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Condition: Hughes Syndrome
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Total 523 results found since Jan 2013.
Antiphospholipid antibodies correlate with stroke severity and outcome in patients with antiphospholipid syndrome.
CONCLUSIONS: In young stroke patients with APS, serum levels of IgM aCL within 48 h are correlated with stroke severity and levels of IgG anti-β2GPI within 48 h are correlated with three-month outcomes.
PMID: 25434364 [PubMed - in process]
Source: Autoimmunity - February 17, 2016 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
AISYF: Argentinean Initiative of Stroke in the Young and Fabry Disease (FD) (P02.038)
CONCLUSIONS: Although FD was not yet identified in our cohort its early recognition in young patients with stroke is essential for appropiate treatment. Despite extensive investigations stroke of undetermined etiology remains a frequent challenge in young patients.Supported by: Shire HGT.Disclosure: Dr. Reisin has received personal compensation for activities with Shire Pharmaceuticals Company as a consultant. Dr. Reisin has received personal compensation in an editorial capacity for Gador. Dr. Reisin has received research support from Shire Pharmaceuticals Company.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Reisin on Behalf of the AISYF Research Group, R. Tags: P02 Cerebrovascular Disease II Source Type: research
Thrombophilia risk is not increased in children after perinatal stroke
Perinatal stroke causes cerebral palsy and lifelong disability. Specific diseases are definable, but mechanisms are poorly understood. Evidence suggests possible associations between arterial perinatal stroke and prothrombotic disorders, but population-based, controlled, disease-specific studies are limited. Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinical management. We conducted a population-based, prospective, case-control study to determine the association of specific perinatal stroke diseases with known thrombophilias. Children with idiopathic magnetic resonance imaging–cl...
Source: Blood - May 18, 2017 Category: Hematology Authors: Curtis, C., Mineyko, A., Massicotte, P., Leaker, M., Jiang, X. Y., Floer, A., Kirton, A. Tags: Pediatric Hematology, Free Research Articles, Thrombosis and Hemostasis, Vascular Biology, CME article Source Type: research
I Never Thought Stroke Would Happen to Me
by Myra Wilson, Stroke Survivor
On November 3, 2014, I was in nursing school working as a student nurse at a hospital in Seattle. My first sign that something was not quite right was when I was walking through the nursing station and both of my eyes went blurry. I could still see color but I couldn't see letters. It was blurry for about 30 seconds before clearing up again.
I was going to lunch and went to give a report to another nurse. The nurse noticed while I was speaking that I slurred my speech. I didn't notice my speech was slurred at all. It was at that time that I experienced a sudden sharp pain on the right s...
Source: Healthy Living - The Huffington Post - May 13, 2016 Category: Consumer Health News Source Type: news
Stroke in systemic lupus erythematosus: epidemiology, mechanism, and long-term outcome.
CONCLUSIONS: The prevalence of stroke in this cohort was 3.1%. Ischemic strokes had a bimodal presentation, occurring either early after SLE diagnosis or after a several-year delay. Half of the hemorrhagic strokes occurred >10 years after the diagnosis of SLE. Clinical outcome was usually good with a relatively low recurrence rate.
PMID: 32151182 [PubMed - as supplied by publisher]
Source: Lupus - March 8, 2020 Category: Rheumatology Authors: Guraieb-Chahín P, Cantú-Brito C, Soto-Mota A, Guerrero-Torres L, Flores-Silva F, Chiquete E, Fragoso-Loyo H, González-Duarte A, Valdés-Ferrer SI Tags: Lupus Source Type: research
Hepatitis C and recurrent treatment-resistant acute ischemic stroke.
Abstract
Since the introduction of recombinant tissue plasminogen activator and thrombolysis, acute ischemic stroke has become a treatable disorder if the patient presents within the 4.5-hour time window. Typically, sporadic stroke is caused by atherosclerotic disease involving large or small cerebral arteries or secondary to a cardioembolic source often associated with atrial fibrillation. In the over-65-year age group, more rare causes of stroke, such as antiphospholipid syndromes, are unusual; such stroke etiologies are mostly seen in a younger age group (<55 years). Here we describe acute ischemic stroke in...
Source: Baylor University Medical Center Proceedings - April 1, 2013 Category: Universities & Medical Training Authors: Saxsena A, Tarsia J, Dunn C, Aysenne A, Shah B, Moore DF Tags: Proc (Bayl Univ Med Cent) Source Type: research
The risk of ischaemic stroke in primary antiphospholipid syndrome patients: a prospective study
ConclusionsPatients with PAPS, including young patients, have a high risk of recurrent thrombosis despite anticoagulation treatment. A careful risk assessment is mandatory to identify patients at risk for recurrence.
Source: European Journal of Neurology - December 2, 2017 Category: Neurology Authors: M. Radin, K. Schreiber, I. Cecchi, D. Roccatello, M. J. Cuadrado, S. Sciascia Tags: Original Article Source Type: research
Yield of Screening Tests for Systemic Vasculitis in Young Adults with Ischemic Stroke
Systemic vasculitis, which can involve the brain, may be one of the causes of stroke in young adults; therefore, a test panel for systemic vasculitis is considered for some young stroke patients. However, little is known about this test ’s yield as a screening test in young adults with ischemic stroke. We evaluated the yield of a panel for systemic vasculitis as a screening test in young patients with ischemic stroke. Consecutive patients aged 18–45 years with ischemic stroke between January 2010 and December 2017 were included . They all underwent screening tests for systemic vasculitis including rheumatoid factor, an...
Source: European Neurology - February 4, 2019 Category: Neurology Source Type: research
Comparison of patients with transient and sustained increments of antiphospholipid antibodies after acute ischemic stroke
ConclusionaPL was rather common in ischemic stroke patients regardless of age. Although the influence of transient positive aPL on ischemic stroke remains uncertain, two or more aPLs and the presence of anti- β2glycoprotein-I IgG may predict a diagnosis of APS.
Source: Journal of Neurology - February 6, 2021 Category: Neurology Source Type: research
A Cryptogenic Stroke Associated With Infective Endocarditis and Antiphospholipid Antibody Syndrome: Case Report and Literature Review
ConclusionA considerable challenge for physicians is evaluating all the signs suggestive of embolic sources in acute stroke and identifying the primary etiology when there are multiple causes. Early diagnosis and surgical intervention for bicuspid aortic valve (BAV) vegetation complicated by acute stroke may yield favorable clinical results.
Source: Frontiers in Neurology - July 25, 2022 Category: Neurology Source Type: research
Analysis of Inpatient Thrombophilia Testing for Adults with an Ischemic Stroke or Transient Ischemic Attack and its Impact on Clinical Management (P1.123)
Conclusions: Inpatient thrombophilia testing did not affect management in the vast majority of patients with an ischemic stroke or TIA despite a positive test result. Therefore, by avoiding inpatient testing, healthcare costs may be reduced without affecting patient care.Disclosure: Dr. Gavva has nothing to disclose. Dr. Alberts has received personal compensation for activities with AGA medical, AstraZeneca, Bayer, Pfizer, Bistol-Myers-Squibb, Boehringer Ingelheim, diaDexus, Genentech, KOS, Medicine Company, PDL biopharma, Pfizer, Photothera, Sanofi. Dr. Johnson has nothing to disclose. Dr. Sarode has received personal com...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gavva, C., Alberts, M., Johnson, M., Sarode, R. Tags: Cerebrovascular Disease: Epidemiology Source Type: research
Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
CONCLUSIONS: There is not enough evidence for or against NOACs or for high-intensity VKA compared to the standard VKA therapy in the secondary prevention of thrombosis in people with APS. There is some evidence of harm for high-intensity VKA regarding minor and any bleeding. The evidence was also not sufficient to show benefit or harm for VKA plus antiplatelet agent or dual antiplatelet therapy compared to a single antiplatelet drug. Future studies should be adequately powered, with proper adherence to treatment, in order to evaluate the effects of anticoagulants, antiplatelets, or both, for secondary thrombosis prevention...
Source: Cochrane Database of Systematic Reviews - October 2, 2017 Category: General Medicine Authors: Bala MM, Celinska-Lowenhoff M, Szot W, Padjas A, Kaczmarczyk M, Swierz MJ, Undas A Tags: Cochrane Database Syst Rev Source Type: research
Subsequent Thrombotic Outcomes in Patients with Ischemic Stroke with Antiphospholipid Antibody Positivity.
CONCLUSION: There was no increased risk of subsequent thrombotic events in ischemic stroke patients with definite APS, compared with those with indefinite APS.
PMID: 29047236 [PubMed - in process]
Source: Yonsei Medical Journal - October 21, 2017 Category: Universities & Medical Training Authors: Pyo JY, Jung SM, Lee SW, Song JJ, Lee SK, Park YB Tags: Yonsei Med J Source Type: research
Acute Cerebral Stroke with Multiple Infarctions and COVID-19, France, 2020.
We describe 2 cases in coronavirus disease patients in France involving presumed thrombotic stroke that occurred during ongoing anticoagulation treatment for atrial fibrillation stroke prophylaxis; 1 patient had positive antiphospholipid antibodies. These cases highlight the severe and unique consequences of coronavirus disease-associated stroke.
PMID: 32453685 [PubMed - indexed for MEDLINE]
Source: Emerging Infectious Diseases - August 31, 2020 Category: Infectious Diseases Authors: Zayet S, Klopfenstein T, Kovẚcs R, Stancescu S, Hagenkötter B Tags: Emerg Infect Dis Source Type: research
