Stroke RSS Page 9

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Source: Brain Research

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Total 501 results found since Jan 2013.

RNA sequencing uncover crucial genes mediating progression of large-artery atherosclerotic and small-artery occlusion ischemic stroke
CONCLUSION: This finding may help to understand the mechanisms of LAAIS and SAOIS and offer novel clues for finding specific biomarkers for LAAIS and SAOIS.PMID:36096198 | DOI:10.1016/j.brainres.2022.148078
Source: Brain Research - September 12, 2022 Category: Neurology Authors: Zhaolin Chen Duncai Wei Xiaopu Chen Yinting Huang Zibin Shen Wenzhen He Source Type: research

Retraction notice to "Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3" Brain Res. Bull. 172 (2021) 220-228
Brain Res Bull. 2022 Sep 9;189:153. doi: 10.1016/j.brainresbull.2022.09.005. Online ahead of print.NO ABSTRACTPMID:36095955 | DOI:10.1016/j.brainresbull.2022.09.005
Source: Brain Research - September 12, 2022 Category: Neurology Authors: Zhibing Ai Chaohui Cheng Lan Zhou Songhe Yin Lei Wang Yong Liu Source Type: research

The relationship between pulse pressure with plasma PCSK9 and interleukin-6 among patients with acute ischemic stroke and dyslipidemia
CONCLUSIONS: Our findings indicated that plasma PCSK9 levels were associated with the low PP subgroup, while IL-6 was associated with the high PP subgroup. Dyslipidemia control is also necessary for those who had a stroke and who have high PP. Further investigation to assess the role of PCSK9 and IL-6 in patients with stroke is required for early treatment and secondary prevention.PMID:36088960 | DOI:10.1016/j.brainres.2022.148080
Source: Brain Research - September 11, 2022 Category: Neurology Authors: Chen-Shu Chang Chen-Ling Kuo Ching-Shan Huang Yu-Shan Cheng Song-Shei Lin Chin-San Liu Source Type: research

Retraction notice to "Long non-coding RNA GAS5 retards neural functional recovery in cerebral ischemic stroke through modulation of the microRNA-455-5p/PTEN axis" Brain Res. Bull., volume 167 (2021) Pages 80-88
Brain Res Bull. 2022 Sep 5;189:151. doi: 10.1016/j.brainresbull.2022.09.001. Online ahead of print.NO ABSTRACTPMID:36075129 | DOI:10.1016/j.brainresbull.2022.09.001
Source: Brain Research - September 8, 2022 Category: Neurology Authors: Rile Wu Qiang Yun Jianping Zhang Jingang Bao Source Type: research

Force acquisition frequency is less impaired compared to grip strength or hand dexterity in individuals with chronic stroke
Exp Brain Res. 2022 Aug 19. doi: 10.1007/s00221-022-06432-5. Online ahead of print.ABSTRACTDespite numerous studies that show force regulation is impaired after stroke, two recent studies suggest that the ability to regulate submaximal, isometric grip forces may remain substantially intact. Here we asked how this aspect of hand motor control, measured for both a power grip and pinch grip, compares to two other key aspects of hand function-grip strength and dexterity. For 20 individuals with a range of hand impairment levels in the chronic phase of stroke (Age: 62 ± 16.0 years, Time post stroke: 958.3 ± 966.5 days, Sex: 1...
Source: Brain Research - August 19, 2022 Category: Neurology Authors: Quentin Sanders Vicky Chan Oliver Stoller David Reinkensmeyer Source Type: research

Treadmill exercise decreases cerebral edema in rats with local cerebral infarction by modulating AQP4 polar expression through the caveolin-1/TRPV4 signaling pathway
This study investigated the influence of treadmill exercise on brain edema and the mechanism of its formation and elimination. The MCAO model was established with Sprague-Dawley (SD) rats, and lentivirus-mediated caveolin-1 shRNA was used to investigate the role of caveolin-1 in brain edema. As expected, we found that treadmill exercise has a beneficial effect on brain edema after stroke. Training led to a significant increase in the expression of caveolin-1 and TRPV4; and reduced brain water content and blood-brain barrier (BBB) damage. This treatment also changed the localization of aquaporin-4 (AQP4). Moreover, the effe...
Source: Brain Research - August 12, 2022 Category: Neurology Authors: Anqi Zhu Yao Lin Xuanbo Hu Zaizai Lin Yongqiang Lin Qingfeng Xie Shaobo Ni Hui Cheng Qiaoya Lu Shanshan Lai Guoyuan Pan Xiang Chen Wei Pang Chan Liu Source Type: research

Preconditioning exercise reduces hippocampal neuronal damage via increasing Klotho expression in ischemic rats
In this study, we assessed neuroprotective effects of preconditioning exercise in rats (treadmill running at a speed of 20m/min,30min/day, six days/week, for3 weeks) on hippocampal Klotho and MnSOD expression in the brain using an animal model of stroke, middle cerebral artery occlusion (MCAO). Our study revealed a reduction in hippocampal Klotho and MnSOD expression as well as CA1 neuronal activity in MCAO compared to the sham group. Exercise prevented the ischemia-induced decline in Klotho and MnSOD expression levels as well as CA1 neuronal activity in Exercise + MCAO compared to the MCAO group. Also, exercise significan...
Source: Brain Research - August 2, 2022 Category: Neurology Authors: Maryam Soleimani Karizmeh Maryam Shabani Mostafa Shabani Maryam Sardari Javad Fahanik Babaei Fatemeh Nabavizadeh Seyed Shahabeddin Sadr Soheila Adeli Source Type: research

Close association between spreading depolarization and development of infarction under experimental ischemia in anesthetized male mice
In conclusion, our findings suggest that the occurrence of SD during ischemia might elicit infarct formation and/or influence infarct development.PMID:35901965 | DOI:10.1016/j.brainres.2022.148023
Source: Brain Research - July 28, 2022 Category: Neurology Authors: Miyuki Unekawa Yutaka Tomita Kazuto Masamoto Iwao Kanno Jin Nakahara Yoshikane Izawa Source Type: research

Storax Protected Primary Cortical Neurons from Oxygen-Glucose Deprivation/Reoxygenation Injury via Inhibiting the TLR4/TRAF6/NF- κB Signaling Pathway
This study aimed to elucidate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The cortical neurons of Wistar rats were primarily cultured in vitro. TheTUNELmethod and CM-H2DCFDA probe were used to detect cell apoptosis and reactive oxygen species (ROS) expression. Enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot were used to detect the expression of inflammatory cytokines and proteins of the TLR4/TRAF6/NF-κB signaling pathway. Immunofluorescence was used to measure NF-κB nuc...
Source: Brain Research - July 25, 2022 Category: Neurology Authors: Lin Li Shaoqian Yue Rui Han Yajun Yu Peng Zhang Ling Lv Jinqiang Zhu Min Zhou Xiang Fan Han Zhang Source Type: research

Bimanual coordination during reach-to-grasp actions is sensitive to task goal with distinctions between left- and right-hemispheric stroke
Exp Brain Res. 2022 Jul 23. doi: 10.1007/s00221-022-06419-2. Online ahead of print.ABSTRACTThe perceptual feature of a task such as how a task goal is perceived influences performance and coordination of bimanual actions in neurotypical adults. To assess how bimanual task goal modifies paretic and non-paretic arm performance and bimanual coordination in individuals with stroke affecting left and right hemispheres, 30 participants with hemispheric stroke (15 right-hemisphere damage-RHD); 15 left-hemisphere damage-LHD) and 10 age-matched controls performed reach-to-grasp and pick-up actions under bimanual common-goal (i.e., ...
Source: Brain Research - July 23, 2022 Category: Neurology Authors: Tessa Johnson Gordon Ridgeway Dustin Luchmee Joshua Jacob Shailesh Kantak Source Type: research

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