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Condition: Diabetes Type 1

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Total 409 results found since Jan 2013.

Neuropeptide α-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes
In conclusion, α-MSH is neuroprotective under hyperglycemic condition against I/R induced brain damage by its anti-inflammatory, anti-oxidative and anti-apoptotic properties. The use of α-MSH analogues may be potential therapeutic agents for diabetic stroke.PMID:34586586 | DOI:10.1007/s11064-021-03453-4
Source: Neurochemical Research - September 29, 2021 Category: Neuroscience Authors: Rajesh Kumar Goit Tsz Chung Ng Ka Cheung Tam Jessica K W Tsang Andrew W Taylor Amy C Y Lo Source Type: research

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study
CONCLUSION: We identified alanine as a new amino acid associated with increased risk of CAD and glutamine as a new amino acid associated with decreased risk of ischemic stroke. We also confirmed that phenylalanine and tyrosine were associated with CAD, ischemic stroke, and CVD events.PMID:34346487 | DOI:10.1210/clinem/dgab562
Source: The Journal of Clinical Endocrinology and Metabolism - August 4, 2021 Category: Endocrinology Authors: Raimo Jauhiainen Jagadish Vangipurapu Annamaria Laakso Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Source Type: research

Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine
ConclusionThe novel reclassification algorithm of patients with adult diabetes was reproducible in this population from northern Ukraine. It may be beneficial for the patients in the SIDD subgroup to initiate earlier insulin treatment or other anti-diabetic modalities to preserve β-cell function. Long-term diabetes cases with preserved β-cell function and lower risk for microvascular complications represent an interesting subgroup of patients for further investigations of protective mechanisms.
Source: Frontiers in Genetics - July 2, 2021 Category: Genetics & Stem Cells Source Type: research

Risk Factors Associated with All-Cause Death Among Dialysis Patients with Diabetes
CONCLUSIONS Deceased patients had higher HbA1c and fructosamine levels and higher comorbidity. However, history of stroke or transient ischemic attack was an independent risk factor of all-cause death, while regular physical activity was associated with the reduction of the risk of all-cause death in patients with type 1 and type 2 diabetes treated with peritoneal dialysis or hemodialysis. Regular physical activity should be recommended to improve survival in this population.PMID:34023847 | DOI:10.12659/MSM.930152
Source: Medical Science Monitor - May 23, 2021 Category: Research Authors: Anna Grzywacz Arkadiusz Lubas Jerzy Smoszna Stanis ław Niemczyk Source Type: research

Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis
CONCLUSION: A weighted GRS for SLE was associated with an increased risk of several autoimmune-related phenotypes including type I diabetes but not with cardiometabolic disorders.PMID:33977795 | DOI:10.1177/09612033211014952
Source: Lupus - May 12, 2021 Category: Rheumatology Authors: Vivian K Kawai Mingjian Shi Ge Liu QiPing Feng WeiQi Wei Cecilia P Chung Theresa L Walunas Adam S Gordon James G Linneman Scott J Hebbring John B Harley Nancy J Cox Dan M Roden C Michael Stein Jonathan D Mosley Source Type: research

Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era
Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes ...
Source: Journal of Translational Medicine - April 1, 2021 Category: Research Authors: Ammira Al-Shabeeb Akil, Esraa Yassin, Aljazi Al-Maraghi, Elbay Aliyev, Khulod Al-Malki and Khalid A. Fakhro Tags: Review Source Type: research

Association of Diabetic Retinopathy With Stroke: A Systematic Review and Meta-Analysis
Conclusions: The presence of DR is associated with an increased risk of stroke in diabetic patients. This correlation is robust in T2DM patients but uncertain in T1DM patients. Our findings indicate that DR is an important biomarker for the prediction of stroke. To further validate the role of DR in stroke-risk stratification, additional research is required on the association between the stage of DR and stroke risk, and more studies including T1DM patients are necessary.
Source: Frontiers in Neurology - March 16, 2021 Category: Neurology Source Type: research

The impact of parental risk factors on the risk of stroke in type 1 diabetes
ConclusionA history of maternal stroke increases the risk of hemorrhagic stroke in individuals with type 1 diabetes. Other parental risk factors seem to have limited impact on the risk of stroke.
Source: Acta Diabetologica - March 15, 2021 Category: Endocrinology Source Type: research

(Ultra-)long-acting insulin analogues for people with type 1 diabetes mellitus
CONCLUSIONS: Comparing insulin detemir with NPH insulin for T1DM showed lower risk of severe hypoglycaemia in favour of insulin detemir (moderate-certainty evidence). However, the 95% prediction interval indicated inconsistency in this finding. Both insulin detemir and insulin glargine compared with NPH insulin did not show benefits or harms for severe nocturnal hypoglycaemia. For all other main outcomes with overall low risk of bias and comparing insulin analogues with each other, there was no true beneficial or harmful effect for any intervention. Data on patient-important outcomes such as QoL, macrovascular and microvas...
Source: Cochrane Database of Systematic Reviews - March 4, 2021 Category: General Medicine Authors: Bianca Hemmingsen Maria-Inti Metzendorf Bernd Richter Source Type: research

Fetal cardiovascular hemodynamics in type 1 diabetic pregnancies at near ‐term gestation
ConclusionsIn maternal type 1 diabetes pregnancies, fetal cardiovascular hemodynamics is impaired. Maternal type 1 diabetes does not seem to alter placental vascular impedance or induce placental inflammation.
Source: Acta Obstetricia et Gynecologica Scandinavica - January 20, 2021 Category: OBGYN Authors: Lara Lehtoranta, Mervi Haapsamo, Olli Vuolteenaho, Pertti Palo, Eeva Ekholm, Juha R äsänen Tags: ORIGINAL ARTICLE Source Type: research

Genes, Vol. 11, Pages 1256: Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
Conclusion: This study presents a platform to discover potential targets for diabesity treatment and helps in understanding the molecular mechanism.
Source: Genes - October 25, 2020 Category: Genetics & Stem Cells Authors: Udhaya Kumar S Bithia Rajan Thirumal Kumar D Anu Preethi V Taghreed Abunada Salma Younes Sarah Okashah Selvarajan Ethiraj George Priya Doss C Hatem Zayed Tags: Article Source Type: research