Validation of predictive equations for resting energy expenditure in treatment-seeking adults with overweight and obesity: Measured versus estimated.
In conclusion, we suggest that these two equations produce the least biased estimations for REE in this population. PMID: 31971355 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 25, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Romosozumab (sclerostin monoclonal antibody) for the treatment of osteoporosis in postmenopausal women: A review.
Authors: Shakeri A, Adanty C Abstract Romosozumab (ROMO) is a recently approved monoclonal antibody (approved by the U.S. Food and Drug Administration [FDA] in April 2019 and Health Canada in June 2019) for the treatment of osteoporosis in postmenopausal women. ROMO works by selectively inhibiting sclerostin-a glycoprotein that inhibits osteoblasts and further promotes bone resorption. The authors reviewed three phase III clinical trials (Fracture Study in Postmenopausal Women with Osteoporosis [FRAME], Active-Controlled Fracture Study in Postmenopausal Women with Osteoporosis at High Risk [ARCH], and STudy evaluat...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 12, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Stakeholders' feedback on the proposed recommendations for updating the patented medicine prices review board (pmprb) budget impact analysis guidelines.
CONCLUSIONS: The present study has provided sufficient insights to enable the creation of a penultimate version for updating the PMPRB BIA guidelines. This penultimate version will be subject to a broader consultation among stakeholders prior to a final revision and approval. Further Canadian stakeholder feedback is required for reaching consensus on inconclusive recommendations. PMID: 31922700 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 12, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Early Biomarkers in Neonatal Necrotizing Enterocolitis: A Pilot Study.
CONCLUSION: FCP, ENA-78, and PCT can be considered as early markers for diagnosis of NEC. PMID: 31904200 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

The Importance of Restoring Body Fat Mass in the Treatment of Anorexia Nervosa: An Expert Commentary.
Authors: Ayton A Abstract Anorexia nervosa is a severe mental disorder that is characterised by dietary restriction, low weight and widespread endocrine abnormalities. Whilst the importance of weight restoration has been recognised in recent guidelines, the significance of normalising body fat mass has received less attention. A recent systematic review and meta-analysis found that a minimum of 20.5% body fat mass is necessary for regular menses in women with anorexia nervosa of reproductive age. This has significant implications for both treatment and research. It is important to help the patient and carers unders...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Case Report of Lethal Toxin Lurking in an Edible Plant.
Authors: Patel P, Konala VM, Adapa S, Gayam V, Sahasranam P, Bose S, Golez CD, Naramala S Abstract Cyanide is notoriously known to the public for more than a century now as a weapon of mass destruction (Zyklon B gas - hydrogen cyanide used by Nazis), an agent for chemical warfare during World War I (hydrogen cyanide) and very infamous "Suicide Pill" used in the past by military and espionage organizations during World War II (potassium cyanide). During the modern industrial era, cyanide poisoning is commonly associated with the industrial exposure and domestic fires. But there is little awareness about po...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Abstracts CAPT / ACTP Annual Meeting 2019.
Authors: PMID: 31904203 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Two-Stage Revision Total Knee Arthroplasty for Suspected Periprosthetic Joint Infection and Metal and Bone Cement Hypersensitivity.
We describe the case of a 69-year-old woman presenting a history of a painful cemented total knee replacement. Postoperative investigations showed loosening of X-ray components, suspected periprosthetic joint infection, and patch test hypersensitivity to nickel sulfate and methyl methacrylate. Two months later, a more specific patch test indicated non-allergy to the solid scratch of one bone cement. The patient underwent a two-stage revision with prosthesis removal and the temporary application of a specific cement spacer followed by the successful reimplantation of a cemented revision prosthesis. All candidates for the re...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Embedment of the gastroduodenal artery stump into the jejunal serosa: A new technique aiming to prevent post-pancreatectomy hemorrhage.
Authors: Klimopoulos S, Charakopoulou A, Pantelis A, Bouchagier K Abstract Post-pancreaticoduodenectomy hemorrhage has an estimated incidence of 5% and a mortality rate of 11-38%. Vascular erosion resulting from pancreatic leak and skeletonization of the arterial wall during pancreatic mobilization may be the two possible mechanisms responsible for this complication, which most commonly affects the gastroduodenal artery stump. A novel technique of wrapping up the gastroduodenal artery stump into the jejunal serosa to decrease postoperative hemorrhage is presented. PMID: 31909574 [PubMed - in process] (Source: J...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Pharmacological management of osteoporosis in postmenopausal women: The current state of the art.
Authors: Gatti D, Fassio A Abstract Osteoporosis is a common disease that increases fracture risk. Fragility fractures bring heavy consequences in terms of mortality and disability, with burdensome health and social costs. In subjects with clinical bone fragility, the first goal is to identify the secondary forms of osteoporosis, especially in young subjects, in males and in patients who recently experienced a fragility fracture. In addition, before considering any sort of treatment, it is fundamental to check for adequate calcium and vitamin D intake, since their deficiency is the most common reason for drug failu...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD).
Authors: Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, Gutiérrez-Hernández R, Sosa-Macías M, Galaviz-Hernández C, Manríquez GGG, Lazalde-Ramos BP Abstract BACKGROUND: Rosemary leaves powder has been reported to reduce in a dose-dependent manner, glucose levels, lipid profile and lipid peroxidation in humans. However, patients should ingest high doses of powder contained in capsules. This formulation constitutes the intake of 10 capsules per day, so the active metabolite must first, be released and then absorbed (for which, rosemary leaf powder must be mixed with gast...
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Determining proton pump inhibitor prescription dispensing patterns and adherence to STOPP criteria for Nova Scotia Seniors Pharmacare Program beneficiaries.
CONCLUSIONS: Many PPI prescriptions dispensed for NSSP beneficiaries fail to adhere to the STOPP criteria. Predictors of lack of adherence to the adapted STOPP criteria were identified. PMID: 31909577 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Dr E. Keith Borden: Inaugural President of the Canadian Association for Population Therapeutics.
Authors: Rawson NSB, West R PMID: 31909578 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - January 8, 2020 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Challenges and new directions in obesity management: lifestyle modification programmes, pharmacotherapy and bariatric surgery.
This article aims to discuss challenges faced by health-care providers when managing patients with obesity and to highlight sustainable policies in clinical practice and future research. All health professionals dealing with obesity should consider lifestyle-modification programmes within a multidisciplinary setting as the key element of weight management. However, standardisation is needed in terms of nature, content and duration of these programmes in order to facilitate their implementation in clinical practice at different levels. Moreover, health professionals should be aware that these programmes, for patients indica...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Preparing for vanessa's law: collaboration between the medical records and pharmacy departments at a canadian hospital center.
CONCLUSION: This study highlights the feasibility of establishing a link between the medical records and pharmacy departments to validate the coding of ADRs. At the study hospital, this linkage has identified serious ADRs, for which reporting will soon be required by Health Canada. PMID: 31577080 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

A new treatment modality to reduce acute tonsillitis healing time.
A NEW TREATMENT MODALITY TO REDUCE ACUTE TONSILLITIS HEALING TIME. J Popul Ther Clin Pharmacol. 2019 Jul 15;26(2):e14-e19 Authors: Keskin H, Guvenmez O Abstract BACKGROUND AND OBJECTIVE: Acute tonsillitis is one of the most common reasons for application to otorhinolaryngology clinics. In the treatment of acute tonsillitis, supportive therapies are mostly used. As antibiotic therapy, penicillin or erythromycin can be used. The aim of this study is to decrease the clinical recovery time of acute tonsillitis by providing parenteral treatment and daily cleaning of tonsillar lesions. MATERIAL AND METHO...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Arthroplasty in alkaptonuric ochronosis.
ARTHROPLASTY IN ALKAPTONURIC OCHRONOSIS. J Popul Ther Clin Pharmacol. 2019 Jul 26;26(2):e20-e24 Authors: Zmerly H, Moscato M, Di Gregori V Abstract Ochronotic degenerative arthropathy occurs in patients with alkaptonuria. Alkaptonuria disorder is an extremely rare disease characterized by black pigmentation of various tissues (e.g., cartilage and connective tissue). Ochronotic arthropathy is a disabling disease that primarily affects the large joints. Like other metabolic diseases that involve the musculoskeletal system, care must be taken with regard to the quality of the affected bones, tendons and l...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Is body fat percentage a good predictor of menstrual recovery in females with anorexia nervosa after weight restoration? a systematic review and exploratory and selective meta-analysis.
In conclusion, a higher %BF seems to be associated with the ROM in weight-restored adolescent and young adult females with anorexia nervosa. Its assessment is important in a clinical setting, especially after complete weight restoration. The PROSPERO Registry - A systematic review and meta-analysis of the factors associated with the resumption of the menstrual cycle in females with anorexia nervosa after weight restoration (CRD42019111841). PMID: 31577083 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Reversible neurotrophic keratopathy associated with rosuvastatin therapy: a case report.
CONCLUSION: Rosuvastatin may result in reversible trigeminal nerve impairment and neurotrophic keratopathy. PMID: 31577084 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Analgesic effect of intravenous ascorbic acid versus acelcofenac post-transalveolar extraction: a case-control study.
This study was aimed to evaluate the efficacy of 2 g intravenous (IV) vitamin C compared to 100 mg aceclofenac on postsurgical pain, swelling and trismus after the surgical removal of third molars. A total of 101 patients were recruited for the study, and theywere divided into two treatment groups; group A (n = 51) received 2 g IV vitamin C and group B (n = 50) received 100 mg aceclofenac. Pain intensity, facial swelling and mouth opening were assessed till day 3 post-surgically. Statistical analysis of pain intensity revealed that IV vitamin C performed slightly better but not significantly different (p>0.05) from acec...
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Clinically Significant Drug-Drug Interaction in a Large Antiretroviral Treatment Centre in Lagos, Nigeria.
This study was carried out in a large HIV treatment centre (APIN clinic) in a Nigerian teaching hospital, in Lagos Nigeria, caring for over 20,000 registered patients. Electronic Medical Records (EMR) of 500 patients  who received treatment between 2005 and 2015, were selected using systematic random sampling, reviewed retrospectively, and evaluated for potential CSDIs using Liverpool HIV Pharmacology Database and other similar databases.                              &nb...
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 21, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Response to Letter to the Editor.
Authors: Rawson NSB Abstract Author's response to comments from Dr Lexchin's Letter to the Editor regarding our article. PMID: 31002485 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 21, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Novel Measures of Benzodiazepine and Z-Drug Utilisation Trends in a Canadian Provincial Adult Population (2001-2016).
CONCLUSION: 1) Z-Drug usage increased markedly from 2001 to 2016 whereas BZD use only increased in terms of DI. 2) DME-based measurements enable further interpretation of BZD utilization compared to sole reliance on DDD. PMID: 31002486 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 21, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Assessing for Fetal Alcohol Spectrum Disorder.
Conclusions This study revealed important information about the use of testing measures in FASD assessment and sheds light on the commonalities in practice across clinics in Alberta. Results demonstrate strong convergence of direct and indirect measures to assess brain function. Ultimately, identifying a comprehensive, reliable, and usable testing battery of measures for FASD assessment will improve the clarity and accuracy of the diagnostic process and facilitate advancements in the field, as well as enable comparisons across clinics. PMID: 31002487 [PubMed - in process] (Source: Journal of Population Therapeutics and...
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 21, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Levetiracetam-Associated Psychogenic Non-epileptic Seizures; A Hidden Paradox.
Conclusion LEV can induce PNES in susceptible populations. Awareness of this association is crucial for timely withdrawal of triggering factor and appropriate management. This will reduce inadvertent additional prescription of antiepileptic agents. PMID: 30725538 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 7, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Activities of the pan-Canadian Pharmaceutical Alliance: An Observational Analysis.
CONCLUSION: These findings revealed a strong alignment between HTA recommendations and pCPA negotiations, an implicit prioritization favouring oncology drug negotiations, and an evolving role for health economics in Canada's reimbursement process. PMID: 30725539 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 7, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Public Reimbursement of Prescription Drugs Used For Off-Label Indications in Ontario.
CONCLUSION: Presently, OPDP only reimburse drugs for off-label use for the treatment of serious, life-threatening or severely debilitating conditions for which no alternative treatment exists. OPDP should not diverge from this approach by allowing cost-savings to trump appropriate drug use, which would set a unique and unprecedented example. PMID: 30725540 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 7, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Editorial.
Authors: Lexchin J Abstract Invited Editorial. PMID: 30725541 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 7, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

CAPT / ACTP Annual Meeting 2018.
Authors: Bryant S Abstract Abstracts from the CAPT / ACTP Annual Meeting 2018. PMID: 30725542 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 7, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Ten-Year Statin Adherence in Survivors of ST-Segment Elevation Myocardial Infarction.
Conclusion Future studies are needed to explore the potential factors associated with concomitant use of ACEI/ARB, and admission to PCI-hospitals that may have optimized statin adherence. Socially deprived patients may benefit from more support and encouragement to enhance their long-term statin adherence. PMID: 30725543 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 7, 2019 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Assessing motor skills to inform a Fetal Alcohol Spectrum Disorder diagnosis focusing on persons older than 12 years: A systematic review of the literature.
Conclusion: A review of functional difficulties in each individual would be required to determine if a motor assessment is warranted. Further research is required using assessments recommended in diagnostic guidelines to determine the common motor difficulties seen in adolescents and adults. PMID: 29949680 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 28, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Meta-Analysis of Pregnancy Outcomes after Exposure to TNF- α Inhibitors During Pregnancy for the Treatment of Arthritic Diseases.
Meta-Analysis of Pregnancy Outcomes after Exposure to TNF-α Inhibitors During Pregnancy for the Treatment of Arthritic Diseases. J Popul Ther Clin Pharmacol. 2018 Apr 10;25(1):e53-e56 Authors: Mirdamadi K, Salinas T, Vali R, Papadimitropoulos M, Piquette-Miller M Abstract TITLE: Pregnancy Outcomes after Exposure to TNF-α Inhibitors During Pregnancy for the Treatment of Arthritic Diseases: A Meta-Analysis   Authors: Mirdamadi K, Salinas T, Vali R, Papadimitripulous M, Piquette-Miller M Background: Auto-immune arthritic diseases affect many women of child-bearing age. Tumor necrosis fact...
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 28, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Prescribing Competency of Medical Students: National Survey of Medical Education Leaders.
Conclusions Amongst Canadian medical school leadership, there is a perceived inadequacy in medical student prescribing competency as well as support for a standardized prescribing competency assessment in curricula and licensing processes. PMID: 29949682 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 28, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Impact of Drug Exposure Definitions on Observed Associations in Pharmacoepidemiology Research.
CONCLUSIONS - The variety of exposure definitions tested in this analysis produced a wide range of associations between metformin and mortality risk. Therefore, pharmacoepidemiological studies should implement sensitivity analyses including at least two exposure definitions to provide more robust and potentially valid study estimates. PMID: 29949683 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 28, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Reduced Out-of-Pocket Costs and Medication Adherence - A Population-Based Study.
CONCLUSION: Reducing out-of-pocket medication costs for seniors was associated with small improvements in medication adherence across the population. PMID: 29949684 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 28, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

What Does the New Ontario Pharmacare Plan offer Children and Young Adults with Rare Disorders?
Authors: Rawson N Abstract A publicly-funded pharmacare program (OHIP+) was announced in the 2017 Ontario budget for all children and young adults that will begin in January 2018 and cover drugs in the Ontario Public Drug Programs (OPDP) formulary. In this commentary, drugs indicated for rare disorders commonly occurring in childhood that were reviewed by the Common Drug Review (CDR) between 2004 and 2016 are examined to assess the Ontario reimbursement situation. OPDP reimburse few of these drugs and only about half of those covered are accessible with consistency and without onerous conditions. Providing reimburs...
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 14, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Development and Validation of an Index Score to Adjust for Healthy User Bias in Observational Studies.
CONCLUSION: Our healthy user index combined age, sex and healthy behaviors to predict healthy users within administrative datasets. This index score may allow for better adjustment of healthy user bias in health services research; however, external validation is further required. Key Words: Administrative Data Uses, Bias, Biostatistical Methods, Observational Data. PMID: 29432672 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 14, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Anticounterfeiting Strategies of Local Drug Manufacturers in Lagos, Nigeria: Implications for Public Health.
CONCLUSION: The current rate of counterfeit medicines is relatively low. Strategies to encourage the use of combination of anticounterfeiting technologies by the manufacturers should be established. PMID: 29432673 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 14, 2018 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Intelligence and Fetal Alcohol Spectrum Disorders: A Review.
CONCLUSIONS: Reduction in intelligence seems to occur on a continuum similar to the fetal alcohol spectrum. The reduction of the Freedom from Distractibility/Working Memory Index appears to be a reflection of a greater impairment of mathematical ability. PMID: 28873290 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - September 6, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Increase in Psychoactive Drug Prescriptions in the Years Following Autism Spectrum Diagnosis: A Population-Based Cohort Study.
CONCLUSIONS: Psychoactive drug use and polypharmacy increases substantially over time after autism spectrum disorder diagnosis in children. PMID: 28873291 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - September 6, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Dose-Exposure Simulation for Piperacillin-Tazobactam Dosing Strategies in Infants and Young Children.
CONCLUSIONS: Up to MICs of 16 mg/L, 90 mg/kg/dose every 8h as a 2h infusion in infants> 2 to 6m and 100 mg/kg/dose every 8h as a 4h infusion in children> 6m-6y achieved PTAs ≥ 90%. PMID: 28873292 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - September 6, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

The Role of Midodrine for Hypotension Outside of the Intensive Care Unit.
Authors: Gutman LB, Wilson BJ Abstract Midodrine is an oral, peripherally acting alpha-adrenergic agonist. After gaining Food and Drug Administration (FDA) approval in 1996 for orthostatic hypotension, its use has evolved to target vasoplegic conditions such as intradialytic hypotension in the end-stage renal disease population, refractory ascites in cirrhotic patients to support diuresis, and in hepatorenal syndrome. Upon oral ingestion, the drug undergoes enzymatic hydrolysis to an active metabolite, desglymidodrine. Its use has been well tolerated at 2.5 mg, 5 mg, and 10 mg oral doses. The most frequently occurr...
Source: Journal of Population Therapeutics and Clinical Pharmacology - September 6, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

A descriptive Study of a Community-Based Home-Visiting Program with Preschool Children Prenatally Exposed to Alcohol.
CONCLUSIONS: This study supports the use of community home-based attachment intervention for caregivers of children with PAE/FASD. PMID: 28632983 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 22, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

What Influences the Cost Effectiveness of Dabigatran versus Warfarin for Stroke Prevention in Atrial Fibrillation: A Systematic Review.
CONCLUSIONS: Several factors should be considered when interpreting the results of economic analyses which are based on randomized clinical trial evidence. Real-world data are needed to further assess the clinical and economic consequences of dabigatran relative to warfarin for the prevention of stroke in AF. PMID: 28594478 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 10, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Does the Number of Pharmacies a Patient Frequents Affect Adherence to Statins?
CONCLUSIONS: Among seniors newly starting statin therapy, using a single community pharmacy was modestly associated with adherence. PMID: 28594479 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 10, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Comparison of Drug Benefits Provided by Veterans Affairs Canada and the Canadian Forces Health Services Group.
CONCLUSIONS: There is significant overlap in the medications covered by the CAF and VAC drug benefit programs. Application of the ATC coding system allowed for discrepancies to be readily identified across the entire formulary, and in specific therapeutic categories of concern. PMID: 28594480 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 10, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Emotional Understanding in School-Aged Children with Fetal Alcohol Spectrum Disorders: A Promising Target for Intervention.
CONCLUSIONS: Despite variability in individual differences, treatments targeting EU may benefit children with FASD as components within a comprehensive, tailored intervention focused on child self-regulation and caregiver behavior management. PMID: 28594481 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 10, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Non-severe Hypoglycemia Risk Difference between Sulfonylurea and Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2-I) as an Add-On to Metformin in Randomized Controlled Trials.
CONCLUSIONS: This study illustrated that a large proportion of patients who had exposure to SU in RCTs of SGLT2-I experienced non-severe hypoglycemia compared to SGLT2-I. There was a close relation between SU dose and increased probability of non-severe hypoglycemia events. PMID: 28594482 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 10, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Effect of an Institutional Medication Adherence Program for Long-Acting Injectable Risperidone on Adherence and Psychiatric Hospitalizations: Evidence from a Prospective Cohort Study.
CONCLUSIONS: IMAPs may improve patient adherence and reduce psychiatric hospitalizations, particularly among patients with difficulties adhering to LAI antipsychotics. PMID: 28594483 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - June 10, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Budget impact analysis of using omeprazole immediate-release oral suspension in replace of intravenous pantoprazole in critically ill patients.
CONCLUSIONS: In the present study, a budget impact analysis was performed to assess the financial consequences of using omeprazole IR oral suspension in place of pantoprazole IV for prevention of upper gastrointestinal bleeding. The better preventive effect of omeprazole IR oral suspension when compared with conventional therapy using pantoprazole IV was the major reason for the final comparative budgetary savings. PMID: 28414416 [PubMed - in process] (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - April 19, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research