Activated Clotting Time Guided Heparinisation During Open Abdominal Aortic Aneurysm Repair (ACTION-1) - Rationale and Design of a Randomised Trial

Unfractionated heparin has been used by vascular surgeons worldwide for more than 70 years during non-cardiac arterial procedures (NCAP) to prevent clot formation and reduce thromboembolic complications (TEC), for example, arterial thrombosis, peripheral emboli, myocardial infarction, colonic ischaemia, deep venous thrombosis, and stroke.1,2 In this Research Letter, shortcomings and high variation in current intra-operative heparin use, the need for scientific evidence, and the design of a randomised controlled trial (RCT) are discussed.

Source: European Journal of Vascular and Endovascular Surgery - January 12, 2023 Category: Surgery Authors: Max Hoebink, Liliane C. Roosendaal, Arno M. Wiersema, Vincent Jongkind, the ACTION-1 research collaborative Tags: Research Letter Source Type: research