Detection of serious adverse drug reactions using diagnostic codes in the International Statistical Classification of Diseases and Related Health Problems.
This study aimed to assess the ability to detect serious ADRs from diagnostic codes and the potential benefit of adding stand-alone diagnostic codes to the regular process for detecting serious ADRs. In this descriptive study, clinical pharmacists and a reference work on drug-induced diseases allowed to identify diagnostic codes in the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Canada (ICD-10-CA), reflecting clinical manifestations related to an ADR. Records for admissions to a large urban mother-child hospital in the fiscal year 2018-2019, as coded by medical archivist...
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

For the future and possible ensuing waves of COVID-19: A perspective to consider when disseminating data.
Authors: Kwok M, Tran TML Abstract During the COVID-19 pandemic, most citizens in North America receive daily updates, which highlight the number of new cases per day in a specified region. However, as this data metric is often presented alone on media and news platforms, the spread of the novel coronavirus may often be misinterpreted. Among these daily updates which are critical to informing the public, the authors emphasize the importance of controlling for variation attributed to changes in surveillance. The number of test results that have been analyzed each day along with the total number of tests being conduc...
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Hemorragic presentation of Listeria Monocytogenes rhombencephalic abscess.
Authors: Feraco P, Incandela F, Stallone F, Alaimo F, Geraci L, Bencivinni F, Tona G, Gagliardo C Abstract Listeria monocytogenes (LM) bacterium is a cause of central nervous system (CNS) infection and the most common cause of rhombencephalitis in immunocompetent elderly.A prompt identification of this condition should be always desirable, since its clinical manifestations are often unspecific with prodromal symptoms leading to high rates of morbidity and mortality if underestimated.CNS listeriosis magnetic resonance imaging (MRI) findings are generally not specific. However, in the appropriate clinical setting, fo...
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Cerebral abscesses imaging: A practical approach.
Authors: Feraco P, Donner D, Gagliardo C, Leonardi I, Piccinini S, Del Poggio A, Franciosi R, Petralia B, van den Hauwe L Abstract Brain abscesses (BAs) are focal infections of the central nervous system (CNS) that start as a localised area of weakening of the brain parenchyma (cerebritis) and develops into a collection of pus surrounded by a capsule. Pyogenic (bacterial) BAs represent the majority of all BAs; in some cases, the diagnostic and therapeutic management can be challenging. Imaging has a primary role in differentiating BAs from other lesions. Conventional magnetic resonance imaging (cMRI) is essential f...
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Handwashing in averting infectious diseases: Relevance to COVID-19.
Authors: Haque M Abstract After officially declared as a pandemic by the World Health Organization (WHO), drastic measures to restrict human movements to contain the COVID-19 infection are employed by most of the countries. Maintaining high personal hygiene by frequent handwashing and be vigilant of clinical signs are widely recommended to reduce the disease burden. The national and international health agencies, including the Centers for Disease Control and Prevention (CDC) and the WHO, have provided guidelines for prevention and treatment suggestions. Here, in this brief article, based on available clinical infor...
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Effect of a standard schema of self-monitoring blood glucose in patients with poorly controlled, non-insulin-treated type 2 diabetes mellitus: A controlled longitudinal study.
Authors: Madeo B, Diazzi C, Granata ARM, Ghoch ME, Greco C, Romano S, Scaltriti S, Rochira V Abstract The effect of self-monitoring of blood glucose (SMBG) on glycemic control with regard to non-insulin-treated Type 2 diabetes mellitus (NIT-Type 2 DM) is still a controversial topic. Against this backdrop, we sought to compare the effect of a continuous short-term SMBG schema with as-usual treatment, based on changes in oral antidiabetic treatment in patients with poorly controlled Type 2 DM. We reviewed 492 NIT-Type 2 DM record charts, selecting 27 patients, with poor glycemic control, who were thought to self-moni...
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Treatment algorithm for the use of psychopharmacological agents in individuals prenatally exposed to alcohol and/or with diagnosis of fetal alcohol spectrum disorder (FASD).
The objective of this work was to generate a treatment algorithm for the use of psychopharmacological agents specifically for individuals with ND-PAE/FASD. The development of decision tree for use to prescribe psychotropic medications incorporated findings from previous research and the collective clinical experience of a multidisciplinary and international panel of experts who work with individuals with ND-PAE/FASD, including an algorithm specialist. After multiple meetings and discussions, the experts reached consensus on how best to streamline prescribing along neurodevelopmental clusters. These were subdivided into fou...
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Treatment completion and implementation by patients initiating ticagrelor.
CONCLUSION: Treatment completion might be improved. Among patients who completed the treatment, implementation was high. The factors associated with completion could help to identify patients who might benefit from interventions that aim to optimize treatment completion. PMID: 32722910 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - August 1, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Let food be the medicine, but not for coronavirus: Nutrition and food science, telling myths from facts.
Authors: El Ghoch M, Valerio A Abstract The entire globe is facing a dangerous pandemic due to the coronavirus disease (COVID-19). The medical and scientific community is trying to figure out and adopt effective strategies that can lead to (i) preventing virus expansion; (ii) identifying medications for the management of critical care and reducing rates of mortality; and (iii) finally discovering the highly anticipated vaccine. Nutritional interventions have attained considerable scientific evidence in disease prevention and treatment. The main question, "What is the role of nutrition and food science in this ...
Source: Journal of Population Therapeutics and Clinical Pharmacology - July 17, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Obesity and Higher Risk for Severe Complications of Covid-19: What to do when the two pandemics meet.
Authors: Valerio A, Nisoli E, Rossi AP, Pellegrini M, Todesco T, Ghoch ME Abstract The coronavirus disease 2019 (COVID-19) pandemic has spread around the globe, infecting more than ten million individuals, with more than 500,000 dead; about one half of the infected people have recovered. Despite this fact, a subgroup of individuals affected by COVID-19 is at greater risk of developing worse outcomes and experience a high rate of mortality. Data on the association between obesity and COVID-19 are growing; the available studies, have reported a high prevalence of overweight and obesity in patients experiencing a seve...
Source: Journal of Population Therapeutics and Clinical Pharmacology - July 12, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Antirheumatic drugs for COVID-19 treatment based on the phases of the disease: Current concept.
Authors: Valentini M, Zmerly H Abstract COVID-19 disease is the most recent pandemic, since it has affected more than four and a half million people and caused more than 300,000 deaths. It is a very complex systemic disease in terms of pathogenesis, treatment, and prognosis. Pharmacological treatment may include antiviral and antimalarial drugs, antibiotics, monoclonal antibodies, corticosteroids as well as low-molecular-weight heparins to prevent the evolution of the disease from reaching the severe inflammatory phase that can lead to respiratory complications, multiple organ failure, disseminated intravascular co...
Source: Journal of Population Therapeutics and Clinical Pharmacology - July 12, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Covid-19: A systemic disease treated with a wide-ranging approach: A case report.
Authors: Massabeti R, Cipriani MS, Valenti I Abstract At the end of December 2019, the Health Commission of the city of Wuhan, China, alerted the World Health Organization (WHO) to a pneumonia cluster in the city. The cause was identified as being a new virus, later named SARS-CoV-2. We can distinguish three clinical phases of the disease with a distinct pathogenesis, manifestations and prognosis. Here, we describe the case of a 45-year-old male, successfully treated for Coronavirus disease (COVID-19). The patient was feeling sick in early April 2020; he had a fever and pharyngodynia. When he came to our COVID hosp...
Source: Journal of Population Therapeutics and Clinical Pharmacology - July 12, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

The Global Gag Rule: The death trap for comprehensive sexual and reproductive healthcare and way to overcome the US gag rule.
This article has attempted to let the readers know about the impacts of GGR around the world and how global leaders are trying to overcome the harmful effects of this rule. Finally, it proposes some solutions to the impacts of the extension of Mexico City Policy. PMID: 32621461 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - July 7, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

How to organize an emergency department during the COVID-19 pandemic.
Authors: Silvagni E, Cipriani MS, Valenti I PMID: 32603562 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - July 2, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Therapeutic effect of inhaled budesonide in transient tachypnea of newborn: A placebo-controlled study.
This study comprised 100 neonates with TTN, which were divided into two groups. The first group (inhaled steroid group) consisted of 50 neonates with TTN who were exposed to inhalation of corticosteroids (budesonide 2 ml, 0.25 mg/ml suspension for nebulizer, AstraZeneca AB, Södertälje, Sweden), the first dose was administered within 6 h of birth and the second dose was given 12 h later. The second group (placebo group) consisted of 50 neonates with TTN who were exposed to placebo inhalation (2 ml of distilled sterile water). There was significant difference between both groups regarding Down score (P = 0.001), TT...
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 17, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Effects of alternate nostril breathing exercise on cardiac functions in healthy young adults leading a stressful lifestyle.
The objectives of this study were to assess the effects of ANB exercise on cardiac physiology among healthy medical students. This was a prospective interventional study that was conducted in the Department of Physiology, Chittagong Medical College (CMC), Chattogram, Bangladesh, from July 2017 to June 2018. A total of 100 research participants (RPs) aged 18-20 years, Year-I medical students of CMC, were selected. A simple random sampling method was adopted. The selection was done after the inclusion and exclusion criteria were applied. The age and body mass index (BMI) of the RPs were analogous in both the control and expe...
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 17, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Regulatory approval and public drug plan listing of new drugs for rare disorders in Canada and New Zealand.
Authors: Rawson NSB Abstract A previous assessment of the alignment of health technology assessments and price negotiations for new drugs for rare disorders in Canada completed between 2014 and 2018 demonstrated that it is working for governments but has yet to lead to improved access in a timely manner for all appropriate patients in all provinces. In this analysis, drugs for rare and ultra-rare disorders with a completed price negotiation or no negotiation between 2014 and 2018 in Canada, and their reimbursement recommendations and listings in Canadian public drug programs are compared with their regulatory appro...
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 17, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

The comparison of the effectiveness of lincocin ® and azitro® in the treatment of covid-19-associated pneumonia: A prospective study.
This study aims to compare the effectiveness of LINCOCIN® and AZITRO® in the treatment of COVID-19 associated pneumonia. A total of 24 hospitalized patients aged between 30-80 years who were admitted to the Tarsus Medical Park Hospital between February to March 2020 was included in the study. The patients were divided into LINCOCIN® and AZITRO® treatment groups. Bronchoalveolar-lavage PCR results were compared after treatment. The mean age was 58.4±15.4 years in the LINCOCIN® group and 59.1±16.6 years in the AZITRO® group. In the LINCOCIN® group, the rate of males was 66.7% and it ...
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 17, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Overconsumption of sugar-sweetened beverages: Why is it difficult to control?
Authors: Razzaque MS Abstract The consumption of sugar-sweetened beverages is a known contributory factor of childhood obesity that is documented around the globe. More importantly, reducing the consumption of sugar-sweetened beverages could reduce weight gain among overweight or obese children. Although sugar is present in many natural foods, artificial sugar is added into sugar-sweetened beverages, which has little or no nutritional value. However, the calories obtained from the sugar-sweetened beverages are linked to overweight and obesity, and an increase serving sizes of sugar-sweetened beverages over the year...
Source: Journal of Population Therapeutics and Clinical Pharmacology - May 31, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

The effects of medication on intraocular pressure in children with attention deficit hyperactivity disorder: A prospective study.
In this study, we primarily aim to investigate the effects of psychopharmacological agents on intraocular pressure (IOP) in children with ADHD. The sample included 82 children with ADHD and 36 healthy children aged between 8 and 12 years who were referred to the Department of Child and Adolescent Psychiatry in Hatay State Hospital, Hatay, Turkey. Children with ADHD were divided into two groups according to the medication used: methylphenidate (MPH) group and atomoxetine (ATX) group. Before treatment and after 1- and 6-month treatment period, IOP was measured by Goldmann applanation tonometry. There were no statistical diff...
Source: Journal of Population Therapeutics and Clinical Pharmacology - May 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Antithrombotics in intracerebral hemorrhage in the era of novel agents and antidotes: A review.
CONCLUSION: Antithrombotic therapy is of great importance when indicated, though it does not come without crucial side-effects, such as ICH. Optimal timing of withdrawal, reversal, and resumption of antithrombotic treatment should be determined by a multidisciplinary team consisting of a stroke specialist, a cardiologist, and a neurosurgeon, who will individually approach the needs and risks of each patient. PMID: 32320168 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 24, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Serological and psychological assessment of patients with oral lichen planus using serum cortisol levels and hads questionnaire-a case control study.
Authors: Chaitanya NC, Reshmapriyanka D, Pallavi K, Ameer S, Appala A, Chowdhary A, Prabhath T, Ratna MP, Sowmya BS, Vaishnavi C, Bontala P Abstract BACKGROUND: Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disorder directed against antigens secreted by the basal cell layer, with an incidence of 0.02-0.22% in Indian population and showing female predilection. Stress is considered one of the etiological factors in the causation, progression, and recurrence of this disease. OBJECTIVES: To evaluate the levels of serum cortisol, anxiety, and depression in patients with symptomatic OLP and to corr...
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 24, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Comparative effectiveness and safety of oral anticoagulants for atrial fibrillation: A retrospective cohort study.
Authors: Holbrook A, Morrow R, Lee AYY, Foster G, Pullenyegum E Abstract Oral anticoagulants (OACs) are high-priority medications, frequently used with clinically important benefit and serious harm. Our objective was to compare the safety and effectiveness of direct-acting oral anticoagulants (DOACs) versus warfarin in a population where anticoagulation management and DOACs were readily available. A retrospective cohort study of all adults living in British Columbia with a diagnosis of atrial fibrillation and a first prescription for an OAC was conducted. Co-primary outcomes were ischemic stroke and systemic emboli...
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 24, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Effects of alternate nostril breathing exercise on respiratory functions in healthy young adults leading stressful lifestyle.
This study was conducted with the objective of assessing the physiological effects of short-term ANB exercise on respiratory function in healthy adult individuals leading a stressful life. This prospective interventional study was conducted in the Department of Physiology, Chittagong Medical College (CMC), Chattogram, Bangladesh from July 2017 to June 2018. A total of 100 participants aged 18-20 years, studying in the first year in CMC, were included by using a simple random sampling method. Among them, 50 participants were enrolled in the experimental group. Age- and BMI-matched 50 participants constituted the control gro...
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 24, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

A narrative review of the effects of sugar-sweetened beverages on human health: A key global health issue.
Authors: Haque M, McKimm J, Sartelli M, Samad N, Haque SZ, Bakar MA Abstract The provision of healthy and safe food is vital for human health, and the addition of unnecessary sugars in foodstuffs is an important global issue, leading to multiple long- and short-term health issues and spiraling costs for individuals and governments alike. The negative effect of excess sugar consumption contributes to adverse health conditions, including obesity, type 2 diabetes, and poor oral health in both high and low resource settings. A key plank of governmental and health promotion bodies' nutritional guidance is to raise publi...
Source: Journal of Population Therapeutics and Clinical Pharmacology - March 15, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Impact of adverse drug reactions on the coding of a hospital stay in Quebec: exploratory descriptive study by simulation.
This study was undertaken to simulate the impact of different adverse drug reactions (ADRs) on the hospital length of stay, thus allowing calculation of the effect of ADRs on the SI, MI, and RIW. This exploratory descriptive study was based on computer simulations. We created, by simulation, seven patient profiles of various complexities representative of our patients. Fifteen types of combination of drug and ADR manifestation comprising 15 ADR caused by eight different drug classes were identified based on the most frequently coded ADR in fiscal years 2016-2017 and 2017-2018. Those 15 combinations were applied to the pati...
Source: Journal of Population Therapeutics and Clinical Pharmacology - March 5, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Alignment of health technology assessments and price negotiations for new drugs for rare disorders in Canada: Does it lead to improved patient access?
Authors: Rawson NSB Abstract A previous assessment of submissions for rare disorder drugs made to the Canadian Agency for Drugs and Technologies in Health (CADTH) found that, from 2012, all positive recommendations included criteria advocating a price reduction. Since 2016, CADTH and the pan-Canadian Pharmaceutical Alliance (pCPA), which conducts drug price negotiations with manufacturers for all public drug programs, have aligned their processes. This analysis examined drugs for rare and ultra-rare disorders (DRDs and DURDs)-prevalence of ≤20 to>2 and ≤2 per 100,000, respectively-with a completed pCPA neg...
Source: Journal of Population Therapeutics and Clinical Pharmacology - March 5, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Validation of predictive equations for resting energy expenditure in treatment-seeking adults with overweight and obesity: Measured versus estimated.
In conclusion, we suggest that these two equations produce the least biased estimations for REE in this population. PMID: 31971355 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 25, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Romosozumab (sclerostin monoclonal antibody) for the treatment of osteoporosis in postmenopausal women: A review.
Authors: Shakeri A, Adanty C Abstract Romosozumab (ROMO) is a recently approved monoclonal antibody (approved by the U.S. Food and Drug Administration [FDA] in April 2019 and Health Canada in June 2019) for the treatment of osteoporosis in postmenopausal women. ROMO works by selectively inhibiting sclerostin-a glycoprotein that inhibits osteoblasts and further promotes bone resorption. The authors reviewed three phase III clinical trials (Fracture Study in Postmenopausal Women with Osteoporosis [FRAME], Active-Controlled Fracture Study in Postmenopausal Women with Osteoporosis at High Risk [ARCH], and STudy evaluat...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 12, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Stakeholders' feedback on the proposed recommendations for updating the patented medicine prices review board (pmprb) budget impact analysis guidelines.
CONCLUSIONS: The present study has provided sufficient insights to enable the creation of a penultimate version for updating the PMPRB BIA guidelines. This penultimate version will be subject to a broader consultation among stakeholders prior to a final revision and approval. Further Canadian stakeholder feedback is required for reaching consensus on inconclusive recommendations. PMID: 31922700 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 12, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Early Biomarkers in Neonatal Necrotizing Enterocolitis: A Pilot Study.
CONCLUSION: FCP, ENA-78, and PCT can be considered as early markers for diagnosis of NEC. PMID: 31904200 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

The Importance of Restoring Body Fat Mass in the Treatment of Anorexia Nervosa: An Expert Commentary.
Authors: Ayton A Abstract Anorexia nervosa is a severe mental disorder that is characterised by dietary restriction, low weight and widespread endocrine abnormalities. Whilst the importance of weight restoration has been recognised in recent guidelines, the significance of normalising body fat mass has received less attention. A recent systematic review and meta-analysis found that a minimum of 20.5% body fat mass is necessary for regular menses in women with anorexia nervosa of reproductive age. This has significant implications for both treatment and research. It is important to help the patient and carers unders...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Case Report of Lethal Toxin Lurking in an Edible Plant.
Authors: Patel P, Konala VM, Adapa S, Gayam V, Sahasranam P, Bose S, Golez CD, Naramala S Abstract Cyanide is notoriously known to the public for more than a century now as a weapon of mass destruction (Zyklon B gas - hydrogen cyanide used by Nazis), an agent for chemical warfare during World War I (hydrogen cyanide) and very infamous "Suicide Pill" used in the past by military and espionage organizations during World War II (potassium cyanide). During the modern industrial era, cyanide poisoning is commonly associated with the industrial exposure and domestic fires. But there is little awareness about po...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Abstracts CAPT / ACTP Annual Meeting 2019.
Authors: PMID: 31904203 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Two-Stage Revision Total Knee Arthroplasty for Suspected Periprosthetic Joint Infection and Metal and Bone Cement Hypersensitivity.
We describe the case of a 69-year-old woman presenting a history of a painful cemented total knee replacement. Postoperative investigations showed loosening of X-ray components, suspected periprosthetic joint infection, and patch test hypersensitivity to nickel sulfate and methyl methacrylate. Two months later, a more specific patch test indicated non-allergy to the solid scratch of one bone cement. The patient underwent a two-stage revision with prosthesis removal and the temporary application of a specific cement spacer followed by the successful reimplantation of a cemented revision prosthesis. All candidates for the re...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Embedment of the gastroduodenal artery stump into the jejunal serosa: A new technique aiming to prevent post-pancreatectomy hemorrhage.
Authors: Klimopoulos S, Charakopoulou A, Pantelis A, Bouchagier K Abstract Post-pancreaticoduodenectomy hemorrhage has an estimated incidence of 5% and a mortality rate of 11-38%. Vascular erosion resulting from pancreatic leak and skeletonization of the arterial wall during pancreatic mobilization may be the two possible mechanisms responsible for this complication, which most commonly affects the gastroduodenal artery stump. A novel technique of wrapping up the gastroduodenal artery stump into the jejunal serosa to decrease postoperative hemorrhage is presented. PMID: 31909574 [PubMed - in process] (Source: J...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Pharmacological management of osteoporosis in postmenopausal women: The current state of the art.
Authors: Gatti D, Fassio A Abstract Osteoporosis is a common disease that increases fracture risk. Fragility fractures bring heavy consequences in terms of mortality and disability, with burdensome health and social costs. In subjects with clinical bone fragility, the first goal is to identify the secondary forms of osteoporosis, especially in young subjects, in males and in patients who recently experienced a fragility fracture. In addition, before considering any sort of treatment, it is fundamental to check for adequate calcium and vitamin D intake, since their deficiency is the most common reason for drug failu...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD).
Authors: Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, Gutiérrez-Hernández R, Sosa-Macías M, Galaviz-Hernández C, Manríquez GGG, Lazalde-Ramos BP Abstract BACKGROUND: Rosemary leaves powder has been reported to reduce in a dose-dependent manner, glucose levels, lipid profile and lipid peroxidation in humans. However, patients should ingest high doses of powder contained in capsules. This formulation constitutes the intake of 10 capsules per day, so the active metabolite must first, be released and then absorbed (for which, rosemary leaf powder must be mixed with gast...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Determining proton pump inhibitor prescription dispensing patterns and adherence to STOPP criteria for Nova Scotia Seniors Pharmacare Program beneficiaries.
CONCLUSIONS: Many PPI prescriptions dispensed for NSSP beneficiaries fail to adhere to the STOPP criteria. Predictors of lack of adherence to the adapted STOPP criteria were identified. PMID: 31909577 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Dr E. Keith Borden: Inaugural President of the Canadian Association for Population Therapeutics.
Authors: Rawson NSB, West R PMID: 31909578 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Challenges and new directions in obesity management: lifestyle modification programmes, pharmacotherapy and bariatric surgery.
This article aims to discuss challenges faced by health-care providers when managing patients with obesity and to highlight sustainable policies in clinical practice and future research. All health professionals dealing with obesity should consider lifestyle-modification programmes within a multidisciplinary setting as the key element of weight management. However, standardisation is needed in terms of nature, content and duration of these programmes in order to facilitate their implementation in clinical practice at different levels. Moreover, health professionals should be aware that these programmes, for patients indica...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Preparing for vanessa's law: collaboration between the medical records and pharmacy departments at a canadian hospital center.
CONCLUSION: This study highlights the feasibility of establishing a link between the medical records and pharmacy departments to validate the coding of ADRs. At the study hospital, this linkage has identified serious ADRs, for which reporting will soon be required by Health Canada. PMID: 31577080 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

A new treatment modality to reduce acute tonsillitis healing time.
A NEW TREATMENT MODALITY TO REDUCE ACUTE TONSILLITIS HEALING TIME. J Popul Ther Clin Pharmacol. 2019 Jul 15;26(2):e14-e19 Authors: Keskin H, Guvenmez O Abstract BACKGROUND AND OBJECTIVE: Acute tonsillitis is one of the most common reasons for application to otorhinolaryngology clinics. In the treatment of acute tonsillitis, supportive therapies are mostly used. As antibiotic therapy, penicillin or erythromycin can be used. The aim of this study is to decrease the clinical recovery time of acute tonsillitis by providing parenteral treatment and daily cleaning of tonsillar lesions. MATERIAL AND METHO...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Arthroplasty in alkaptonuric ochronosis.
ARTHROPLASTY IN ALKAPTONURIC OCHRONOSIS. J Popul Ther Clin Pharmacol. 2019 Jul 26;26(2):e20-e24 Authors: Zmerly H, Moscato M, Di Gregori V Abstract Ochronotic degenerative arthropathy occurs in patients with alkaptonuria. Alkaptonuria disorder is an extremely rare disease characterized by black pigmentation of various tissues (e.g., cartilage and connective tissue). Ochronotic arthropathy is a disabling disease that primarily affects the large joints. Like other metabolic diseases that involve the musculoskeletal system, care must be taken with regard to the quality of the affected bones, tendons and l...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Is body fat percentage a good predictor of menstrual recovery in females with anorexia nervosa after weight restoration? a systematic review and exploratory and selective meta-analysis.
In conclusion, a higher %BF seems to be associated with the ROM in weight-restored adolescent and young adult females with anorexia nervosa. Its assessment is important in a clinical setting, especially after complete weight restoration. The PROSPERO Registry - A systematic review and meta-analysis of the factors associated with the resumption of the menstrual cycle in females with anorexia nervosa after weight restoration (CRD42019111841). PMID: 31577083 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Reversible neurotrophic keratopathy associated with rosuvastatin therapy: a case report.
CONCLUSION: Rosuvastatin may result in reversible trigeminal nerve impairment and neurotrophic keratopathy. PMID: 31577084 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Analgesic effect of intravenous ascorbic acid versus acelcofenac post-transalveolar extraction: a case-control study.
This study was aimed to evaluate the efficacy of 2 g intravenous (IV) vitamin C compared to 100 mg aceclofenac on postsurgical pain, swelling and trismus after the surgical removal of third molars. A total of 101 patients were recruited for the study, and theywere divided into two treatment groups; group A (n = 51) received 2 g IV vitamin C and group B (n = 50) received 100 mg aceclofenac. Pain intensity, facial swelling and mouth opening were assessed till day 3 post-surgically. Statistical analysis of pain intensity revealed that IV vitamin C performed slightly better but not significantly different (p>0.05) from acec...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Clinically Significant Drug-Drug Interaction in a Large Antiretroviral Treatment Centre in Lagos, Nigeria.
This study was carried out in a large HIV treatment centre (APIN clinic) in a Nigerian teaching hospital, in Lagos Nigeria, caring for over 20,000 registered patients. Electronic Medical Records (EMR) of 500 patients  who received treatment between 2005 and 2015, were selected using systematic random sampling, reviewed retrospectively, and evaluated for potential CSDIs using Liverpool HIV Pharmacology Database and other similar databases.                              &nb...
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 21, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Response to Letter to the Editor.
Authors: Rawson NSB Abstract Author's response to comments from Dr Lexchin's Letter to the Editor regarding our article. PMID: 31002485 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 21, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Novel Measures of Benzodiazepine and Z-Drug Utilisation Trends in a Canadian Provincial Adult Population (2001-2016).
CONCLUSION: 1) Z-Drug usage increased markedly from 2001 to 2016 whereas BZD use only increased in terms of DI. 2) DME-based measurements enable further interpretation of BZD utilization compared to sole reliance on DDD. PMID: 31002486 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 21, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research