Stroke RSS Page 11

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Source: Brain Research

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Total 501 results found since Jan 2013.

Cortical mapping of active and passive upper limb training in stroke patients and healthy people: A functional near-infrared spectroscopy study
Brain Res. 2022 Apr 29:147935. doi: 10.1016/j.brainres.2022.147935. Online ahead of print.ABSTRACTActive exercise for upper limb training has been widely used to improve hemiplegic upper limb function, and its effect may be boosted by extrinsic visual feedback. The passive movement of the hemiplegic upper limb is also commonly used. We conducted a functional near-infrared spectroscopy experiment to compare cortical activation during the following three conditions: active left upper limb movement (on the hemiplegic sides in stroke patients), with or without extrinsic motor performance visual feedback (LAV, LAnV), and passiv...
Source: Brain Research - May 2, 2022 Category: Neurology Authors: Weili Xia Rongxia Dai Xiaojin Xu Baoyu Huai Zhongfei Bai Jiaqi Zhang Minxia Jin Wenxin Niu Source Type: research

Xueshuantong injection combined with Salvianolate lyophilized injection improves the synaptic plasticity against focal cerebral ischemia/ reperfusion injury in rats through PI3K/ AKT/ mTOR and RhoA/ROCK pathways
In this study, we investigated the neuroprotective effects of XST combined with SLI in the recovery stage of middle cerebral artery occlusion / reperfusion (MCAO/R) injury rat. Wistar rats were subjects to MCAO/R, then were treated with SLI or XST alone, or with their combination (1X1S) via tail injection daily for 14 days. The pathological status of the brain was detected by neurological deficit scores, TTC, regional cerebral blood flow and Nissl staining. Golgi-Cox staining was used to assess dendritic, axonal and synaptic remodeling. The expression of MAP-2, β-Tubulin, PSD95, SYN, BDNF and VEGF were analyzed by western...
Source: Brain Research - April 24, 2022 Category: Neurology Authors: Qing Yuan Fu-Jiang Wang Zhuang-Zhuang Jia Tong Zhang Jin Sun Xin-Yuan Du Shao-Xia Wang Li-Juan Chai Li-Min Hu Source Type: research

LncRNA NEAT1 stabilized Wnt3a via U2AF2 and activated Wnt/ β-catenin pathway to alleviate ischemia stroke induced injury
CONCLUSIONS: LncRNA NEAT1 protected cells against OGD/R-induced apoptosis and the inflammatory response by activating the Wnt/β-catenin pathway through upregulation of Wnt3a in a U2AF2-dependent manner. LncRNA NEAT1 could be a promising therapeutic candidate for ischaemic stroke treatment in the future.PMID:35452660 | DOI:10.1016/j.brainres.2022.147921
Source: Brain Research - April 22, 2022 Category: Neurology Authors: Zhiwen Zhou Xiang Ren Lijun Zheng Aiping Li Wensheng Zhou Source Type: research

Influence of task complexity on movement planning and release after stroke: insights from startReact
This study highlights the unique potential for startReact to be used as a clinical tool to probe the capacity to plan and release movement following stroke and how that capacity is affected by the complexity of the task being performed. Such a tool may be useful for assessing functional impairments and tracking changes during the rehabilitation process.PMID:35445354 | DOI:10.1007/s00221-022-06368-w
Source: Brain Research - April 21, 2022 Category: Neurology Authors: Hyunglae Lee Claire Honeycutt Eric Perreault Source Type: research

Effect of retinoic acid on the neurovascular unit: A review
Brain Res Bull. 2022 Mar 26:S0361-9230(22)00080-6. doi: 10.1016/j.brainresbull.2022.03.011. Online ahead of print.ABSTRACTRetinoic acid is a metabolic product derived from vitamin A, acting at a nuclear level to maintain the proper transcriptional activity. Moreover, this molecule contributes to the development and maturation of the cerebral vascular system, playing a pivotal role in development and maintenance of neurovascular unit integrity. This physiological structure is comprised of glial cells, vascular cells, and neurons, ensuring the correct function of the blood-brain barrier and, at last instance, the homeostasis...
Source: Brain Research - March 30, 2022 Category: Neurology Authors: Manuel R Pouso Elisa Cairrao Source Type: research

Attenuation of histone H4 lysine 16 acetylation (H4K16ac) elicits a neuroprotection against ischemic stroke by alleviating the autophagic/lysosomal dysfunction in neurons at the penumbra
Brain Res Bull. 2022 Mar 26:S0361-9230(22)00082-X. doi: 10.1016/j.brainresbull.2022.03.013. Online ahead of print.ABSTRACTA modest autophagy benefits neuroprotection while an excessive autophagy leads to neuronal death after cerebral ischemia, but what governs an appropriate autophagy remains to be understood. Studies indicated that acetylation of histone H4 at lysine16 (H4K16ac) strongly modulated autophagic/lysosomal signaling pathway. Thus, this study was to investigate whether the autophagic neuronal injury could be alleviated by amending H4K16ac level after ischemic stroke. A rat model of middle cerebral artery occlus...
Source: Brain Research - March 30, 2022 Category: Neurology Authors: Dong Lingling Qiu Miaomiao Liu Yili He Hongyun Deng Yihao Source Type: research

Sex and age dimorphism of the gut-brain axis in ischemic stroke: a systematic review of preliminary studies
Brain Res. 2022 Mar 18:147888. doi: 10.1016/j.brainres.2022.147888. Online ahead of print.ABSTRACTRecent studies have shown that stroke risk and outcomes are influenced by the microbiota composition and its strict relationship with the immune system. Age and sex are the main non-modifiable factors that shape microbiome composition. In order to evaluate the effects of these two variables on the microbiome in stroke pathogenesis we performed a systematic review of literature, including 10 studies in the final selection. In the critical analysis of data we focused on three aspects: gut permeability, molecular mediators (both ...
Source: Brain Research - March 22, 2022 Category: Neurology Authors: Giorgio Guido Elisa Crivellaro Giulia De Fortunato Lorenzo Melloni Source Type: research

Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00077-6. doi: 10.1016/j.brainresbull.2022.03.008. Online ahead of print.ABSTRACTIschemic stroke in rodents is usually induced by intraluminal occlusion of the middle cerebral artery (MCA) via the external carotid artery (ECA) or the common carotid artery (CCA). The latter route requires permanent CCA occlusion after ischemia, and here, we assess its effects on long-term outcomes. Transient occlusion of MCA and CCA was performed at normal body temperature. After 90minutes of ischemia, mice were randomized to permanent CCA occlusion or no occlusion (control group). Body weight, and m...
Source: Brain Research - March 19, 2022 Category: Neurology Authors: Zhong Yang Xuan Li Zhipeng Cao Peng Wang David S Warner Huaxin Sheng Source Type: research

Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of Drp1 and reduces neuronal apoptosis in experimental subarachnoid hemorrhage both in vivo and in vitro
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00079-X. doi: 10.1016/j.brainresbull.2022.03.010. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH) is a hemorrhagic stroke with a high mortality and disability rate. Nitric oxide (NO) can promote blood supply through vasodilation, leading to protein S-nitrosylation. However, the function of S-nitrosylation in neurons after SAH remains unclear. Excessive NO in the pathological state is converted into S-nitrosoglutathione (GSNO) and stored in cells, which leads to high S-nitrosylation of intracellular proteins and causes nitrosative stress. S-nitrosoglutathione reductase (...
Source: Brain Research - March 19, 2022 Category: Neurology Authors: Lingling Wang Zongqi Wang Wanchun You Zhengquan Yu Xiang Li Haitao Shen Haiying Li Qing Sun Wen Li Gang Chen Source Type: research

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