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Total 276 results found since Jan 2013.

Anesthetic Management of Emergency Endovascular Thrombectomy for Acute Ischemic Stroke, Part 1: Patient Characteristics, Determinants of Effectiveness, and Effect of Blood Pressure on Outcome.
Abstract In the United States, stroke ranks fifth among all causes of death and is the leading cause of serious long-term disability. The 2018 American Heart Association stroke care guidelines consider endovascular thrombectomy to be the standard of care for patients who have acute ischemic stroke in the anterior circulation when arterial puncture can be made within 6 hours of symptom onset or within 6-24 hours of symptom onset when specific eligibility criteria are satisfied. The aim of this 2-part review is to provide practical perspective on the clinical literature regarding anesthesia care of patients treated ...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Hindman BJ Tags: Anesth Analg Source Type: research

A missing gene makes a big difference in patients ’ recovery from mild stroke
More than 6 million Americans live with disabilities following a stroke. Even mild strokes can leave survivors with arm and leg weakness, poor muscle control and memory lapses that worsen with age. Now UCLA neuroscientists have found that patients born without a gene called CCR5 recover better from mild stroke than patients with the gene. The team partnered with Israeli researchers to study the missing gene ’s effect on brain function.Published Feb. 21 in the journal Cell,  the findings could lead to the first pill to reverse the physical and mental aftermath of mild stroke.“This is the first time that a human gene h...
Source: UCLA Newsroom: Health Sciences - February 21, 2019 Category: Universities & Medical Training Source Type: news

Ekso Bionics Steps Up to Develop Exoskeleton Market in Asia
China is expected to have 30 million stroke patients by 2030, and many of those patients will have some degree of disability. And yet, the stroke and spinal cord rehabilitation industry in China is not as developed as it is in the United States. A new joint venture between Ekso Bionics, Zhejiang Youchuang Venture Capital Investment (ZYVC) and Zhejiang Silicon Paradise Asset Management Group could change that. "This joint venture is a transformative opportunity both for Ekso Bionics and for the millions of Chinese stroke and spinal cord injury patients who currently have limited access to advanced rehabilitation...
Source: MDDI - January 30, 2019 Category: Medical Devices Authors: MDDI Staff Tags: Orthopedics Source Type: news

Management of Stroke in the Neurocritical Care Unit
This article provides updated information regarding the diagnosis and treatment (specifically critical care management) of acute ischemic stroke. This article also discusses the increased use of thrombolysis and thrombectomy in clinical practice. RECENT FINDINGS Stroke is the leading cause of disability in the United States. A significant proportion of patients with acute ischemic stroke require critical care management. Much has changed in the early evaluation and treatment of patients presenting with acute ischemic stroke. The introduction of embolectomy in large vessel occlusions for up to 24 hours post–symptom ons...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2018 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Roles of integrins and extracellular matrix in stroke.
Abstract Ischemic stroke is a leading cause of death and disability in the United States, but recent advances in treatments (i.e. endovascular thrombectomy and tissue plasminogen activator (t-PA)) that target the stroke-causing blood clot, while improving overall stroke mortality rates, have had much less of an impact on overall stroke morbidity. This may in part be attributed to the lack of therapeutics targeting reperfusion induced injury after the blood clot has been removed, which, if left unchecked, can expand injury from its core into the surrounding at risk tissue (penumbra). This occurs in two phases of in...
Source: Am J Physiol Cell Ph... - November 21, 2018 Category: Cytology Authors: Edwards D, Bix GJ Tags: Am J Physiol Cell Physiol Source Type: research

Debilitating Headache after an Excited Reaction
​BY GREGORY TAYLOR, DO, & MATTHEW WARPINSKI, DOA 35-year-old man with a history of uncontrolled hypertension and medical noncompliance was brought to the emergency department by EMS complaining of a headache. The family said the patient was watching football and developed an acute headache after he stood up screaming in excitement.His family said he had not taken his blood pressure medication for years. He was afebrile, his blood pressure was 245/129 mm Hg, his respiratory rate was 18 bpm, his heart rate was 68 bpm, and he weighed 340 pounds. The patient was obtunded with a Glasgow Coma Scale score of 4 and was subse...
Source: The Case Files - November 20, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Inflammatory Signaling in Post-Stroke Fatigue and Depression
Background: In the United States, stroke continues to be the cause for long-term disability. Of the patients with a first stroke, up to 75% will experience post-stroke fatigue (PSF) in the first year following stroke. PSF is one of the most disabling symptoms in stroke survivors; it decreases quality of life, increases mortality, and is a barrier to stroke rehabilitation. Given the incidence of stroke and the prevalence and detrimental impact of PSF on quality of life, independent living, and overall survival, efficient management of PSF must be a priority in stroke rehabilitation. The cause of PSF remains unknown. The bur...
Source: European Neurology - November 16, 2018 Category: Neurology Source Type: research

Tenecteplase utility in acute ischemic stroke patients: A clinical review of current evidence
Acute ischemic stroke is leading cause of disability in the United States. Treatment is aimed at reducing impact of cerebral clot burden and life-long disability. Traditional fibrinolytic treatment with recombinant tissue plasminogen activator (tPA) has shown to be effective but at high risk of major bleeding. Multiple studies have evaluated tenecteplase as an alternative to tPA.
Source: The American Journal of Emergency Medicine - November 14, 2018 Category: Emergency Medicine Authors: Amelia Nelson, Gregory Kelly, Richard Byyny, Catherine Dionne, Candice Preslaski, Kevin Kaucher Source Type: research

Ischemic Stroke: Management by the Nurse Practitioner
This article addresses preischemic stroke, acute, and postischemic stroke care by the NP with a focus on the American Heart Association 8 D ’s of stroke chain of survival.
Source: The Journal for Nurse Practitioners - November 10, 2018 Category: Nursing Authors: Susan E. Wilson, Susan Ashcraft Tags: Featured Article Source Type: research

Tobacco Product Use Among Adults - United States, 2017.
Abstract Cigarette smoking harms nearly every organ of the body and causes adverse health consequences, including heart disease, stroke, and multiple types of cancer (1). Although cigarette smoking among U.S. adults has declined considerably, tobacco products have evolved in recent years to include various combustible, noncombustible, and electronic products (1,2). To assess recent national estimates of tobacco product use among U.S. adults aged ≥18 years, CDC, the Food and Drug Administration (FDA), and the National Institutes of Health's National Cancer Institute analyzed data from the 2017 National Health Int...
Source: MMWR Morb Mortal Wkl... - November 9, 2018 Category: Epidemiology Authors: Wang TW, Asman K, Gentzke AS, Cullen KA, Holder-Hayes E, Reyes-Guzman C, Jamal A, Neff L, King BA Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Stroke Survivor and Caregiver Perspectives on Post-Stroke Visual Concerns and Long-Term Consequences.
This study employed a qualitative design using semistructured interviews conducted with a convenience sample of stroke survivors and caregivers recruited from either a community support group or skilled nursing and long-term care facilities. Interviews were recorded and transcribed verbatim. Comparative content analysis was used to identify vision-related themes by two independent coders. All research team members completed quality checking of coding. Twenty participants (11 stroke survivors and 9 caregivers) expressed visual concerns or consequences following stroke: (1) eye movement problems, (2) perceptual issues, and (...
Source: Behavioural Neurology - November 8, 2018 Category: Neurology Authors: Smith TM, Pappadis MR, Krishnan S, Reistetter TA Tags: Behav Neurol Source Type: research

Community-Based Stroke Recognition Education and Response: An Evidence-Based Intervention Project.
CONCLUSIONS: FAST was simple to teach and engaging for participants. Using the FAST curriculum in senior center populations increased the participants' awareness of stroke signs and symptoms, and their willingness to activate the 911 emergency system. IMPLICATIONS FOR PRACTICE: Educational interventions in the community with older adults can produce increased awareness of stroke symptoms and willingness to respond when necessary. PMID: 30567968 [PubMed - in process]
Source: Creative Nursing - November 1, 2018 Category: Nursing Authors: Sposito J, Zipf A, Alhowaymel F, Almutairi MT, Breda K Tags: Creat Nurs Source Type: research

Economic and Societal Aspects of Stroke Management
Stroke is a major health burden worldwide with attendant mortality, morbidity, and cost. In 2010, there were approximately 16.9 million strokes and an estimated 33 million stroke survivors worldwide. Also, in the United States, stroke is the third leading cause of death, with ischemic stroke resulting in 8% 30-day mortality (20% for hemorrhagic stroke). The staggering economic cost of the disease is driven largely by disability and long term care. Efforts in stroke healthcare delivery are focusing on performance, efficiency and value to better serve the consumer.
Source: Neuroimaging Clinics - October 13, 2018 Category: Radiology Authors: Govind Mukundan, David J. Seidenwurm Source Type: research

Current advances in ischemic stroke research and therapies
Publication date: Available online 15 September 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Derek Barthels, Hiranmoy DasAbstractWith more than 795,000 cases occurring every year, stroke has become a major problem in the United States across all demographics. Stroke is the leading cause of long-term disability and is the fifth leading cause of death in the US. Ischemic stroke represents 87% of total strokes in the US, and is currently the main focus of stroke research. This literature review examines the risk factors associated with ischemic stroke, changes in cell morphology and s...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - September 16, 2018 Category: Molecular Biology Source Type: research

Anesthesia for stroke rescue
Purpose of review To highlight the potential implications of recent advances in the management of large vessel occlusions for intraprocedural anesthetic management. Recent findings Stroke remains the leading cause of disability in the United States and the second leading cause of death in the world. Several randomized control trials published within the past decade have helped to make endovascular thrombectomy the standard of care for all eligible patients. However, whether intraprocedural anesthesia care practices may significantly improve in-hospital and out-of-hospital morbidity and mortality outcomes are not clear...
Source: Current Opinion in Anaesthesiology - September 8, 2018 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Federico Bilotta Source Type: research