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Source: Brain Research
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Total 501 results found since Jan 2013.
Injectable biomaterial shuttles for cell therapy in stroke
Brain Res Bull. 2021 Aug 12:S0361-9230(21)00242-2. doi: 10.1016/j.brainresbull.2021.08.002. Online ahead of print.ABSTRACTIschemic stroke (IS) is the leading cause of disability and contributes to a significant socio-economic cost in the western world. Brain repair strategies investigated in the pre-clinical models include the delivery of drug or cell-based therapeutics; which is hindered by the complex anatomy and functional organization of the brain. Biomaterials can be instrumental in alleviating some of these challenges by providing a structural support, localization, immunomodulation and/or modulating cellular cross-t...
Source: Brain Research - August 15, 2021 Category: Neurology Authors: Juhi Samal Tatiana Segura Source Type: research
c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression
CONCLUSION: Overall, c-myc protects mice from IS through elevating miR-200b-5p-targeted SIRT1 expression.PMID:34371139 | DOI:10.1016/j.brainresbull.2021.07.006
Source: Brain Research - August 9, 2021 Category: Neurology Authors: Xiaodan Liu Heng Guo Xiao Wang Hong Jiao Lei Li Jiaolin Zheng Source Type: research
Specific stimulation of PV < sup > + < /sup > neurons at early stage ameliorates prefrontal ischemia-induced spatial working memory impairment
Behav Brain Res. 2021 Aug 3:113511. doi: 10.1016/j.bbr.2021.113511. Online ahead of print.ABSTRACTPrefrontal ischemia can cause impairments in learning and memory, executive functions and cognitive flexibility. However, the related cellular mechanisms at the early stage are still elusive. The present study used ischemic stroke in medial prefrontal cortex and systemically investigated the electrophysiological changes of the parvalbumin (PV+) interneurons 12 h post ischemia. We found that Ih and the related voltage sags in PV+ interneurons are downregulated post ischemia, which correlates with hyperpolarization of the membra...
Source: Brain Research - August 6, 2021 Category: Neurology Authors: Lin Chen Jun Hu Jiankun Mu Chao Li Guang-Yan Wu Chao He Youhong Xie Jian-Ning Ye Source Type: research
Case-Fatality, Disability and Recurrence Rates After First-ever Stroke: a study from Bigdata Observatory Platform for Stroke of China
CONCLUSION: Our results support the hypothesis that the prognosis of Chinese stroke patients appears to have improved and is not very bad.PMID:34329730 | DOI:10.1016/j.brainresbull.2021.07.020
Source: Brain Research - July 30, 2021 Category: Neurology Authors: Wen-Jun Tu Bao-Hua Chao Lin Ma Feng Yan Lei Cao Hancheng Qiu Xun-Ming Ji Long-De Wang Source Type: research
Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats
This study aimed to evaluate the effect of different combinations of rTMS and cognitive training (rTMS-COG) on PSCI and identify the optimal combination protocol. A cerebral infarction rat model was established by transient middle cerebral artery occlusion (tMCAO). The Morris water maze test was conducted to assess the cognitive function of rats. RNA sequencing and bioinformatics analysis were employed to study the underlying mechanisms. rTMS, COG and rTMS-COG all had beneficial effects on PSCI, while cognitive training immediately after rTMS (rTMS-COG0h) achieved a better effect than cognitive training 1 h and 4 h after r...
Source: Brain Research - July 19, 2021 Category: Neurology Authors: Jiena Hong Jiemei Chen Yan Zeng Xue Zhang Mengshu Xie Chao Li Hongmei Wen Source Type: research
Long non-coding RNA MIAT impairs neurological function in ischemic stroke via up-regulating microRNA-874-3p-targeted IL1B
CONCLUSION: Shortly, this study figures out that MIAT impairs neurological function in IS via up-regulating miR-874-3p-targeted IL1B.PMID:34265390 | DOI:10.1016/j.brainresbull.2021.07.005
Source: Brain Research - July 15, 2021 Category: Neurology Authors: Shuai Zhang Yue Zhang Na Wang Yu Wang Huan Nie Yueyue Zhang Huiying Han Shan Wang Wenjuan Liu Chunrui Bo Source Type: research
Association between GFAP-positive astrocytes with clinically important parameters including neurological deficits and/or infarct volume in stroke-induced animals
Brain Res. 2021 Jul 5:147566. doi: 10.1016/j.brainres.2021.147566. Online ahead of print.ABSTRACTThe effect of GFAP-positive astrocytes, as positive or negative factors on stroke complications such as infarct volume and neurological deficits is currently under debate. This review was aimed to evaluate and compare the frequency of studies that showed a positive or negative relationship between astrocyte activation with the improvement of neurological deficits and/or the decrease of infarct volume. In addition, we reviewed two possible causes of differences in results including timepoint of stroke and stroke severity. Time o...
Source: Brain Research - July 8, 2021 Category: Neurology Authors: Kobra Akhoundzadeh Sakineh Shafia Source Type: research
Downregulation of lncRNA SNHG14 alleviates neurons injury by modulating the miR-181c-5p/BMF axis in ischemic stroke
CONCLUSION: Our results indicated that SNHG14 promoted neurons injury through the regulation of miR-181c-5p/BMF axis, suggesting that SNHG14 might be a potential target to alleviate IS-induced brain injury.PMID:34224818 | DOI:10.1016/j.brainresbull.2021.06.026
Source: Brain Research - July 5, 2021 Category: Neurology Authors: Xiancong Bu Yuhua Zhao Meizhi Chang Xuchun Ge Source Type: research
Orexin-A inhibits cerebral ischaemic inflammatory injury mediated by the nuclear factor- κB signalling pathway and alleviates stroke-induced immunodepression in mice
Brain Res Bull. 2021 Jun 30:S0361-9230(21)00195-7. doi: 10.1016/j.brainresbull.2021.06.021. Online ahead of print.ABSTRACTCerebral ischaemia is accompanied by infectious complications due to immunosuppression, known as stroke-induced immunodepression (SIID). Orexin-A (OXA), a neuropeptide produced in the hypothalamus, has been reported to have neuroprotective properties after stroke and is known to modulate inflammatory processes in peripheral tissues. The aim of this study was to determine the effects of orexin-A (OXA) on cerebral ischaemic inflammatory injury and SIID following experimental stroke. Cerebral ischaemia was...
Source: Brain Research - July 3, 2021 Category: Neurology Authors: Dong Zhao Zhaofu Zeng Huaheng Mo Weihua Hu Sumei Tian Die Hu Lin Gong Ke Hu Source Type: research
Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: a snapshot of their underlying mechanisms
Brain Res Bull. 2021 Jun 30:S0361-9230(21)00194-5. doi: 10.1016/j.brainresbull.2021.06.020. Online ahead of print.ABSTRACTRehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & Mey., and Gardenia, the fruit of Gardenia jasminoides Ellis from Rubiaceae, both are famous traditional Chinese medicines that have been traditionally used in China. Catalpol and geniposide, as two kinds of iridoid glycosides with high activities, are the main bioactive components in Rehmannia glutinosa and Gardenia jasminoides Ellis, respectively. Over the past few decades, catalpol and geniposide hav...
Source: Brain Research - July 3, 2021 Category: Neurology Authors: Xumin Zhang Kai Liu Mingyi Shi Long Xie Mao Deng Huijuan Chen Xiaofang Li Source Type: research
Characteristics of rectus femoris activation and rectus femoris-hamstrings coactivation during force-matching isometric knee extension in subacute stroke
Exp Brain Res. 2021 Jul 2. doi: 10.1007/s00221-021-06162-0. Online ahead of print.ABSTRACTThe spectral properties of surface electromyographic (EMG) signal in the rectus femoris (RF) and the coactivation in the medial hamstrings (MH) were investigated in 45 stroke subjects (22 ± 12 days post-onset) and 30 age-matched healthy controls who performed unilateral knee extensions at maximum effort (100% MVC) and during 5-s force-matching tasks (10, 30, 50% MVC). The spectral properties were obtained through a power spectrum analysis based on Fast Fourier Transform. The coactivation was measured as the MH amplitude (%max) and MH...
Source: Brain Research - July 2, 2021 Category: Neurology Authors: John W Chow Dobrivoje S Stokic Source Type: research
Per- and post-remote ischemic conditioning attenuates ischemic brain injury via inhibition of the TLR4/MyD88 signaling pathway in aged rats
In this study, we aim to investigate whether RIC performed either during brain ischemia or after reperfusion has a protective effect and further explore the mechanistic basis for the protective effects of RIC against IRI in an aged rat model. We investigated brain IRI in 16-18 months old SD rats. Animals underwent: (i) sham laparotomy, (ii) brain IRI, (iii) brain IRI + RIC during ischemia (IRI + RIperC), or (iv) brain IRI + RIC after reperfusion (IRI + RIpostC). RIC consists of three cycles of 10 min of hind limb ischemia followed by 10 min reperfusion. After 24 h of reperfusion, the infarct size, neurological deficit scor...
Source: Brain Research - June 29, 2021 Category: Neurology Authors: Jinglei Lv Wenjing Yan Jie Zhou Haitao Pei Renliang Zhao Source Type: research
The 2-(2-Benzofuranyl)-2-imidazoline provides neuroprotection against focal cerebral ischemia-reperfusion injury in diabetic rats: Influence of microglia and possible mechanisms of action
Brain Res Bull. 2021 Jun 24:S0361-9230(21)00190-8. doi: 10.1016/j.brainresbull.2021.06.016. Online ahead of print.ABSTRACTIncreased microglial NADPH oxidase (NOX2) production may make an important contribution to the increased incidence and severity of ischemic stroke associated with diabetes. Imidazoline receptors are closely associated with neuroprotection, but the neuroprotective effects of the selective I2-imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline (2BFI) in diabetes has not been established. The effect of 2BFI on microglial NOX2 production was investigated using a co-culture of neurons and microglia,...
Source: Brain Research - June 27, 2021 Category: Neurology Authors: Hongjie Xi Tao Tao Ruru Zhang Xinxin Xue Yana Zhu Jiuyang Liu Xianyi Xin Xianzhang Zeng Source Type: research
