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Specialty: Drugs & Pharmacology
Condition: Heart Disease
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Total 187 results found since Jan 2013.
Gender and Cardiovascular Mortality in Northern and Ssouthern European Populations.
CONCLUSION: No doubt might still exist that all efforts were undertaken for both men and women, for health and prolongation of life to effectively treat common risk factors such as cigarette consumption, high blood pressure, cholesterol levels and physical inactivity by also paying attention to optimal diet.
PMID: 27138925 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - May 1, 2016 Category: Drugs & Pharmacology Authors: Puddu PE, Schiariti M, Torromeo C Tags: Curr Pharm Des Source Type: research
Neurotrophic and Neuroprotective effects of muscle contraction.
CONCLUSION: Physical activity could represent an additional approach to fight against such diseases.
PMID: 27121507 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - April 27, 2016 Category: Drugs & Pharmacology Authors: Arnao V, Di Raimondo D, Tuttolomondo A, Pinto A Tags: Curr Pharm Des Source Type: research
Atypical chest pain in ACS: a trap especially for women.
Abstract
Not all acute coronary syndromes (ACS) exhibit the classic symptoms of chest pain. The diagnosis of ACS in patients without typical chest pain is often challenging. These patients are at increased risk for delayed or incorrect diagnosis, less aggressive treatment and high in-hospital mortality. The association between diabetes mellitus and absence of chest pain in ischemic heart disease is established. As well, it is known that women, more frequently than men, have atypical presentation. However, there is a lack of standardization in characterizing the population of patients with ACS and atypical presenta...
Source: Current Pharmaceutical Design - March 8, 2016 Category: Drugs & Pharmacology Authors: Ricci B, Cenko E, Varotti E, Puddu PE, Manfrini O Tags: Curr Pharm Des Source Type: research
The emerging role of galectins in cardiovascular disease.
Abstract
Galectins are an ancient family of β-galactoside-specific lectins and consist of 15 different types, each with a specific function. They play a role in the immune system, inflammation, wound healing and carcinogenesis. In particular the role of galectin in cancer is widely studied. Lately, the role of galectins in the development of cardiovascular disease has gained attention. Worldwide cardiovascular disease is still the leading cause of death. In ischemic heart disease, atherosclerosis limits adequate blood flow. Angiogenesis and arteriogenesis are highly important mechanisms relieving ischemia by rest...
Source: Vascular Pharmacology - March 2, 2016 Category: Drugs & Pharmacology Authors: van der Hoeven NW, Hollander MR, Yıldırım C, Jansen MF, Teunissen PF, Horrevoets AJ, van der Pouw Kraan TC, van Royen N Tags: Vascul Pharmacol Source Type: research
Merck Receives Complete Response Letter from the U.S. FDA for ZETIA® (ezetimibe) and VYTORIN® (ezetimibe and simvastatin)
Dateline City:
KENILWORTH, N.J.
KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE:MRK), known as MSD outside the United States and Canada,
announced today that the U.S. Food and Drug Administration (FDA) has
issued a Complete Response Letter regarding Merck's Supplemental New
Drug Applications for ZETIA® and VYTORIN® for the reduction of the risk
of cardiovascular events (cardiovascular death, nonfatal myocardial
infarction, nonfatal stroke, hospitalization for unstable angina, or
need for revascularization) in patients with coronary heart disease.
Language:
...
Source: Merck.com - Product News - February 15, 2016 Category: Drugs & Pharmacology Tags: Prescription Medicine News Corporate News Latest News Source Type: news
Merck Receives Complete Response Letter from the U.S. FDA for ZETIA ® (ezetimibe) and VYTORIN® (ezetimibe and simvastatin)
Dateline City:
KENILWORTH, N.J. KENILWORTH, N.J.--( BUSINESS WIRE )--Merck (NYSE:MRK), known as MSD outside the United States and Canada,
announced today that the U.S. Food and Drug Administration (FDA) has
issued a Complete Response Letter regarding Merck ' s Supplemental New
Drug Applications for ZETIA ® and VYTORIN® for the reduction of the risk
of cardiovascular events (cardiovascular death, nonfatal myocardial
infarction, nonfatal stroke, hospitalization for unstable angina, or
need for revascularization) in patients with coronary heart disease. Language:
English ...
Source: Merck.com - Product News - February 15, 2016 Category: Drugs & Pharmacology Tags: Prescription Medicine News Corporate News Latest News Source Type: news
Effects of salvianolic acid B and tanshinone IIA on the pharmacokinetics of losartan in rats by regulating the activities and expression of CYP3A4 and CYP2C9
Publication date: 2 March 2016 Source:Journal of Ethnopharmacology, Volume 180 Author(s): Rong Wang, Hai Zhang, Yujie Wang, Xiaoyan Yu, Yongfang Yuan Losartan (LST) is a common chemical drug used to treat high blood pressure and reduce the risk of stroke in certain people with heart disease. Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge, has been widely used for prevention and treatment of various cardiovascular and cerebrovascular diseases. There are more than 35 formulations containing Danshen indexed in the 2010 Chinese Pharmacopoeia, which are often combined with LST to treat car...
Source: Journal of Ethnopharmacology - February 6, 2016 Category: Drugs & Pharmacology Source Type: research
Antidepressant Medication Use and Its Association With Cardiovascular Disease and All-Cause Mortality in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
CONCLUSIONS: In fully adjusted models, antidepressant use was associated with a small increase in all-cause mortality.
PMID: 26783360 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - January 18, 2016 Category: Drugs & Pharmacology Authors: Hansen RA, Khodneva Y, Glasser SP, Qian J, Redmond N, Safford MM Tags: Ann Pharmacother Source Type: research
The problem of atrial fibrillation in patients with chronic kidney disease.
Abstract
Chronic kidney disease (CKD) is associated with the risk of multiple life-threatening complications such as: progression to chronic renal failure and cardiovascular disease including coronary heart disease, heart failure and peripheral arterial disease. Also, atrial fibrillation (AF) is common in this group of patients. Factors contributing to the occurrence of AF in patients undergoing dialysis include: age, presence of coronary heart disease, echocardiographic abnormalities (low ejection fraction, atrial enlargement, valvular calcification, left ventricular hypertrophy), heart failure, chronic obstructi...
Source: Current Vascular Pharmacology - January 15, 2016 Category: Drugs & Pharmacology Authors: Franczyk B, Gluba-Brzózka A, Ciałkowska-Rysz A, Banach M, Rysz J Tags: Curr Vasc Pharmacol Source Type: research
Atherosclerotic cardiovascular disease: a review of initiators and protective factors
Abstract
Atherosclerotic cardiovascular disease (CVD) is a collective term comprising of a group of disorders of the heart and blood vessels. These diseases are the largest cause of morbidity and premature death worldwide. Coronary heart disease and cerebrovascular disease (stroke) are the most frequently occurring diseases. The two major initiators involved in the development of atherosclerotic CVD are vascular production of reactive oxygen species (ROS) and lipid oxidation. In atherosclerosis development, ROS is associated with rapid loss of anti-inflammatory and anti-atherogenic activities of the endothelium-de...
Source: Inflammopharmacology - January 11, 2016 Category: Drugs & Pharmacology Source Type: research
Transdermal delivery of heparin: Physical enhancement techniques
Publication date: 30 December 2015 Source:International Journal of Pharmaceutics, Volume 496, Issue 2 Author(s): Kevin Ita Thromboembolic complications are the most common preventable cause of mortality and morbidity in trauma patients. Thrombosis is also the common cause of ischemic heart disease (acute coronary syndrome), stroke, and venous thromboembolism. Heparin, as a potent anticoagulant, has been used in clinical practice for more than five decades and remains the major medicine for the prevention and treatment of venous thromboembolism. However it binds to the endothelium and has a high affinity for plasma prote...
Source: International Journal of Pharmaceutics - December 12, 2015 Category: Drugs & Pharmacology Source Type: research
Exploring the Distribution of Prescription for Sulfonylureas in Patients with Type 2 Diabetes According to Cardiovascular Risk Factors Within a Canadian Primary Care Setting.
ConclusionThis study illustrated that in this dataset of Canadian patients with diabetes in a primary care setting, a substantial proportion of patients treated with an SU in 2013 had established CV disease and/or an aggregation of multiple CV risk factors. In light of recent data reporting on an association between SU utilization and CV events and increased mortality, pharmacovigilance programs should actively monitor SU utilization in patients with diabetes and a high risk CV profile in real world clinical settings.
PMID: 26567749 [PubMed - in process]
Source: Journal of Population Therapeutics and Clinical Pharmacology - November 19, 2015 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research
Delineation of platelet activation pathway of Scutellarein revealed its intracellular target as Protein Kinase C.
This study clarifies the PKC-related signaling pathway involved in antiplatelet action of scutellarein, and may be beneficial for the treatment of cardiovascular diseases.
PMID: 26581323 [PubMed - as supplied by publisher]
Source: Biological and Pharmaceutical Bulletin - November 18, 2015 Category: Drugs & Pharmacology Authors: Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X, Zhu Y Tags: Biol Pharm Bull Source Type: research
Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications
ABSTRACTCarthami flos, the dried floret of Carthamus tinctorius L., Asteraceae (safflower), has been widely used in traditional Chinese medicine to treat a broad range of ailments, such as coronary heart disease, angina pectoris, gynecologic disease, stroke, and hypertension. However, although several studies on Carthami flos have been done consecutively, the results are usually scattered across various documents. This review aims to provide up-to-date information on the traditional uses, pharmacology, clinical applications, and toxicology of Carthami flos in China and thereby to provide a basis for further investigation o...
Source: Revista Brasileira de Farmacognosia - November 17, 2015 Category: Drugs & Pharmacology Source Type: research
Validation of methods for assessing cardiovascular disease using electronic health data in a cohort of Veterans with diabetes
ConclusionsICD‐9 codes for acute MI events during follow‐up had high PPV and sensitivity. The sensitivity of ICD‐9 codes for previous acute events at baseline was low, but a composite variable for baseline CHD had good accuracy. Copyright © 2015 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - November 11, 2015 Category: Drugs & Pharmacology Authors: James S. Floyd, Marc Blondon, Kathryn P. Moore, Edward J. Boyko, Nicholas L. Smith Tags: Brief Report Source Type: research
