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Condition: Thrombosis
Procedure: Gastroschisis Repair

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Total 175 results found since Jan 2013.

Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke Basic Sciences
Conclusions— Our data suggest that DM exacerbates neurovascular damage and hinders brain repair processes, which likely contribute to the impairment of stroke recovery.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Zhang, L., Chopp, M., Zhang, Y., Xiong, Y., Li, C., Sadry, N., Rhaleb, I., Lu, M., Zhang, Z. G. Tags: Basic Science Research, Cognitive Impairment, Neurogenesis Basic Sciences Source Type: research

Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Technical improvements in carotid revascularization based on the mechanism of procedural stroke.
In conclusion, this review provides an overview of the pathophysiological mechanism of stroke following carotid revascularization (both CAS and CEA) and of the technical improvements that have contributed to reducing this stroke risk. PMID: 30827087 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - February 28, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Fassaert LM, de Borst GJ Tags: J Cardiovasc Surg (Torino) Source Type: research

Hemorrhagic Transformation and Stroke Recurrence in Children with Cardiac Disease Receiving Antithrombotic Therapy for Secondary Stroke Prevention
CONCLUSIONS: In spite of the 24% hemorrhagic transformation rate, antithrombotic therapy has a positive risk-balance in certain cardioembolic stroke subgroups, particularly in those with single-ventricle physiology, when accounting for stroke volume.PMID:34152075 | DOI:10.1111/jth.15428
Source: Thrombosis and Haemostasis - June 21, 2021 Category: Hematology Authors: Elizabeth Pulcine Mike Seed Leonardo R Brand ão Mahmoud Slim Sunitha Palasamudram Manohar Shroff Mahendranath Moharir Gabrielle deVeber Nomazulu Dlamini Source Type: research

Inflammatory Disequilibrium in Stroke.
Abstract Over the past several decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to the development of thrombolytic therapy as the cornerstone of current management of ischemic stroke, but there remains much to be learned about mechanisms of neuronal ischemic and reperfusion injury and associated inflammation. For ischemic stroke, novel therapeutic targets have continued to remain elusive. When considering modern molecular biological techniques, advanced translational stroke models, and clinical studies, a consi...
Source: Circulation Research - June 23, 2016 Category: Cardiology Authors: Petrovic-Djergovic D, Goonewardena SN, Pinsky DJ Tags: Circ Res Source Type: research

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.
CONCLUSIONS: Heat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection. Coagulation markers may serve as accessible biomarkers for heat stroke severity and therapeutic strategies. PMID: 32367690 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - May 3, 2020 Category: Hematology Authors: Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR Tags: J Thromb Haemost Source Type: research

Preoperative risk factor analysis of postoperative stroke after Cox-maze procedure with mitral valve repair
Conclusions: In the group of patients who underwent the Cox-Maze procedure with mitral valve repair, having a stroke history was the only preoperative risk factor that could lead to a stroke event after surgery. Accordingly, patients with affliction of ischemic stroke, albeit sustained sinus rhythm, may require prophylactic anticoagulation.
Source: BMC Cardiovascular Disorders - September 11, 2014 Category: Cardiology Authors: Jun Seok KimSong Am LeeJae Bum ParkHyun Keun CheeJin Woo Chung Source Type: research

The Role of Blood-Brain Barrier Transporters in Pathophysiology and Pharmacotherapy of Stroke.
Abstract Cerebral ischemia is one of the major causes of disability worldwide. In cerebral ischemic stroke, occlusion of a major cerebral artery by an embolus or local thrombosis can result in transient or permanent reduction of cerebral blood flow to a portion of the brain, resulting in deprivation of glucose and oxygen. Since the brain relies on a continuous supply of nutrients and ions via mostly carrier mediated processes across the blood-brain barrier (BBB), any irregularity in these transport mechanisms dramatically affects neuronal function and outcome after acute and chronic stroke. Despite numerous encour...
Source: Current Pharmaceutical Design - June 19, 2013 Category: Drugs & Pharmacology Authors: Shah K, Abbruscato T Tags: Curr Pharm Des Source Type: research

Neutrophil Extracellular Trap Targeting Protects Against Ischemic Damage After Fibrin-Rich Thrombotic Stroke Despite Non-Reperfusion
Stroke is one of the most prevalent diseases worldwide caused primarily by a thrombotic vascular occlusion that leads to cell death. To date, t-PA (tissue-type plasminogen activator) is the only thrombolytic therapy approved which targets fibrin as the main component of ischemic stroke thrombi. However, due to its highly restrictive criteria, t-PA is only administrated to less than 10% of all stroke patients. Furthermore, the research in neuroprotective agents has been extensive with no translational results from medical research to clinical practice up to now. Since we first described the key role of NETs (Neutrophil Ext...
Source: Frontiers in Immunology - February 16, 2022 Category: Allergy & Immunology Source Type: research

Pericyte-Mediated Molecular Mechanisms Underlying Tissue Repair and Functional Recovery after Ischemic Stroke
J Atheroscler Thromb. 2023 Jun 30. doi: 10.5551/jat.RV22007. Online ahead of print.ABSTRACTThere are still many patients suffering from ischemic stroke and related disabilities worldwide. To develop a treatment that promotes functional recovery after acute ischemic stroke, we need to elucidate endogenous tissue repair mechanisms. The concept of a neurovascular unit (NVU) indicates the importance of a complex orchestration of cell-cell interactions and their microenvironment in the physiology and pathophysiology of various central nervous system diseases, particularly ischemic stroke. In this concept, microvascular pericyte...
Source: Journal of Atherosclerosis and Thrombosis - July 2, 2023 Category: Cardiology Authors: Kuniyuki Nakamura Tetsuro Ago Source Type: research

Iatrogenesis imperfecta: stroke caused by accidental carotid artery catheterization.
CONCLUSION:: Even with ultrasound-guided central venous catheterization, it is essential to remain vigilant for the early detection of vascular complications. Clinical suspicion combined with diagnostic modalities such as chest radiograph, transduction and manometry can increase the detection rates. PMID: 25041919 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - November 27, 2014 Category: Surgery Tags: J Vasc Access Source Type: research

Efficacy of Balloon Guide Catheter-Assisted Thrombus Repair in Stroke Treatment: A Retrospective Survey in China
CONCLUSION: We showed that BGC shortened the procedural time and increased the rate of the successful FP. We recommend that BGC could be considered the preferred technique for endovascular intervention in stroke.PMID:36212711 | PMC:PMC9534624 | DOI:10.1155/2022/4278048
Source: Biomed Res - October 10, 2022 Category: Research Authors: Qiang Li Tengfei Zhou Yingkun He Min Guan Zhaoshuo Li Liheng Wu Changming Wen Haibo Wang Guang Feng Ziliang Wang Liangfu Zhu Tianxiao Li Source Type: research