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The burden of undertreatment and non-treatment among patients with non-valvular atrial fibrillation and elevated stroke risk: a systematic review
CONCLUSIONS: Rates of nontreatment and undertreatment among NVAF patients remain high and are associated with preventable cardiovascular events and death. Strategies to increase rates of treatment may improve clinical outcomes.PMID:34632887 | DOI:10.1080/03007995.2021.1982684
Source: Current Medical Research and Opinion - October 11, 2021 Category: Research Authors: Matthew Sussman Geoffrey D Barnes Jennifer D Guo Charles Y Tao John A Gillespie Mauricio Ferri Nicholas Adair Matthew S Cato Ilnaz Shirkhorshidian Manuela Di Fusco Source Type: research

Neutrophil-to-Lymphocyte Ratio and Early Neurological Deterioration in Stroke Patients: A Systematic Review and Meta-Analysis
Biomed Res Int. 2022 Aug 17;2022:8656864. doi: 10.1155/2022/8656864. eCollection 2022.ABSTRACTIn light of the growing emphasis on classifying stroke patients for different levels of monitoring intensity and emergency treatments, we conducted a systematic review of a wide range of clinical studies, according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines, with no restrictions on the language or publication date, to analyze the potential of the neutrophil-to-lymphocyte ratio (NLR) as an early neurological deterioration (END) risk predictor. A comprehensive search was carried out ...
Source: Biomed Res - August 29, 2022 Category: Research Authors: Shirin Sarejloo Hadis Kheradjoo Sarvin Es Haghi Samaneh Hosseini Morad Kohandel Gargari Amir Azarhomayoun Shokoufeh Khanzadeh Shahram Sadeghvand Source Type: research

Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms.
Authors: Semyachkina-Glushkovskaya O, Borisova E, Namikin A, Fedosov I, Abdurashitov A, Zhinchenko E, Gekalyuk A, Ulanova M, Rezunbaeva V, Avramov L, Zhu D, Luo Q, Tuchin V Abstract We studied the level of blood oxygen saturation (SpO2) in the brain in newborn rats in the pre- and post-stroke periods, as well as the changes in cerebral blood flow and beta-arrestin-1 as a marker of hypoxic stress. Our results show that mild hypoxia precedes the stroke development and is associated with venous relaxation and decrease blood outflow from the brain resulting in the elevation of synthesis of beta-arrestin-1 in the brain....
Source: Advances in Experimental Medicine and Biology - August 17, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Characteristics of Hemorrhagic Stroke following Spine and Joint Surgeries.
Abstract Hemorrhagic stroke can occur after spine and joint surgeries such as laminectomy, lumbar spinal fusion, tumor resection, and total joint arthroplasty. Although this kind of stroke rarely happens, it may cause severe consequences and high mortality rates. Typical clinical symptoms of hemorrhagic stroke after spine and joint surgeries include headache, vomiting, consciousness disturbance, and mental disorders. It can happen several hours after surgeries. Most bleeding sites are located in cerebellar hemisphere and temporal lobe. A cerebrospinal fluid (CSF) leakage caused by surgeries may be the key to intra...
Source: Biomed Res - February 7, 2017 Category: Research Authors: Yang F, Zhao J, Xu H Tags: Biomed Res Int Source Type: research

The safety and efficacy of tPA intravenous thrombolysis for treating acute ischemic stroke patients with a history of cerebral hemorrhage.
Abstract Alteplase (tPA) intravenous thrombolysis is an effective treatment for acute ischemic stroke (AIS) when administered within 4.5 h of initial stroke symptoms. Here, its safety and efficacy were evaluated among AIS patients with a previous history of cerebral hemorrhage. Patients who arrived at the hospital within 4.5 h of initial stroke symptoms and who were treated with tPA intravenous thrombolysis or conventional therapies were analyzed. The 90-day modified Rankin scale (90-d mRS) was used alongside mortality and incidence of symptomatic intracerebral hemorrhage (SICH) rates to evaluate the curative effe...
Source: Braz J Med Biol Res - January 24, 2019 Category: Research Authors: Zhao GJ, Wang ZR, Lin FZ, Cui YS, Xu SL Tags: Braz J Med Biol Res Source Type: research

Systematic Understanding of Mechanism of Yi-Qi-Huo-Xue Decoction Against Intracerebral Hemorrhagic Stroke Using a Network Pharmacology Approach.
CONCLUSIONS The present results may serve as a pharmacological framework for TCM studies in the future, helping to promote the use of YQHXD in clinical treatment of ICH. PMID: 32769962 [PubMed - in process]
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A comparison of safety and efficacy between long-term DAPT and intensive statins combined with short-term DAPT for acute ischemic stroke
ConclusionsCompared to long-term DAPT, intensive rosuvastatin with short-term DAPT was equivalent in reducing the risk of recurrent ischemic stroke. It alleviated symptoms more rapidly, and significantly reduced the risk of bleeding, without causing an increase in transaminase or muscle enzymes.Clinical trial registrationChina Clinical Trial Registration Center (ChiCTR1800017809)
Source: European Journal of Medical Research - April 21, 2023 Category: Research Source Type: research

Potential molecular targets of peroxynitrite in mediating blood-brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment.
Authors: Chen H, Chen X, Luo Y, Shen J Abstract Tissue plasminogen activator (t-PA) remains to be the only FDA-approved drug for ischaemic stroke, but it has a restrictive therapeutic window with 4.5 hours. Beyond the golden time window, thrombolytic treatment carries the risk of haemorrhagic transformation (HT). The blood-brain barrier (BBB) disruption is a critical step in the t-PA-mediated HT. Although large efforts are made to explore the mechanisms of the BBB disruption and HT, the underlying mechanisms are largely unknown. Thrombolytic treatment for recanalization could produce reactive oxygen species (ROS)...
Source: Free Radical Research - November 25, 2018 Category: Research Tags: Free Radic Res Source Type: research

Efficacy and Safety of Mechanical Thrombectomy for Acute Mild Ischemic Stroke with Large Vessel Occlusion.
CONCLUSIONS The efficacy of MT and IVT was comparable in AMIS patients with LVO. While MT had a higher incidence of systemic complications, its short- and long-term effects were equivalent to IVT. PMID: 32628645 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - July 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Autophagy and Hemorrhagic Stroke.
Authors: Zhang Y, Liu C Abstract Hemorrhagic stroke includes cerebral hemorrhage and subarachnoid hemorrhage. An increasing number of studies have found that autophagy also occurs in brain tissues after cerebral hemorrhage and subarachnoid hemorrhage. The potential role of selective autophagy in the clinical treatment of hemorrhagic stroke has been recognized, but a consensus on the exact effect and function of autophagy has not been reached, and the mechanism needs to be further studied. In this chapter, the mechanism of brain injury after cerebral hemorrhage and subarachnoid hemorrhage is briefly introduced, and ...
Source: Advances in Experimental Medicine and Biology - July 18, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Gender heterogeneity in the influencing factors for cerebral microbleeds in acute ischemic stroke patients
CONCLUSION: There are gender differences in the influencing factors for CMBs in AIS patients. Age, old LIs, and blood glucose are independent risk or protective factors for comorbid CMBs in female AIS patients, although they are not associated with the risk of developing CMBs in male AIS patients.PMID:37259500 | DOI:10.1080/03007995.2023.2219581
Source: Current Medical Research and Opinion - June 1, 2023 Category: Research Authors: Xin Guo Yuan Xing Zhenjie Teng Zhiyuan Shen Xiaosu Guo Peiyuan Lv Shujuan Tian Source Type: research

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