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Total 134 results found since Jan 2013.

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: A systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios N Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: a systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

Wrist-hand extension function recovery in spastic hemiplegia patient by botulinum toxin injection plus surface electromyography biofeedback therapy: A case report
We reported a 46-year-old male suffered a spastic hemiplegia with wrist- hand extension deficit. Diagnoses: Computed tomography showed cerebral hemorrhage in the left basal ganglia region. Interventions: Four hundred units of BoNTA were injected into the spasticity flexors, and four-week post injection surface electromyography (sEMG) biofeedback therapy was applied to the patient. Outcomes: The patient exhibited post-intervention improvement in wrist-hand extensors performance (strength, range of motion, sEMG signals), the flexors spasticity, and upper extremity function. Lessons: The present ca...
Source: Medicine - April 9, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Combination therapy with Repetitive Facilitative Exercise Program and Botulinum Toxin Type A to improve motor function for the upper-limb spastic paresis in Chronic Stroke: A Randomized Controlled Trial
To promote recovery from a paretic upper limb after stroke, various rehabilitation approaches have been effective.1 Regardless of the kind of training, a previous neurophysiological study suggests that repeating identical movements is important for motor relearning.2 In accordance with that observation, Kawahira3 developed the repetitive facilitative exercise (RFE) program, which combines repetitive volitional flexion and extension movements with modified traditional neurofacilitation approaches.
Source: Journal of Hand Therapy - January 26, 2021 Category: Rehabilitation Authors: Akihiko Hokazono, Seiji Etoh, Jonoshita Yuiko, Kazumi Kawahira, Megumi Shimodozono Source Type: research

Intracortical Circuits in the Contralesional Primary Motor Cortex in Patients With Chronic Stroke After Botulinum Toxin Type A Injection: Case Studies
In this study, we assessed the intracortical inhibitory and facilitatory circuits in the contralesional M1 area in four patients with severe upper limb spasticity after chronic stroke and treated with botulinum toxin-A (BoNT-A) injection and 12 weeks of upper limb rehabilitation. There was little to no change in the level of spasticity post-injection, and only one participant experienced a small improvement in arm function. All reported improvements in quality of life. However, the levels of intracortical inhibition and facilitation in the contralesional hemisphere were different at baseline for all four participants, and ...
Source: Frontiers in Human Neuroscience - August 23, 2020 Category: Neuroscience Source Type: research

“Poststroke Postural Sway Improved by Botulinum Toxin: A Multicenter Randomized Double-blind Controlled Trial”
We read the article by Kerzoncuf et al1 with great interest. We appreciate the authors’ efforts to assess the effects of injecting botulinum toxin type A (BTX-A) into the lower limb muscles of people with hemiparesis post stroke. However, we have 2 concerns that may alter their conclusion.
Source: Archives of Physical Medicine and Rehabilitation - August 19, 2020 Category: Rehabilitation Authors: Yoshitaka Wada, Akihiro Shiroshita, Yasushi Tsujimoto Tags: Departments Source Type: research

Combined effects of backward treadmill training and botulinum toxin type A therapy on gait and balance in patients with chronic stroke: A pilot, single-blind, randomized controlled trial.
CONCLUSIONS: Greater improvement in gait and balance was noted after BTT than after FTT as an adjunct to botulinum toxin therapy in patients with chronic stroke. PMID: 32508341 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - June 10, 2020 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Diagnostic nerve block in prediction of outcome of botulinum toxin treatment for spastic equinovarus foot after stroke: A pilot retrospective observational study.
CONCLUSION: This study confirmed diagnostic nerve block as a valuable screening tool in deciding whether to treat spastic equinovarus with botulinum toxin. However, the results support the evidence that diagnostic nerve block results in a greater reduction in muscle overactivity than does botulinum toxin type A in patients with spastic equinovarus due to stroke. PMID: 32432331 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - May 22, 2020 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Botulinum Toxin Type A for Upper Limb Spasticity in Poststroke Patients: A Meta-analysis of Randomized Controlled Trials
Background and Aim: Botulinum toxin type A is considered to be an effective antispasmodic in recent years. We assess the effectiveness of botulinum toxin type A for the treatment of poststroke spasticity in the upper extremity using a meta-analysis. Methods: We searched several databases including PubMed, Web of Science, Embase, and Cochrane database for relevant studies, up until October 2017. All randomized controlled trials of botulinum toxin type A treat poststroke upper limb spasticity published were included.
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2020 Category: Neurology Authors: Shiyu Jia, Yang Liu, Liuyan Shen, Xue Liang, Xiaomin Xu, Youdong Wei Source Type: research

Contralateral Upper Limb Weakness Following Botulinum Toxin A Injection for Poststroke Spasticity.
We report the case of a 33-year-old female who had been receiving regular injections of incobotulinum toxin A due to spasticity of the right limbs after a hemorrhagic stroke. A switch was made to abobotulinum toxin A with an overall conversion ratio of 1:3.83. The patient presented contralateral upper limb paresis, especially of the deltoid muscle, in the second week post-injection. The electroneuromyography showed neuromuscular block due to botulinum toxin A. She recovered completely after eight months. A switch between different formulations of botulinum toxin type A should prompt caution when carrying out unit conv...
Source: Acta Medica Portuguesa - November 25, 2019 Category: General Medicine Tags: Acta Med Port Source Type: research

Clinical effectiveness of ultrasound guided subacromial-subdeltoid bursa injection of botulinum toxin type A in hemiplegic shoulder pain: A retrospective cohort study
Hemiplegic shoulder pain (HSP), which occurs in most patients with hemiplegia, causes considerable distress and worsens outcomes in rehabilitation. Although they have received the treatments such as anti-inflammatory drugs or physical therapy, many of the individuals remain suffering from shoulder pain 6 months after acute stroke event. In this retrospective study, we evaluated the effectiveness of ultrasound guided subacromial-subdeltoid (SASD) bursa injections with botulinum toxin type A (BoNT/A) compared to steroids for refractory HSP. The data were collected retrospectively by reviewing the patient's medical records a...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Botuloscope: 1-year follow-up of upper limb post-stroke spasticity treated with botulinum toxin
ConclusionThis is the first long-term follow-up of BoNT-A treatment for upper limb spasticity involving a large cohort independent of industry. Quality of life was improved by treating upper limb spasticity with BoNT-A, even at 5 years post-stroke. Personalizing objectives of the treatment amplified its efficacy. BoNT-A was a powerful analgesic when pain was spasticity-related. Treating the spastic upper limb also improved balance and gait abilities.
Source: Annals of Physical and Rehabilitation Medicine - June 25, 2019 Category: Rehabilitation Source Type: research

Botuloscope: 1-year follow-up of upper-limb post-stroke spasticity treated with botulinum toxin
Conclusion. This is the first long-term follow-up of BoNT-A treatment for upper-limb spasticity involving a large cohort independent of industry. Quality of life was improved by treating upper-limb spasticity with BoNT-A, even at 5 years post-stroke. Personalizing objectives of the treatment amplified its efficacy. BoNT-A was a powerful analgesic when pain was spasticity-related. Treating the spastic upper limb also improved balance and gait abilities.
Source: Annals of Physical and Rehabilitation Medicine - June 22, 2019 Category: Rehabilitation Source Type: research

Electrical stimulation of antagonist muscles after botulinum toxin type A for post-stroke spastic equinus foot. A randomized single-blind pilot study
Conclusions. ES of antagonist muscles does not improve clinical outcomes in the post-stroke spastic equinus foot after BoNT-A injection.
Source: Annals of Physical and Rehabilitation Medicine - June 20, 2019 Category: Rehabilitation Source Type: research

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