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Total 134 results found since Jan 2013.

Analysis of a 15-years' experience in including shoulder muscles, when treating upper-limb spasticity post-stroke with botulinum toxin type A.
Conclusion When treating ULS, including shoulder muscles, the most frequent goals were IM, PD e MOB. The most injected muscles were SC and PM. The treatment was successful in a large percentage of cases. Achieving the PD goal was associated with greater success at other goals of treatment. BoNTA demonstrated a positive effect in controlling symptoms and improving function. PMID: 29322885 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - January 11, 2018 Category: Neurology Authors: Carvalho MP, Pinto D, Gorayeb M, Jacinto J Tags: Top Stroke Rehabil Source Type: research

Patient Registry of Spasticity Care World: Data Analysis Based on Physician Experience
Objective The aim of the study was to report physician experience–based “real-world” treatment patterns with botulinum toxin type A in patients with stroke and traumatic brain injury. Design A prospective, multicenter, international observational registry design was used. Results Six hundred twenty-seven participants with stroke and 132 participants with traumatic brain injury were assessed and treated by 17 more experienced physicians and 12 less experienced physicians. Due to the limited usage of abobotulinumtoxinA Dysport and incobotulinumtoxinA Xeomin, data were reported on onabotulinumtoxinA BOTOX only. ...
Source: American Journal of Physical Medicine and Rehabilitation - November 17, 2017 Category: Rehabilitation Tags: Original Research Articles Source Type: research

A survey of the current practice of intramuscular Botulinum toxin injections for hemiplegic shoulder pain in the UK.
CONCLUSIONS: Current UK practice of Botulinum Toxin type A injections for hemiplegic shoulder pain associated with spasticity is highly variable. There are large gaps between current practice and available evidence with regards to muscle selection and doses used. A number of areas for further investigation have been identified to progress current understanding of this intervention. Implications for rehabilitation There are wide variations in practice for this complex intervention and clinicians should consider that their individual decision-making could be based on their own beliefs rather than available evidence. Pectoral...
Source: Disability and Rehabilitation - November 10, 2017 Category: Rehabilitation Authors: Holmes RJ, Connell LA Tags: Disabil Rehabil Source Type: research

Effect of Ultrasound-Guided Injection Of Botulinum Toxin Type A for Shoulder Pain On Post-Stroke Patients
To study the effect of ultrasound-guided injection of botulinum toxin type A for shoulder pain on patients with stroke.
Source: Archives of Physical Medicine and Rehabilitation - September 24, 2017 Category: Rehabilitation Authors: Xiao Bao, Howe Liu, Hao Liu, Jiewen Tan, Ying Long, Myles Quiben Source Type: research

Heart Rate Variability modifications induced by high doses of IncobotulinumtoxinA and OnabotulinumtoxinA in hemiplegic chronic stroke patients: A single blind randomized controlled, crossover pilot study.
CONCLUSIONS: Our data show that high doses (>600 U) of incobotulinumtoxinA and onabotulinumtoxinA do not influence the cardiovascular activity of the autonomic nervous system in chronic hemiplegic spastic stroke survivors. PMID: 28877510 [PubMed - as supplied by publisher]
Source: Toxicon - September 3, 2017 Category: Toxicology Authors: Baricich A, Grana E, Carda S, Santamato A, Molinari C, Cisari C, Invernizzi M Tags: Toxicon Source Type: research

Poster 307: Non-Rhythmic Recurrent Shaking After Right Basal Ganglia Stroke: A Case Report
Aaron Hanyu-Deutmeyer: My spouse/partner has a relationship with Allergan Speakers bureau, My spouse/partner has a relationship with Allergan provided Botox for injection
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Aaron A. Hanyu-Deutmeyer, Padma K. Srigiriraju Source Type: research

Benefits and Risks of Non-Approved Injection Regimens for Botulinum Toxins in Spasticity
AbstractSpasticity with muscle paresis and loss of dexterity is a common feature of upper motor neuron syndrome due to injuries or the pyramidal tract in several neurological conditions. Botulinum toxin type A has been considered the gold standard treatment for spasticity and movement disorders, with efficacy, reversibility, and low prevalence of complications. During the last 30  years, thousands of studies of its use have been performed, but few guidelines are available. Therefore, there is great variability in both the doses and intervals of administration and the approaches taken by clinicians with considerable experi...
Source: Drugs - July 19, 2017 Category: Drugs & Pharmacology Source Type: research

The Italian real-life post-stroke spasticity survey: unmet needs in the management of spasticity with botulinum toxin type A.
Authors: Picelli A, Baricich A, Cisari C, Paolucci S, Smania N, Sandrini G Abstract The present national survey seeking to identify unmet needs in the management of spasticity with botulinum toxin type A focused on the use of OnabotulinumoxinA, since this is the brand with the widest range of licensed indications in Italy. Physicians from twenty-four Italian neurorehabilitation units compiled a questionnaire about "real-life" post-stroke spasticity management. OnabotulinumtoxinA was reported to be used in the following average doses: upper limb 316.7 ± 79.1 units; lower limb 327.8 ± 152.3; upper and lower limb 54...
Source: Functional Neurology - July 7, 2017 Category: Neurology Tags: Funct Neurol Source Type: research

Detection of Botulinum Toxin Muscle Effect in Humans Using Magnetic Resonance Imaging: A Qualitative Case Series
Conclusions This descriptive case series is among the first attempts to quantify BTME within human muscle. Our findings are preliminary and are limited by a few inconsistencies. However, we conclude that use of magnetic resonance imaging to detect the volume of BTME is feasible and may assist researchers in modeling the spread and diffusion of BT within human muscle. Level of Evidence To be determined.
Source: PMandR - May 31, 2017 Category: Rehabilitation Source Type: research

Outcomes of Botulinum Toxin Type A for equinovarus deformity in patients with CVA: A case series.
CONCLUSION: Although BTX-A injections improved spasticity, this improvement did not translate to gait outcomes. Addition of physical therapy interventions appeared to improve gait outcomes in this case series. We suggest future randomized control studies to compare effects of physical therapy alone to BTX-A combined with physical therapy on gait outcomes. PMID: 28481738 [PubMed - as supplied by publisher]
Source: Physiotherapy Theory and Practice - May 8, 2017 Category: Physiotherapy Authors: Karakkattil P, Trudelle-Jackson E, Brown HH, Hammontree P, Okolo M Tags: Physiother Theory Pract Source Type: research

Long-term safety of repeated high doses of incobotulinumtoxinA injections for the treatment of upper and lower limb spasticity after stroke
Current guidelines suggested a dosage up to 600units (U) of botulinum toxin type A (BoNT-A) (onabotulinumtoxinA or incobotulinumtoxinA) in reducing spastic hypertonia with low prevalence of complications, although a growing body of evidence showed efficacy with the use of high doses (>800U). The available evidence mainly referred to a single set of injections evaluating the efficacy and safety of the neurotoxin 30days after the treatment. In a prospective, non-randomized, open-label study, we studied the safety of repeated higher doses of incobotulinumtoxinA in post-stroke upper and lower limb spasticity.
Source: Journal of the Neurological Sciences - May 1, 2017 Category: Neurology Authors: Andrea Santamato, Francesco Panza, Domenico Intiso, Alessio Baricich, Alessandro Picelli, Nicola Smania, Francesca Fortunato, Davide Seripa, Pietro Fiore, Maurizio Ranieri Source Type: research

Assessing the immediate impact of botulinum toxin injection on impedance of spastic muscle
Since the 1980s, Botulinum toxin type A (BoNT-A) has been widely used in the management of spasticity caused by stroke, spinal cord injury, or cerebral palsy [1 –5]. The underlying mechanisms of BoNT-A is that it can effectively block the release of acetylcholine from the nerve endings, thus producing a progressive paralysis of the muscle [1,6]. Subsequent to the intramuscular BoNT-A injection, alterations in the physiological and mechanical properties of muscle have been reported in histological, mechanical, and medical imaging studies [7–11].
Source: Medical Engineering and Physics - February 3, 2017 Category: Biomedical Engineering Authors: Xiaoyan Li, Henry Shin, Le Li, Elaine Magat, Sheng Li, Ping Zhou Tags: Technical note Source Type: research

Efficacy and safety of Botulinum Toxin type A for upper limb spasticity after stroke or traumatic brain injury: a systematic review with meta-analysis and trial sequential analysis.
CONCLUSIONS: As compared with placebo, Botulinum Toxin type A injections have beneficial effects with improved muscle tone and well-tolerated treatment for patients with upper limb spasticity post stroke or traumatic brain injury. PMID: 27834471 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - November 10, 2016 Category: Rehabilitation Authors: Dong Y, Wu T, Hu X, Wang T Tags: Eur J Phys Rehabil Med Source Type: research

Combined effects of robot-assisted gait training and botulinum toxin type A effect on spastic equinus foot in patients with chronic stroke: a pilot, single blind, randomized controlled trial.
CONCLUSIONS: Our preliminary findings support the hypothesis that robot-assisted gait training does not enhance the effect of botulinum toxin type A on spastic equinus foot in patients with chronic stroke. CLINICAL REHABILITATION IMPACT: Our observations should be taken into account in daily clinical rehabilitation practice in order to develop effective treatment protocols based on the enhancement of antispastic drugs effect. PMID: 27098300 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - April 20, 2016 Category: Rehabilitation Authors: Picelli A, Bacciga M, Melotti C, LA Marchina E, Verzini E, Ferrari F, Pontillo A, Corradi J, Tamburin S, Saltuari L, Corradini C, Waldner A, Smania N Tags: Eur J Phys Rehabil Med Source Type: research

Comparison of Effects of Botulinum Toxin Injection Between Subacute and Chronic Stroke Patients: A Pilot Study
In conclusion, botulinum toxin injection in subacute patients was more helpful for spasticity, contracture, and function than in chronic patients. However, beneficial effects of botulinum toxin injection on spasticity and function in chronic patients were found in the assessments of the modified Tardieu scale and Fugl-Meyer scale.
Source: Medicine - February 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research