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Specialty: Research
Condition: Hemorrhagic Stroke
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Total 217 results found since Jan 2013.
Animal Models in Studying Cerebral Arteriovenous Malformation.
Abstract
Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke. The etiology is largely unknown and the therapeutics are controversial. A review of AVM-associated animal models may be helpful in order to understand the up-to-date knowledge and promote further research about the disease. We searched PubMed till December 31, 2014, with the term "arteriovenous malformation," limiting results to animals and English language. Publications that described creations of AVM animal models or investigated AVM-related mechanisms and treatments using these models were reviewed. More than 100 articl...
Source: Biomed Res - December 12, 2015 Category: Research Authors: Xu M, Xu H, Qin Z Tags: Biomed Res Int Source Type: research
Mp13: important role of prothrombin time (pt) and partial thromboplastin time (ptt) in predicting tpa-related hemorrhagic transformation
Conclusions
Higher PT/PTT level within 72 hr of IV tPA is early marker of tPA-induced HT. Whether these routine labs have value in symptomatic hemorrhage will require further study in a larger cohort. But this proof-of-concept study suggests that tPA efficacy can potentially be followed in real time. The development of a reliable blood test would be of clinical utility to gauge thrombolytic efficacy in real time to guide and triage adjunct treatments.
Abstract MP13 Figure 1
Source: Journal of Investigative Medicine - February 25, 2016 Category: Research Authors: Deng, W., Wickham, T., McMullin, D., Feeney, K., Buonanno, F., Lo, E., Ning, M. Tags: Moderated Poster, 11:45 PM - 1:05 PM, Wednesday, April 13, 2016 Source Type: research
Significance of cyclooxygenase-2 elevation in middle cerebral artery for patients with hemorrhagic moyamoya disease
In this study, tiny pieces of middle cerebral artery (MCA) and superficial temporal artery (STA) from 13 MMD patients were surgically harvested. The MCA and STA samples from 5 control patients were also collected by using the same technique. The expression of COX-2 was immunohistochemically detected and the average absorbance (A) of positively-stained areas was measured. High-level COX-2 expression was found in all layers of the MCA samples from all 5 hemorrhagic MMD patients, while positive but weak expression of COX-2 was observed only in the endothelial layer of the MCA samples from most ischemic MMD patients (6/8, 75%)...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - March 31, 2016 Category: Research Source Type: research
Intracerebral and Intravenous Transplantation Represents a Favorable Approach for Application of Human Umbilical Cord Mesenchymal Stromal Cells in Intracerebral Hemorrhage Rats.
CONCLUSIONS Both intracerebral and intravenous administration of UC-MSCs could have a favorable effect on recovery of neurological function in ICH rats, although the fundamental mechanisms may be different between the two groups. Our data suggest that intravenous implantation of UC-MSCs could serve as a favorable approach for cell-based therapy in central nervous system (CNS) diseases according to clinical needs.
PMID: 27703134 [PubMed - in process]
Source: Medical Science Monitor - October 7, 2016 Category: Research Tags: Med Sci Monit Source Type: research
Effect of Admission Hyperglycemia on 6-Month Functional Outcome in Patients with Spontaneous Cerebellar Hemorrhage.
CONCLUSIONS To the best of our knowledge, this is the first study focusing on the relationship between hyperglycemia and long-term functional outcome after CH. The study combined with previous pertinent reports definitely indicates the poor effect of hyperglycemia on both supra- and infratentorial ICH independent of hemorrhage site. Therefore, further controlled trials are urgently needed to evaluate the benefits of glucose-lowing treatment.
PMID: 28273059 [PubMed - in process]
Source: Medical Science Monitor - March 9, 2017 Category: Research Tags: Med Sci Monit Source Type: research
α7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage.
This study aimed to evaluate whether α7 nicotinic acetylcholine receptor (α7nAChR) stimulation ameliorates neuroinflammation after ICH. Male CD-1 mice and Sprague-Dawley were subjected to intracerebral injection of autologous blood or bacterial collagenase. ICH animals received either α7nAChR agonist PHA-543613 alone or combined with α7nAChR antagonist methyllycaconitine (MLA) or Janus kinase 2 (JAK2) antagonist AG490. Neurobehavioral deficits were evaluated at 24 hours, 72 hours, and 10 weeks after ICH induction. Perihematomal expressions of JAK2, signal transducer and activator of transcription 3 (STAT3), tumor necro...
Source: Biomed Res - May 24, 2017 Category: Research Authors: Krafft PR, McBride D, Rolland WB, Lekic T, Flores JJ, Zhang JH Tags: Biomed Res Int Source Type: research
White Matter Injury and Recovery after Hypertensive Intracerebral Hemorrhage.
Abstract
Hypertensive intracerebral hemorrhage (ICH) could very probably trigger white matter injury in patients. Through the continuous study of white matter injury after hypertensive ICH, we achieve a more profound understanding of the pathophysiological mechanism of its occurrence and development. At the same time, we found a series of drugs and treatment methods for the white matter repair. In the current reality, the research paradigm of white matter injury after hypertensive ICH is relatively obsolete or incomplete, and there are still lots of deficiencies in the research. In the face of the profound changes...
Source: Biomed Res - July 7, 2017 Category: Research Authors: Zuo S, Pan P, Li Q, Chen Y, Feng H Tags: Biomed Res Int Source Type: research
Effects of Mannitol 20% on Outcomes in Nontraumatic Intracerebral Hemorrhage.
CONCLUSIONS: Mannitol injection was not effective in reducing hemorrhage size, and its use is not recommended, also, further studies in this field have been proposed.
PMID: 28706883 [PubMed]
Source: Biomed Res - July 16, 2017 Category: Research Authors: Aminmansour B, Tabesh H, Rezvani M, Poorjafari H Tags: Adv Biomed Res Source Type: research
No Awakening in Supratentorial Intracerebral Hemorrhage Is Potentially Caused by Sepsis-Associated Encephalopathy.
CONCLUSIONS NA in sICH patients with coma is potentially caused by secondary SAE.
PMID: 28900072 [PubMed - in process]
Source: Medical Science Monitor - September 15, 2017 Category: Research Tags: Med Sci Monit Source Type: research
Mystery of Retinal Vein Occlusion: Vasoactivity of the Vein and Possible Involvement of Endothelin-1.
Abstract
Retinal vein occlusion (RVO) is a common vascular disease of retina; however, the pathomechanism leading to RVO is not yet clear. In general, increasing age, hypertension, arteriosclerosis, diabetes mellitus, dyslipidemia, cardiovascular disorder, and cerebral stroke are systemic risk factors of RVO. However, RVO often occur in the unilateral eye and sometimes develop in young subjects who have no arteriosclerosis. In addition, RVO show different variations on the degrees of severity; some RVO are resolved without any treatment and others develop vision-threatening complications such as macular edema, com...
Source: Biomed Res - September 15, 2017 Category: Research Authors: Kida T Tags: Biomed Res Int Source Type: research
Applications for Electrical Impedance Tomography (EIT) and Electrical Properties of the Human Body.
In conclusion, Electrical Impedance Tomography is a promising method for the development of noninvasive diagnostic medicine, since it is able to provide imaging of the interior of the human body in real time without causing harm or putting the human body in risk.
PMID: 28971420 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - October 4, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage.
CONCLUSIONS These results suggest that ANGPTL4 is a relevant target for vasculoprotection and cerebral protection during stroke.
PMID: 29432410 [PubMed - in process]
Source: Medical Science Monitor - February 15, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Autonomic dysfunction in the neurological intensive care unit
AbstractAutonomic dysfunction is common in neuro-critical care patients and may compromise the function of various organs. Among the many diseases causing or being associated with autonomic dysfunction are traumatic brain injury, cerebrovascular diseases, epilepsy, Guillain –Barré syndrome (GBS), alcohol withdrawal syndrome, botulism and tetanus, among many others. Autonomic dysfunction may afflict various organs and may involve hyper- or hypo-activity of the sympathetic or parasympathetic system. In this short overview, we address only a small number of neuro-inten sive care diseases with autonomic dysfunction. In GBS,...
Source: Clinical Autonomic Research - July 18, 2018 Category: Research Source Type: research
Cerebral microbleeds: hearing through the silence - a narrative review.
CONCLUSIONS: It is critical for nonradiologist clinicians (primary care, internists, neurologists, hematologists) to be aware of the potential importance of the finding of a CMB, and the fact that these lesions are not always truly silent or without important clinical consequences. As additional studies appear, clinicians may be able to "hear" more clearly through the silence of the CMB and understand potential clinical implications in patients.
PMID: 30193542 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - September 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research
Central Poststroke Pain, Comorbidity, and Associated Symptoms in Animal and Human Models.
The objective of the present review paper was to comprehensively introduce the pain symptom and comorbidities of depression, anxiety, and learning and memory dysfunctions in the central poststroke pain (CPSP) of human and animal models. CPSP is a disease in which the lesion or dysfunction of the spinothalamocortical circuits is due to thalamic stroke hemorrhage. According to previous literature, CPSP patients experience impaired explicit and implicit learning and memory in addition to the pain symptom. Moreover, there are associated depression and anxiety comorbidities for CPSP. However, the data from some clinical studies...
Source: Advances in Experimental Medicine and Biology - October 13, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research
