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Specialty: Drugs & Pharmacology
Condition: Heart Disease

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Total 187 results found since Jan 2013.

The  effect of partial patients’ adherence to antihypertensive drugs: scope for pharmacists’ role in hypertension care
AbstractIn many individuals, blood pressure varies between clinic visits conducted days, weeks, or months apart. This visit-to-visit variability (VVV) of blood pressure has been recently related with an increased risk of coronary heart disease, stroke, and mortality, independently of mean blood pressure. As for other chronical diseases, patients ’ adherence to hypertensive therapies remains low and partial adherence to antihypertensive treatment may constitute a source of VVV, as suggested by recent studies. This data should lead to a new clinical approach for hypertension care, based on patients’ real adherence to tre...
Source: International Journal of Clinical Pharmacy - November 7, 2017 Category: Drugs & Pharmacology Source Type: research

Targeting 12-Lipoxygenase As a Potential Novel Antiplatelet Therapy
Publication date: Available online 29 August 2017 Source:Trends in Pharmacological Sciences Author(s): Benjamin E. Tourdot, Michael Holinstat Platelets are key contributors to the formation of occlusive thrombi; the major underlying cause of ischemic heart disease and stroke. Antiplatelet therapy has reduced the morbidity and mortality associated with thrombotic events; however, the utility of current antiplatelet therapies is limited by the concomitant risk of an adverse bleeding event. Novel antiplatelet therapies that are more efficacious at inhibiting thrombosis while minimally affecting hemostasis are required. Plate...
Source: Trends in Pharmacological Sciences - August 30, 2017 Category: Drugs & Pharmacology Source Type: research

Curative treatment of hypertension by physical exercise.
Authors: Lou M, Zong XF, Wang LL Abstract Hypertension, one of the most common chronic and sporadic conditions, figures among the important worldwide public-health challenges, and it is a major risk for heart disease, stroke, kidney disease and other complications, including dementia. Hypertension is neglected by individuals, and the prevalence of this condition continues to rise across the world. A great number of patients receiving medical intervention is not successfully treated, while adequate curative health services are dependent on the exact update data of the countrywide prevalence of known and undetected c...
Source: European Review for Medical and Pharmacological Sciences - August 6, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Catheter Ablation of Atrial Fibrillation: An Overview for Clinicians
AbstractCatheter ablation (CA) of atrial fibrillation (AF) is currently one of the most commonly performed electrophysiology procedures. Ablation of paroxysmal AF is based on the elimination of triggers by pulmonary vein isolation (PVI), while different strategies for additional AF substrate modification on top of PVI have been proposed for ablation of persistent AF. Nowadays, various technologies for AF ablation are available. The radiofrequency point-by-point ablation navigated by electro-anatomical mapping system and cryo-balloon technology are comparable in terms of the efficacy and safety of the PVI procedure. Long-te...
Source: Advances in Therapy - July 21, 2017 Category: Drugs & Pharmacology Source Type: research

Targeting the role of lipoprotein (a) in stroke.
Authors: Garelnabi M, Mazhar Z, Hughes A Abstract Stroke is the third leading cause of death in the United States, behind only heart disease and cancer, with over 140,000 associated deaths per year. Considerable research is ongoing to examine the role of modifiable risk factors which may cause or contribute to a stroke occurring. Although age and family history are generally considered to be major risk factors, there are several modifiable and non-modifiable risk factors that are linked to the pathogenesis of a stroke. Lipoprotein (a), or Lp(a), is a type of low-density lipoprotein containing an integral apoB100 co...
Source: Cardiovascular and Hematological Disorders Drug Targets - April 22, 2017 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Current and future perspectives on the treatment of cerebral ischemia.
Authors: Christophe BR, Mehta SH, Garton AL, Sisti J, Connolly ES Abstract INTRODUCTION: After heart disease and combined forms of cancer, stroke is the leading cause of death in the United States. Currently, tissue-plasminogen activator (tPA) thrombolysis is the only thrombolytic therapy that has been shown to improve patient outcome. Presently, the only antithrombotic drug treatment that has proven effective at improving acute ischemic stroke patient outcome is aspirin administration. Despite these studies, no clinical trials have yet demonstrated a reliably effective pharmacological treatment. Areas covered: We ...
Source: Expert Opinion on Pharmacotherapy - April 11, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Managing Cardiovascular Risk of Macrolides: Systematic Review and Meta-Analysis
ConclusionsMore studies are required to investigate the short-term cardiovascular outcomes associated with different types of macrolides. Future studies are warranted to evaluate the effect of statins for preventing excess acute cardiovascular events associated with clarithromycin or other macrolides.
Source: Drug Safety - April 10, 2017 Category: Drugs & Pharmacology Source Type: research

Use of Lipid-Modifying Therapy and LDL-C Goal Attainment in a High-Cardiovascular-Risk Population in the Netherlands.
This study investigates lipid-modifying therapy (LMT) and LDL-C goal attainment in a real-world, high-cardiovascular-risk population in the Netherlands. METHODS: From the PHARMO Database Network, patients aged ≥18 years with an LDL-C measurement in 2012 (index date) were selected and hierarchically classified into the following mutually exclusive high-cardiovascular-risk categories: familial hypercholesterolemia (FH), recent acute coronary syndrome (ACS), coronary heart disease, ischemic stroke, peripheral arterial disease, and diabetes mellitus. LMT use and LDL-C goal attainment at the index date was assessed. ...
Source: Clinical Therapeutics - March 24, 2017 Category: Drugs & Pharmacology Authors: Kuiper JG, Sanchez RJ, Houben E, Heintjes EM, Penning-van Beest FJ, Khan I, van Riemsdijk M, Herings RM Tags: Clin Ther Source Type: research

Medication and Driving-Appropriate Interventions.
Abstract  Sudden illness while driving has been identified as a major cause of vehicle collisions, accounting for approximately 1 in 10 collisions. Because most drivers who experience sudden illnesses while driving do not perform avoidance maneuvers, the improvement of drivers' health is being promoted as a traffic safety strategy. Although stroke, heart disease, and epilepsy are common causes of sudden illness, common symptoms, such as abdominal cramps, vertigo, and syncope can also cause problems during driving. We found that regular referral to physicians was significantly less common among drivers who experi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 4, 2017 Category: Drugs & Pharmacology Authors: Hitosugi M Tags: Yakugaku Zasshi Source Type: research

Nutraceuticals and dietary supplements to improve quality of life and outcomes in heart failure patients.
CONCLUSIONS: Evidence suggests that the supplementation with nutraceuticals may be a useful option for effective management of HF, with the advantage of excellent clinical tolerance. PMID: 28120718 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - January 23, 2017 Category: Drugs & Pharmacology Authors: Cicero AF, Colletti A Tags: Curr Pharm Des Source Type: research

Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C.
This study clarifies the PKC-related signaling pathway involved in antiplatelet action of scutellarein, and may be beneficial for the treatment of cardiovascular diseases. PMID: 26581323 [PubMed - indexed for MEDLINE]
Source: Biological and Pharmaceutical Bulletin - November 4, 2016 Category: Drugs & Pharmacology Authors: Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X, Zhu Y Tags: Biol Pharm Bull Source Type: research

Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats
Conclusions DZSM significantly affects the pharmacokinetics of clopidogrel and its active metabolite by inhibiting the P-gp-mediated efflux transport and CYP450-mediated metabolism of clopidogrel. Thus, caution is needed when DZSM is co-administered with clopidogrel in the clinic because the interaction of these drugs may result in altered plasma concentrations of clopidogrel and its active metabolite. Graphical abstract
Source: Journal of Ethnopharmacology - August 7, 2016 Category: Drugs & Pharmacology Source Type: research

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications
Publication date: Available online 2 August 2016 Source:Pharmacology & Therapeutics Author(s): Elise Belaidi, Jessica Morand, Emmanuelle Gras, Jean-Louis Pépin, Diane Godin-Ribuot Obstructive sleep apnea (OSA) is now recognized as an independent and important risk factor for cardiovascular diseases such as hypertension, coronary heart disease, heart failure and stroke. Clinical and experimental data have confirmed that intermittent hypoxia is a major contributor to these deleterious consequences. The repetitive occurrence of hypoxia-reoxygenation sequences generates significant amounts of free radicals, particula...
Source: Pharmacology and Therapeutics - August 2, 2016 Category: Drugs & Pharmacology Source Type: research

The interaction between gender and diabetes mellitus in the coronary heart disease risk.
CONCLUSION: The connection between diabetes mellitus and cardiovascular disease is variable according to gender and further studies are needed to elucidate the lenient differentiations in gender specific hormones, risk factor profile, and therapeutic implications between genders. PMID: 27280390 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - June 5, 2016 Category: Drugs & Pharmacology Authors: Oikonomou E, Tsigkou V, Lazaros G, Papamikroulis GA, Papaioannou S, Siasos G, Tousoulis D Tags: Curr Pharm Des Source Type: research

Traditional Chinese Medicines in the management of cardiovascular diseases: a comprehensive systematic review
ConclusionsCertain TCM compounds appear to have significant anti‐hypertensive effects, and although some are associated in some studies with improved outcomes in coronary heart disease, heart failure and type 2 diabetes mellitus the data are inconsistent and will require large‐scale randomised‐controlled trials to allow full evaluation of any potential therapeutic benefit in these areas.
Source: British Journal of Clinical Pharmacology - May 13, 2016 Category: Drugs & Pharmacology Authors: Kerry Layne, Albert Ferro Tags: Review ‐ Themed Issue Source Type: research