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Treatment strategies for giant pituitary adenomas in the era of endoscopic transsphenoidal surgery: a multicenter series
CONCLUSIONS: ETS as a primary treatment modality to relieve mass effect in GPAs and extent of resection are dependent on GPA morphology. The pattern of residual pituitary adenoma guides further treatment strategies, including early transcranial reoperation, delayed endoscopic transsphenoidal/transcranial reoperation, and adjuvant radiosurgery.PMID:34388714 | DOI:10.3171/2021.1.JNS203982
Source: Journal of Neurosurgery - August 13, 2021 Category: Neurosurgery Authors: Alexander Micko Matthew S Agam Andrew Brunswick Ben A Strickland Martin J Rutkowski John D Carmichael Mark S Shiroishi Gabriel Zada Engelbert Knosp Stefan Wolfsberger Source Type: research

Complication avoidance protocols in endoscopic pituitary adenoma surgery: a retrospective cohort study in 514 patients
ConclusionThis study suggests that conformance to established protocols for endoscopic pituitary surgery may minimize complications, re-admissions and LOS while enhancing the likelihood of preserving gland function, although there remains opportunity for further improvements.
Source: Pituitary - July 2, 2021 Category: Endocrinology Source Type: research

Arterial Ischemic Stroke —Peculiarities of Clinical Presentation and Risk Factors in Indian Children
Neuropediatrics DOI: 10.1055/s-0041-1728773There are not enough recent studies on arterial ischemic stroke (AIS) in Indian children. We retrospectively reviewed data on 95 children (69 boys), aged 3 months to 17 years, with AIS. Focal signs were noted in 84 (88%) with hemiparesis in 72 (76%). Diffuse signs were present in 33 (35%) with fever in 22 (23%), altered mental status in 20 (21%), and headache in 12 (13%). Seizures occurred in 29 (31%) children. Arteriopathy was observed in 57 (60%) children with mineralizing lenticulostriate vasculopathy (mLSV) in 22 (23%) being the most common, followed by moyamoya in 14 (15%), a...
Source: Neuropediatrics - June 8, 2021 Category: Neurology Authors: Goraya, Jatinder Singh Berry, Shivankshi Kaur, Amandeep Singh, Gagandeep Tags: Original Article Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Transcranial Doppler Ultrasonographic Evaluation of Cerebrovascular Abnormalities in Children With Acute Bacterial Meningitis
Conclusions: Abnormal TCD flow patterns were common in children with BM and identified those at high risk of poor neurological outcome.
Source: Frontiers in Neurology - February 12, 2021 Category: Neurology Source Type: research

Cerebral venous sinus thrombosis in children: A study from a tertiary care hospital of eastern India
Conclusion: CVST is an underdiagnosed but important cause of stroke in childhood, occurring most often in the neonatal period. Mortality and morbidity are significant. Infections hyper coagulative disorders are the two primary associations. Magnetic resonance venography is the investigation of choice. Early diagnosis with management along with plan for secondary prevention can save from catastrophic consequences.
Source: Journal of Pediatric Neurosciences - January 19, 2021 Category: Neuroscience Authors: Shubhankar Mishra Ashok K Mallick Geeta Mohanty Priyabrata Nayak Source Type: research

Neurological manifestations in COVID-19: a systematic review and meta-analysis.
CONCLUSIONS: Stroke is the most frequently reported neurological manifestation in COVID-19 and has the highest mortality rate. Neurological manifestations tend to develop one to two weeks after the onset of respiratory disease. There is significant morbidity and mortality associated with COVID-19 neurological manifestations. PMID: 33074036 [PubMed - as supplied by publisher]
Source: Brain Injury - October 22, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Predictors of deep-vein thrombosis in subarachnoid hemorrhage: a retrospective analysis
ConclusionElevated d-dimer level at the time of hospitalization, motor deficit, and the presence of an intraparenchymal hemorrhage are independent risk factors for deep-vein thrombosis. Patients with DVT also had a significantly longer hospital stay. Even though further studies are needed, patients with elevated d-dimer at hospitalization and intraparenchymal cerebral hemorrhage may benefit from a more aggressive screening strategy for deep-vein thrombosis.
Source: Acta Neurochirurgica - August 13, 2020 Category: Neurosurgery Source Type: research

Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
CONCLUSION: Poldip2 inhibition alleviated brain edema and preserved the integrity of BBB partially by relieving the loss of AQP4 polarity via MMPs/β-DG pathway. PMID: 32790044 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - August 11, 2020 Category: Neuroscience Authors: Gao M, Lu W, Shu Y, Yang Z, Sun S, Xu J, Gan S, Zhu S, Qiu G, Zhuo F, Xu S, Wang Y, Chen J, Wu X, Huang J Tags: CNS Neurosci Ther Source Type: research

Trends in Age of Cochlear Implant Recipients, and the Impact on Perioperative Complication Rates
Objective: The aim of the study is to examine trends in the age of patients receiving cochlear implants and to determine the effect of age on the rate of perioperative complications. Study Design: Retrospective analysis of deidentified administrative claims data from a US commercial insurance database (Optum). Patients: Individuals undergoing cochlear implantation between 2003 and 2016. Setting: US hospital and outpatient facilities serving commercially insured patients. Intervention: Cochlear implantation. Main Outcome Measures: Age at implantation, incidence of perioperative complications within 30 days ...
Source: Otology and Neurotology - March 17, 2020 Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research

Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India.
CONCLUSION: No single biomarker correlated with NPSLE. Among different NPSLE manifestations, the prevalence of IgG β2GP1 in stroke, LA in demyelination, anti-ribosomal P in psychosis and anti-myelin oligodendrocyte glycoprotein in mood disorder were higher. Further studies on the pathogenic mechanisms underlying NPSLE and its different manifestations may help us to identify better biomarkers. PMID: 32106787 [PubMed - as supplied by publisher]
Source: Lupus - February 26, 2020 Category: Rheumatology Authors: Seth G, Sundaresh A, Mariaselvam CM, Kumar G, Chengappa KG, Adarsh MB, Tamouza R, Negi VS Tags: Lupus Source Type: research

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