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Condition: Cirrhosis
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Total 302 results found since Jan 2013.
Reduction in the risk of major adverse cardiovascular events with the BET protein inhibitor apabetalone in patients with recent acute coronary syndrome, type 2 diabetes, and moderate to high likelihood of non-alcoholic fatty liver disease
CONCLUSIONS: Amongst patients with T2DM, recent ACS, and a moderate-to-high likelihood of advanced liver fibrosis, apabetalone was associated with a significantly lower rate of ischemic MACE and HHF and attenuated the increase in hepatic FS over time.PMID:36039183 | PMC:PMC9419281 | DOI:10.1016/j.ajpc.2022.100372
Source: Atherosclerosis - August 30, 2022 Category: Cardiology Authors: Peter P Toth Gregory G Schwartz Stephen J Nicholls Aziz Khan Michael Szarek Henry N Ginsberg Jan O Johansson Kamyar Kalantar-Zadeh Ewelina Kulikowski Ken Lebioda Norman C W Wong Michael Sweeney Kausik K Ray BETonMACE Investigators Source Type: research
Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study
J Clin Med. 2022 Sep 1;11(17):5193. doi: 10.3390/jcm11175193.ABSTRACTHepatitis C infection is one of the main reasons for liver cirrhosis and hepatocellular carcinoma. In recent years, more and more is being heard about extrahepatic manifestations of the hepatitis C infection including its possible influence on the development of hypertension and cardiovascular diseases. In the given work, the frequency analysis of the incidence of hypertension and cardiovascular diseases among 2898 HCV-infected patients treated in Poland and the assessment of their relevance to the HCV genotype and the progression of liver fibrosis can be...
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Pawe ł Rajewski Dorota Zar ębska-Michaluk Ewa Janczewska Andrzej Gietka W łodzimierz Mazur Magdalena Tudrujek-Zdunek Krzysztof Tomasiewicz Teresa Belica-Wdowik Barbara Baka- Ćwierz Dorota Dybowska Waldemar Halota Beata Lorenc Marek Sitko Aleksander Ga Source Type: research
Letter to the Editor: An isolated insular stroke mimics a bout of overt hepatic encephalopathy in a patient with cirrhosis
The manifestations of hepatic encephalopathy (HE) vary from mild neuropsychiatric abnormalities to coma 1,2. Diagnosis and differential diagnosis can be challenging, especially in the hospital setting, where patients may suffer from other metabolic encephalopathies or neurological/psychiatric disorders 1,2,3. Moreover, HE might also occur on top of pre-existing disease, such as dementia 1. Any potential HE precipitating factor should be identified and treated promptly 1. In patients with delirium and cirrhosis, even those with a working diagnosis of HE, a set of laboratory tests including a full blood count, glucose, elect...
Source: Journal of Hepatology - March 19, 2023 Category: Gastroenterology Authors: Chiara Mangini, Roberta Gagliardi, Francesco Causin, Paolo Angeli, Sara Montagnese Tags: Letter to the Editor Source Type: research
Child-Pugh Class B or C Liver Disease Increases the Risk of Early Mortality in Patients With Hepatitis C Undergoing Elective Total Joint Arthroplasty Regardless of Treatment Status
CONCLUSION: Patients with HCV and a Child-Pugh Class B or C at the time of elective TJA had substantially increased odds of death, regardless of liver function, cirrhosis, age, Model for End-Stage Liver Disease level, HCV treatment, and viral load status. This is similar to the risk of early mortality observed in patients with chronic liver disease undergoing abdominal and cardiac surgery. Surgeons should avoid these major elective procedures in patients with Child-Pugh Class B or C whenever possible. For patients who feel their arthritic symptoms and pain are unbearable, surgeons need to be clear that the risk of death is...
Source: Clinical Orthopaedics and Related Research - March 24, 2023 Category: Orthopaedics Authors: Kyle H Cichos Eric Jordan Kian Niknam Antonia F Chen Erik N Hansen Gerald McGwin Elie S Ghanem Source Type: research
An isolated insular stroke mimics a bout of overt hepatic encephalopathy in a patient with cirrhosis
The manifestations of hepatic encephalopathy (HE) vary from mild neuropsychiatric abnormalities to coma.1,2 Diagnosis and differential diagnosis can be challenging, especially in the hospital setting, where patients may suffer from other metabolic encephalopathies or neurological/psychiatric disorders.1 –3 Moreover, HE might also occur on top of pre-existing disease, such as dementia.1 Any potential HE precipitating factor should be identified and treated promptly.1 In patients with delirium and cirrhosis, even those with a working diagnosis of HE, a set of laboratory tests including a full blood count, glucose, electrol...
Source: Journal of Hepatology - March 19, 2023 Category: Gastroenterology Authors: Chiara Mangini, Roberta Gagliardi, Francesco Causin, Paolo Angeli, Sara Montagnese Tags: Letter to the Editor Source Type: research
Prevention of Venous Thromboembolism in Medical Patients with Thrombocytopenia or with Platelet Dysfunction: The Last 10 Years
Semin Thromb Hemost DOI: 10.1055/s-0043-1769013Current guideline recommendations for primary prophylaxis of venous thromboembolism (VTE) are based on randomized clinical trials that usually exclude subjects at a potentially high risk of bleeding complications. For this reason, no specific guideline is available for thromboprophylaxis in hospitalized patients with thrombocytopenia and/or platelet dysfunction. However, except in patients with absolute contraindications to anticoagulant drugs, antithrombotic prophylaxis should always be considered, for example, in hospitalized cancer patients with thrombocytopenia, especially...
Source: Seminars in Thrombosis and Hemostasis - May 18, 2023 Category: Hematology Authors: Tufano, Antonella Brenner, Benjamin Tags: Review Article Source Type: research
GSE230287 Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Contributors : Wouter Claeys ; Clint De Nolf ; Roosmarijn VandenbrouckeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present. The interplay between hyperammonemia and inflammation is thought to drive HE development. As such, astrocytes, the most important ammonia-metabolizing cells in the brain, and microglia, the main immunomodulatory cells in the brain, have been heavily implicated in HE development. As insight into c...
Source: GEO: Gene Expression Omnibus - May 30, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Alcohol consumption and risks of more than 200 diseases in Chinese men
Nat Med. 2023 Jun 8. doi: 10.1038/s41591-023-02383-8. Online ahead of print.ABSTRACTAlcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped for ALDH2- rs671 and ADH1B- rs1229984 , with >1.1 million ICD-10 coded hospitalized events. At baseline, 33% of men drank alcohol regularly. Among men, alcohol intake was positively associated with 61 diseases, including 33 not defi...
Source: Cancer Control - June 8, 2023 Category: Cancer & Oncology Authors: Pek Kei Im Neil Wright Ling Yang Ka Hung Chan Yiping Chen Yu Guo Huaidong Du Xiaoming Yang Daniel Avery Shaojie Wang Canqing Yu Jun Lv Robert Clarke Junshi Chen Rory Collins Robin G Walters Richard Peto Liming Li Zhengming Chen Iona Y Millwood China Kadoo Source Type: research
Insulin Regulation of Hepatic Lipid Homeostasis
Compr Physiol. 2023 Jun 26;13(3):4785-4809. doi: 10.1002/cphy.c220015.ABSTRACTThe incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise worldwide. The liver is a central insulin-responsive metabolic organ that governs whole-body metabolic homeostasis. Therefore, defining the mechanisms underlying insulin action in the liver is essential to our understanding of the pathogenesis of insulin resistance. During periods of fasting, the liver catabolizes fatty acids and stored glycogen to meet the metabolic demands of the body. In postprandial conditions, insulin signals to the liver to store exc...
Source: Atherosclerosis - June 26, 2023 Category: Cardiology Authors: Kahealani Uehara Dominic Santoleri Anna E Garcia Whitlock Paul M Titchenell Source Type: research
