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Specialty: Research
Condition: Hemorrhagic Stroke
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Total 217 results found since Jan 2013.
Gender heterogeneity in the influencing factors for cerebral microbleeds in acute ischemic stroke patients
CONCLUSION: There are gender differences in the influencing factors for CMBs in AIS patients. Age, old LIs, and blood glucose are independent risk or protective factors for comorbid CMBs in female AIS patients, although they are not associated with the risk of developing CMBs in male AIS patients.PMID:37259500 | DOI:10.1080/03007995.2023.2219581
Source: Current Medical Research and Opinion - June 1, 2023 Category: Research Authors: Xin Guo Yuan Xing Zhenjie Teng Zhiyuan Shen Xiaosu Guo Peiyuan Lv Shujuan Tian Source Type: research
An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke.
Conclusions: In conclusion, our analysis supports that EBT, regardless of format (e.g., ET or IAT), is superior to the best medical therapy alone (e.g., IVT) in terms of mRS score in patients with AIS. In addition, the safety of EBT is similar to IVT.
PMID: 29707581 [PubMed - in process]
Source: Biomed Res - May 1, 2018 Category: Research Authors: Chen SY, Zhang XR, Chen J, Ge WQ, Wang WW, Wang XS, Xie CL Tags: Biomed Res Int Source Type: research
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
Authors: Zheng Y, Liu Y, Karatas H, Yigitkanli K, Holman TR, van Leyen K
Abstract
Ischemic strokes are caused by one or more blood clots that typically obstruct one of the major arteries in the brain, but frequently also result in leakage of the blood-brain barrier and subsequent hemorrhage. While it has long been known that the enzyme 12/15-lipoxygenase (12/15-LOX) is up-regulated following ischemic strokes and contributes to neuronal cell death, recent research has shown an additional major role for 12/15-LOX in causing this hemorrhagic transformation. These findings have important implications for the use of 12/...
Source: Advances in Experimental Medicine and Biology - September 30, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research
Efficacy and safety of intravenous thrombolysis for acute ischemic stroke in cancer patients: a systemic review and meta-analysis.
Authors: Huang S, Lu X, Tang LV, Hu Y
Abstract
The efficacy and safety of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) in cancer patients remained uncertain due to low level evidence in the latest guideline for AIS. The aim of this study was to assess the efficacy and safety of IVT in cancer patients with stronger evidence. We searched Medline, Embase, CENTRAL and ClinicalTrials.gov until April 2020 for studies reporting outcomes of functional independence, hemorrhagic transformation (HT), symptomatic intracranial hemorrhage (SICH), major bleeding (MB), in-hospital mortality or 3-month mortality a...
Source: American Journal of Translational Research - September 13, 2020 Category: Research Tags: Am J Transl Res Source Type: research
MRI predictors of intracranial hemorrhage in acute ischemic stroke after endovascular thrombectomy therapy.
CONCLUSIONS: DWI volume, PWI volume and >3 passes with the retriever were able to predict the ICH in patients with AIS after EVT therapy.
PMID: 32913526 [PubMed]
Source: American Journal of Translational Research - September 13, 2020 Category: Research Tags: Am J Transl Res Source Type: research
Glycine attenuates cerebrovascular remodeling via glycine receptor alpha 2 and vascular endothelial growth factor receptor 2 after stroke.
The objective of this study was to determine the mechanism of action of GlyRa2 in cerebrovascular remodeling. After induction of rat tMCAO, levels of the GLRA2 gene and GlyRa2 protein were examined using q-PCR, western blot, and immunohistochemical analyses. Blood-brain barrier permeability, and the presence of hemorrhage and arteriosclerosis were also analyzed. The underlying mechanism of vascular remodeling was examined using immunohistochemical and immunofluorescence analyses. Both the GLRA2 gene and GlyRa2 protein were altered sharply after stroke. GlyRa2 of vascular origin appears to play a protective role after glyci...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research
The Natural History and Reperfusion Therapy Outcomes of Acute Ischemic Stroke due to Isolated M2 Occlusions
CONCLUSIONS: For acute, isolated M2 occlusions, EVT could dramatically and rapidly improve neurological deficits with high safety and effectiveness. These changes were observed at 24 hours after treatment and were maintained over the long term.PMID:33997031 | PMC:PMC8096556 | DOI:10.1155/2021/6626604
Source: Biomed Res - May 17, 2021 Category: Research Authors: Hongmin Gong Libo Zhao Ge Tang Yu Chen Deyu Yang Shudong Liu Source Type: research
A study on endovascular treatment alone and bridging treatment for acute ischemic stroke
ConclusionsAlthough there was no difference in clinical efficacy and safety between the abovementioned two groups, treatment with IVT + EVT could increase the risk of bleeding compared to EVT. Moreover, in the 6–8 h subgroup, the efficacy of EVT alone was better than that of IVT + EVT.
Source: European Journal of Medical Research - January 7, 2023 Category: Research Source Type: research
Low (0 –5) Alberta Stroke Program Early Computed Tomography Score on admission predictive of worse functional outcome after mechanical thrombectomy for anterior circulation large vessel occlusion
ConclusionsASPECTS values ≤ 5 correspond with worse long-term functional improvement (mRS scores > 2) in patients undergoing MT for ACLVO-related AIS. Other independent determinants of functional outcomes after MT are age, baseline NIHSS score, HbA1c concentration, and successful recanalization.
Source: European Journal of Medical Research - August 4, 2023 Category: Research Source Type: research
Frequency and determinants for hemorrhagic transformation of posterior cerebral stroke
hemorrhagic transformation is a threatening ischemic stroke complication. Frequency of hemorrhagic transformation differs greatly among studies, and its risk factors have been usually studied in patients with ...
Source: BMC Research Notes - November 13, 2017 Category: Research Authors: Francesca Valentino, Luana Gentile, Valeria Terruso, Sergio Mastrilli, Paolo Aridon, Paolo Ragonese, Caterina Sarno, Giovanni Savettieri and Marco D ’Amelio Tags: Research article Source Type: research
Science Saturday: Researching stem cell therapy for hemorrhagic stroke
Stroke is the leading cause of permanent disability in the U.S., striking nearly 800,000 people each year, according to the Centers for Disease Control and Prevention. In the last decade, there has been preclinical research that led to a small number of early phase clinical trials using mesenchymal stem cells (MSCs) as a possible treatment to reverse [...]
Source: Mayo Clinic Research News - August 9, 2019 Category: Research Source Type: news
New drugs could reduce risk of stroke happening again
A wide-reaching EU-funded project is testing new anti-blood clotting treatment in patients who have suffered a brain haemorrhage. Researchers hope to reduce the risk of the patient suffering from another stroke, which would impair their quality of life and life expectancy.
Source: EUROPA - Research Information Centre - October 28, 2019 Category: Research Source Type: news
Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke
Alcohol consumption is one of the modifiable risk factors for intracerebral hemorrhage, which accounts for approximately 10 –20% of all strokes worldwide. We evaluated the association of stroke with genetic pol...
Source: Journal of Translational Medicine - May 29, 2021 Category: Research Authors: Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Mochly-Rosen Daria, Che-Hong Chen and Yung-Po Liaw Tags: Research Source Type: research
ICH-LR2S2: a new risk score for predicting stroke-associated pneumonia from spontaneous intracerebral hemorrhage
We develop a new risk score to predict patients with stroke-associated pneumonia (SAP) who have an acute intracranial hemorrhage (ICH).
Source: Journal of Translational Medicine - May 4, 2022 Category: Research Authors: Jing Yan, Weiqi Zhai, Zhaoxia Li, LingLing Ding, Jia You, Jiayi Zeng, Xin Yang, Chunjuan Wang, Xia Meng, Yong Jiang, Xiaodi Huang, Shouyan Wang, Yilong Wang, Zixiao Li, Shanfeng Zhu, Yongjun Wang & hellip; Tags: Research Source Type: research
