Giant Osteoma in the Mastoid of the Temporal Bone: Complete Excision of a Rare Tumor
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Imaging Case of the Month Source Type: research

Cerebellar Abscess Caused by Extension of an Otogenic Infection Through the Labyrinth and Internal Auditory Canal
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Imaging Case of the Month Source Type: research

Imaging Case of the Month: Cystic Facial Nerve Schwannoma
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Imaging Case of the Month Source Type: research

Otopathology in the United States: History, Current Situation, and Future Perspectives
Human temporal bone studies have documented the pathophysiologic basis of many pathologic conditions and diseases affecting the ear, contributing to the development of specific clinical knowledge and pathology-oriented treatments. Researchers dedicated to the study of anatomy and histology of the temporal bone emanated from Europe to the United States during the first part of the 20th Century. The first otopathology laboratory was founded in the United States in 1924, at Johns Hopkins University; over time, the otopathology laboratories—considered by some authors as “gold mines” for studying ear diseases&...
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: History of Otology Source Type: research

Patient Positioning During In-Office Otologic Procedures Impacts Physician Ergonomics
This study aims to substantiate these findings during the routine care of patients in an otolaryngology practice setting. Study Design: Observational study. Setting: Outpatient otology clinic within tertiary care facility. Study Subjects: Two neurotology attending physicians. Interventions: Physicians performed cerumen removal procedures in the office with patients either in the seated position (n = 24) or supine position (n = 24). Main Outcome Measures: The rapid upper limb assessment (RULA), a validated instrument that measures body positioning with a focus on the upper arm, was used to measure erg...
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

Electronic Health Record Use Among American Neurotology Society Members
Conclusions: The majority of ANS members felt their efficiency decreased as a result of EHR. These findings provide specific changes to the EHR that would improve efficiency and satisfaction among neurotologists. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

Factors That Affect Length of Hospital Stay After Vestibular Schwannoma Surgery
Conclusions: VS surgery and postoperative care can be carried out efficiently with a minimal LOS. Identifying factors that may prolong LOS may help the operative team anticipate and address needs to optimize LOS. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

Normal Variant Occipital Pneumatization
Conclusions: The occipital bone is an accessory site of skull base pneumatization in 11.8% of the population undergoing temporal bone CT, while air cell extension into the occipital condyle occurs more rarely. These occipital air cells have a left-sided predilection and are always in direct proximity to the occipitomastoid suture, suggesting developmental egress from the mastoid. OP is a normal variant and lacks features of craniocervical pneumatization, which is a rare disorder. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Basic Science Source Type: research

Next Generation Sequencing of Sporadic Vestibular Schwannoma: Necessity of Biallelic NF2 Inactivation and Implications of Accessory Non-NF2 Variants
Conclusions: To date, few studies have used whole-exome sequencing, mate-pair analysis, and RNA-seq to profile genome-wide alterations in sporadic VS. Using high-throughput deep sequencing, “two-hit” alterations in the NF2 gene were identified in every tumor and were not present in peripheral blood supporting that all events were somatic. Type of NF2 gene alteration and accessory mutations outside the NF2 locus may predict phenotypic expression and clinical course. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Basic Science Source Type: research

A Polymer-Based Extended Release System for Stable, Long-term Intracochlear Drug Delivery
Conclusions: The polymer-based extended release system is effective in providing long-term, stable drug delivery for at least 90 days with good hearing outcomes. The results of this study support the potential for achieving long-term drug delivery with a single intracochlear administration. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Basic Science Source Type: research

Sequential Imaging in Patient With Suspected Menière's Disease Identifies Endolymphatic Sac Tumor
Conclusions: A patient with a longstanding diagnosis of MD demonstrated interval development of an ELST. While ELSTs are rare, the study raises the question regarding whether interval imaging is indicated in patients with MD. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Incidence of Intralabyrinthine Schwannoma: A Population-based Study Within the United States
Conclusion: The incidence of ILS exceeds 1 per 100,000 person-years with modern diagnostic imaging. The rising incidence of ILS in recent years most likely reflects improved capacity for disease detection rather than a true increase in tumor development. Given the reputability of the REP consortium, these data suggest that ILS comprises a more common entity than previously considered. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Persistent Oxidative Stress in Vestibular Schwannomas After Stereotactic Radiation Therapy
Conclusions: VSs exhibit oxidative stress up to 7 years after radiotherapy, yet these VSs continued to enlarge. Thus, VSs that grow following radiation appear to possess mechanisms for cell survival and proliferation despite radiation-induced oxidative stress. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Osteoradionecrosis of the Temporal Bone: An Evidence-Based Approach
Conclusions: ORNTB is a rare complication of radiotherapy that may present years after initial radiation exposure. Management should be aimed at relief of presenting symptoms and treatment of ORNTB associated complications. Both conservative and surgical measures may adequately control the disease process and symptomatology; however, randomized controlled studies comparing treatments would serve to further corroborate these findings. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Superior Canal Dehiscence Involving the Superior Petrosal Sinus: A Novel Classification Scheme
Conclusions: SSCD involving the SPS represents a small but distinct subset of SSCD cases. This scenario can create a unique set of symptoms and surgical challenges when intervention is sought. Clinical findings and considerations for surgical intervention are provided to facilitate effective diagnosis and management. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Vestibular Disorders Source Type: research

Spontaneous Canalith Jam and Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo: Considerations on a Particular Case Mimicking an Acute Vestibular Deficit
Conclusions: Canalith jam is rarely described and is overall observed as a repositioning manoeuvre complication, not as a mimicker of a vestibular neuritis. Furthermore, our case represents the first observation of a recurrent canalith jam and apogeotropic variant of horizontal canal benign paroxysmal positional vertigo. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Vestibular Disorders Source Type: research

Unique Clinical Language Patterns Among Expert Vestibular Providers Can Predict Vestibular Diagnoses
Conclusions: These results indicate that expert providers utilize unique language patterns in vestibular notes that are highly conserved. These patterns have strong predictive power toward specific vestibular diagnoses. Such language elements can provide a simple vocabulary to aid nonexpert providers in formulating a differential diagnosis. They can also be incorporated into clinical decision support systems to facilitate accurate vestibular diagnosis in ambulatory settings. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Vestibular Disorders Source Type: research

Audiometric and cVEMP Thresholds Show Little Correlation With Symptoms in Superior Semicircular Canal Dehiscence Syndrome
Objective: Evaluate the relationship between objective audiometric and vestibular tests and patient symptoms in superior canal dehiscence (SCD) syndrome. Study Design: Retrospective chart review. Setting: Tertiary care center. Patients: Ninety-eight patients with SCD, preoperative threshold audiograms, cervical vestibular evoked myogenic potential (cVEMP) thresholds, and computed tomography (CT) imaging were included. Clinical reports were reviewed for self-reported SCD symptoms. Twenty-five patients completed the Hearing Handicap Inventory (HHI), Dizziness Handicap Inventory (DHI), Autophony Index (AI), and the...
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Vestibular Disorders Source Type: research

Direct Acoustic Cochlear Implants Lead to an Improved Speech Perception Gap Compared to Conventional Hearing Aid
Conclusions: For patients with moderate-to-severe inner ear hearing loss between 45 and 65 dB HL, better speech perception in quiet is obtained with the DACI system. Compared with conventional hearing aids, speech performance with the DACI is closer to the maximally possibly score PBmax. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Prosthetic Devices Source Type: research

Treatment of Ciprofloxacin-resistant Ear Infections
This study investigates ciprofloxacin-resistant infections and seeks to develop a better understanding of treatment options and outcomes. Study Design: Retrospective review of 141 ciprofloxacin-resistant otologic infections. Setting: Tertiary-care hospital. Patients: Patients with culture-proven ciprofloxacin-resistant infections from 2008 to 2017. Intervention(s): Antibiotic treatment with ciprofloxacin topical drops, ciprofloxacin plus oral antibiotics, and nonciprofloxacin therapy. Main Outcome Measure(s): Bacteriology for ciprofloxacin-resistant infections and treatment effectiveness of various therapies...
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

The Bone Mineral Density of the Lateral Skull Base and its Relation to Obesity and Spontaneous Cerebrospinal Fluid Leaks
Conclusion: There appears to be no difference between the BMD of the lateral skull base as it relates to obesity or spontaneous CSF leaks compared with normal weight controls. These findings suggest the BMD does not have a significant role in the development of lateral skull base thinning or dehiscence leading to CSF leaks. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

Feasibility and Safety of Transtympanic Balloon Dilatation of Eustachian Tube
Conclusion: Transtympanic dilatation increases the patency of the Eustachian tube immediately after instrumentation. No carotid complications were observed. Continuous endoscopic control is essential to avoid subluxation of stapes. Further study of this technique is warranted to identify its role, if any, in chronic ear surgery. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

Interplay Between Socioeconomic Status and Otitis Media Disease Burden in Resource-rich and Resource-poor Nations
Objectives/Hypothesis: To characterize global differences in otitis media (OM)-related disease burden between socioeconomically advantaged and disadvantaged nations. Methods: Using the Global Health Data Exchange, worldwide OM burden was evaluated using age-standardized disability-adjusted life years (DALYs) per 100,000 individuals in 183 countries from 1990 to 2015. Countries were organized by socioeconomic status using Human Development Index (HDI) values collected from the United Nations Development Program. Gini coefficients and concentration indices were employed to analyze disparities in OM disease burden. Resu...
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

Outcomes Following Modified Tympanomastoidectomy With Soft-wall Reconstruction
Conclusions: MTMSWR is an option for restoring the posterior EAC wall following CWD surgery. Recidivism is comparable to canal wall up surgery, and hearing outcomes are generally better than CWD. Other advantages include rapid epithelialization, low rates of otorrhea, and restoration of a self-cleaning EAC regardless of retraction into the mastoid cavity. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

The Performance of Patient-reported Outcome Measures as Diagnostic Tools for Eustachian Tube Dysfunction
Conclusions: The CETDA and ETDQ-7 are not disease-specific and cannot distinguish obstructive from patulous ETD subtypes. A relatively weak correlation between sonotubometry and tubomanometry results, PROM scores, and the clinical diagnosis suggests that a varied core set of outcome measures is required to monitor response to treatments for ETD. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

Unilateral Versus Bilateral Cochlear Implantation in Children With Auditory Neuropathy Spectrum Disorder (ANSD)
Conclusions: Both bilateral CI and unilateral CI + HA groups achieved high rates of open-set speech perception. Bilateral CI may be beneficial in patients with bilateral hearing loss or those that fail to progress with unilateral CI + HA. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Single Sided Deaf Cochlear Implant Users in the Difficult Listening Situation: Speech Perception and Subjective Benefit
Conclusion: Patients with single-sided deafness do benefit from a CI in difficult listening environments and are able to localize sound based on interaural level differences. Considering these outcomes, cochlear implantation represents a promising treatment option for patients with single-sided deafness. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

What to Do When Cochlear Implant Users Plateau in Performance: a Pilot Study of Clinician-guided Aural Rehabilitation
Conclusions: CGAR represents a potentially efficacious approach to improving speech recognition and QOL for experienced CI users. Limitations and considerations in implementing and studying aural rehabilitation approaches are discussed. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Cochlear Implantation With a Novel Long Straight Electrode: the Insertion Results Evaluated by Imaging and Histology in Human Temporal Bones
Conclusion: Comparable insertion results as reported for other arrays were also found for the EVO. Insertion trauma can be mostly avoided with meticulous insertion techniques to prevent bulging and by limiting the insertion depth angle to 360 degrees. The image fusion technique is a reliable tool for evaluating electrode placement and is feasible for trauma grading. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Cochlear Implantation in Organ Transplant Recipients
Conclusion: This study demonstrates that organ transplant recipients, and especially children, are at increased risk of postoperative complications after cochlear implantation in comparison with healthy CI recipients. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Cognitive Performance of Severely Hearing-impaired Older Adults Before and After Cochlear Implantation: Preliminary Results of a Prospective, Longitudinal Cohort Study Using the RBANS-H
Objective: To evaluate cognitive change in severely hearing-impaired older adults after cochlear implantation. Study Design: Prospective, longitudinal cohort study with assessments before, and at 6 and 12 months after implantation. Patients: Twenty older adults (median age: 71.5 yr). Main Outcome Measures: Change in the Repeatable Battery for the Assessment of Neuropsychological Status for Hearing-impaired individuals (RBANS-H) total score and subdomain scores were used to assess cognitive evolution. In addition, change in best-aided speech audiometry in quiet (monosyllabic words) and in noise (Leuven Intelligib...
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Assessing Cochlear Length Using Cone Beam Computed Tomography in Adults With Cochlear Implants
Conclusion: A novel method for calculating outer- and inner-wall cochlear length using CBCT images has been developed which is feasible in clinical settings. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Evaluation of Outcome Variability Associated With Lateral Wall, Mid-scalar, and Perimodiolar Electrode Arrays When Controlling for Preoperative Patient Characteristics
Conclusion: While previous studies have demonstrated superior postoperative speech recognition scores in LW electrode array recipients, these differences lose significance when controlling for baseline hearing and speech recognition ability. These data demonstrate the proclivity for implanting individuals with greater residual hearing with LW electrodes and its impact on postoperative results. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Incidence for Tip Foldover During Cochlear Implantation
Conclusion: In a large academic center with experienced surgeons, tip foldover verified by CT/DVT arose at a rate of 0.87%. PM electrode carriers inherited the highest risk for this electrode malposition. Revision surgery was feasible in these cases. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Hearing Preservation With Standard Length Electrodes in Pediatric Cochlear Implantation
Conclusion: Hearing preservation is achievable to varying degrees in pediatric cochlear implantation using standard length electrodes though it is difficult to predict preoperatively which children may benefit. This study is among the largest additions to the knowledge base for this patient group. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Adolescent Obesity Is an Independent Risk Factor for Sensorineural Hearing Loss: Results From the National Health and Nutrition Examination Survey 2005 to 2010
Objective: We investigated the hypothesis that childhood obesity is a risk factor for sensorineural hearing loss (SNHL) independent of other metabolic risk factors. Study Design: A complex, multistage, stratified geographic area design for collecting representative data from noninstitutionalized US population. Methods: A total of 5,638 adolescents between age 12 and 19 from the NHANES database (2005–2010) were studied. Subjects with body mass index>= 95th percentile were classified as obese. SNHL was defined as average pure-tone greater than 15 dB HL for 0.5, 1, and 2 kHz or 3, 4, 6, and 8 kHz in at ...
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

Primary Endoscopic Stapes Surgery: Audiologic and Surgical Outcomes
Conclusions: Endoscopic stapedotomy and stapedectomy are effective techniques to manage stapes fixation resulting in a median postoperative ABG of 6.25 dB and ABG closure to within 10 dB in 84% of patients. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Otosclerosis Source Type: research

Is There a Relationship Between Bone Quality and Hearing Level?
Conclusion: We could not find a relationship between hearing loss and bone quality. Hearing levels can be affected by various factors, so further studies are needed to assess regional temporal bone quality. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Audiology Source Type: research

Use of Systemic Antibiotics for Acute Otitis Externa: Impact of a Clinical Practice Guideline
Conclusion: Publication of an AOE clinical guideline did not lead to a decline in systemic antibiotic therapy as initial AOE treatment. Additional efforts will be needed to curb systemic antibiotic treatment for AOE. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Research Methodology Source Type: research

Outcomes of Primary Radiosurgery Treatment of Glomus Jugulare Tumors: Systematic Review With Meta-analysis
Conclusions: In the short term, PRS is safe and effective at controlling growth and clinical symptoms for patients with GJTs, though there exists significant selection bias, inconsistent reporting, and clinical heterogeneity among existing studies. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Review Articles Source Type: research

Generic Quality of Life in Persons With Hearing Loss: A Review of the Recent Literature
Conclusion: Most of the studies suggest that HL is associated with reduced generic QoL. Using HA seems to improve general QoL. Further research is needed to explore the relationship between HL and generic QoL, in addition to the importance of influencing variables on this relationship. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Review Articles Source Type: research

Book Review: Pediatric Sensorineural Hearing Loss Clinical Diagnosis and Management. Edited by Samantha Ann, Judith Lieu, Margaret Kenna. Plural Publishing, San Diego, California, 2018.
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 15, 2018 Category: ENT & OMF Tags: Book Review Source Type: research

Light Chain Amyloidosis Presenting as Bilateral External Auditory Canal Obstructing Masses
A morbidly-obese 57-year-old diabetic and hypertensive man with chronic kidney disease, diastolic heart failure, and bilateral hearing loss was found to have soft tissue masses/densities in the lateral aspect of both auditory canals on local examination and on imaging. He underwent biopsies of both ear canal masses and histologic examination revealed amyloid deposits in the dermis. These deposits were confirmed as AL (amyloid light chain) kappa-type amyloid by laser mass spectrometry. A systemic work-up showed plasma cell dyscrasia with 9% kappa light chain restricted plasma cells in the bone marrow as well as amyloid depo...
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Temporal Bone Histopathology Case of the Month Source Type: research

Unilateral Brainstem Herniation Into a Bulbous Internal Auditory Canal, With Elevated Intracranial Pressure, Profound Hearing Loss, and Facial Palsy: Serial Imaging Findings
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Imaging Cases of the Month Source Type: research

Petrous Bone CT Findings in Patient With 3MC Syndrome
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Imaging Cases of the Month Source Type: research

Mri identification of the saccule? do it yourself!
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Letter to the Editor Source Type: research

Novel Computed Tomography Findings Suggestive of Perilymph Gusher
Conclusions: High resolution CT with oblique image reformatting is essential to identify focal communication between the IAC and basal turn of the cochlea in ears with PLG. (Source: Otology and Neurotology)
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

Prevention of Chlorhexidine Ototoxicity With Poloxamer in Rats
Conclusion: The use of a poloxamer barrier may be an effective approach to prevent ototoxicity before chlorhexidine disinfection of the ear with a nonintact tympanic membrane. (Source: Otology and Neurotology)
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Basic Science Source Type: research

The Novel Peptide Vaccine GV1001 Protects Hearing in a Kanamycin-induced Ototoxicity Mouse Model
Hypothesis: We tested whether GV1001 has any ototoxic side effects at different doses and whether it protects hearing in an aminoglycoside-induced ototoxicity mouse model. Background: GV1001, a novel peptide vaccine currently being examined in a Phase 3 clinical trial to treat pancreatic cancer, also has anti-inflammatory and antioxidant effects. Methods: In the first experiment, C57/BL6 mice were injected with GV1001 preparations at concentrations of 0.1 to 100 mg/kg for 7 days to evaluate the toxicity of GV1001 on the inner ear and kidneys. In the second experiment, the protective effect of GV1001 was tested in...
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Basic Science Source Type: research

The SLC26A4 c.706C>G (p.Leu236Val) Variant is a Frequent Cause of Hearing Impairment in Filipino Cochlear Implantees
Conclusion: The SLC26A4 c.706C>G (p.Leu236Val) variant is a frequent cause of congenital hearing impairment in Filipinos and is associated with bilateral EVA and increased presurgical audiometric thresholds, but does not adversely affect post-implant outcomes. (Source: Otology and Neurotology)
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Basic Science Source Type: research