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Specialty: Research
Condition: Hemorrhagic Stroke

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Total 217 results found since Jan 2013.

The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia
Muscle tissue oxygenation (SmO2) can track central blood volume loss associated with hemorrhage. Traditional peripheral measurement sites (e.g., forearm) may not be practical due to excessive movement or injury (e.g., amputation). The aim of this study was to evaluate the efficacy of three novel anatomical sites for the assessment of SmO2 under progressive central hypovolemia. 10 male volunteers were exposed to stepwise prone lower body negative pressure to decrease central blood volume, while SmO2 was assessed at four sites—the traditional site of the flexor carpi ulnaris (ARM), and three novel sites not previously ...
Source: Experimental Biology and Medicine - October 3, 2016 Category: Research Authors: Sprick, J. D., Soller, B. R., Rickards, C. A. Tags: Physiology Source Type: research

Endovascular Treatment of Thrombosis and Embolism.
Authors: Goktay AY, Senturk C Abstract Deep venous thrombosis (DVT) is a common disorder with a significant mortality rate. Successful endovascular treatment of acute DVT is most likely to be achieved in patients with recently formed thrombus, (<10-14 days) with acute iliofemoral DVT. Endovascular treatment options include: Catheter-directed thrombolysis (CDT), pharmacomechanical catheter-directed thrombolysis (PCDT), percutaneous aspiration thrombectomy (PAT), vena cava filter protection, venous balloon dilatation and venous stent implantation. Current practice shows strong clinical tendency for the use of PCDT...
Source: Advances in Experimental Medicine and Biology - September 26, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Real-World Evidence of Stroke Prevention in Patients with Nonvalvular Atrial Fibrillation in the United States: the REVISIT-US Study.
CONCLUSIONS: Rivaroxaban and apixaban were associated with less ICH than warfarin and both are likely associated with reductions in the combined endpoint. Further investigation to validate the numerically higher rate of ischemic stroke with apixaban versus warfarin is required. PMID: 27633045 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - September 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Cerebral Venous Thrombosis.
Authors: Zuurbier SM, Coutinho JM Abstract Cerebral venous thrombosis is an important cause of stroke in the young. Unlike venous thromboembolism (VTE), women are affected three times more often than men by CVT. The most common symptoms are headache, seizures and focal neurological deficits. The diagnosis can be confirmed with MRI, CT-venography, or catheter angiography. An intracerebral hemorrhage is found on cerebral imaging in approximately 40 % of patients, and can range from small juxtacortical hemorrhages to large space-occupying lesions. Many risk factors for CVT have been reported, most of which overlap wi...
Source: Advances in Experimental Medicine and Biology - September 19, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Elevated Homocysteine Level Related to Poor Outcome After Thrombolysis in Acute Ischemic Stroke.
CONCLUSIONS High serum homocysteine level could potentially predict poor prognosis in acute ischemic stroke patients after tPA treatment. PMID: 27629768 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - September 16, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms.
Authors: Semyachkina-Glushkovskaya O, Borisova E, Namikin A, Fedosov I, Abdurashitov A, Zhinchenko E, Gekalyuk A, Ulanova M, Rezunbaeva V, Avramov L, Zhu D, Luo Q, Tuchin V Abstract We studied the level of blood oxygen saturation (SpO2) in the brain in newborn rats in the pre- and post-stroke periods, as well as the changes in cerebral blood flow and beta-arrestin-1 as a marker of hypoxic stress. Our results show that mild hypoxia precedes the stroke development and is associated with venous relaxation and decrease blood outflow from the brain resulting in the elevation of synthesis of beta-arrestin-1 in the brain....
Source: Advances in Experimental Medicine and Biology - August 17, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Efficacy of Solitaire™ Stent Arterial Embolectomy in Treating Acute Cardiogenic Cerebral Embolism in 17 Patients.
CONCLUSIONS Solitaire stent embolectomy is a safe and effective alternative to simple venous thrombolytic therapy, and it can significantly improve short-term neurological function and long-term prognosis in acute cardiogenic cerebral embolism. PMID: 27090916 [PubMed - in process]
Source: Medical Science Monitor - April 20, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Significance of cyclooxygenase-2 elevation in middle cerebral artery for patients with hemorrhagic moyamoya disease
In this study, tiny pieces of middle cerebral artery (MCA) and superficial temporal artery (STA) from 13 MMD patients were surgically harvested. The MCA and STA samples from 5 control patients were also collected by using the same technique. The expression of COX-2 was immunohistochemically detected and the average absorbance (A) of positively-stained areas was measured. High-level COX-2 expression was found in all layers of the MCA samples from all 5 hemorrhagic MMD patients, while positive but weak expression of COX-2 was observed only in the endothelial layer of the MCA samples from most ischemic MMD patients (6/8, 75%)...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - March 31, 2016 Category: Research Source Type: research

Quality of anticoagulation therapy in neurological patients in a tertiary care hospital in north India.
CONCLUSIONS: It may be concluded that stable therapeutic INR is difficult to maintain in neurological patients. Optimal modification of diet, drug and dose of oral anticoagulant may help in stabilization of INR. PMID: 27377498 [PubMed - in process]
Source: Indian J Med Res - March 31, 2016 Category: Research Authors: Singh P, Kalita J, Misra UK Tags: Indian J Med Res Source Type: research

Mp13: important role of prothrombin time (pt) and partial thromboplastin time (ptt) in predicting tpa-related hemorrhagic transformation
Conclusions Higher PT/PTT level within 72 hr of IV tPA is early marker of tPA-induced HT. Whether these routine labs have value in symptomatic hemorrhage will require further study in a larger cohort. But this proof-of-concept study suggests that tPA efficacy can potentially be followed in real time. The development of a reliable blood test would be of clinical utility to gauge thrombolytic efficacy in real time to guide and triage adjunct treatments. Abstract MP13 Figure 1
Source: Journal of Investigative Medicine - February 25, 2016 Category: Research Authors: Deng, W., Wickham, T., McMullin, D., Feeney, K., Buonanno, F., Lo, E., Ning, M. Tags: Moderated Poster, 11:45 PM - 1:05 PM, Wednesday, April 13, 2016 Source Type: research

Diffusion tensor tractography measurement of the distance between corticospinal tracts in patients with spontaneous intraventricular haemorrhage
Conclusion These results suggest that the absolute and relative distances between CSTs might be used to diagnose hydrocephalus in stroke patients.
Source: Journal of International Medical Research - February 17, 2016 Category: Research Authors: Ho Jang, S., Do Lee, H. Tags: Clinical Note Source Type: research

Animal Models in Studying Cerebral Arteriovenous Malformation.
Abstract Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke. The etiology is largely unknown and the therapeutics are controversial. A review of AVM-associated animal models may be helpful in order to understand the up-to-date knowledge and promote further research about the disease. We searched PubMed till December 31, 2014, with the term "arteriovenous malformation," limiting results to animals and English language. Publications that described creations of AVM animal models or investigated AVM-related mechanisms and treatments using these models were reviewed. More than 100 articl...
Source: Biomed Res - December 12, 2015 Category: Research Authors: Xu M, Xu H, Qin Z Tags: Biomed Res Int Source Type: research

Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R Abstract Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in specific...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Early prediction and outcome of septic encephalopathy in acute stroke patients with nosocomial coma.
CONCLUSION: High fever and severe SIRS are two early predictors of stroke patients with SE, and survival rates were worse in stroke patients with SE than those without SE. PMID: 26015818 [PubMed]
Source: Clin Med Res - May 29, 2015 Category: Research Authors: Tong DM, Zhou YT, Wang GS, Chen XD, Yang TH Tags: J Clin Med Res Source Type: research

Small vessel disease/white matter disease of the brain and its association with osteoporosis.
CONCLUSION: WMD severity of the brain was associated with osteoporosis in the elderly. PMID: 25780476 [PubMed]
Source: Clin Med Res - March 18, 2015 Category: Research Authors: Alagiakrishnan K, Hsueh J, Zhang E, Khan K, Senthilselvan A Tags: J Clin Med Res Source Type: research