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Evidence for and risks of endovascular treatment of asymptomatic acute type B aortic dissection.
Abstract Acute aortic dissection is a challenging disease to manage. Type B aortic dissection has traditionally been divided temporally into acute and chronic cases but more recently this classification has been modified to include a sub-acute phase. Computed tomography is the imaging technique used most frequently in diagnosis and management. Active management of blood pressure is essential and should include beta-blockade unless contra-indicated. In-hospital outcomes are generally acceptable in patients with medically managed acute uncomplicated type B aortic dissection, with up to 90% of patients surviving to h...
Source: The Journal of Cardiovascular Surgery - January 2, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Clough RE, Nienaber CA Tags: J Cardiovasc Surg (Torino) Source Type: research

Clinical Value of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio After Aneurysmal Subarachnoid Hemorrhage
ConclusionsNLR and PLR as novel inflammatory biomarkers are independent predictors of DCI development and functional outcome after acute aSAH. When combined together, they may help to identify high-risk patients more powerfully.
Source: Neurocritical Care - December 26, 2016 Category: Neurology Source Type: research

Aortic Remodeling After Endovascular Repair of Complicated Acute Type B Aortic  Dissection
Conclusions TEVAR for complicated aTBAD results in low 30-day and 1-year mortality rates, with higher reintervention rates than observed with open operations. TEVAR is effective in thrombosing and stabilizing the size of the thoracic FL. The abdominal aortic FL remains patent and must be carefully scrutinized for long-term aneurysm formation.
Source: The Annals of Thoracic Surgery - December 17, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Aortic Remodeling After Endovascular Repair of Complicated Acute Type B Aortic  Dissection.
CONCLUSIONS: TEVAR for complicated aTBAD results in low 30-day and 1-year mortality rates, with higher reintervention rates than observed with open operations. TEVAR is effective in thrombosing and stabilizing the size of the thoracic FL. The abdominal aortic FL remains patent and must be carefully scrutinized for long-term aneurysm formation. PMID: 27993378 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - December 15, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Leshnower BG, Duwayri YM, Chen EP, Li C, Zehner CA, Binongo JN, Veeraswamy RK Tags: Ann Thorac Surg Source Type: research

2016 Russell Ross Memorial Lecture in Vascular Biology: Molecular-Cellular Mechanisms in the Progression of Atherosclerosis.
Abstract Atherosclerosis is initiated by the subendothelial accumulation of apoB-containing lipoproteins, which initiates a sterile inflammatory response dominated by monocyte-macrophages but including all classes of innate and adaptive immune cells. These inflammatory cells, together with proliferating smooth muscle cells and extracellular matrix, promote the formation of subendothelial lesions or plaques. In the vast majority of cases, these lesions do not cause serious clinical symptoms, which is due in part to a resolution-repair response that limits tissue damage. However, a deadly minority of lesions progres...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 14, 2016 Category: Cardiology Authors: Tabas I Tags: Arterioscler Thromb Vasc Biol Source Type: research

Twenty ‐five year outcomes following composite graft aortic root replacement
ConclusionsComposite graft aortic root replacement is associated with low operative risk, excellent long‐term survival, and low incidence of reoperation and late events.
Source: Journal of Cardiac Surgery - November 30, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Salvior C.M. Mok, Wei ‐Guo Ma, Ahmed Mansour, Paris Charilaou, Alan S. Chou, Sven Peterss, Maryann Tranquilli, Bulat A. Ziganshin, John A. Elefteriades Tags: Original Article Source Type: research

Acute bithalamic infarct manifesting as sleep-like coma: A diagnostic challenge
Publication date: December 2016 Source:Journal of Clinical Neuroscience, Volume 34 Author(s): Asaf Honig, Ruth Eliahou, Roni Eichel, Ari Aharon Shemesh, Tamir Ben-Hur, Eitan Auriel Bilateral thalamic infarction (BTI) typically presents as a sleep-like coma (SLC) without localizing signs, posing a diagnostic challenge that may lead the treating physician to search for toxic or metabolic causes and delay treatment. We review our experience with BTI of different etiologies, and emphasize the critical role of timely imaging, diagnosis, and management in a series of 12 patients with a presentation of SLC and acute BTI who were...
Source: Journal of Clinical Neuroscience - November 10, 2016 Category: Neuroscience Source Type: research

Combined brachial embolectomy and stent graft endovascular exclusion in the treatment of acute arm ischemia due to subclavian artery aneurysms thrombosis or distal embolization.
CONCLUSION: Endovascular repair is a less invasive alternative to open repair especially in high risk patients. long term results must still be confirmed in further studies. KEY WORDS: Arm ischemia, Endovascular treatment, Subclavian aneurysm. PMID: 27807319 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - November 5, 2016 Category: Surgery Tags: Ann Ital Chir Source Type: research

E-067 Endovascular Approach in the Repair of the Middle Cerebral Artery Aneurysm Including Those with Wide Neck and Complex in Morphology-A Case Series
ConclusionsEndovascular repair of the MCA aneurysm inclosing those with wide neck and complex are not only safe and feasible, but associated with high long-term functional outcome. Therefore, endovascular options must be offered to patients prior to surgical clipping of a MCA aneurysm. Further study may be warranted.DisclosuresY. Lodi: None. V. Reddy: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Lodi, Y., Reddy, V. Tags: Electronic poster abstracts Source Type: research

Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke Basic Sciences
Conclusions— Our data suggest that DM exacerbates neurovascular damage and hinders brain repair processes, which likely contribute to the impairment of stroke recovery.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Zhang, L., Chopp, M., Zhang, Y., Xiong, Y., Li, C., Sadry, N., Rhaleb, I., Lu, M., Zhang, Z. G. Tags: Basic Science Research, Cognitive Impairment, Neurogenesis Basic Sciences Source Type: research

Late Retrograde Migration of a Left Subclavian Artery Chimney Stent-Graft Into the Innominate Artery
Conclusion: Migration of the proximal end of an overly long chimney graft that moved freely in the aortic arch exposed the patient to a high risk of stroke and death. Because of the high-risk situation, open repair under circulatory arrest was elected to remove the proximal end of the chimney graft, with no major complications.
Source: Journal of Endovascular Therapy - July 12, 2016 Category: Surgery Authors: Leopardi, M., Tshomba, Y., Castiglioni, A., Baccellieri, D., Kahlberg, A., Negri, G., Melissano, G., Chiesa, R. Tags: Case Reports Source Type: research

Safety and Feasibility of Treatment with Rivaroxaban for Non-Canonical Indications: A Case Series Analysis
Conclusions Rivaroxaban is a valuable treatment option for patients with biological prostheses, repaired mitral valves, or a tubular aortic graft in order to prevent thromboembolic complications.
Source: Clinical Drug Investigation - July 10, 2016 Category: Drugs & Pharmacology Source Type: research

Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay.
Abstract Pro-coagulant, anti-coagulant and fibrinolytic pathways are responsible for maintaining haemostatic balance under physiological conditions. Any deviation from these pathways would result in hypercoagulability leading to life threatening diseases like myocardial infarction, stroke, portal vein thrombosis, deep vein thrombosis (DVT) and pulmonary embolism (PE). Angiogenesis is the process of sprouting of new blood vessels from pre-existing ones and plays a critical role in vascular repair, diabetic retinopathy, chronic inflammation and cancer progression. Serpins; a superfamily of protease inhibitors, play ...
Source: Archives of Biochemistry and Biophysics - June 28, 2016 Category: Biochemistry Authors: Bhakuni T, Ali MF, Ahmad I, Bano S, Ansari S, Jairajpuri MA Tags: Arch Biochem Biophys Source Type: research

Inflammatory Disequilibrium in Stroke.
Abstract Over the past several decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to the development of thrombolytic therapy as the cornerstone of current management of ischemic stroke, but there remains much to be learned about mechanisms of neuronal ischemic and reperfusion injury and associated inflammation. For ischemic stroke, novel therapeutic targets have continued to remain elusive. When considering modern molecular biological techniques, advanced translational stroke models, and clinical studies, a consi...
Source: Circulation Research - June 23, 2016 Category: Cardiology Authors: Petrovic-Djergovic D, Goonewardena SN, Pinsky DJ Tags: Circ Res Source Type: research

Contemporary Management of Type B Aortic Dissection in the Endovascular Era.
Authors: Bannazadeh M, Tadros RO, McKinsey J, Chander R, Marin ML, Faries PL Abstract Aortic dissection (AD) is one of the most common catastrophic pathologies affecting the aorta. Anatomic classification is based on the origin of entry tear and its extension. Type A dissections originate in the ascending aorta, whereas the entry tear in Type B dissections starts distal to the left subclavian artery. The patients with aortic dissection who manifest complications such as rupture, malperfusion, aneurysmal degeneration, and intractable pain are classified as complicated AD. Risk factors for developing aortic dissectio...
Source: Surgical Technology International - May 15, 2016 Category: Surgery Tags: Surg Technol Int Source Type: research

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