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Total 134 results found since Jan 2013.
Diagnosis and management of patients with Bell's palsy.
This article discusses potential causes of the condition and identifies the differences between Bell's palsy and stroke. In addition, appropriate strategies for the care of patients with the condition are suggested. Management includes antiviral medication, corticosteroid therapy, eye care, botulinum toxin type A injection, physiotherapy, surgery and acupuncture. Psychological and emotional care of these patients is also important because any facial disability caused by facial nerve paralysis can result in anxiety and stress.
PMID: 24299386 [PubMed - in process]
Source: Nursing Standard - December 4, 2013 Category: Nursing Authors: Mooney T Tags: Nurs Stand Source Type: research
OnabotulinumtoxinA Muscle Injection Patterns in SpasticityOnabotulinumtoxinA Muscle Injection Patterns in Spasticity
This systematic review summarizes the injection sites and dosing patterns of Botox injections for adult spasticity due to a variety of causes such as MS, stroke, or brain or cord injury. BMC Neurology
Source: Medscape Today Headlines - November 13, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
47. Botulinum toxin for the upper limb after stroke: Comparison between incobotulinumtoxin A, botulinum toxin drug free of complexing proteins, and conventional botulinum toxin formulation. A preliminary study
Botulinum toxin type A (BoNT/A) provides a valuable tool in the multi-modal treatment of spasticity. Incobotulinumtoxin A (InBoNT/A) is a highly purified BoNT/A agent, free of any complexing clostridial proteins.Clinical experience suggests that InBoNT/A is identical from efficacy, duration of therapeutic effect and tolerability profile. Our aim was to compare the effect of the CBoNT/A vs InBoNT/A on spasticity of the upper limb, evaluated with Modificated Aswhort Scale (MAS), and on amplitude of compound motor action potentials (CMAP) of biceps muscle in patients after brain stroke. A randomized, double-blind, parallel-gr...
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: C. Cesaretti, A. Grippo, A. Vettori, T. Atzori, C. Baldini, C. Falsini, M. Martini, R. Carrai, A. Pizzi Tags: Society Proceedings Source Type: research
Balancing Burdens and Benefits: Ethical Issues of Off-Label Prescription Pharmaceutical Use
I remember when Botox (Allergen, Irvine, CA) was becoming all the rage in rehabilitation in the mid 1990s. As I recall, the only U.S. Food and Drug Administration (FDA) approved uses at the time were for spasmodic torticollis and blepharospasm. In a short period of time, however, Botox was the new treatment du jour for adults and children alike with spasticity from CP, traumatic brain injury (TBI), and stroke. I also remember feeling a bit queasy about it. Perhaps having recently completed a fellowship in clinical medical ethics colored my view. Images of thousands of people with limb deficiencies, the tragic consequence ...
Source: PM and R - October 1, 2013 Category: Rehabilitation Authors: Ford Vox, Alexander M. Capron, Marilyn F. Kraus, G. Caleb Alexander, Kristi L. Kirschner Tags: Ethical Legal Source Type: research
Botox Reveals New Wrinkle In Brain Communication
National Institutes of Health researchers used the popular anti-wrinkle agent Botox to discover a new and important role for a group of molecules that nerve cells use to quickly send messages. This novel role for the molecules, called SNARES, may be a missing piece that scientists have been searching for to fully understand how brain cells communicate under normal and disease conditions. "The results were very surprising," said Ling-Gang Wu, Ph.D., a scientist at NIH's National Institute of Neurological Disorders and Stroke...
Source: Health News from Medical News Today - May 6, 2013 Category: Consumer Health News Tags: Epilepsy Source Type: news
NIH study uses Botox to find new wrinkle in brain communication
(NIH/National Institute of Neurological Disorders and Stroke) National Institutes of Health researchers used the popular anti-wrinkle agent Botox to discover a new and important role for a group of molecules that nerve cells use to quickly send messages. This novel role for the molecules, called SNARES, may be a missing piece that scientists have been searching for to fully understand how brain cells communicate under normal and disease conditions.
Source: EurekAlert! - Medicine and Health - May 2, 2013 Category: Global & Universal Source Type: news
Safety and efficacy of incobotulinum toxin type A (NT 201-Xeomin) for the treatment of post-stroke lower limb spasticity: a prospective open-label study.
Conclusion: BTX-A NT 201 for the treatment of post-stroke lower limb spasticity was safe and efficacious reducing muscle tone and spasms, and improving passive ankle dorsi-flexion movement. Clinical rehabilitation impact. These results confirmed the safety and effectiveness of a new type of BTX-A, with low immunogenity, useful to improve rehabilitative treatment of post-stroke lower limb spasticity.
PMID: 23480980 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - March 13, 2013 Category: Rehabilitation Authors: Santamato A, Micello MF, Panza F, Fortunato F, Pilotto A, Giustini A, Testa A, Fiore P, Ranieri M, Spidalieri R Tags: Eur J Phys Rehabil Med Source Type: research
Assessing the efficacy of different upper limb hemiparesis interventions on improving health-related quality of life in stroke patients: a systematic review.
CONCLUSION: The review demonstrates the need for upper limb intervention studies to focus on QOL as a primary outcome measure in addition to the functional outcomes currently used.
PMID: 23611858 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - March 1, 2013 Category: Neurology Authors: Pulman J, Buckley E Tags: Top Stroke Rehabil Source Type: research
OnabotulinumtoxinA in Lower Limb Spasticity: Safety Results from a Pooled Analysis (P03.266)
CONCLUSIONS: OnabotulinumtoxinA treatment in lower limb spasticity was found to be safe and well-tolerated. Majority of AEs were considered not related to onabotulinumtoxinA and treatment-related AEs are consistent with the known mechanism of action of onabotulinumtoxinA.Supported by: Allergan, Inc.Disclosure: Dr. Earl has received personal compensation for activities with Allergan, Inc. as an employee. Dr. Earl holds stock and/or stock options in AGN and GlaxoSmithKline, Inc. Dr. James has received personal compensation for activities with Allergan, Inc as an employee. Dr. Li has received personal compensation for activit...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Earl, N., James, L., Li, H.-I., Shi, G., Demos, G., Dimitrova, R. Tags: P03 Neural Repair Source Type: research
OnabotulinumtoxinA Efficacy in Lower Limb Spasticity: Results of Three Studies (P03.264)
CONCLUSIONS: OnabotulinumtoxinA (300U) significantly decreases ankle flexor tone in adults with post-stroke lower-limb spasticity.Supported by: Allergan, Inc.Disclosure: Dr. Dimitrova has received personal compensation for activities with Allergan, Inc. as an employee. Consulting service from Glaxo-Smith-Kline, Japan.....Financial support from GSK Japan, Eisai Dr. Kaji has received personal compensatino for activities with Glaxo-Smith-Kline, Japan as a consultant. Dr. Kaji has received research support from GSK Japan, Eisai. Dr. Ward has received personal compensation for activities with Allergan Inc. as a participant on a...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Dimitrova, R., Kaji, R., Ward, A., Li, H.-I., Fulford-Smith, A., Earl, N. Tags: P03 Neural Repair Source Type: research
Treatment With Botulinum Toxin Improves Upper-Extremity Function Post Stroke: A Systematic Review and Meta-Analysis
Abstract: Objective: To examine whether treatment with botulinum toxin type A (BTX-A) is associated with improvements in activity capacity or performance associated with poststroke spasticity in the upper extremity.Data Sources: MEDLINE, EMBASE, Scopus, and ISI Web of Science databases were searched from 1985 to November 2011.Data Selection: Studies were included if (1) the study design was a randomized controlled trial comparing injection of BTX-A with placebo or a nonpharmacologic treatment condition; (2) at least 60% of the sample was composed of adult subjects recovering from either first or subsequent stroke; (3) sub...
Source: Archives of Physical Medicine and Rehabilitation - December 20, 2012 Category: Rehabilitation Authors: Norine Foley, Shelialah Pereira, Katherine Salter, Manuel Murie Fernandez, Mark Speechley, Keith Sequeira, Thomas Miller, Robert Teasell Tags: Review Articles (Meta-Analyses) Source Type: research
SBOTE Study: Extracorporeal Shock Wave Therapy Versus Electrical Stimulation After Botulinum Toxin Type A Injection for Post-Stroke Spasticity–A Prospective Randomized Trial
Abstract: Research is on-going to identify new methods of biostimulation to increase the effect of botulinum toxin type A (BTX-A) in the treatment of spasticity. The Spasticity treated by Botulinum Toxin and ESWT (SBOTE) study is a prospective, randomized controlled trial assessing the effectiveness of extracorporeal shock wave therapy (ESWT) given immediately after BTX-A injections compared with electrical stimulation (ES) given immediately after BTX-A therapy for the management of focal upper limb spasticity in stroke patients. ES was given for 30 min twice a day for 5 days starting at 5 Hz; ESWT was given once a day for...
Source: Ultrasound in Medicine and Biology - December 17, 2012 Category: Radiology Authors: Andrea Santamato, Angela Notarnicola, Francesco Panza, Maurizio Ranieri, Maria Francesca Micello, Paolo Manganotti, Biagio Moretti, Francesca Fortunato, Serena Filoni, Pietro Fiore Tags: Original Contributions Source Type: research
Evidence for therapeutic interventions for hemiplegic shoulder pain during the chronic stage of stroke: a review.
CONCLUSIONS: Positive outcomes were noted with the use of corticosteroid injections and electrical stimulation and conflicting results were seen regarding the use of BTx-A. Overall, these targeted therapies provide benefit in the treatment of HSP in individuals who are more than 6 months post stroke.
PMID: 23192716 [PubMed - indexed for MEDLINE]
Source: Topics in Stroke Rehabilitation - November 1, 2012 Category: Neurology Authors: Viana R, Pereira S, Mehta S, Miller T, Teasell R Tags: Top Stroke Rehabil Source Type: research
Systematic review of the effectiveness of pharmacological interventions in the treatment of spasticity of the hemiparetic lower extremity more than six months post stroke.
CONCLUSIONS: Pharmacological treatment initiated 6 months post stroke reduced lower limb spasticity. Relevant areas of exploration for future research could include the period of effectiveness, long-term complications, and a cost-benefit analysis of such treatments.
PMID: 23192713 [PubMed - indexed for MEDLINE]
Source: Topics in Stroke Rehabilitation - November 1, 2012 Category: Neurology Authors: McIntyre A, Lee T, Janzen S, Mays R, Mehta S, Teasell R Tags: Top Stroke Rehabil Source Type: research
