Assessing the immediate impact of botulinum toxin injection on impedance of spastic muscle

Since the 1980s, Botulinum toxin type A (BoNT-A) has been widely used in the management of spasticity caused by stroke, spinal cord injury, or cerebral palsy [1 –5]. The underlying mechanisms of BoNT-A is that it can effectively block the release of acetylcholine from the nerve endings, thus producing a progressive paralysis of the muscle [1,6]. Subsequent to the intramuscular BoNT-A injection, alterations in the physiological and mechanical properties of muscle have been reported in histological, mechanical, and medical imaging studies [7–11].

Source: Medical Engineering and Physics - February 3, 2017 Category: Biomedical Engineering Authors: Xiaoyan Li, Henry Shin, Le Li, Elaine Magat, Sheng Li, Ping Zhou Tags: Technical note Source Type: research