain Research - May 2, 2022 Category: Neurology Authors: Weili Xia Rongxia Dai Xiaojin Xu Baoyu Huai Zhongfei Bai Jiaqi Zhang Minxia Jin Wenxin Niu Source Type: research
