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Total 17689 results found since Jan 2013.

Circulating Endothelial Progenitor and Mesenchymal Stromal Cells as Biomarkers for Monitoring Disease Status and Responses to Exercise
Rev Cardiovasc Med. 2022 Dec 2;23(12):396. doi: 10.31083/j.rcm2312396.ABSTRACTNoncommunicable chronic diseases, such as obesity, cardiovascular disease (CVD), and type 2 diabetes (T2D), pose significant health challenges globally. Important advances have been made in the understanding of the pathophysiologal mechanisms and treatment of noncommunicable diseases in recent years. Lack of physical activity is a primary contributor to many noncommunicable diseases including metabolic syndrome, T2D, CVD, and obesity. Certain diabetes medications and non-pharmaceutical interventions, such as physical activity and exercise, are sh...
Source: Reviews in Cardiovascular Medicine - September 8, 2023 Category: Cardiology Authors: Jared M Gollie Sabyasachi Sen Source Type: research

Antidepressant use in people with both physical health problems and depression
Many people with diseases such as cancer or diabetes or those who have had a heart attack or stroke also suffer from depression. How effective are antidepressants for these patients? And are they just as safe for these people as for those without physical health problems? Researchers from Charité - Universitätsmedizin Berlin and Aarhus University in Denmark have teamed up to investigate these questions.
Source: World Pharma News - September 8, 2023 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke ? Discordance between randomised controlled trials and observational studies
Diabetes Metab. 2023 Sep 5:101474. doi: 10.1016/j.diabet.2023.101474. Online ahead of print.ABSTRACTStroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested that glucagon peptide-1 receptor agonists (GLP-1RAs) exert a better protection against stroke than sodium-glucose cotransporter 2 inhibitors (SGLT2is). However, this conclusion was derived from indirect comparisons in absence of any head-to-head randomised controlled trial (RCT). The present...
Source: Diabetes and Metabolism - September 7, 2023 Category: Endocrinology Authors: Andr é J Scheen Source Type: research

Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research

Determinants and Temporal Trends of Dual Antiplatelet Therapy After Mild Noncardioembolic Stroke
CONCLUSIONS: Despite a temporal trend increase in DAPT prescription after mild NCIS, we found substantial underutilization of evidence-based DAPT associated with significant disparities in stroke care.PMID:37675611 | DOI:10.1161/STROKEAHA.123.043769
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Victor J Del Brutto Ruijie Yin Hannah Gardener Hao Ying Carolina M Gutierrez Angus M Jameson David Z Rose Ayham Alkhachroum Dianne Foster Chuanhui Dong Selina Ancheta Nicole B Sur Gillian Gordon Perue Tatjana Rundek Negar Asdaghi Ralph L Sacco Jose G Roma Source Type: research

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study
This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study. The active group included patients who developed HT during hospitalization (55 persons). There were no significant differences in age, gender distribution, time to admission, or time to blood sample collection for MMPs measurement between patients in the active and control groups. IS patients from...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Elena Costru-Tasnic Mihail Gavriliuc Elena Manole Source Type: research

Disparities in ethnicity and metabolic disease burden in referrals to nephrology
CONCLUSION: A disproportionately large number of Malay patients are referred for kidney disease. These patients have higher metabolic disease burden, tend to miss appointments and are referred at lower eGFR. Reasons underpinning these associations should be identified to facilitate efforts for targeting this at-risk population, ensuring kidney health for all.PMID:37675684 | DOI:10.4103/singaporemedj.SMJ-2022-193
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Yan Ting Chua Cheang Han Leo Horng Ruey Chua Weng Kin Wong Gek Cher Chan Anantharaman Vathsala Ye Lu Mavis Gan Boon Wee Teo Source Type: research

Determinants and Temporal Trends of Dual Antiplatelet Therapy After Mild Noncardioembolic Stroke
CONCLUSIONS: Despite a temporal trend increase in DAPT prescription after mild NCIS, we found substantial underutilization of evidence-based DAPT associated with significant disparities in stroke care.PMID:37675611 | DOI:10.1161/STROKEAHA.123.043769
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Victor J Del Brutto Ruijie Yin Hannah Gardener Hao Ying Carolina M Gutierrez Angus M Jameson David Z Rose Ayham Alkhachroum Dianne Foster Chuanhui Dong Selina Ancheta Nicole B Sur Gillian Gordon Perue Tatjana Rundek Negar Asdaghi Ralph L Sacco Jose G Roma Source Type: research

Diabetes mellitus and functional limitations among older adults: Evidence from a large, representative Ghanaian aging study
CONCLUSIONS: In this representative study, older adults with DM showed higher odds for FL, and this association was partially explained by physical activity and health variables. Investing in a holistic management approach might be helpful for public health planning efforts to address DM-induced FL in old age.PMID:37677886 | DOI:10.1016/j.jpsychores.2023.111481
Source: Pain Physician - September 7, 2023 Category: Anesthesiology Authors: Razak M Gyasi Julius Odei Mohammed Gazali Hambali Nelson Gyasi-Boadu Bernard Obeng Moses Asori Andr é Hajek Louis Jacob Yvonne Ami Dodzi Adjakloe Jones Opoku-Ware Lee Smith Ai Koyanagi Source Type: research