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Results of carotid artery stenting with transcervical access
Conclusions: CAS with the transcervical approach is a safe procedure with low incidence of stroke and complications. It can be used as an alternative to femoral access in patients with unfavorable aortoiliac or aortic arch anatomy.
Source: Journal of Vascular Surgery - September 26, 2013 Category: Surgery Authors: George S. Sfyroeras, Konstantinos G. Moulakakis, Fotis Markatis, Constantinos N. Antonopoulos, George A. Antoniou, John D. Kakisis, Elias N. Brountzos, Christos D. Liapis Tags: Review article Source Type: research

117 * long-term results of the frozen elephant trunk technique for acute type a aortic dissection from a 15-year experience
Conclusions: The FET technique resulted in excellent aortic remodelling on the downstream aorta and could improve the long-term outcome for AAAD.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Uchida, N., Katayama, A., Katayama, K., Takahashi, S., Takasaki, T., Sueda, T. Tags: Proximal aorta surgery: Extending to the descending aorta Source Type: research

The Role of Blood-Brain Barrier Transporters in Pathophysiology and Pharmacotherapy of Stroke.
Abstract Cerebral ischemia is one of the major causes of disability worldwide. In cerebral ischemic stroke, occlusion of a major cerebral artery by an embolus or local thrombosis can result in transient or permanent reduction of cerebral blood flow to a portion of the brain, resulting in deprivation of glucose and oxygen. Since the brain relies on a continuous supply of nutrients and ions via mostly carrier mediated processes across the blood-brain barrier (BBB), any irregularity in these transport mechanisms dramatically affects neuronal function and outcome after acute and chronic stroke. Despite numerous encour...
Source: Current Pharmaceutical Design - June 19, 2013 Category: Drugs & Pharmacology Authors: Shah K, Abbruscato T Tags: Curr Pharm Des Source Type: research

Mitral valve repair and bioprosthetic replacement without postoperative anticoagulation does not increase the risk of stroke or mortality ADULT CARDIAC
CONCLUSIONS Despite current guidelines recommending postoperative anticoagulation following MVRR or bioprosthetic replacement, the avoidance of warfarin does not increase perioperative complications and has no impact on intermediate survival. Accordingly, a prospective randomized study to adjudicate the role of extended warfarin thromboprophylaxis in mitral valve surgery is warranted.
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Schwann, T. A., Engoren, M., Bonnell, M., Clancy, C., Khouri, S., Kabour, A., Jamil, T., Habib, R. H. Tags: ADULT CARDIAC Source Type: research

Platelet lysates stimulate angiogenesis, neurogenesis and neuroprotection after stroke.
In conclusion, local delivery of PLT to the lateral ventricles induces angiogenesis, neurogenesis and neuroprotection and reduces behavioural deficits after brain ischaemia. PMID: 23765126 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 13, 2013 Category: Hematology Authors: Hayon Y, Dashevsky O, Shai E, Varon D, Leker RR Tags: Thromb Haemost Source Type: research

Management of common carotid artery dissection due to extension from acute type A (DeBakey I) aortic dissection
Conclusions: CCAD, due to extension from aortic arch dissection, has a low risk of subsequent stroke after the initial event. Based on current data, there is little evidence to suggest that aortic origin CCAD requires repair in the absence of recurrent symptoms, regardless of the degree of stenosis or false-lumen patency. Recommended optimal medical therapy includes either aspirin or anticoagulation for 6 months after initial presentation. Additional longitudinal studies are needed.
Source: Journal of Vascular Surgery - May 13, 2013 Category: Surgery Authors: Kristofer M. Charlton-Ouw, Ali Azizzadeh, Harleen K. Sandhu, Ali Sawal, Samuel S. Leake, Charles C. Miller, Anthony L. Estrera, Hazim J. Safi Tags: Clinical research studies Source Type: research

Carotid Artery Free-Floating Thrombus Caused by Paradoxical Embolization From Greater Saphenous Vein Ascending Thrombophlebitis
We report a case of a young woman without cardiovascular risk factors who was admitted to our emergency department with listlessness and altered mental status. The clinical examination revealed right lower limb swelling. Magnetic resonance imaging and contrast-enhanced computed tomographic scans revealed a free floating thrombus of the left internal carotid artery (ICA) with a large bilateral frontal ischemic lesion. The diagnosis of a medium-sized PFO with moderate right-to-left contrast shunting was made after transesophageal echocardiography. No other cardiac sources for embolization were detected, while an ascending th...
Source: Annals of Vascular Surgery - April 28, 2013 Category: Surgery Authors: Luigi Irace, Roberto Gabrielli, Maria Sofia Rosati, Maria Fabrizia Giannoni, Anna Castiglione, Antonella Laurito, Bruno Gossetti Tags: Case Report Abstracts Source Type: research

Allogeneic bone marrow mesenchymal stem cells transplantation for stabilizing and repairing of atherosclerotic ruptured plaque
Abstract: Introduction: There have been no satisfactory therapies on stabilizing and repairing ruptured plagues nowadays, which are the fundamental causes of acute coronary syndrome (ACS) and stroke. The aim of this study was to investigate the therapeutic potential of bone marrow mesenchymal stem cells (MSCs) in stabilizing and repairing ruptured plaques.Materials and Methods: 28 male New Zealand rabbits were randomly divided into 2 groups after establishment of atherosclerotic disrupted plaque model by liquid nitrogen frostbite: MSCs transplantation group and control group. MSCs were isolated, cultured in vitro, and labe...
Source: Thrombosis Research - April 25, 2013 Category: Hematology Authors: Shun-Miao Fang, Da-Yong Du, Yun-Tian Li, Xing-Li Ge, Peng-Tao Qin, Qing-Hua Zhang, Yang Liu Tags: Platelets and Cell Biology Source Type: research

Systematic review of outcomes of combined proximal stent grafting with distal bare stenting for management of aortic dissection
Conclusions: Combined proximal stent grafting with distal bare stenting for management of aortic dissection appears to be a reasonable approach for type B aortic dissection, clearly improved true-lumen perfusion and diameter although failing to suppress false-lumen patency completely. Contemporary information on this approach is mainly provided by small series with a wide range of results.
Source: The Journal of Thoracic and Cardiovascular Surgery - March 25, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Ludovic Canaud, Benjamin O. Patterson, George Peach, Robert Hinchliffe, Ian Loftus, Matt M. Thompson Tags: Expert Review Source Type: research

Psychiatric remission with warfarin: Should psychosis be addressed as plasminogen activator imbalance?
Conclusion: Our findings suggest that normalization of plasminogen activator levels in the brain may induce long-term remission of psychotic symptoms. Randomized controlled studies may help clarify the role of anticoagulation in the treatment of psychosis.
Source: Medical Hypotheses - December 3, 2012 Category: Biomedical Science Authors: Silvia Hoirisch-Clapauch, Antonio E. Nardi Tags: Articles Source Type: research

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