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Specialty: Drugs & Pharmacology
Condition: Heart Disease
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Total 187 results found since Jan 2013.
Superior Stroke Prevention with Angiotensin Receptor Blockers Compared with Other Antihypertensive Drugs
Expert Opin Drug Saf. 2023 Mar 7. doi: 10.1080/14740338.2023.2189236. Online ahead of print.ABSTRACTINTRODUCTION: Stroke is a major cause of death and disability and its incidence is linearly increased with the elevation of blood pressure (BP) and the advancement of age in both men and women, with its incidence being higher in older subjects, the blacks and women.AREAS COVERED: The annual worldwide incidence of stroke is 7.6 million for subjects ≥ 20 years of age with the average direct and indirect annual costs of stroke care, is expected to be $94.3 billion between 2014 and 2015. With respect to the cause of stroke, th...
Source: Expert Opinion on Drug Safety - March 7, 2023 Category: Drugs & Pharmacology Authors: Steven G Chrysant Source Type: research
Utilization of triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention
ConclusionsThe utilization of TAT following PCI among high-stroke risk AF patients steadily increased from 2011 to 2020, reaching 65.4% by the end of the study period. However, in 2020, a significant proportion of 29.4% of patients still received DAPT, indicating that many AF patients undergoing PCI did not receive adequate antithrombotic therapy.
Source: European Journal of Clinical Pharmacology - February 24, 2023 Category: Drugs & Pharmacology Source Type: research
Protective effect of antihypertensive drugs on the risk of Parkinson ’s disease lacks causal evidence from mendelian randomization
Conclusion: Our data suggest that BP and commonly prescribed AHMs may not have a prominent role in PD etiology.
Source: Frontiers in Pharmacology - February 23, 2023 Category: Drugs & Pharmacology Source Type: research
Preparation and optimization of surface stabilized cryptotanshinone nanocrystals with enhanced bioavailability
In conclusion, the results of this study suggest a feasible formulation for the oral delivery of CTS.
Source: Frontiers in Pharmacology - February 3, 2023 Category: Drugs & Pharmacology Source Type: research
Panax notoginseng preparation plus aspirin versus aspirin alone on platelet aggregation and coagulation in patients with coronary heart disease or ischemic stroke: A meta-analysis of randomized controlled trials
Conclusion: PNP combined with ASA might produce stronger antiplatelet aggregation and anticoagulation effects without increasing bleeding risk, gastrointestinal side effects, and urticaria compared with ASA alone.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42022339234.
Source: Frontiers in Pharmacology - December 7, 2022 Category: Drugs & Pharmacology Source Type: research
Effectiveness of Simvastatin Versus Gemfibrozil for Primary Prevention of Cardiovascular Events: A Retrospective Cohort Study of 223,699 Primary Care Patients
ConclusionThe results of this study showed better population-level effectiveness of simvastatin compared with gemfibrozil for the primary prevention of MACE; however, a definitive randomized controlled trial is required to compare simvastatin with gemfibrozil among patients with low HDL cholesterol, as they appear to obtain benefit with gemfibrozil.
Source: Clinical Drug Investigation - October 14, 2022 Category: Drugs & Pharmacology Source Type: research
A network-based approach for isolating the chronic inflammation gene signatures underlying complex diseases towards finding new treatment opportunities
Complex diseases are associated with a wide range of cellular, physiological, and clinical phenotypes. To advance our understanding of disease mechanisms and our ability to treat these diseases, it is critical to delineate the molecular basis and therapeutic avenues of specific disease phenotypes, especially those that are associated with multiple diseases. Inflammatory processes constitute one such prominent phenotype, being involved in a wide range of health problems including ischemic heart disease, stroke, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, and autoimmune and neurodege...
Source: Frontiers in Pharmacology - October 12, 2022 Category: Drugs & Pharmacology Source Type: research
Comparative Risks of Nonsteroidal Antiinflammatory Drugs on Cardiovascular Diseases: A Population-Based Cohort Study
This article is protected by copyright. All rights reserved.PMID:36063443 | DOI:10.1002/jcph.2142
Source: The Journal of Clinical Pharmacology - September 5, 2022 Category: Drugs & Pharmacology Authors: Eric Yuk Fai Wan Esther Yee Tak Yu Linda Chan Anna Hoi Ying Mok Yuan Wang Esther Wai Yin Chan Ian Chi Kei Wong Cindy Lo Kuen Lam Source Type: research
An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis
Angiogenesis, the formation of new capillaries from pre-existing vascular networks, plays an important role in many physiological and pathological processes. The use of pro-angiogenic agents has been proposed as an attractive approach for promoting wound healing and treating vascular insufficiency-related problems, such as ischemic heart disease and stroke, which are the leading causes of death worldwide. Traditional herbal medicine has a long history; however, there is still a need for more in-depth studies and evidence-based confirmation from controlled and validated trials. Many in vitro and in vivo studies have reporte...
Source: Frontiers in Pharmacology - July 19, 2022 Category: Drugs & Pharmacology Source Type: research
Cardiodiabetology: Newer Pharmacologic Strategies for Reducing Cardiovascular Disease Risks
Can J Physiol Pharmacol. 2022 Jun 30. doi: 10.1139/cjpp-2022-0065. Online ahead of print.ABSTRACTGlobally, nearly 500 million adults currently have diabetes, which is expected to increase to approximately 700 million by 2040. Cardiovascular diseases (CVD), including coronary heart disease, stroke, heart failure, and peripheral arterial disease, are the principal causes of death in persons with diabetes. Key to the prevention of CVD is optimization of associated risk factors. However, few persons with diabetes are at recommended targets for key CVD risk factors including LDL-cholesterol, blood pressure, HbA1c, nonsmoking st...
Source: Canadian Journal of Physiology and Pharmacology - June 30, 2022 Category: Drugs & Pharmacology Authors: Nathan D Wong Source Type: research
