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Infectious Disease: Meningitis
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Total 171 results found since Jan 2013.
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Inj...
Source: The Lancet Neurology - March 16, 2019 Category: Neurology Source Type: research
Ischemic stroke and infectious diseases in low-income and middle-income countries
Purpose of review
To address the important relationships between stroke and infection, focusing on the most frequent infections found in low-income and middle-income countries.
Recent findings
Stroke is one of the leading causes of mortality and disability worldwide, with a great proportion of the stroke burden occurring in low-income and middle-income countries. Infectious diseases are still a great health problem in developing countries and it is possible that the proportion of infection-related strokes is greater in these nations. Infectious diseases and stroke have a bidirectional relationship. Common infections m...
Source: Current Opinion in Neurology - January 13, 2019 Category: Neurology Tags: CEREBROVASCULAR DISEASE: Edited by Didier Leys Source Type: research
Lumbar drain trial outcomes of normal pressure hydrocephalus: a single-center experience of 254 patients.
CONCLUSIONSThe LD trial is generally safe and well tolerated. The best predictors of passing the LD trial include a negative history of stroke and having disproportionate subarachnoid spaces.
PMID: 30611143 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 4, 2019 Category: Neurosurgery Authors: El Ahmadieh TY, Wu EM, Kafka B, Caruso JP, Neeley OJ, Plitt A, Aoun SG, Olson DM, Ruchinskas RA, Cullum CM, Barnett S, Welch BG, Batjer HH, White JA Tags: J Neurosurg Source Type: research
Cardiac surgery in infective endocarditis with neurological complications: Identifying prognosis risk factors in mortality and handicap at 6 months
ConclusionMain risk factors of death or handicap at six month, after a cardiac surgery in context of IE with neurological complication were hemodynamic presentation, micro organism and diabetes.
Source: Archives of Cardiovascular Diseases Supplements - December 25, 2018 Category: Cardiology Source Type: research
Hydroxyurea Therapy Does Not Impact Current Survival Estimates in the East London Sickle Cell Newborn Cohort Study
Conclusions: The study is the first to evaluate survival in a newborn cohort past the age of 20 years. We have confirmed a low mortality rate in childhood, but increased number of deaths in young adults including those with HbSC. This study provides evidence of the benefit of newborn screening and comprehensive care which is accessible at all ages, free of charge. The uptake of HU, particularly at a young age, has been low and a positive effect of HU on survival as described in other studies has not yet been observed in this cohort. Earlier initiation of disease-modifying treatment and longer-term follow-up will be require...
Source: Blood - November 21, 2018 Category: Hematology Authors: Telfer, P., Kaya, B., Tsitsikas, D. A., Barroso, F., Sangarappillai, C. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster III Source Type: research
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium ‐pilocarpine‐induced status epilepticus
ConclusionsGlycyrrhizin may exert neuroprotective effects via inhibiting HMGB1 and protect BBB permeability in lithium ‐pilocarpine‐induced rats with SE.
Source: Journal of Pharmacy and Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Ya ‐jun Li,
Lin Wang,
Bei Zhang,
Fei Gao,
Chun‐Mei Yang Tags: Research Paper Source Type: research
Stroke in pediatric bacterial meningitis: Population-based epidemiology
Bacterial meningitis is a severe infection of the nervous system with a high complication rate including stroke. The purpose of this study is to assess the incidence, risk factors, patterns and outcomes in pediatric meningitis complicated by stroke.
Source: Pediatric Neurology - September 21, 2018 Category: Neurology Authors: Mary Dunbar, Hely Shah, Siddharth Shinde, Joseph Vayalumkal, Otto G. Vanderkooi, Xing-Chang Wei, Adam Kirton Tags: Original Articles Source Type: research
Hypovolemia due to cerebral salt wasting may contribute to stroke in tuberculous meningitis
ConclusionIn TBM, stroke occurred in 39.5% of the patients, 50% of whom had CSW. Volume contraction due to CSW may contribute to stroke.
Source: QJM - April 9, 2018 Category: Internal Medicine Source Type: research
Feasibility of endoscopic endonasal approach for clip application of cerebral aneurysms: a systematic review.
CONCLUSIONS: Despite a moderate increase in utilization, caution should be exercised when choosing an endonasal strategy for treatment of aneurysmal pathology over more traditional and established methods such as microsurgical clip application and endovascular methods. Anecdotal evidence suggests that inferior and/or medial projecting aneurysms involving the paraclinoid ICA not amenable to traditional open/endovascular strategies may be reasonable to consider for EEA clip application. Wide-necked, midline, ventrolaterally-projecting aneurysms involving the vertebrobasilar system may represent an additional exception, as lo...
Source: Journal of Neurosurgical Sciences - March 29, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Treatment of Tuberculous Meningitis and Its Complications in Adults
AbstractPurpose of reviewTuberculous meningitis (TBM) is a global health problem. In this review, we systematically evaluate the evidence for current and emerging antimicrobials, host-directed therapies and supportive managements.Recent findingsCurrent antimicrobial regimes do not factor the differing ability of drugs to cross the blood-brain barrier. Rifampicin may be more effective at higher doses yet the most recent clinical trial failed to demonstrate survival benefit at 15 mg/kg/day. Dose finding studies suggest that higher doses still may be safe and more effective. Fluoroquinolones are currently listed as importan...
Source: Current Treatment Options in Neurology - February 28, 2018 Category: Neurology Source Type: research
Does restricted diffusion in the splenium indicate an acute infarct?
ConclusionNot every diffuse restriction observed on MRI indicates an ischemic stroke. Although radiologic images of the splenium may suggest acute ischemic infarction, the actual cause may be another pathology. Therefore, the symptoms and aetiologies of patients with splenium lesions should be considered and investigated from a wide range of perspectives.
Source: Acta Neurologica Belgica - January 6, 2018 Category: Neurology Source Type: research
Characterisation of Cronobacter strains isolated from hospitalised adult patients.
In this study, the presence of Cronobacter strains from adult patients in the University Hospital in Bratislava was investigated and overall 18 confirmed isolates from 321 patients (5.3%) were recovered. No Cronobacter positive sample was detected in 215 sputum samples from outpatients. The highest occurrence of Cronobacter strains was observed from stroke patients and this may be associated with an abnormal swallowing ability. The isolated strains belonged to the species Cronobacter sakazakii and Cronobacter malonaticus. In silico genotyping (MLST, CRISPR-cas array profiling) of whole genome sequences assigned the strains...
Source: Antonie van Leeuwenhoek - December 21, 2017 Category: Microbiology Authors: Kadlicekova V, Kajsik M, Soltys K, Szemes T, Slobodnikova L, Janosikova L, Hubenakova Z, Ogrodzki P, Forsythe S, Turna J, Drahovska H Tags: Antonie Van Leeuwenhoek Source Type: research
Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study PEDIATRICS
CONCLUSIONS:
Childhood arteriopathy subtypes have some typical features that aid diagnosis. Better imaging methods, including vessel wall imaging, are needed for improved classification of focal cerebral arteriopathy of childhood.
Source: American Journal of Neuroradiology - November 15, 2017 Category: Radiology Authors: Wintermark, M., Hills, N. K., DeVeber, G. A., Barkovich, A. J., Bernard, T. J., Friedman, N. R., Mackay, M. T., Kirton, A., Zhu, G., Leiva-Salinas, C., Hou, Q., Fullerton, H. J., the VIPS Investigators Tags: PEDIATRICS Source Type: research
Spectrum of hyperosmolar hyperglycaemic state in neurology practice.
Abstract
Background & objectives: Hyperosmolar hyperglycaemic state (HHS) is a medical emergency, but there is a paucity of studies reporting the spectrum of neurological manifestations of HHS. We, therefore, report the neurological spectrum, triggering factors and outcome of HHS in general neurology practice.
Methods: The records of the patients with HHS were extracted from computerized hospital information system and those managed currently were prospectively included. The demographic, clinical manifestations, duration of diabetes and precipitating events such as infection, stress and stroke were noted....
Source: The Indian Journal of Medical Research - November 1, 2017 Category: Biomedical Science Authors: Misra UK, Kalita J, Bhoi SK, Dubey D Tags: Indian J Med Res Source Type: research
Not as Simple as Canker Sores
BY NANA P. MATSUMOTO, & DEREK MEEKS, DOA 16-year-old boy presented to a rural ED with a swollen jaw, painful blisters in the mouth, and earache for the past day. One week before, he had a fever with chills, sore throat, and dry coughs. He was not taking any medications, and his immunizations were up-to-date. He had a mild learning disorder but no significant past medical or surgical history.An apthous ulcer, the most common and one of the earliest signs of Behçet's disease.The patient's vital signs were within normal limits, and his physical examination revealed anterior cervical lymphadenopathy, sinus con...
Source: The Case Files - October 11, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research
