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Condition: Cirrhosis

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Total 302 results found since Jan 2013.

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications
Abstract Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, albumin molecule is susceptible to modifications that may alter its biological activity. During the last decades, different methods to measure albumin function have been developed. Recent studies have shown that not only albumin concentration but also albumin function is reduced in liver failure. This observation ...
Source: Hepatology - February 19, 2013 Category: Internal Medicine Authors: Rita Garcia‐Martinez, Paolo Caraceni, Mauro Bernardi, Pere Gines, Vicente Arroyo, Rajiv Jalan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

'Early death map' shows English health inequality
“North and South health divide: Chilling study reveals premature death is 'postcode lottery',” the Daily Mirror reports. The news is based on a new interactive map showing the variation in premature death rates across England. The Longer Lives map, created by the new organisation Public Health England, ranks 150 local authorities by their premature death rates (deaths occurring before age 75). The interactive map also enables users to compare these areas by five common causes of premature (and potentially preventable) deaths: cancer heart disease stroke lung diseases, such as chronic obstructive pulmonary ...
Source: NHS News Feed - June 11, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Cancer QA articles Source Type: news

Systematic bias in surgeons' predictions of the donor‐specific risk of liver transplant graft failure
In conclusion, transplant surgeons vary widely in their predictions of the donor‐specific risk of graft failure, and they demonstrate a systematic bias toward inaccurately low estimates of graft failure, particularly for higher risk organs. Liver Transpl, 2013. © 2013 AASLD.
Source: Liver Transplantation - June 19, 2013 Category: Transplant Surgery Authors: Michael L. Volk, Meghan Roney, Robert M. Merion Tags: Original Article Source Type: research

Reduced thoracic fluid content in early stage primary biliary cirrhosis that associates with impaired cardiac inotropy.
Conclusion: This study has confirmed that TFC is reduced in those with PBC, that this is specific to PBC and that it associates independently with markers of cardiac inotropy. PMID: 23868409 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - July 18, 2013 Category: Gastroenterology Authors: Zalewski P, Jones DE, Lewis I, Frith J, Newton JL Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Oral hypoglycemic agents and the development of non‐fatal cardiovascular events in patients with type 2 diabetes mellitus
ConclusionsT2DM patients taking metformin and glimepiride are at lowered risk of non‐fatal CV events than those taking glyburide. This article is protected by copyright. All rights reserved.
Source: Diabetes/Metabolism Research and Reviews - July 1, 2013 Category: Endocrinology Authors: Yi‐Chih Hung, Che‐Chen Lin, Tzu‐Yuan Wang, Man‐Ping Chang, Fung‐Chang Sung, Ching‐Chu Chen Tags: Research Article Source Type: research

Blood transfusion for upper gastrointestinal bleeding: is less more again?
The objective was to prove that the restrictive threshold for red blood cell transfusion in patients with acute upper GI bleeding (UGIB) was safer and more effective than a liberal transfusion strategy.Design: A single-center, randomized controlled trial was conducted.Setting: Patients with GI bleeding were admitted to the de la Santa Creu i Sant Pau hospital in Barcelona, Spain.Subjects: The subjects were adult intensive care unit patients admitted with high clinical suspicion of UGIB (hematomemesis, melena, or both). Patients were excluded if they had massive exsanguinating bleeding, acute coronary syndrome, symptomatic ...
Source: Critical Care - September 24, 2013 Category: Intensive Care Authors: Mohammed Al-JaghbeerSachin Yende Source Type: research

Bilirubin labeling of borderzone and anterior cerebral artery territory infarction
A 50-year-old woman developed multiorgan system failure secondary to sepsis. She became obtunded during a period of hypotension, and cranial CT demonstrated diffuse borderzone infarction. Brain autopsy revealed green pigmentation in areas of infarction due to vascular leakage of bilirubin at sites of blood–brain barrier disruption, mapping the borderzone regions and bilateral anterior cerebral artery territories with this endogenous label (total bilirubin at time of death was 24 mg/dL; direct bilirubin 19 mg/dL) (figure). This brain–liver association evokes the first description of pathology in the borderzone r...
Source: Neurology - September 30, 2013 Category: Neurology Authors: Berkowitz, A. L., Sheu, S.-H., Rose, M. F., Delalle, I., Folkerth, R. D. Tags: Gastrointestinal, All Cerebrovascular disease/Stroke NEUROIMAGES Source Type: research

Oral hypoglycaemic agents and the development of non‐fatal cardiovascular events in patients with type 2 diabetes mellitus
ConclusionsT2DM patients taking metformin and glimepiride are at lower risk of non‐fatal cardiovascular events than those taking glyburide. Copyright © 2013 John Wiley & Sons, Ltd.
Source: Diabetes/Metabolism Research and Reviews - November 14, 2013 Category: Endocrinology Authors: Yi‐Chih Hung, Che‐Chen Lin, Tzu‐Yuan Wang, Man‐Ping Chang, Fung‐Chang Sung, Ching‐Chu Chen Tags: Research Article Source Type: research

Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies
Conclusions: Our findings strongly support the suggestion that patients with some immune-mediated diseases have an increased risk of SAH. Further studies of the mechanisms behind this association are warranted.
Source: BMC Neurology - November 14, 2013 Category: Neurology Authors: Sreeram RamagopalanJulia PakpoorOlena SeminogRaph GoldacreLee GrahamMichael Goldacre Source Type: research

N-terminal prohormone of brain natriuretic peptide—how far can we extrapolate?
We read the article by Velibey et al with interest. Their result is consistent with various other studies done in the past, but long-term (4 years) survival prediction on hospital admission with a single plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) level is a new and important finding. The mean value of NT-proBNP is significantly correlated with ejection fraction and the functional class (New York Heart Association Class) of heart failure . The author had neither commented on the functional status of the patients nor on the etiology of acute shortness of breath at the time of admission. Testing the...
Source: The American Journal of Emergency Medicine - December 23, 2013 Category: Emergency Medicine Authors: Nayer Jamshed, Fouzia F. Ozair, Meera Ekka, Praveen Aggarwal Tags: Correspondence Source Type: research

IL‐20 and IL‐20R1 antibodies protect against liver fibrosis
Conclusion: We identified a pivotal role of IL‐20 in liver injury and showed that 7E and 51D may be therapeutics for liver fibrosis. (Hepatology 2014;)
Source: Hepatology - April 25, 2014 Category: Internal Medicine Authors: Yi‐Shu Chiu, Chi‐Chen Wei, Yih‐Jyh Lin, Yu‐Hsiang Hsu, Ming‐Shi Chang Tags: Liver Injury and Regeneration Source Type: research

Agent Orange exposure and disease prevalence in Korean Vietnam veterans: The Korean veterans health study.
In conclusion, Agent Orange exposure increased the prevalence of endocrine disorders, especially in the thyroid and pituitary gland; various neurologic diseases; COPD; and liver cirrhosis. Overall, this study suggests that Agent Orange/2,4-D/TCDD exposure several decades earlier may increase morbidity from various diseases, some of which have rarely been explored in previous epidemiologic studies. PMID: 24906069 [PubMed - as supplied by publisher]
Source: Environmental Research - June 3, 2014 Category: Environmental Health Authors: Yi SW, Hong JS, Ohrr H, Yi JJ Tags: Environ Res Source Type: research

HCV, but not HIV, is a risk factor for cerebral small vessel disease
Conclusions: This tissue-based analysis of cerebral arteriolar disease demonstrates that HCV constitutes an independent risk, in addition to African American race, hypertension, and cART. Further study is needed to understand what aspects of HCV and cART contribute to cerebrovascular neuropathogenesis.
Source: Neurology Neuroimmunology and Neuroinflammation - September 4, 2014 Category: Neurology Authors: Morgello, S., Murray, J., Van Der Elst, S., Byrd, D. Tags: Other cerebrovascular disease/ Stroke, HIV Article Source Type: research

Ten-point plan to tackle liver disease published
"Doctors call for tougher laws on alcohol abuse to tackle liver disease crisis," The Guardian reports. But this is just one of 10 recommendations for tackling the burden of liver disease published in a special report in The Lancet.The report paints a grim picture of an emerging crisis in liver disease in the UK, saying it is one of the few countries in Europe where liver disease and deaths have actually increased rapidly over the last 30 years. It concludes with 10 recommendations to tackle the burden of liver disease.The media has approached the recommendations from many different angles, with many sources only ...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise QA articles Source Type: news

FloTrac® Monitoring System: What Are Its Uses in Critically Ill Medical Patients?
Abstract : The FloTrac®/Vigileo device uses arterial pressure waveform analysis to calculate stroke volume and cardiac output; it does not require calibration against an independent measurement of cardiac output. Consequently, it provides a method to determine hemodynamic status, changes in the clinical course and responses to therapeutic interventions in patients who have arterial catheters in place. These devices perform relatively well in stable patients undergoing surgery and having an acceptable percentage error in differences between the FloTrac® device and invasive monitoring using pulmonary catheters. Ho...
Source: The American Journal of the Medical Sciences - January 12, 2015 Category: Journals (General) Authors: Argueta E, Berdine G, Pena C, Nugent KM Tags: Am J Med Sci Source Type: research