LncRNA NEAT1 stabilized Wnt3a via U2AF2 and activated Wnt/ β-catenin pathway to alleviate ischemia stroke induced injury

CONCLUSIONS: LncRNA NEAT1 protected cells against OGD/R-induced apoptosis and the inflammatory response by activating the Wnt/β-catenin pathway through upregulation of Wnt3a in a U2AF2-dependent manner. LncRNA NEAT1 could be a promising therapeutic candidate for ischaemic stroke treatment in the future.PMID:35452660 | DOI:10.1016/j.brainres.2022.147921
Source: Brain Research - Category: Neurology Authors: Source Type: research