Stroke in systemic lupus erythematosus: epidemiology, mechanism, and long-term outcome.
CONCLUSIONS: The prevalence of stroke in this cohort was 3.1%. Ischemic strokes had a bimodal presentation, occurring either early after SLE diagnosis or after a several-year delay. Half of the hemorrhagic strokes occurred>10 years after the diagnosis of SLE. Clinical outcome was usually good with a relatively low recurrence rate. PMID: 32151182 [PubMed - as supplied by publisher]
In conclusion, the results from the present study suggested that miR‑29a may affect IgG antibody secretion in B cells by regulating CRKL, thereby contributing to the development and progression of SLE, which offers a novel candidate target for treatment. PMID: 32467986 [PubMed - as supplied by publisher]
In conclusion, the findings of the present study suggested that miR‑340‑5p may protect PC12 cells against OGD/R through targeting Neurod4, which could provide important implications for the treatment of ischemia‑reperfusion injury based on miR‑340‑5p expression levels in vivo. PMID: 32468054 [PubMed - as supplied by publisher]
Authors: Susmitha K, Chandrasekhar V, Kiran G, Divya A, Rani GS, Sarangapani M Abstract Stroke is becoming a main cause of early death and disability in developing countries like India, and it is mostly enhanced by increased predominance of major risk factors. A detailed knowledge about the nature and magnitude of the stroke cases in this particular area is not only important for acute treatment but also it helps to prevent hospital admissions due to reoccurring stroke. The present study was conducted in the Department of Stroke at MGM Hospital, Warangal, India, to study the patterns of stroke admissions. All the c...
Contributors : Yejie Shi ; Jun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSenescence-associated alterations in microglia may have profound impact on cerebral homeostasis and stroke outcomes. However, the lack of a transcriptome-wide comparison between young and aged microglia in the context of ischemia limits our understanding of aging-related mechanisms. Herein, we performed bulk RNA sequencing analysis of microglia purified from cerebral hemispheres of young adult (10-week-old) and aged (18-month-old) mice 5 days after distal middle cerebral artery occlusion or sham operati...
Abstract Stroke is a leading cause of death and disability in developed countries. N-methyl-D-aspartate glutamate receptors (NMDARs) have important roles in stroke pathology and recovery. Depending on their subtypes and locations, these NMDARs may promote either neuronal survival or death. Recently, the functions of previously overlooked NMDAR subtypes during stroke were characterized, and NMDARs expressed at different subcellular locations were found to have synergistic rather than opposing functions. Moreover, the complexity of the neuronal survival and death signaling pathways following NMDAR activation was fur...
Publication date: Available online 29 May 2020Source: The Egyptian RheumatologistAuthor(s): Diana Nagy, Noha H. Shaheen, Heba M. Selim, Mai M. Sherif, Salma M. Saed, Hala R. Youssef, Omneya Osman, Taghrid Gaafar
CONCLUSION: A detailed contemporary description of paediatric mastoiditis presentation and management is presented. The findings broadly mirror those published by other UK centres, but suggest a higher rate of identified disease complications and surgical interventions. PMID: 32463007 [PubMed - as supplied by publisher]
Publication date: Available online 29 May 2020Source: Pregnancy HypertensionAuthor(s): Mamoru Morikawa, Michinori Mayama, Yoshihiro Saito, Kinuko Nakagawa, Takeshi Umazume, Kentaro Chiba, Satoshi Kawaguchi, Kazutoshi Cho, Hidemichi Watari
Publication date: Available online 29 May 2020Source: Pregnancy HypertensionAuthor(s): Adebamike A. Oshunbade, Arsalan Hamid, Seth T. Lirette, Semiu O. Gbadamosi, Wondwosen K. Yimer, Olusola A. Orimoloye, Donald Clark, Daisuke Kamimura, Stephen D. Grado, Elizabeth A. Lutz, Robert J. Mentz, Ervin R. Fox, Javed Butler, B. Gwen Windham, Kenneth R. Butler, Thomas H. Mosley, Michael E. Hall
Publication date: Available online 29 May 2020Source: Pregnancy HypertensionAuthor(s): Sunitha Suresh, Ariel Mueller, Saira Salahuddin, Heba Naseem, Rohin Dhir, Sarosh Rana