Filtered By:
Source: Brain Research
This page shows you your search results in order of date. This is page number 12.
Order by Relevance | Date
Total 501 results found since Jan 2013.
Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of Drp1 and reduces neuronal apoptosis in experimental subarachnoid hemorrhage both in vivo and in vitro
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00079-X. doi: 10.1016/j.brainresbull.2022.03.010. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH) is a hemorrhagic stroke with a high mortality and disability rate. Nitric oxide (NO) can promote blood supply through vasodilation, leading to protein S-nitrosylation. However, the function of S-nitrosylation in neurons after SAH remains unclear. Excessive NO in the pathological state is converted into S-nitrosoglutathione (GSNO) and stored in cells, which leads to high S-nitrosylation of intracellular proteins and causes nitrosative stress. S-nitrosoglutathione reductase (...
Source: Brain Research - March 19, 2022 Category: Neurology Authors: Lingling Wang Zongqi Wang Wanchun You Zhengquan Yu Xiang Li Haitao Shen Haiying Li Qing Sun Wen Li Gang Chen Source Type: research
Long-term iTBS promotes neural structural and functional recovery by enhancing neurogenesis and migration via miR-551b-5p/BDNF/TrkB pathway in a rat model of cerebral ischemia-reperfusion injury
Brain Res Bull. 2022 Mar 4:S0361-9230(22)00071-5. doi: 10.1016/j.brainresbull.2022.03.002. Online ahead of print.ABSTRACTAs a novel form of repetitive transcranial stimulation, intermittent theta burst stimulation (iTBS) has potentials to be widely used in patients with stroke. Yet little is known about the idiographic actions of iTBS with different stimulation parameters on rehabilitative aspects of stroke patients, nor is the molecular mechanism underlying. In the present study, effects of iTBS with different stimulation parameters were evaluate to identify the optimal protocol of iTBS against damage induced by ischemia/...
Source: Brain Research - March 8, 2022 Category: Neurology Authors: Linxiao Wang Yan Zhou Xia Chen Juan Liu Xihu Qin Source Type: research
Preserved Intersegmental Coordination During Locomotion after Cervical Spinal Cord Injury in Common Marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research
Normal aging affects unconstrained three-dimensional reaching against gravity with reduced vertical precision and increased co-contraction: a pilot study
Exp Brain Res. 2022 Feb 16. doi: 10.1007/s00221-021-06280-9. Online ahead of print.ABSTRACTReaching for an object in space forms the basis for many activities of daily living and is important in rehabilitation after stroke and in other neurological and orthopedic conditions. It has been the object of motor control and neuroscience research for over a century, but studies often constrain movement to eliminate the effect of gravity or reduce the degrees of freedom. In some studies, aging has been shown to reduce target accuracy, with a mechanism suggested to be impaired corrective movements. We sought to explore how such cha...
Source: Brain Research - February 16, 2022 Category: Neurology Authors: George F Wittenberg Jing Tian Nick Kortzorg Lore Wyers Florian Van Halewyck Matthieu P Boisgontier Oron Levin Stephan P Swinnen Ilse Jonkers Source Type: research
A passive exoskeleton can assist split-belt adaptation
Exp Brain Res. 2022 Feb 14. doi: 10.1007/s00221-022-06314-w. Online ahead of print.ABSTRACTAn exoskeletal device can assist walking in those with gait deficits. A passive exoskeleton can be a favorable choice for local or home rehabilitation settings because it is affordable, light weight, and less complex to utilize. While there is research that investigates the effects of exoskeleton on gait research examining the effects of such devices on gait adaptation, is rare. This is important because in diseases like stroke, the ability to flexibly adapt is affected, such that functional recovery becomes difficult. The purpose of...
Source: Brain Research - February 15, 2022 Category: Neurology Authors: Takashi Sado James Nielsen Brian Glaister Kota Z Takahashi Philippe Malcolm Mukul Mukherjee Source Type: research
Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2 α and XBP-1 pathways after stroke
Brain Res Bull. 2022 Feb 7:S0361-9230(22)00036-3. doi: 10.1016/j.brainresbull.2022.02.003. Online ahead of print.ABSTRACTStroke leads to disturbance in the physiology of the ER (Endoplasmic Reticulum) that triggers UPR (Unfolded Protein Response) pathways aimed to compensate neuronal cell damage. However, sustained UPR causes stressful conditions in the ER lumen forming abnormal protein aggregates. Stroke-induced oxidative stress also amalgamates with UPR to safeguard and ensure the proper functioning of brain cells. Thus we tested the effect of apocynin (a potent antioxidant) post-treatment in experimental stroke on the o...
Source: Brain Research - February 10, 2022 Category: Neurology Authors: Venkata Prasuja Nakka Raghu Gogada Praveen Kumar Simhadri Mohammed Abdul Qadeer Prakash Babu Phanithi Source Type: research
Can prior exposure to repeated non-paretic slips improve reactive responses on novel paretic slips among people with chronic stroke?
This study examined if people with chronic stroke (PwCS) could adapt following non-paretic overground gait-slips and whether such prior exposure to non-paretic slips could improve reactive responses on novel paretic slip. Forty-nine PwCS were randomly assigned to either adaptation group, which received eight unexpected, overground, nonparetic-side gait-slips followed by two paretic-side slips or a control group, which received two paretic-side slips. Slip outcome, recovery strategies, center of mass (CoM) state stability, post-slip stride length and slipping kinematics were analyzed. The adaptation group demonstrated fall-...
Source: Brain Research - February 2, 2022 Category: Neurology Authors: Shamali Dusane Tanvi Bhatt Source Type: research
GrpEL1 Regulates Mitochondrial Unfolded Protein Response after Experimental Subarachnoid Hemorrhage in vivo and in vitro
In conclusion, the reduced GrpEL1-mtHSP70 complex is an essential factor affecting UPRmt in EBI after SAH. Increasing GrpEL1 promotes GrpEL1 and mtHSP70 binding, promoting the neuronal mitochondrial homeostasis, and might be an essential clinical intervention target for EBI after SAH.PMID:35093469 | DOI:10.1016/j.brainresbull.2022.01.014
Source: Brain Research - January 30, 2022 Category: Neurology Authors: Chao Ma Bixi Gao Zongqi Wang Wanchun You Zhengquan Yu Haitao Shen Xiang Li Haiying Li Xuwei Zhang Zhong Wang Gang Chen Source Type: research
Effect of cognitive task complexity on dual task postural stability: a systematic review and meta-analysis
Exp Brain Res. 2022 Jan 16. doi: 10.1007/s00221-021-06299-y. Online ahead of print.ABSTRACTThe dual task experimental paradigm is used to probe the attentional requirements of postural control. However, findings of dual task postural studies have been inconsistent with many studies even reporting improvement in postural stability during dual tasking and thus raising questions about cognitive involvement in postural control. A U-shaped non-linear relationship has been hypothesized between cognitive task complexity and dual task postural stability suggesting that the inconsistent results might have arisen from the use of cog...
Source: Brain Research - January 16, 2022 Category: Neurology Authors: Abubakar Tijjani Salihu Keith D Hill Shapour Jaberzadeh Source Type: research
