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Condition: Hughes Syndrome

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Total 523 results found since Jan 2013.

Developmental venous anomaly associated ischemic stroke caused by minor head trauma: A case report
We report a case of ischemic stroke in the area of a DVA after minor head trauma in a patient with DVA and without a predisposition thrombosis. Patient concerns: A healthy 17-year-old male was admitted to the emergency room due to left hemiparesis, which was caused by a ball hitting the right side of his head during a soccer game. Diagnosis: Brain magnetic resonance (MR) susceptibility-weighted image showed several small veins draining to the central vein in the area from the right posterior putamen to the periventricular white matter. Interventions: We diagnosed the patient with an ischemic stroke associated with...
Source: Medicine - September 18, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Was Antiphospholipid Syndrome a Risk Factor of Stroke? A Systemic Review and Meta-Analysis of Cohort Studies
Dis Markers. 2021 Dec 16;2021:4431907. doi: 10.1155/2021/4431907. eCollection 2021.ABSTRACTAntiphospholipid syndrome (APS) is characterized by thrombosis. This systemic review and meta-analysis was to verify the hypothesis that APS might increase the risk of stroke. Studies were identified after literature searching of PubMed, Embase, and Cochrane. Newcastle-Ottawa Quality Assessment Scale Cohort Studies (NOQAS-C) was used to assess the quality of studies. The pooled effect with 95% confidence interval (95% CI) was calculated by random-effect model. I-square (I 2) was used to test heterogeneity. Funnel plot was used to eva...
Source: Disease Markers - December 27, 2021 Category: Laboratory Medicine Authors: Kai Zhao Ping Zhou Ling Xu Ruili Li Jincai Yang Qiang Zhang Mingfei Yang Xiaoxing Wei Source Type: research

Advances in Management of the Stroke Etiology One-Percenters
AbstractPurpose of ReviewUncommon causes of stroke merit specific attention; when clinicians have less common etiologies of stoke in mind, the diagnosis may come more easily. This is key, as optimal management will in many cases differs significantly from “standard” care.Recent FindingsRandomized controlled trials (RCT) on the best medical therapy in the treatment of cervical artery dissection (CeAD) have demonstrated low rates of ischemia with both antiplatelet and vitamin K antagonism. RCT evidence supports the use of anticoagulation with vitamin K antagonism in “high-risk” patients with antiphospholipid antibody...
Source: Current Neurology and Neuroscience Reports - May 29, 2023 Category: Neuroscience Source Type: research

The Therapeutic Value of Laboratory Testing for Hypercoagulable States in Secondary Stroke Prevention
Although screening for hypercoagulable states is commonly performed as part of the evaluation of first arterial ischemic stroke in young adults, available evidence does not support this as a routine practice, even in patients with cryptogenic stroke and a positive family history of early thrombotic events or in patients with a patent foramen ovale. Testing for antiphospholipid antibodies is a possible exception because persistent antibodies are associated with an increased risk of recurrent stroke. Despite the lack of supporting data, screening for hypercoagulable states in recurrent early-onset cryptogenic cerebral ischem...
Source: Neurologic Clinics - February 28, 2015 Category: Neurology Authors: Chandni Kalaria, Steven Kittner Source Type: research

Antiphospholipid Syndrome-Associated Crescendo Stroke Events Treated with Rituximab (P4.351)
Discussion APS is an autoimmune condition associated with persistent antiphospholipid antibodies, characterised by thrombosis and pregnancy morbidity [1].Regarding APS and stroke the optimal antithrombotic agent, intensity of anticoagulation, and duration of treatment remains controversial[2]. Analysis of the APASS subgroup in the WARS study found aspirin and warfarin to be equally effective agents for secondary stroke prevention [2]. The majority of panel members at the International Congress on Antiphospholipid Antibodies recommended warfarin or combination aspirin and warfarin for patients with definite APS and arterial...
Source: Neurology - April 3, 2016 Category: Neurology Authors: O' Connor, A., Murphy, G., Cronin, S. Tags: Cerebrovascular Case Reports Source Type: research

Classical and additional antiphospholipid antibodies in blood samples of ischemic stroke patients and healthy controls
AbstractClassical antiphospholipid antibodies (aPLa) are found in 6 –25% of blood samples from stroke patients. The frequency of novel aPLa antibodies in blood samples of CVA patients is not known. Enzyme-linked immunosorbent assays (ELISA) were performed on blood samples from 209 CVA patients (170 samples were obtained during the acute phase and 39 samples were f rom patients with complete carotid stenosis) and compared to 54 healthy controls. Subjects were tested for the presence of the classical aPL antibodies anticardiolipin (aCL) and anti-beta2-glycoprotein (aβ2gI), in addition to antiphosphatidylethanolamine (aPE)...
Source: Immunologic Research - January 22, 2017 Category: Allergy & Immunology Source Type: research

Stroke in systemic lupus erythematosus and antiphospholipid syndrome: risk factors, clinical manifestations, neuroimaging, and treatment.
This article updates the data regarding the risk factors, clinical manifestations, neuroimaging, and treatment of stroke in SLE and APS. PMID: 28394226 [PubMed - in process]
Source: Lupus - April 1, 2017 Category: Rheumatology Authors: de Amorim LC, Maia FM, Rodrigues CE Tags: Lupus Source Type: research

Risk of hemorrhagic transformation after ischemic stroke in patients with antiphospholipid antibody syndrome.
CONCLUSION: APS is an independent risk factor for hemorrhagic transformation in both thrombolytic and non-thrombolytic treated patients. APS is also associated with longer length and cost of hospital stay. Further research is warranted to identify the unique risk factors in these patients to identify strategies to reduce the risk of hemorrhagic transformation in this subgroup of the population. PMID: 28475479 [PubMed - as supplied by publisher]
Source: Neurological Research - May 8, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Stroke is Different in Systemic Lupus Erythematosus: Implications for Survival and Functionality
J Rheumatol. 2021 Mar 1:jrheum.201209. doi: 10.3899/jrheum.201209. Online ahead of print.ABSTRACTUndoubtedly, individuals with systemic lupus erythematosus (SLE) are at higher risk for developing cerebrovascular disease than counterparts from the general population without SLE. In a metaanalysis of studies from around the world, the likelihood of individuals with SLE developing both ischemic and hemorrhagic stroke (intracerebral and/or subarachnoid hemorrhage) was more than 2 times that of the general population1 Risks for stroke appear to be highest soon after SLE diagnosis, and concomitant antiphospholipid syndrome (APS)...
Source: J Rheumatol - March 2, 2021 Category: Rheumatology Authors: Marios Rossides Source Type: research