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Condition: Hemorrhagic Stroke

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Total 217 results found since Jan 2013.

Iron Pathophysiology in Stroke.
Authors: Almutairi MMA, Xu G, Shi H Abstract Ischemic and hemorrhagic stroke are the common types of stroke that lead to brain injury neurological deficits and mortality. All forms of stroke remain a serious health issue, and there is little successful development of drugs for treating stroke. Incomplete understanding of stroke pathophysiology is considered the main barrier that limits this research progress. Besides mitochondria and free radical-producing enzymes, labile iron is an important contributor to oxidative stress. Although iron regulation and metabolism in cerebral stroke are not fully understood, much p...
Source: Advances in Experimental Medicine and Biology - August 29, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Disorder Genes Regulate the Progression of Ischemic Stroke through the NF- < em > κ < /em > B Signaling Pathway
Biomed Res Int. 2021 Oct 27;2021:2464269. doi: 10.1155/2021/2464269. eCollection 2021.ABSTRACTStroke is an acute cerebrovascular disease, including ischemic and hemorrhagic stroke. Stroke is the second leading cause of death after ischemic heart disease, which accounts for 9% of the global death toll. To explore the molecular mechanisms of the effects of the dysregulated factors, in the GEO database, we obtained transcriptome data from 24 h/72 h of mice with ischemic stroke and 24 h/72 h of normal mice. We then performed differential gene analysis, coexpression analysis, enrichment analysis, and regulator prediction bioinf...
Source: Biomed Res - November 8, 2021 Category: Research Authors: Wei Wei Wenqiang Xin Yufeng Tang Zhonglun Chen Yue Heng Mingjun Pu Bufan Yang Jiacai Zuo Jingfeng Duan Source Type: research

Reinforced feedback in virtual environment for rehabilitation of upper extremity dysfunction after stroke: preliminary data from a randomized controlled trial.
Conclusion. These results indicated that some poststroke patients may benefit from RFVE program for the recovery of upper limb motor function. This trial is registered with NCT01955291. PMID: 24745024 [PubMed - in process]
Source: Biomed Res - April 23, 2014 Category: Research Authors: Kiper P, Agostini M, Luque-Moreno C, Tonin P, Turolla A Tags: Biomed Res Int Source Type: research

Perioperative Stroke and Thirty-Day Hospital Readmission After Cardiac Surgeries: State Inpatient Database Study
CONCLUSION: Baseline patient characteristics and perioperative complications are significant predictors of readmission. More than one in five patients who develop a stroke after cardiac surgery are readmitted to the hospital within 30 days of discharge.PMID:35211215 | PMC:PMC8827220 | DOI:10.14740/jocmr4647
Source: Clin Med Res - February 25, 2022 Category: Research Authors: Nada Alrifai Laith Alhuneafat Khaled AlRobaidi Samir S Al Ghazawi Parthasarathy D Thirumala Source Type: research

Analysis of risk factors for first seizure after stroke in chinese patients.
Abstract The aim of this study is to assess related risk factors and predict early- and late-onset seizure after first-ever stroke. A total of 2474 consecutive patients with initial stroke in China from 1997 to 2007 were retrospectively investigated, in which, 24 clinical and radiological indexes were used for evaluation. Odds ratio (OR) and 95% confidence interval (CI) were calculated by logistic regression. A total of 232 (11.1%) of patients developed seizures during a mean follow-up period of 18 months, with 123 experiencing early-onset and 109 late-onset seizure. The independent risk factors for early-onset se...
Source: Biomed Res - December 5, 2013 Category: Research Authors: Wang G, Jia H, Chen C, Lang S, Liu X, Xia C, Sun Y, Zhang J Tags: Biomed Res Int Source Type: research

TRPC Channels and Stroke.
Authors: Huang J Abstract TRPC channels play important roles in neuronal death/survival in ischemic stroke, vasospasm in hemorrhagic stroke, thrombin-induced astrocyte pathological changes, and also in the initiation of stroke by affecting blood pressure and atherogenesis. TRPCs' unique channel characters and downstream pathways make them possible new targets for stroke therapy. TRPC proteins have different functions in different cell types. Considering TRPCs' extensive distribution in various tissues and cell types, drugs targeting them could induce more complicated effects. More specific agonists/antagonists and ...
Source: Advances in Experimental Medicine and Biology - May 17, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Role of Glial Fibrillary Acidic protein as a biomarker in differentiating intracerebral hemorrhage from ischemic stroke and stroke mimics: A meta-analysis.
Conclusion: Our meta-analysis suggests that GFAP has a promising diagnostic accuracy for the differentiation of ICH from IS and mimics. Further, phase II and phase III diagnostic test studies are required to validate the findings before using GFAP as a blood based biomarker for clinical use.Trial Registration: This study was registered in OSF registries 10.17605/OSF.IO/B9JP4. PMID: 31702405 [PubMed - as supplied by publisher]
Source: Biomarkers - November 10, 2019 Category: Research Tags: Biomarkers Source Type: research

Elevated Homocysteine Level Related to Poor Outcome After Thrombolysis in Acute Ischemic Stroke.
CONCLUSIONS High serum homocysteine level could potentially predict poor prognosis in acute ischemic stroke patients after tPA treatment. PMID: 27629768 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - September 16, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Cost-effectiveness analysis of dabigatran versus rivaroxaban for stroke prevention in patients with non-valvular atrial fibrillation using real-world evidence in elderly US Medicare beneficiaries.
CONCLUSIONS: In this study using US Medicare real-world data, dabigatran was found to dominate rivaroxaban. The analyses were limited by the short follow-up period of the real-world data and results may not be generalizable to other patient populations. PMID: 28862479 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - September 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The Roles of Thrombospondins in Hemorrhagic Stroke.
Abstract Hemorrhagic stroke is a devastating cerebrovascular disease with significant morbidity and mortality worldwide. Thrombospondins (TSPs), as matricellular proteins, belong to the TSP family which is comprised of five members. All TSPs modulate a variety of cellular functions by binding to various receptors. Recently, TSPs gained attention in the area of hemorrhagic stroke, especially TSP-1. TSP-1 participates in angiogenesis, the inflammatory response, apoptosis, and fibrosis after hemorrhagic stroke through binding to various molecules including but not limited to CD36, CD47, and TGF-β. In this review, we...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Wu X, Luo X, Zhu Q, Zhang J, Liu Y, Luo H, Cheng Y, Xie Z Tags: Biomed Res Int Source Type: research

Pericytes in Ischemic Stroke.
Authors: Dalkara T, Alarcon-Martinez L, Yemisci M Abstract Recent stroke research has shifted the focus to the microvasculature from neuron-centric views. It is increasingly recognized that a successful neuroprotection is not feasible without microvascular protection. On the other hand, recent studies on pericytes, long-neglected cells on microvessels have provided insight into the regulation of microcirculation. Pericytes play an essential role in matching the metabolic demand of nervous tissue with the blood flow in addition to regulating the development and maintenance of the blood-brain barrier (BBB), leukocyte...
Source: Advances in Experimental Medicine and Biology - June 1, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Aspiration Thrombectomy in Patients with Large Vessel Occlusion and Mild Stroke: A Single-Center Experience
CONCLUSIONS Immediate aspiration thrombectomy may be a safe and feasible first-line treatment option in patients suffering from mild stroke due to large vessel occlusion in the anterior and posterior circulation.PMID:34016941 | DOI:10.12659/MSM.930014
Source: Medical Science Monitor - May 21, 2021 Category: Research Authors: Jozef Haring Miroslav Mako J án Haršány Georgi Krastev Mat úš Hoferica Andrej Klepanec Source Type: research