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Condition: Cerebral Palsy

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Total 550 results found since Jan 2013.

The reliability and validity of the Timed Up and Go as a clinical tool in individuals with and without disabilities across a lifespan: a systematic review.
Conclusions: Based on the literature assessed, the Timed Up and Go is clinically applicable and reliable across multiple populations. The Timed Up and Go has a wide variety of clinical use making it a diverse measure that should be considered when choosing an outcome an activity based outcome measure. However, there are some limitations in the validity of the utilization of the Timed Up and Go to some populations due to a lack of data and/or poor choice of comparison outcome measures when assessing validity. Additional research is needed for young to middle aged adults. IMPLICATIONS FOR REHABILITATION Outcome measures are ...
Source: Disability and Rehabilitation - October 25, 2019 Category: Rehabilitation Authors: Christopher A, Kraft E, Olenick H, Kiesling R, Doty A Tags: Disabil Rehabil Source Type: research

Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations
by Carmichael F. Ong, Thomas Geijtenbeek, Jennifer L. Hicks, Scott L. Delp Deficits in the ankle plantarflexor muscles, such as weakness and contracture, occur commonly in conditions such as cerebral palsy, stroke, muscular dystrophy, Charcot-Marie-Tooth disease, and sarcopenia. While these deficits likely contribute to observed gait pathologies, determining cause-effect relationships is difficult due to the often co-occurring biomechanical and neural deficits. To elucidate the effects of weakness and contracture, we systematically introduced isolated deficits into a musculoskeletal model and generated simulations of walk...
Source: PLoS Computational Biology - October 6, 2019 Category: Biology Authors: Carmichael F. Ong Source Type: research

Demystifying spasticity in primary care.
CONCLUSION: Managing spasticity might be unfamiliar to many practitioners. It is important for physicians to understand spasticity and the potential treatment options available to improve quality of life. The current review provides concise information on the clinical relevance of spasticity in primary care and how to assess and manage it effectively and efficiently in those with chronic neurologic conditions. PMID: 31604736 [PubMed - in process]
Source: Canadian Family Physician Medecin de Famille Canadien - September 30, 2019 Category: Primary Care Authors: Milligan J, Ryan K, Lee J Tags: Can Fam Physician Source Type: research

US WorldMeds lands new FDA approval
Louisville-based pharmaceutical company US WorldMeds LLC received Food and Drug Administration approval for a new use of its drug Myobloc. Myobloc can now be used to treat sialorrhea, commonly known as drooling. It's a common and unfortunate symptom that follows many neurological disorders such as Parkinson's Disease, amyotrophic lateral sclerosis (ALS), cerebral palsy and stroke to name a few. "We are committed to helping patients who struggle with confidence due to their sialorrhea," US WorldMeds…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - August 28, 2019 Category: Pharmaceuticals Authors: Chris Larson Source Type: news

A Scoping Review of Neuromuscular Electrical Stimulation to Improve Gait in Cerebral Palsy: The Arc of Progress and Future Strategies
Conclusions: Research on single-channel gait-specific NMES found that it improved ankle motion in swing but was insufficient to address more complex gait abnormalities common in CP, such as flexed-knee and stiff-knee gait. Early evidence indicates that multi-channel gait-specific NMES may improve gait patterns in CP, however significantly more research is needed. The conclusions of this review are highly limited by the low level of evidence of the studies included. This review provides a historical record of past work and a technical context, with implications for future research on gait-specific NMES to improve walking pa...
Source: Frontiers in Neurology - August 20, 2019 Category: Neurology Source Type: research

Health related quality of life and manual ability 5 years after neonatal ischemic stroke.
CONCLUSION: Five years after NAIS, HRQOL is comparable to that of typically developing peers, but reduced in children with CP. Poorer manual ability is associated with lower HRQOL. Interventions improving hand function might influence HRQOL and should be considered early on. PMID: 31473077 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - August 11, 2019 Category: Neurology Authors: Caspar-Teuscher M, Studer M, Regényi M, Steinlin M, Grunt S, Swiss Neuropediatric Stroke Registry Group Tags: Eur J Paediatr Neurol Source Type: research

A Comparison of the Physiology of Sedentary Behavior and Light Physical Activity in Adults With and Without a Physical Disability.
CONCLUSIONS: Physiologic responses during sedentary behavior are comparable for controls and adults with mild to moderate stroke and CP, whereas higher metabolic demands and muscle activity (stroke only) were observed in severely affected individuals. PMID: 31382243 [PubMed - as supplied by publisher]
Source: Journal of Physical Activity and Health - August 7, 2019 Category: Sports Medicine Tags: J Phys Act Health Source Type: research

The Effect of a Low-Cost Body Weight-Supported Treadmill Trainer on Walking Speed and Joint Motion.
Conclusions: The AccesSportAmerica Gait Trainer has the potential to improve the walking speed of people with ambulatory difficulty. PMID: 31366161 [PubMed - in process]
Source: Medicina (Kaunas) - July 29, 2019 Category: Universities & Medical Training Authors: Ventura JD, Charrette AL, Roberts KJ Tags: Medicina (Kaunas) Source Type: research

Intrathecal baclofen as a treatment for spasticity: Review of the cases treated in our hospital.
CONCLUSIONS: Intrathecal baclofen is a simple technique with good results for improving the quality of life of patients with spasticity. PMID: 31208871 [PubMed - as supplied by publisher]
Source: Neurocirugia - June 13, 2019 Category: Neurosurgery Authors: Santin-Amo JM, Flores-Justa A, Román-Pena P, Raposo-Furelos M, Frieiro-Dantas C, Serramito García R, Villa JM, Gelabert-González M Tags: Neurocirugia (Astur) Source Type: research

Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY).
Conclusions: The SAVVY survey provides estimates of mortality burden of ND in Tanzania. The study provides a basis for monitoring trends of ND and contributes to advancing knowledge of the burden of diseases. Integrating morbidities measures into the SAVVY design will provide comprehensive measures of burden of ND taking into account lifetime disabilities created by ND. PMID: 31144608 [PubMed - in process]
Source: Global Health Action - June 1, 2019 Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research

NHS funds headache relieving device
The handheld device delivers low-level electric currents to disrupt cluster headaches Related items fromOnMedica NICE calls for consistent clinical and social care in cerebral palsy Stroke survivors need more help taking medicine Ending the postcode lottery of stroke care BMA calls for ‘national standard for autism care’ Clinicians need better options if we are to stop over-medication
Source: OnMedica Latest News - May 6, 2019 Category: UK Health Source Type: news

Simulating Hemiparetic Gait in Healthy Subjects Using TPAD With a Closed-Loop Controller
Hemiparetic gait is abnormal asymmetric walking, often observed among patients with cerebral palsy or stroke. One of the major features of asymmetric gait is excessive reliance on the healthy leg, which results in improper load shift, slow walking speed, higher metabolic cost, and weakness of the unused leg. Hence, clinically it is desirable to promote gait symmetry to improve walking. While there are no clear methods to achieve this goal, we are exploring new methods where we guide the pelvis to change the gait symmetry. This controller is designed to mimic the hands of a physical therapist holding the pelvis and guiding ...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - April 30, 2019 Category: Neuroscience Source Type: research

Muscle Synergies During Repetitive Stoop Lifting With a Bioelectrically-Controlled Lumbar Support Exoskeleton
Conclusions Our current study aims to examine the effects of a lumbar support exoskeleton from the perspective of muscle coordination with muscle synergy analysis. For our experimental protocol, we assumed a fixed spatial set of muscle synergy weights, but variable recruitment (timing coefficients) for each condition. Chvatal and Ting (2012) provided evidence in their results and cited a multitude of studies that strongly support the assumption that modifications in human walking can be attributed to variances in the recruitment of spatially-fixed muscle synergies. Our results indicate that muscle coordination patterns a...
Source: Frontiers in Human Neuroscience - April 29, 2019 Category: Neuroscience Source Type: research

Diffusion Imaging of Cerebral Diaschisis in Neonatal Arterial Ischemic Stroke
Neonatal arterial ischemic stroke (NAIS) is a leading cause of cerebral palsy and lifelong disability. Diffusion-weighted imaging (DWI) has revolutionized diagnosis and facilitated outcome prognostication in acute NAIS. Diaschisis refers to changes in brain areas functionally connected but structurally remote from primary injury. We hypothesized that acute DWI can quantify cerebral diaschisis and is associated with outcome from NAIS.
Source: Pediatric Neurology - April 25, 2019 Category: Neurology Authors: Srivastava R, Rajapakse T, Carlson HL, Keess J, Wei X, Kirton A Tags: Research Paper Source Type: research