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Total 186 results found since Jan 2013.

Hemodynamic changes and stress response during BIS-guided TCI anesthesia with propofol-fentanyl in laparoscopic versus open cholecystectomy
Conclusion BIS-guided TCI anesthesia with propofol-fentanyl offers a good and safe anesthesia technique for patients undergoing either laparoscopic or open cholecystectomy. The hemodynamic stability guided by esophageal Doppler monitor makes it a very appealing choice.
Source: Egyptian Journal of Anaesthesia - November 27, 2015 Category: Anesthesiology Source Type: research

Nitrous oxide-based techniques versus nitrous oxide-free techniques for general anaesthesia.
CONCLUSIONS: Given the evidence from this Cochrane review, the avoidance of nitrous oxide may be reasonable in participants with pre-existing poor pulmonary function or at high risk of postoperative nausea and vomiting. Since there are eight studies awaiting classification, selection bias may exist in our systematic review. PMID: 26545294 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 6, 2015 Category: Journals (General) Authors: Sun R, Jia WQ, Zhang P, Yang K, Tian JH, Ma B, Liu Y, Jia RH, Luo XF, Kuriyama A Tags: Cochrane Database Syst Rev Source Type: research

Hemodynamic effects of target-controlled infusion of propofol alone or in combination with a constant-rate infusion of remifentanil in dogs.
In conclusion, the hemodynamic changes observed in this study indicate a compromise of the cardiovascular system, although the dogs in this study were healthy/euvolemic and there was no change in preload. More studies are required in order to evaluate the actual safety of the combination of propofol and remifentanil in patients with reduced cardiac reserve. PMID: 26424912 [PubMed - in process]
Source: Canadian Journal of Veterinary Research - October 1, 2015 Category: Veterinary Research Authors: Beier SL, Mattoso CR, Aguiar AJ, Vianna PT, Massone F Tags: Can J Vet Res Source Type: research

Continuous infusion of propofol in calves: bispectral index and hemodynamic effects
Conclusions and clinical relevanceA continuous infusion of propofol at 0.6 or 0.8 mg kg−1 minute−1 caused minimal hemodynamic changes without clinical relevance in calves. BIS could not be reliably used to discriminate the anesthetic depth during the two propofol infusion rates.
Source: Veterinary Anaesthesia and Analgesia - September 11, 2015 Category: Veterinary Research Authors: Mauricio Deschk, Juliana T Wagatsuma, Marcelo A Araújo, Guilherme GF Santos, Sergio SR Júnior, Caio JX Abimussi, Carlos E Siqueira, Jéssica CL Motta, Silvia HV Perri, Paulo SP Santos Tags: Research Paper Source Type: research

Cerebral protection during neurosurgery and stroke
This article reviews the recent evidence on perioperative neuroprotection in patients undergoing brain surgery and in patients with acute stroke. Recent findings: With varying degrees of success, numerous pharmacological and nonpharmacological therapies have been employed to provide neuroprotection for patients during the perioperative period and after acute ischemic stroke (IAS). Recent studies have failed to demonstrate neuroprotective effects of intraoperative remifentanil or propofol use, although hypertonic saline may provide better brain relaxation than mannitol during elective intracranial surgery for tumor. Magnesi...
Source: Current Opinion in Anaesthesiology - September 3, 2015 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Keith J. Ruskin Source Type: research

Treatment of status migrainosus by general anesthesia: a case report
Conclusion Status migrainosus is a rare disabling complication and anesthetics have been the subject of research in its treatment; the option for general anesthesia with agents that stimulate GABA receptors, propofol and isoflurane, in association with fentanyl, proved effective and should encourage new research.
Source: Brazilian Journal of Anesthesiology - August 29, 2015 Category: Anesthesiology Source Type: research

Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy
There is limited data on the safety, hemodynamic profile, and outcome of patients undergoing intra-arterial therapy (IAT) for acute ischemic stroke (AIS) under sedation with dexmedetomidine (DEX) versus propofol (PROP).
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2015 Category: Neurology Authors: Seby John, Jaspreet Somal, Umera Thebo, Muhammad S. Hussain, Ehab Farag, Suzanne Dupler, Joao Gomes Source Type: research

Differential effects of phenylephrine and norepinephrine on peripheral tissue oxygenation during general anaesthesia: A randomised controlled trial
BACKGROUND: Phenylephrine and norepinephrine are two vasopressors commonly used to counteract anaesthesia-induced hypotension. Their dissimilar working mechanisms may differentially affect the macro and microcirculation, and ultimately tissue oxygenation. OBJECTIVES: We investigated the differential effect of phenylephrine and norepinephrine on the heart rate (HR), stroke volume (SV), cardiac index (CI), cerebral tissue oxygenation (SctO2) and peripheral tissue oxygenation (SptO2), and rate-pressure product (RPP). DESIGN: A randomised controlled study. SETTING: Single-centre, University Medical Center Groningen, The Nether...
Source: European Journal of Anaesthesiology - July 3, 2015 Category: Anesthesiology Tags: Perioperative medicine: the cardiac patient Source Type: research

Update on anesthetic neuroprotection
Purpose of review: Perioperative cerebral injury can result in a wide range of clinical consequences from subtle cognitive changes to devastating or fatal strokes. Although the overall incidence of perioperative stroke is low, the large and growing number of aging patients undergoing surgery and anesthesia is placing an increasing number of vulnerable patients at risk. The purpose of this review is to evaluate recent evidence concerning the use of pharmacological and nonpharmacological strategies to protect against perioperative cerebral injury. Recent findings: Although a growing body of preclinical literature suggests th...
Source: Current Opinion in Anaesthesiology - July 3, 2015 Category: Anesthesiology Tags: DRUGS IN ANESTHESIA: Edited by Tong J. Gan Source Type: research

New therapy in cardioprotection
Purpose of review: An increasing number of patients are presenting for major surgery with cardiovascular comorbidities. Evidence of myocardial injury was found in 8% of all noncardiac surgery patients older than 45 years and was associated with adverse outcome. For this reason, there has been a lot of interest in finding and evaluating effective cardioprotective interventions. Recent findings: Current evidence suggests that statins, volatile anesthetic agents, and propofol are cardioprotective. Beta blockers reduce myocardial injury, but the resultant hypotension may contribute to the increased all-cause mortality and stro...
Source: Current Opinion in Anaesthesiology - July 3, 2015 Category: Anesthesiology Tags: DRUGS IN ANESTHESIA: Edited by Tong J. Gan Source Type: research

Hemodynamic responses during induction: comparison of Marsh and Schnider pharmacokinetic models.
CONCLUSIONS: When target concentrations are titrated according to NI during induction of anesthesia, Marsh's model could induce sedation faster than Schnider's. Meanwhile, hemodynamic changes were not observed to be statistically different between the two models. Hypotension induced by plasma target-controlled infusion of propofol could mainly be attributed to decreased stroke volume instead of vascular dilation. PMID: 25500489 [PubMed - in process]
Source: International Journal of Clinical Pharmacology and Therapeutics - June 4, 2015 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Methodology of Motor Evoked Potentials in a Rabbit Model
This study provides the basis for a reproducible model of SCI to be used for novel therapeutic drug development.
Source: Translational Stroke Research - May 20, 2015 Category: Neurology Source Type: research

Hemodynamic effects of etomidate, propofol and electrical shock in patients undergoing implantable cardioverter-defibrillator testing.
CONCLUSIONS: Propofol significantly decreased BP by both reducing cardiac output and causing vasodilatation whereas etomidate only slightly decreased dBP and mBP without affecting other parameters. Propofol-induced changes were independent of LVEF or NYHA class. Induction of VF and internal defibrillation did not cause clinically significant changes apart from very modest drop in dBP and mBP values. PMID: 24846355 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - May 20, 2014 Category: Cardiology Authors: Zgoła K, Kułakowski P, Czepiel A, Swiątkowski M, Makowska E, Błachnio E, Soszyńska M, Misiewicz M Tags: Kardiol Pol Source Type: research

A Pilot Study for a Prospective, Randomized, Double-Blind Trial of the Influence of Anesthetic Depth on Long-Term Outcome.
CONCLUSIONS:: This pilot study demonstrated that depth of anesthesia targeting with BIS or SE was achievable in a high-risk population with adequate separation of processed electroencephalogram monitor targets. The expected incidence of postoperative complications and mortality occurred. We conclude that a large, multicenter, randomized controlled trial is feasible. PMID: 24781568 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - May 1, 2014 Category: Anesthesiology Authors: Short TG, Leslie K, Campbell D, Chan MT, Corcoran T, O'Loughlin E, Frampton C, Myles P Tags: Anesth Analg Source Type: research

Comparison of the cardiorespiratory effects of a combination of ketamine and propofol, propofol alone, or a combination of ketamine and diazepam before and after induction of anesthesia in dogs sedated with acepromazine and oxymorphone.
Conclusions and Clinical Relevance-In dogs, K-P treatment maintained mean arterial blood pressure better than propofol alone and increased heart rate, cardiac output, or oxygen delivery, as did the K-D treatment. Supplemental 100% oxygen should be provided during IoA with all 3 treatments. PMID: 24564308 [PubMed - in process]
Source: American Journal of Veterinary Research - March 1, 2014 Category: Veterinary Research Authors: Henao-Guerrero N, Riccó CH Tags: Am J Vet Res Source Type: research