Tilt-evoked, breathing-driven blood pressure oscillations: Independence from baroreflex-sympathoneural function
ConclusionsThe results of this observational cohort study confirm those based on our case report and lead us to propose that even in the setting of vascular-sympathetic baroreflex failure orthostasis increases HF power of BP variability. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 6, 2024 Category: Research Source Type: research

In memoriam: a celebration of the autonomic contributions of David Robertson (1947 –2024)
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 4, 2024 Category: Research Source Type: research

Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study
ConclusionLevodopa decreases blood pressure in both PD with and without autonomic failure, but it does not cause a greater fall in blood pressure from supine to standing at 3  min. Levodopa-induced baroreflex sympathetic noradrenergic impairment may contribute to lower blood pressure. Lower standing blood pressure with levodopa may increase the risks of fall and syncope. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 2, 2024 Category: Research Source Type: research

Clinical Autonomic Research: welcome to 2024
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 28, 2024 Category: Research Source Type: research

In Memoriam: Carl-Albrecht Haensch, M.D.
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 26, 2024 Category: Research Source Type: research

Acknowledgment to Reviewers
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 26, 2024 Category: Research Source Type: research

Asystole on loop recorder in patients with unexplained syncope and negative tilt testing: age distribution and clinical predictors
ConclusionsIn patients with unexplained syncope and negative HUTT, the age distribution of asystolic syncope detected by ILR is bimodal, suggesting a different mechanism responsible for asystole in both younger and older patients. The absence of prodromes and the use of beta blockers are independent predictors of ILR-detected asystole. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 25, 2024 Category: Research Source Type: research

The differences in the anatomy of the thoracolumbar and sacral autonomic outflow are quantitative
ConclusionOne hundred seventy studies were included in the systematic  review, providing information on 389 anatomical structures. Catecholaminergic nerve fibers are present in most spinal and all cranial nerves and ganglia, including those that are known for their parasympathetic function. Along the entire spinal autonomic outflow pathways, proximal and distal cate cholaminergic cell bodies are common in the head, thoracic, and abdominal and pelvic region, which invalidates the “short-versus-long preganglionic neuron” argument.Contrary to the classically confined outflow levels T1-L2 and S2-S4, preganglionic neurons...
Source: Clinical Autonomic Research - February 25, 2024 Category: Research Source Type: research

The relevance of the superior cervical ganglion for cardiac autonomic innervation in health and disease: a systematic review
ConclusionCurrent literature mainly supports an indirect involvement of the SCG in cardiac innervation, via other structures and plexuses or via sympathetic overdrive in response to cardiac diseases. Morphological evidence of a direct involvement was found, but its contribution seems limited. The relevance of SCG sidedness, sex, and developmental stage in health and disease remains unclear and warrants further exploration.Graphical abstractAn overview of the current literature derived from morphological and functional data on the involvement of SCG in cardiac innervation, relevance of sidedness, sex differences, and pre- a...
Source: Clinical Autonomic Research - February 23, 2024 Category: Research Source Type: research

Higher arterial stiffness and blunted vagal control of the heart in young women with compared to without a clinical diagnosis of PTSD
ConclusionPTSD in young women is associated with higher brachial and central pressures, increased arterial stiffness and blunted parasympathetic control of the heart. These findings illustrate potential mechanisms underlying high risk for CVD in young women with PTSD, suggesting possible treatment targets for this at-risk group. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 7, 2024 Category: Research Source Type: research

Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND)
ConclusionsThis small randomized controlled trial of IVIG in POTS found no statistical difference in response compared with albumin infusion. Both groups showed improvement possibly related to volume expansion or other effects obscuring group differences. These findings inform development of future immunomodulatory clinical trials in POTS. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 4, 2024 Category: Research Source Type: research

Differential control of sympathetic outflow to muscle and skin during physical and cognitive stressors
ConclusionsThis study has provided evidence to support the literature which claims cognitive stressors increase sympathetic activity, and provides much needed SSNA data in response to stressors. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 3, 2024 Category: Research Source Type: research

What lies beneath: cyclical giant bursts of SNA during vasovagal syncope
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 2, 2024 Category: Research Source Type: research

Muscarinic control of cardiovascular function in humans: a review of current clinical evidence
ConclusionUnderstanding the muscarinic control of cardiovascular function is of paramount importance and may contribute to the development of novel therapeutic strategies for treating cardiovascular disease. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 2, 2024 Category: Research Source Type: research