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Source: Brain Research
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Total 501 results found since Jan 2013.
Effectiveness and Electrophysiological Mechanisms of Focal Vibration on Upper Limb Motor Dysfunction in Patients with Subacute Stroke: A Randomized Controlled Trial
This study showed that FV was effective in improving upper limb motor function in subacute stroke patients. The underlying mechanism of FV may be that it enhances the efficacy of sensory pathways and induces plastic changes in the sensorimotor cortex.PMID:36990135 | DOI:10.1016/j.brainres.2023.148353
Source: Brain Research - March 29, 2023 Category: Neurology Authors: Lian Wang Saihua Wang Song Zhang Zulin Dou Tiecheng Guo Source Type: research
Differences in the prefrontal cortex responses of healthy young men performing either water-based or land-based exercise at light to moderate intensity
Exp Brain Res. 2023 Mar 21. doi: 10.1007/s00221-023-06583-z. Online ahead of print.ABSTRACTCerebral blood flow increases more during water-based exercise than land-based exercise owing to the effects of end-tidal CO2 (PETCO2) and mean arterial pressure (MAP) changes due to water immersion. However, it is unclear whether oxygenated hemoglobin (oxy-Hb) concentrations in the prefrontal cortex (PFC) are increased more by water-based or land-based exercise. We hypothesized that oxy-Hb concentrations in the PFC are higher during water-based exercise than land-based exercise when the exercise intensity is matched. To test this hy...
Source: Brain Research - March 21, 2023 Category: Neurology Authors: Tatsuya Hashitomi Daisuke Hoshi Marina Fukuie Takashi Tarumi Jun Sugawara Koichi Watanabe Source Type: research
The role of T cells in acute ischemic stroke
Brain Res Bull. 2023 Mar 9:S0361-9230(23)00055-2. doi: 10.1016/j.brainresbull.2023.03.005. Online ahead of print.ABSTRACTAcute ischemic stroke (AIS) is associated with high rates of disability and mortality, exerting a substantial impact on overall survival and health-related quality of life. Treatment of AIS remains challenging given that the underlying pathologic mechanisms remain unclear. However, recent research has demonstrated that the immune system plays a key role in the development of AIS. Numerous studies have reported infiltration of T cells into ischemic brain tissue. While some types of T cells can promote the...
Source: Brain Research - March 11, 2023 Category: Neurology Authors: Yi-Ran Wang Wen-Qiang Cui Hong-Yun Wu Xiang-Dong Xu Xiang-Qing Xu Source Type: research
Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the NAc...
Source: Brain Research - February 28, 2023 Category: Neurology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoud Reza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research
Epigenetic modifications in the motor cortex caused by exercise or pharmacological inhibition of histone deacetylases (HDACs) after intracerebral hemorrhage (ICH)
This study sought to examine the effect of epigenetic treatment using a histone deacetylase (HDAC) inhibitor, sodium butyrate (NaB), and exercise on epigenetic markers in the bilateral motor cortex after intracerebral hemorrhage (ICH) to identify a more enriched neuronal condition for neurorehabilitation. Forty-one male Wistar rats were randomly divided into five groups: sham (n=8), control (n=9), NaB, exercise (n=8), and NaB and exercise (n=8). Intraperitoneal administration of an HDAC inhibitor (300 mg/kg NaB) and treadmill exercise (11 m/min for 30 min) was conducted five days a week for approximately four weeks. ICH sp...
Source: Brain Research - February 21, 2023 Category: Neurology Authors: Hiroshi Maejima Misato Okamura Takahiro Inoue Yasuyuki Takamatsu Taichi Nishio Yushan Liu Source Type: research
Abnormal resting-state function within language network and its improvement among post-stroke aphasia
Behav Brain Res. 2023 Feb 11:114344. doi: 10.1016/j.bbr.2023.114344. Online ahead of print.ABSTRACTSeveral studies with resting-state magnetic resonance imaging (rs-fMRI) have examined functional impairments and plasticity within language network in patients with post-stroke aphasia (PSA). However, there is still ubiquitous inconsistency across these studies, partly due to restricted to very small sample size and the absence of validation with follow-up data. In the current study, we aimed at providing relatively strong evidence to support functional impairments and its reorganization in PSA. Here, the amplitude of low fre...
Source: Brain Research - February 13, 2023 Category: Neurology Authors: Xiaohui Xie Panpan Hu Yanghua Tian Bensheng Qiu Kai Wang Tongjian Bai Source Type: research
Carnosol Inhibits Cerebral Ischemia-Reperfusion Injury by Promoting AMPK Activation
CONCLUSION: Carnosol has a protective effect on ischemic stroke, and this effect is achieved through AMPK activation. Our study demonstrates the protective effect of carnosol on cerebral ischemia-reperfusion injury and provides a new perspective for the clinical treatment of ischemic stroke.PMID:36775042 | DOI:10.1016/j.brainresbull.2023.02.003
Source: Brain Research - February 12, 2023 Category: Neurology Authors: Wen-Chang Xiao Gang Zhou Lu Wan Jun Tu Yong-Jie Yu Zhi-Gang She Chun-Lin Xu Lei Wang Source Type: research
Thiolutin attenuates ischemic stroke injury via inhibition of NLRP3 inflammasome: an in vitro and in vivo study
Exp Brain Res. 2023 Feb 7. doi: 10.1007/s00221-023-06566-0. Online ahead of print.ABSTRACTA recent study confirmed that thiolutin is effective in the treatment of nucleotide-binding domain-like receptor protein 3 (NLRP3)-related inflammatory diseases. Nevertheless, whether thiolutin (THL) is involved in the regulation of NLRP3 inflammasome in ischemic stroke is not known. The murine neuronal cell oxygen-glucose deprivation (OGD) model was first established, and then different concentrations (25 nM and 50 nM) of THL were administered for 48 h incubation, respectively. Subsequently, cell viability and toxicity, and the level...
Source: Brain Research - February 7, 2023 Category: Neurology Authors: Yujie Jia Kun Xue Ying Luo Chang Liu Source Type: research
The relationship between the prefrontal cortex and limb motor function in stroke: A study based on resting-state functional near-infrared spectroscopy
CONCLUSION: These study results showed that stroke can cause cerebral haemodynamic changes in the PFC, and the functional imbalance of the left and right PFC in the resting state is correlated with the severity of limb motor dysfunction. Furthermore, we emphasize that the cerebral haemodynamic activity reflected by fNIRS could be used as a reliable neural biomarker for assessing limb motor dysfunction in stroke.PMID:36736871 | DOI:10.1016/j.brainres.2023.148269
Source: Brain Research - February 3, 2023 Category: Neurology Authors: Dan Wang Jie Wang Hongbo Zhao Yahui Liang Wenyue Zhang Mingxi Li Hua Liu Di Hu Sibin Zhang Enlong Xing Ying Su Wanchen Yu Jinyan Sun Aoran Yang Source Type: research
Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis
Exp Brain Res. 2023 Feb 3. doi: 10.1007/s00221-023-06555-3. Online ahead of print.ABSTRACTThe pivotal regulatory role of circular RNAs (circRNAs) in ischemic stroke (IS) has been expounded. The study aimed to probe the exact role and underlying mechanism of circVRK1 in oxygen-glucose deprivation (OGD)-induced human brain microvascular endothelial cells (HBMECs) injury. HBMECs challenged by OGD were used as in vitro models of IS. Quantitative real-time PCR was used to examine the levels of circVRK1, vaccinia-related kinase 1 (VRK1), miR-150-5p and MLLT1 mRNA. Cell viability, migration angiogenesis ability and death were eva...
Source: Brain Research - February 3, 2023 Category: Neurology Authors: Lina Tan Lingjun Wang Jiajun Liu Yue Yu Source Type: research
