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Specialty: Research
Condition: Hemorrhagic Stroke

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Total 217 results found since Jan 2013.

CLOCK disruption aggravates carotid artery stenosis through endoplasmic reticulum stress-induced endothelial-mesenchymal transition.
In conclusion, the disruption of CLOCK function aggravates EndMT via the IRE1α-XBP1 axis, contributing to carotid artery stenosis. PMID: 33437367 [PubMed]
Source: American Journal of Translational Research - January 14, 2021 Category: Research Tags: Am J Transl Res Source Type: research

Hypertension Among Hemorrhagic Stroke Patients in Northeast China: A Population-Based Study 2017-2019.
CONCLUSIONS The high prevalence of uncontrolled hypertension and high rates of blood pressure at stages 2 and 3 in patients with prior hemorrhagic stroke indicated a considerable stroke burden in northeast China. Therefore, effective and long-time management of hypertension in stroke survivors should be a priority. PMID: 33376232 [PubMed - in process]
Source: Medical Science Monitor - January 1, 2021 Category: Research Tags: Med Sci Monit Source Type: research

Comparative effectiveness and safety of non-vitamin k antagonist oral anticoagulants and warfarin in older adults with atrial fibrillation and diabetes.
CONCLUSION: Oral anticoagulation therapy with NOACs was found to be more effective than warfarin therapy among older adults with NVAF and comorbid DM. PMID: 33327796 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Glycine attenuates cerebrovascular remodeling via glycine receptor alpha 2 and vascular endothelial growth factor receptor 2 after stroke.
The objective of this study was to determine the mechanism of action of GlyRa2 in cerebrovascular remodeling. After induction of rat tMCAO, levels of the GLRA2 gene and GlyRa2 protein were examined using q-PCR, western blot, and immunohistochemical analyses. Blood-brain barrier permeability, and the presence of hemorrhage and arteriosclerosis were also analyzed. The underlying mechanism of vascular remodeling was examined using immunohistochemical and immunofluorescence analyses. Both the GLRA2 gene and GlyRa2 protein were altered sharply after stroke. GlyRa2 of vascular origin appears to play a protective role after glyci...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Stroke Incidence in Survivors of Carbon Monoxide Poisoning in South Korea: A Population-Based Longitudinal Study.
CONCLUSIONS CO poisoning is a high-risk factor for the development of stroke, evidenced by high incidences of stroke after CO poisoning. Practical strategies for preventing stroke after CO poisoning are needed, because stroke after CO poisoning affects adults of almost all ages, significantly increasing their socioeconomic burden. PMID: 33106468 [PubMed - in process]
Source: Medical Science Monitor - October 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and safety of intravenous thrombolysis for acute ischemic stroke in cancer patients: a systemic review and meta-analysis.
Authors: Huang S, Lu X, Tang LV, Hu Y Abstract The efficacy and safety of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) in cancer patients remained uncertain due to low level evidence in the latest guideline for AIS. The aim of this study was to assess the efficacy and safety of IVT in cancer patients with stronger evidence. We searched Medline, Embase, CENTRAL and ClinicalTrials.gov until April 2020 for studies reporting outcomes of functional independence, hemorrhagic transformation (HT), symptomatic intracranial hemorrhage (SICH), major bleeding (MB), in-hospital mortality or 3-month mortality a...
Source: American Journal of Translational Research - September 13, 2020 Category: Research Tags: Am J Transl Res Source Type: research

MRI predictors of intracranial hemorrhage in acute ischemic stroke after endovascular thrombectomy therapy.
CONCLUSIONS: DWI volume, PWI volume and >3 passes with the retriever were able to predict the ICH in patients with AIS after EVT therapy. PMID: 32913526 [PubMed]
Source: American Journal of Translational Research - September 13, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Systematic Understanding of Mechanism of Yi-Qi-Huo-Xue Decoction Against Intracerebral Hemorrhagic Stroke Using a Network Pharmacology Approach.
CONCLUSIONS The present results may serve as a pharmacological framework for TCM studies in the future, helping to promote the use of YQHXD in clinical treatment of ICH. PMID: 32769962 [PubMed - in process]
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Outcomes of VA-ECMO with and without Left Centricular (LV) Decompression Using Intra-Aortic Balloon Pumping (IABP) versus Other LV Decompression Techniques: A Systematic Review and Meta-Analysis.
CONCLUSIONS ECMO combined with LVD is more beneficial than using ECMO alone and helps to lower patient mortality. PMID: 32729556 [PubMed - in process]
Source: Medical Science Monitor - August 1, 2020 Category: Research Tags: Med Sci Monit Source Type: research

No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis.
Conclusion: Ischemic stroke might not be associated with portal vein thrombosis in liver cirrhosis. PMID: 32714987 [PubMed - in process]
Source: Biomed Res - July 29, 2020 Category: Research Authors: Zheng K, Guo X, Yi F, Wang L, Mancuso A, Qi X Tags: Biomed Res Int Source Type: research

Autophagy and Hemorrhagic Stroke.
Authors: Zhang Y, Liu C Abstract Hemorrhagic stroke includes cerebral hemorrhage and subarachnoid hemorrhage. An increasing number of studies have found that autophagy also occurs in brain tissues after cerebral hemorrhage and subarachnoid hemorrhage. The potential role of selective autophagy in the clinical treatment of hemorrhagic stroke has been recognized, but a consensus on the exact effect and function of autophagy has not been reached, and the mechanism needs to be further studied. In this chapter, the mechanism of brain injury after cerebral hemorrhage and subarachnoid hemorrhage is briefly introduced, and ...
Source: Advances in Experimental Medicine and Biology - July 18, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Efficacy and Safety of Mechanical Thrombectomy for Acute Mild Ischemic Stroke with Large Vessel Occlusion.
CONCLUSIONS The efficacy of MT and IVT was comparable in AMIS patients with LVO. While MT had a higher incidence of systemic complications, its short- and long-term effects were equivalent to IVT. PMID: 32628645 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - July 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prevalence of Stroke Cases in Warangal, Telangana Region, India: A Hospital-Based Case Study.
Authors: Susmitha K, Chandrasekhar V, Kiran G, Divya A, Rani GS, Sarangapani M Abstract Stroke is becoming a main cause of early death and disability in developing countries like India, and it is mostly enhanced by increased predominance of major risk factors. A detailed knowledge about the nature and magnitude of the stroke cases in this particular area is not only important for acute treatment but also it helps to prevent hospital admissions due to reoccurring stroke. The present study was conducted in the Department of Stroke at MGM Hospital, Warangal, India, to study the patterns of stroke admissions. All the c...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Significant reduction in the LDL cholesterol increases the risk of intracerebral hemorrhage: a systematic review and meta-analysis of 33 randomized controlled trials.
Authors: Cheng Y, Qiao L, Jiang Z, Dong X, Feng H, Gui Q, Lu Y, Liang Y Abstract The dose-dependent pleiotropic effects of statin therapy may have unwanted side effects such as increasing the risk of intracerebral hemorrhage (ICH). The relationships among statin therapy, LDL-cholesterol levels, and ICH risk remain controversial. Here, we conduct a systematic review and meta-analysis of dose-dependent statin therapy and ICH risk. Eligible articles were identified by searching MEDLINE from inception up to December 1, 2018. Reference lists of previous meta-analyses were manually searched to retrieve all relevant publi...
Source: American Journal of Translational Research - March 22, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Assessment of the Implementation of Critical Pathway in Stroke Patients: A 10-Year Follow-Up Study.
Conclusion: The implementation of CP allows for better application of evidence- and guideline-based key interventions and helps to provide early, comprehensive, organized, and more specialized care to stroke patients. Despite limited evidence, CP is still recommended as a means of promoting best practices in hospital care for stroke patients. PMID: 32190659 [PubMed - in process]
Source: Biomed Res - March 21, 2020 Category: Research Authors: Jang YJ, Park D, Kim HS, Lee CH, Byun HY, Yoon CH, Lee ES, Shin H, Chun SW, Lim SK, Oh MK Tags: Biomed Res Int Source Type: research