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HMGB1, angel or devil, in ischemic stroke
CONCLUSIONS: HMGB1 plays a complex role in cerebral infarction, which is related to not only the modification of HMGB1 and bound receptors but also different stages and subtypes of cerebral infarction. future studies on HMGB1 should investigate the spatial and temporal dynamics of HMGB1 after cerebral infarction. Moreover, future studies on HMGB1 should attempt to integrate different stages and infarct subtypes of cerebral infarction.PMID:37062906 | DOI:10.1002/brb3.2987
Source: Atherosclerosis - April 17, 2023 Category: Cardiology Authors: Bin Gao Shuwen Wang Jiangfeng Li Nannan Han Hanming Ge Gejuan Zhang Mingze Chang Source Type: research

Outcomes of aortic arch repair using the frozen elephant trunk technique: analysis of a Scandinavian center's results over 14 years
CONCLUSIONS: Despite the advantages of the FET technique, repair of extensive aortic arch disease remains associated with high rates of mortality and major neurologic complications. FET repair of CAD induces favorable remodeling in the thoracic aorta.PMID:36987817 | DOI:10.23736/S0021-9509.23.12490-6
Source: The Journal of Cardiovascular Surgery - March 29, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Tina Hellgren Anders Wanhainen Rafael Astudillo Per Vikholm Laila Hellgren Kevin Mani Source Type: research

Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Mol Cell Biochem. 2023 Mar 23:1-12. doi: 10.1007/s11010-023-04714-2. Online ahead of print.ABSTRACTAtherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of emboli leading to hypoxia/ischemia to the organs by occluding the terminal branches and precipitate myocardial infarction and stroke. Such delibitating events could be controlled by the strategies that prevent plaque development o...
Source: Molecular and Cellular Biochemistry - March 23, 2023 Category: Biochemistry Authors: Prathosh Velpuri Vikrant Rai Devendra K Agrawal Source Type: research

Custom-Made Candy-Plug for Distal False Lumen Occlusion in Aortic Dissection: International Experience
CONCLUSION: This international CP technique experience confirmed its feasibility and low mortality and morbidity. Aortic remodelling and false lumen thrombosis rates were high and support the concept of distal FL occlusion in AD using the CP technique.PMID:36958480 | DOI:10.1016/j.ejvs.2023.03.020
Source: PubMed: Eur J Vasc Endovasc ... - March 23, 2023 Category: Surgery Authors: Ahmed Eleshra Stephan Haulon Luca Bertoglio Thomas Lindsay Fiona Rohlffs Nuno Dias Nikolaos Tsilimparis Giuseppe Panuccio Tilo K ölbel Candy-Plug Collaborators Source Type: research

Use of Secondary Iliac Branch Devices after Previous Endovascular Abdominal and Thoraco-Abdominal Aortic Aneurysm Repair < sup > † < /sup >
CONCLUSION: Secondary IBD after EVAR is a safe and effective procedure with high technical success and low complication rates. The technique of choice to revascularise the IIA seems to not affect early and follow up results. Long term durability of IBD repair is acceptable with low rates of IIA re-interventions.PMID:36707020 | DOI:10.1016/j.ejvs.2023.01.033
Source: PubMed: Eur J Vasc Endovasc ... - January 27, 2023 Category: Surgery Authors: Paolo Spath Yamel Cardona-Gloria Giovanni Torsello Enrico Gallitto Tugce Öz Efthymios Beropoulis Jan Stana Mauro Gargiulo Nikolaos Tsilimparis Source Type: research

Activated Clotting Time Guided Heparinisation During Open Abdominal Aortic Aneurysm Repair (ACTION-1) - Rationale and Design of a Randomised Trial
Unfractionated heparin has been used by vascular surgeons worldwide for more than 70 years during non-cardiac arterial procedures (NCAP) to prevent clot formation and reduce thromboembolic complications (TEC), for example, arterial thrombosis, peripheral emboli, myocardial infarction, colonic ischaemia, deep venous thrombosis, and stroke.1,2 In this Research Letter, shortcomings and high variation in current intra-operative heparin use, the need for scientific evidence, and the design of a randomised controlled trial (RCT) are discussed.
Source: European Journal of Vascular and Endovascular Surgery - January 12, 2023 Category: Surgery Authors: Max Hoebink, Liliane C. Roosendaal, Arno M. Wiersema, Vincent Jongkind, the ACTION-1 research collaborative Tags: Research Letter Source Type: research

Annexins and cardiovascular diseases: Beyond membrane trafficking and repair
Front Cell Dev Biol. 2022 Oct 14;10:1000760. doi: 10.3389/fcell.2022.1000760. eCollection 2022.ABSTRACTCardiovascular diseases (CVD) remain the leading cause of mortality worldwide. The main cause underlying CVD is associated with the pathological remodeling of the vascular wall, involving several cell types, including endothelial cells, vascular smooth muscle cells, and leukocytes. Vascular remodeling is often related with the development of atherosclerotic plaques leading to narrowing of the arteries and reduced blood flow. Atherosclerosis is known to be triggered by high blood cholesterol levels, which in the presence o...
Source: Atherosclerosis - October 31, 2022 Category: Cardiology Authors: Nerea M éndez-Barbero Irene San Sebastian-Jaraba Rafael Bl ázquez-Serra Jose L Mart ín-Ventura Luis M Blanco-Colio Source Type: research

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