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Total 17689 results found since Jan 2013.

Too Little Sleep Destroys DNA?
I talk to my patients about the danger of not sleeping all the time. Unfortunately, it’s a common problem that affects 75 million Americans. People who don’t sleep, or sleep poorly, have up to 400% more accidents that those who get a good night’s rest. Not getting enough sleep also increases your risk of developing chronic diseases. Studies, including a large meta-analysis of 470,000 adults, found that those who slept less than six hours developed a:1,2,3,4,5 48% increase in the incidence of coronary heart disease 30% increased risk of dementia 15% increase in the incidence of stroke 50% cancer risk 17% higher risk ...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news

Clinical characteristics and predictors for in-hospital mortality in adult COVID-19 patients: A retrospective single center cohort study in Vilnius, Lithuania
ConclusionsAge, congestive heart failure, obesity, COPD, prior stroke, and increased concentration of urea, LDH, CRP, IL-6, troponin I, ALT to AST ratio were identified to be the predictors for in-hospital mortality of COVID-19 patients.
Source: PLoS One - August 25, 2023 Category: Biomedical Science Authors: Ieva Kubiliute Source Type: research

Glycated hemoglobin variability and the risk of cardiovascular events in patients with prediabetes and type  2 diabetes mellitus: A post‐hoc analysis of a prospective and multicenter study
ConclusionHigh HbA1c variability in the highest quartile showed a statistically significant association with multiple adverse cardiovascular events in an Asian population. Minimizing HbA1c fluctuation during long-term follow up should be another important objective for type  2 diabetes patients.
Source: Journal of Diabetes Investigation - August 24, 2023 Category: Endocrinology Authors: Worapaka Manosroi, Mattabhorn Phimphilai, Nipawan Waisayanand, Supawan Buranapin, Chaicharn Deerochanawong, Siriluck Gunaparn, Arintaya Phrommintikul, Wanwarang Wongcharoen, for the CORE ‐Thailand investigators Tags: Original Article Source Type: research

Circular RNA ciRS-7 signature as a potential biomarker for the early detection of diabetes with Alzheimer's disease: a hypothesis
Mol Biol Rep. 2023 Aug 24. doi: 10.1007/s11033-023-08729-2. Online ahead of print.ABSTRACTIn the 1970s, Circular RNAs (CircRNAs) were first discovered in RNA viruses as viroids and were initially assumed to be RNA splicing defects. The roles and topologies of these circular RNA loops were later revealed using computer analysis and RNA-sequencing. They were found to demonstrate various functions, including protein scaffolding, parental gene regulation, microRNA sponges, and RNA-protein interactions. CircRNAs play a crucial role in controlling gene expression and are essential for biological development and illness detection...
Source: Molecular Biology Reports - August 24, 2023 Category: Molecular Biology Authors: Mahima Singh Ajay Guru Raghul Murugan Muthukaruppan Gopi Jesu Arockiaraj Source Type: research

Decreasing national trends in diabetic complications hide regional differences: a prospective population-based study using health care registers in Finland
Conclusions. The decrease in the incidence of first cardiovascular events among patients with diabetes continued from 2010 to 2017 in Finland. However, the declining national incidence rates hide regional differences which should be a target for improvement.PMID:37614115 | DOI:10.1080/14017431.2023.2247190
Source: Scandinavian Cardiovascular Journal - August 24, 2023 Category: Cardiology Authors: Klas Winell Martti Arffman Veikko Salomaa Source Type: research

Circular RNA ciRS-7 signature as a potential biomarker for the early detection of diabetes with Alzheimer's disease: a hypothesis
Mol Biol Rep. 2023 Aug 24. doi: 10.1007/s11033-023-08729-2. Online ahead of print.ABSTRACTIn the 1970s, Circular RNAs (CircRNAs) were first discovered in RNA viruses as viroids and were initially assumed to be RNA splicing defects. The roles and topologies of these circular RNA loops were later revealed using computer analysis and RNA-sequencing. They were found to demonstrate various functions, including protein scaffolding, parental gene regulation, microRNA sponges, and RNA-protein interactions. CircRNAs play a crucial role in controlling gene expression and are essential for biological development and illness detection...
Source: Mol Biol Cell - August 24, 2023 Category: Molecular Biology Authors: Mahima Singh Ajay Guru Raghul Murugan Muthukaruppan Gopi Jesu Arockiaraj Source Type: research

Association of systolic blood pressure after discharge and the risk of clinical outcomes in ischemic stroke patients with diabetes: A cohort study
Chin Med J (Engl). 2023 Aug 23. doi: 10.1097/CM9.0000000000002819. Online ahead of print.NO ABSTRACTPMID:37612247 | DOI:10.1097/CM9.0000000000002819
Source: Chinese Medical Journal - August 23, 2023 Category: General Medicine Authors: Pinni Yang Zhengbao Zhu Shuyao Wang Mengyao Shi Yanbo Peng Chongke Zhong Aili Wang Tan Xu Hao Peng Tian Xu Xiaowei Zheng Jing Chen Yonghong Zhang Jiang He Source Type: research

Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Endocrinology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research

Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke
CONCLUSIONS AND RELEVANCE: In this observational study, TMAO was associated with cerebral small vessel disease determined by WMHV and acute lacunar infarction. The association was independent of traditional vascular risk factors.PMID:37610752 | DOI:10.1001/jamanetworkopen.2023.30446
Source: Atherosclerosis - August 23, 2023 Category: Cardiology Authors: Naruchorn Kijpaisalratana Zsuzsanna Ament Matthew B Bevers Varun M Bhave Ana-Lucia Garcia Guarniz Catharine A Couch M Ryan Irvin W Taylor Kimberly Source Type: research