Elevated cerebral blood flow in patients with pure autonomic failure
ConclusionsFindings suggest that PAF patients may exhibit elevated CBF and provide evidence that this condition exerts a hemodynamic impact in the central nervous system. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 7, 2021 Category: Research Source Type: research

Cardiac autonomic function in patients with early multiple sclerosis
ConclusionOur results show normal cardiac sympathetic and baroreflex cardiovagal function in MS patients with relapsing –remitting MS with lesions at the post-acute/early resolving stage.Trial registrationThe study was registered at ClinicalTrials.gov under the Identifier: NCT 03052595 and complies with the STROBE checklist for cohort, case –control, and cross-sectional studies. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 4, 2021 Category: Research Source Type: research

Orthostatic intolerance with Klippel-Trenaunay syndrome
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - March 2, 2021 Category: Research Source Type: research

Peripheral neuroimmune interactions: selected review and some clinical implications
ConclusionsPeripheral neuroimmune interactions are complex and importantly contribute to the pathophysiology of several disorders, including skin, respiratory, and intestinal inflammatory disorders typically associated with pain and altered barrier function. These interactions may be relevant for persistence of symptoms in disorders associated with intense immune activation. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 28, 2021 Category: Research Source Type: research

Autonomic cardiovascular alterations as therapeutic targets in chronic kidney disease
ConclusionsFurther studies are needed to clarify several aspects of the autonomic responses to therapeutic interventions in chronic renal disease. These include (1) the potential to normalize sympathetic activity in uremic patients by the various therapeutic approaches and (2) the definition of the degree of sympathetic deactivation to be achieved during treatment. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 19, 2021 Category: Research Source Type: research

Chronic vagus nerve stimulation is associated with multi-year improvement in intrinsic heart rate recovery and left ventricular ejection fraction in ANTHEM-HF
AbstractPurposeDisturbed autonomic function is implicated in high mortality rates in heart failure patients. High-intensity vagus nerve stimulation therapy was shown to improve intrinsic heart rate recovery and left ventricular ejection fraction over a period of 1 year. Whether these beneficial effects are sustained across multiple years and are related to improved baroreceptor response was unknown.MethodsAll patients (n  = 21) enrolled in the ANTHEM-HF clinical trial (NCT01823887, registered 4/3/2013) with 24  h ambulatory electrocardiograms at all time points and 54 normal subjects (PhysioNet database)...
Source: Clinical Autonomic Research - February 16, 2021 Category: Research Source Type: research

The privilege and responsibility of caring for patients with rare genetic disorders
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 12, 2021 Category: Research Source Type: research

Blunted sympathetic neurovascular transduction is associated to the severity of obstructive sleep apnea
ConclusionsWe have demonstrated that the prevailing MSNA frequency is unmatched to the level of sNVT, and this can be altered by acute hyperoxia. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 9, 2021 Category: Research Source Type: research

Insular damage causing transient baroreflex dysfunction in a teenager with Allgrove syndrome
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 9, 2021 Category: Research Source Type: research

A comparison of health-related quality of life in autonomic disorders: postural tachycardia syndrome versus vasovagal syncope
This study was conducted to test the hypothesis that HRQoL is worse in POTS.MethodsPOTS patients were recruited from the Dysautonomia International Annual Patient and Caregiver Conference. VVS patient data came from those enrolled in the Second Prevention of Syncope Trial. Participants aged  ≥ 18 years (177 POTS and 72 VVS) completed the RAND 36-Item Health Survey, a generic and coherent health-related quality of life survey.ResultsPOTS patients reported reduced HRQoL compared to VVS patients in physical functioning (42.5  ± 1.7 vs. 76.5 ± 2.9,p 
Source: Clinical Autonomic Research - February 7, 2021 Category: Research Source Type: research

Limitations of the Unified Multiple System Atrophy Rating Scale as outcome measure for clinical trials and a roadmap for improvement
ConclusionsBecause of the limitations of the UMSARS, developing and validating an improved COA is a priority. The time is right for academic MSA clinicians together with industry, professional societies, and patient advocacy groups to develop and validate a new COA. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 7, 2021 Category: Research Source Type: research

Factors contributing to racial differences in neurogenic orthostatic hypotension
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 7, 2021 Category: Research Source Type: research

Orthostatic responses in Caucasian, South Asian, and Middle Eastern women
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 6, 2021 Category: Research Source Type: research

A case of Ross syndrome associated with systemic sclerosis
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 4, 2021 Category: Research Source Type: research

Thirty years of fatal familial insomnia and autonomic research: celebrating the past, embracing the future
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 3, 2021 Category: Research Source Type: research

Paroxysmal hypothermia and hyperhidrosis with exacerbation after COVID-19 Infection
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 2, 2021 Category: Research Source Type: research

Autonomic function test during the COVID-19 pandemic: is it safe and sound?
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - February 2, 2021 Category: Research Source Type: research

Thirty years of research on autonomic dysfunction, non-motor features, and endophenotypes in Parkinson disease
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 30, 2021 Category: Research Source Type: research

RT-QUiC in multiple system atrophy: the biomarker of the future? and other  updates on recent autonomic research
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 29, 2021 Category: Research Source Type: research

The Lov én reflex: the renaissance of a long-forgotten reflex involving autonomic and nociceptive pathways
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 29, 2021 Category: Research Source Type: research

A novel detrusor contractility parameter to distinguish multiple system atrophy from Parkinson ’s disease
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 28, 2021 Category: Research Source Type: research

Clinical and neurohormonal characteristics in African Americans with neurogenic orthostatic hypotension
ConclusionOur findings demonstrate that AA with nOH have similar clinical characteristics and hemodynamic autonomic profiles, but lower upright renin activity and aldosterone levels, compared to non-Hispanic whites. Renin suppression persists in AA with severe autonomic failure and can potentially contribute to postural changes and supine hypertension. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 27, 2021 Category: Research Source Type: research

Frequency of spinocerebellar ataxia mutations in patients with multiple system atrophy
ConclusionOccurrence ofTBP CAG/CAA repeat length of longer alleles (>  38 repeats) is significantly associated with increased multiple system atrophy risk. This discovery warrants further investigation and supports a possible genetic overlap of multiple system atrophy with SCA17. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 27, 2021 Category: Research Source Type: research

Acknowledgement to Reviewers
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 27, 2021 Category: Research Source Type: research

Clinical and neuroendocrinological characteristics of delayed orthostatic hypotension in Parkinson ’s disease
ConclusionCompared with patients without OH, patients with DOH had severe hyposmia. Relatively preserved peripheral sympathetic nervous system function in patients with DOH suggests that DOH might be an early and milder form of OH in PD. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 26, 2021 Category: Research Source Type: research

Observations of a syncope doctor during self-induced (near)syncope episodes
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 25, 2021 Category: Research Source Type: research

Fifty years of research on the physiology and pharmacology of the autonomic nervous system
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 22, 2021 Category: Research Source Type: research

The relation between habitual physical activity and sympathetic vascular transduction in healthy young adults
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 21, 2021 Category: Research Source Type: research

Women in clinical autonomic research and the autonomic societies: how far have we come in thirty years?
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 17, 2021 Category: Research Source Type: research

Reflections on the past four decades of mental stress research in autonomic cardiology
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 12, 2021 Category: Research Source Type: research

Three decades of Clinical Autonomic Research and beyond
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 10, 2021 Category: Research Source Type: research

Thirty years of questions and beyond
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 9, 2021 Category: Research Source Type: research

My good fortune to become a syncope doctor
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 8, 2021 Category: Research Source Type: research

Reflections on the past three decades of high-altitude exercise research and the autonomic nervous system
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 5, 2021 Category: Research Source Type: research

Correction to: Hypothalamic injury in spontaneous subarachnoid hemorrhage: a diffusion tensor imaging study
Unfortunately, the electronic supplementary material (ESM) has been incorrectly published in the original publication. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 5, 2021 Category: Research Source Type: research

Dorsal root ganglion stimulation: a new target for autonomic neuromodulation?
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 4, 2021 Category: Research Source Type: research

Autonomic function test during the COVID-19 pandemic: the Stanford experience
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 2, 2021 Category: Research Source Type: research

“Dysautonomia”: a plea for precision
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 2, 2021 Category: Research Source Type: research

Herpes simplex encephalitis manifested as hemifacial anhidrosis
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 1, 2021 Category: Research Source Type: research

Reflections on the past three  decades of autonomic neurology
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - January 1, 2021 Category: Research Source Type: research

The insular cortex as a vestibular area in relation to autonomic function
AbstractThe forebrain cerebral network including the insular cortex plays a crucial role in the regulation of the central autonomic nervous system in relation to emotional stress. Numerous studies have recently shown that the insular cortex also has roles as a vestibular area in addition to auditory function. In this review, we summarize the recent literature regarding the relationship between the insular cortex and vestibular function, and we describe our hypothesis that the insular cortex has a pivotal role in vestibular-cardiovascular integration. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - December 1, 2020 Category: Research Source Type: research

Correction to: A 20-year evolution of cardiac performance in microgravity in a male astronaut
Unfortunately, the first name of 8th author was incorrectly published in the original publication. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - November 28, 2020 Category: Research Source Type: research

Hypothalamic injury in spontaneous subarachnoid hemorrhage: a diffusion tensor imaging study
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - November 28, 2020 Category: Research Source Type: research

Gastrointestinal dysfunction in the synucleinopathies
AbstractInterest in gastrointestinal dysfunction in Parkinson ’s disease has blossomed over the past 30 years and has generated a wealth of investigation into this non-motor aspect of the disorder, research that has encompassed its pathophysiology, its clinical features, and its impact on quality of life. The question of gastrointestinal dysfunction in the other synucleinopathies has not received nearly as much attention, but information and knowledge are growing. In this review, the current knowledge, controversies, and gaps in our understanding of the pathophysiology of gastrointestinal dysfunction in Parkinso...
Source: Clinical Autonomic Research - November 27, 2020 Category: Research Source Type: research

The shock of it: sympathetic activation promotes hair greying, and other updates on recent autonomic research
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - November 19, 2020 Category: Research Source Type: research

Autonomic nervous system dysfunction in narcolepsy type 1: time to move forward to the next level?
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - November 12, 2020 Category: Research Source Type: research

Ablating the renal nerves to treat heart failure with reduced ejection fraction: another treatment option in a crowded space?
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - November 11, 2020 Category: Research Source Type: research

Synergistic but separable sensory changes in postural tachycardia syndrome and chronic migraine
ConclusionsThese findings reveal an underappreciated aspect of disease burden in PoTS, and suggest network sensitization similar to, but separable from, that of migraine. The presence of both photophobia and allodynia in PoTS is reflective of exteroceptive rather than strictly interoceptive disruption, and expands our fundamental understanding of the disorder. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - November 10, 2020 Category: Research Source Type: research

Aerobic fitness and sympathetic responses to spontaneous muscle sympathetic nerve activity in young males
AbstractPurposeLower aerobic fitness increases the risk of developing hypertension. Muscle sympathetic nerve activity (MSNA) is important for the beat-by-beat regulation of blood pressure. Whether the cardiovascular consequences of lower aerobic fitness are due to augmented transduction of MSNA into vascular responses is unclear. We tested the hypothesis that aerobic fitness is inversely related to peak increases in total peripheral resistance (TPR) and mean arterial pressure (MAP) in response to spontaneous MSNA bursts in young males.MethodsRelative peak oxygen consumption (VO2peak, indirect calorimetry) was assessed in 1...
Source: Clinical Autonomic Research - October 9, 2020 Category: Research Source Type: research

Pupillometry in critically ill patients with COVID-19: a prospective study
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - October 6, 2020 Category: Research Source Type: research