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Total 40 results found since Jan 2013.

P155/200 Usefulness of quadri-axial system in mechanical thrombectomy in acute ischemic stroke: redefining the boundaries of trans-femoral access
ConclusionQAS via TFA for MT in AIS is a safe and effective technique, even in challenging cases, allowing faster and more successful procedures without increasing complications. QAS could redefine and widen the boundaries of TFA in AIS.Disclosure of InterestNothing to disclose.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Politi, M. A., Kuncha, G., Conte, M., Cavallaro, T., Corsale, G., Borzi, S. R., Monaco, E., Travali, M., Concetto, C. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

Sensors, Vol. 23, Pages 5017: A Serious Game for the Assessment of Visuomotor Adaptation Capabilities during Locomotion Tasks Employing an Embodied Avatar in Virtual Reality
acqua Domenico Buongiorno The study of visuomotor adaptation (VMA) capabilities has been encompassed in various experimental protocols aimed at investigating human motor control strategies and/or cognitive functions. VMA-oriented frameworks can have clinical applications, primarily in the investigation and assessment of neuromotor impairments caused by conditions such as Parkinson’s disease or post-stroke, which affect the lives of tens of thousands of people worldwide. Therefore, they can enhance the understanding of the specific mechanisms of such neuromotor disorders, thus being a potential biomarker...
Source: Sensors - May 24, 2023 Category: Biotechnology Authors: Vladimiro Suglia Antonio Brunetti Guido Pasquini Mariapia Caputo Tommaso Maria Marvulli Elena Sibilano Sara Della Bella Paola Carrozza Chiara Beni David Naso Vito Monaco Giovanna Cristella Vitoantonio Bevilacqua Domenico Buongiorno Tags: Article Source Type: research

The changing landscape of the vulnerable plaque: A call for fine-tuning of preclinical models
Vascul Pharmacol. 2021 Oct 1:106924. doi: 10.1016/j.vph.2021.106924. Online ahead of print.ABSTRACTFor decades, the pathological definition of the vulnerable plaque led to invaluable insights into the mechanisms that underlie myocardial infarction and stroke. Beyond plaque rupture, other mechanisms, such as erosion, may elicit thrombotic events underlining the complexity and diversity of the atherosclerotic disease. Novel insights, based on single-cell transcriptomics and other "omics" methods, provide tremendous opportunities in the ongoing search for cell-specific determinants that will fine-tune the description of the t...
Source: Vascular Pharmacology - October 4, 2021 Category: Drugs & Pharmacology Authors: Michele F Buono Lotte Slenders Marian Wesseling Robin J G Hartman Claudia Monaco Hester M den Ruijter Gerard Pasterkamp Michal Mokry Source Type: research

Effects of gait rehabilitation on motor coordination in stroke survivors: an UCM-based approach
Exp Brain Res. 2021 May 6. doi: 10.1007/s00221-021-06117-5. Online ahead of print.ABSTRACTPost-stroke locomotion is usually characterized by asymmetrical gait patterns, compensatory movements of trunk and nonparetic limb, altered motor coordination, and wide inter-stride variability. This pilot study was designed to test a twofold hypothesis: post-stroke survivors can exploit the redundancy of the segmental angles to stabilize the 3D footpath trajectory during the swing phase, in accordance with the Uncontrolled Manifold (UCM) theory; an intense rehabilitative treatment improves both motor performance and outcomes of the U...
Source: Experimental Brain Research - May 6, 2021 Category: Neuroscience Authors: Margherita Lofrumento Peppino Tropea Michela Picardi Paola Antoniotti Silvestro Micera Massimo Corbo Vito Monaco Source Type: research

Direct oral anticoagulants and therapeutic adherence: do not let your guard down
CONCLUSIONS: Polypharmacy, patient's isolation, such as a low education level were statistically associated with a low therapeutic adherence. Therapeutic adherence remains an unsolved problem for anticoagulated patient. To identify patients at higher risk of poor compliance and therapeutic failure and establish targeted care pathways is a priority.PMID:33896375 | DOI:10.1080/00015385.2021.1908702
Source: Acta Cardiologica - April 26, 2021 Category: Cardiology Authors: Leonardo Di Gennaro Martina Monaco Claudia Riccio Erica De Candia Maria Adele Alberelli Cinzia di Martino Maria Basso Maria Antonietta Ferretti Stefano Lancellotti Raimondo De Cristofaro Source Type: research

3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)
Background and Aims: Intra-plaque angiogenesis (IP), present in advanced human atherosclerotic plaques, promotes unstable vascular disease and contributes to increased risk of myocardial infarction and stroke. Because proliferating endothelial cells (ECs) rely on glycolysis for up to 85% of their energy demand, glycolysis inhibition may represent a novel strategy to prevent IP neovascularization, thereby promoting plaque stabilization. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is a key enzyme of the glycolysis pathway and plays an essential role in angiogenesis.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: B. Emini Veseli, P. Perrotta, A. Abdali, P. Van Wielendaele, G. Monaco, A.-M. Lambeir, M.L. Gelmi, G. Bultynck, W. Martinet, G. De Meyer Source Type: research

Literature Commentary
In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD will discuss the following 6 articles: Markus HS, Levi C, King A, Madigan J, Norris J; Cervical Artery Dissection in Stroke Study (CADISS) Investigators. Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results. JAMA Neurol. [published ahead of print February 25, 2019] doi: 10.1001/jamaneurol.2019.0072.Cortese I, Muranski P, Enose-Akahata Y, Ha SK, Smith B, Monaco M, Ryschkewitsch C, Major EO, Ohayon J, Schindler MK...
Source: Journal of Neuro-Ophthalmology - August 30, 2019 Category: Opthalmology Tags: Literature Commentary Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis
Conclusion Recent advances in research on HTLV-1 provide better understanding of the molecular pathogenesis and mechanisms of HAM/TSP, and several clinical trials of novel therapies for patients with HAM/TSP have been initiated. However, long-term improvement of motor disability and quality of life still have not been achieved in HAM/TSP patients, and the clinical management remains challenging. Given that HAM/TSP is characterized by activated T-cells in both the periphery and CNS, studies in HAM/TSP will be highly informative for clarifying the pathogenesis of other neuroinflammatory disorders such as multiple sclerosis....
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research