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Total 186 results found since Jan 2013.

The safety and efficacy of dexmedetomidine versus propofol for patients undergoing endovascular therapy for acute stroke: A prospective randomized control trial
Background: It is uncertain if dexmedetomidine has more favorable pharmacokinetic profile than the traditional sedative drug propofol in patients who undergo endovascular therapy for acute stroke. We conducted a prospective randomized control trial to compare the safety and efficacy of dexmedetomidine with propofol for patients undergoing endovascular therapy for acute stroke. Methods: A total of 80 patients who met study inclusion criteria were received either propofol (n = 45) or dexmedetomidine (n = 35) between January 2016 and August 2018. We recorded the favorable neurologic outcome (modified Rankin score...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Pharmacodynamic Analysis of the Influence of Propofol on Left Ventricular Long-Axis Systolic Performance in Cardiac Surgical Patients.
CONCLUSION: Propofol reduces LV systolic long-axis performance in a dose-dependent manner. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01826149. PMID: 31020819 [PubMed - in process]
Source: Journal of Korean Medical Science - April 26, 2019 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

The Outcome of Status Epilepticus and Long-Term Follow-Up
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Evaluation of Propofol in Comparison with Other General Anesthetics for Surgery in Children Younger than 3 Years: a Systematic Review and Meta-Analysis.
CONCLUSION: This systematic review and meta-analysis indicates that propofol use for general anesthesia in young healthy children undergoing surgery does not increase complications and that propofol could be at least comparable to other anesthetic agents. PMID: 31001938 [PubMed - in process]
Source: Journal of Korean Medical Science - April 20, 2019 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy —A Matched Pair Analysis
ConclusionAn SOP using a novel sedation regimen and optimization of equipment and procedures directed at a leaner, more integrative and compact periinterventional management can reduce in-house treatment delays significantly in stroke patients receiving thrombectomy in light sedation and demonstrated the safety and feasibility of our improved approach.
Source: Neurocritical Care - January 18, 2019 Category: Neurology Source Type: research

Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia.
In conclusion, propofol inhibited the excessive activation of microglia through the A2b receptor and attenuated the inflammatory injury following cerebral infarction. The current study may provide a reliable basis for further clinical studies on propofol and its putative role in improving the prognosis of patients with cerebral infarction. PMID: 30431058 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - November 5, 2018 Category: Molecular Biology Authors: Yu H, Wang X, Kang F, Chen Z, Meng Y, Dai M Tags: Int J Mol Med Source Type: research

Volatile anaesthetics versus propofol in the cardiac surgical setting of remote ischaemic preconditioning: a secondary analysis of a Cochrane Systematic Review.
CONCLUSIONS: Present data do not permit a final assessment regarding the role of volatile or intravenous anaesthetics as a possible confounding factor in RIPC trials. PMID: 29945432 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - June 28, 2018 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Effect of different analgesic techniques on hemodynamic variables recorded with an esophageal Doppler monitor during ovariohysterectomy in dogs.
This study compared the efficacy of intravenous (IV) fentanyl and ketamine with lumbosacral epidural lidocaine in dogs undergoing ovariohysterectomy. Dogs with esophageal Doppler monitoring (n = 112) were included in this retrospective study. All dogs were premedicated with dexmedetomidine and methadone, induced with IV propofol or alfaxalone and maintained using isoflurane and IV fentanyl, IV ketamine, or epidural lidocaine. Heart rate (HR), mean arterial pressure (MAP), expired fraction of isoflurane (ETIso), stroke distance (SD), minute distance (MD), peak velocity (PV) and mean acceleration (MA) were recorded before an...
Source: The Canadian Veterinary Journal - April 1, 2018 Category: Veterinary Research Authors: Sández I, Soto M, Torralbo D, Rioja E Tags: Can Vet J Source Type: research

Total Intravenous Versus Volatile Induction and Maintenance of Anesthesia in Elective Carotid Endarterectomy: Effects on Cerebral Oxygenation and Cognitive Functions
Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD.
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 2, 2018 Category: Anesthesiology Authors: Vsevolod V. Kuzkov, Maxim Y. Obraztsov, Oleg Y. Ivashchenko, Nadezhda Y. Ivashchenko, Valery M. Gorenkov, Mikhail Y. Kirov Tags: Original Article Source Type: research

Maternal and fetal effects of dexmedetomidine infusion in pregnant ewes anesthetized with sevoflurane.
CONCLUSIONS AND CLINICAL RELEVANCE Pregnant ewes receiving a combination of sevoflurane and an infusion of dexmedetomidine without a loading dose had cardiac index in acceptable ranges and maintained normoxia. This balanced anesthesia did not produce significant changes in fetal blood pressure or heart rate. However, the increase in fetal plasma lactate concentration and changes in maternal pulmonary vascular resistance and uterine blood flow require further investigation to better elucidate these effects. PMID: 29076367 [PubMed - in process]
Source: American Journal of Veterinary Research - October 28, 2017 Category: Veterinary Research Authors: Lépiz ML, Sayre R, Sawant O, Barr J, Pashmakova M, Washburn K, Washburn S Tags: Am J Vet Res Source Type: research

Propofol Attenuates Inflammatory Response in LPS-Activated Microglia by Regulating the miR-155/SOCS1 Pathway
This study explored the anti-inflammatory effects of propofol in LPS-activated BV2 microglia. Propofol potently decreased the pro-inflammatory mediators, such as nitric oxide, TNF- α, and IL-6, at both the transcriptional and translational levels. Furthermore, propofol suppressed the expression of miR-155 in LPS-activated cells. Knockdown of miR-155 attenuated the anti-inflammatory effect of propofol in cells after LPS exposure. miR-155 was also confirmed as a negative regula tor of SOCS1 expression. The inhibitory effect of propofol on LPS-induced inflammation involved the upregulation of SOCS1. Overall, these results su...
Source: Inflammation - September 5, 2017 Category: Allergy & Immunology Source Type: research

Anaesthesia practices for endovascular therapy of acute ischaemic stroke: a Nordic survey
ConclusionsThis survey indicates that the majority of Nordic anaesthesia departments who manage anaesthesia for EVT are able to provide immediate 24‐h response to an EVT request. Most of these departments have institutional guidelines for EVT anaesthesia and haemodynamic management. Conscious sedation appears to be the preferred method of anaesthetic care.
Source: Acta Anaesthesiologica Scandinavica - July 1, 2017 Category: Anesthesiology Authors: M. Rasmussen, C. Z. Simonsen, L. H. S ørensen, S. Dyrskog, D. A. Rusy, D. Sharma, N. Juul Tags: Original Article Source Type: research

Pre-anesthetic stroke volume variation can predict cardiac output decrease and hypotension during induction of general anesthesia
In conclusions, pre-anesthetic SVV can predict incidence of decreased CO and hypotension during induction of general anesthesia.
Source: Journal of Clinical Monitoring and Computing - June 24, 2017 Category: Information Technology Source Type: research

Lactate/pyruvate monitoring during carotid endarterectomy under general anaesthesia versus cervical plexus block: A randomised controlled study
Conclusion: In patients undergoing Carotid endarterectomy, serum levels of both lactate and pyruvate were higher under general versus regional anaesthesia.
Source: Indian Journal of Anaesthesia - May 9, 2017 Category: Anesthesiology Authors: Gomaa Z Hussien Ahmed M Elbadawy Hossam A Elshamaa Source Type: research