The reliability and validity of the Timed Up and Go as a clinical tool in individuals with and without disabilities across a lifespan: a systematic review.

Conclusions: Based on the literature assessed, the Timed Up and Go is clinically applicable and reliable across multiple populations. The Timed Up and Go has a wide variety of clinical use making it a diverse measure that should be considered when choosing an outcome an activity based outcome measure. However, there are some limitations in the validity of the utilization of the Timed Up and Go to some populations due to a lack of data and/or poor choice of comparison outcome measures when assessing validity. Additional research is needed for young to middle aged adults. IMPLICATIONS FOR REHABILITATION Outcome measures are a vital component of clinical practice across all populations. The Timed Up and Go is a highly studied outcome measure in the geriatric population, but lacks research of its applicability to other populations. This study was able to highlight the clinical utility of the Timed Up and Go in populations that under utilize this outcome measure. PMID: 31656104 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research

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Source: Social Work in Health Care - Category: International Medicine & Public Health Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Ayşe A. KüçükdeveciAbstractThe goals in the management of established rheumatoid arthritis (RA) are to control pain and disease activity, prevent further joint damage, and enhance functioning and quality of life. Despite the fact that aggressive and the early use of biological and nonbiological disease-modifying antirheumatic drugs have been associated with substantial gains in clinical, radiological, and disability outcomes, a considerable proportion of patients still report significant p...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsThe results from our small study have significant implications––symptoms, clinical presentation or classic radiological findings perhaps cannot reliably separate MS from NMOSD. If our study findings can be replicated, guidelines to diagnose MS ought to recommend that NMOSD be excluded first despite typical clinical and radiological findings pointing to MS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: Our findings indicate that acute MOG-Ab ON shows florid intra-orbital and peri-optic inflammation, likely to involve meninges and nociceptive fibers around the optic nerve. This may explain the frequent and often severe frontal or orbital headache that precedes the visual deficit, sometimes misdiagnosed as migraine.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusions and Relevance: The goal of disease modifying therapies in MS is effectiveness over long periods of time with minimal risk. The preservation, reduction or elimination of immunosurveillance should be an important consideration in deciding on the optimal disease modifying treatments (DMT) for an individual MS patient. IRTs have the advantage of providing long term control of disease activity with short term immunosuppression followed by long term immunomodulation without retreatment. For most MS patients with mild or modest disease activity, initial immunomodulation followed by IRT for breakthrough disease may be ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 24 January 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Asiye Tuba Ozdogar, Ozge Ertekin, Turhan Kahraman, Pinar Yigit, Serkan OzakbasBackground: Developments in rehabilitation technology such as video-based exergaming contributes to the treatment process as well as to increase the active participation of persons with multiple sclerosis (pwMS). The aim was to investigate the effect of video-based exergaming training on upper extremity and cognitive function as well as core stability, walking, depression, fatigue, and quality of life in pwMS.Methods: This randomized contr...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionThis is the first study to assess attitudes and practices of pediatric neurologists and epileptologists regarding sexual and reproductive healthcare for adolescent and young adult WWE. Our findings suggest that there is a need for development of improved systems for sexual and reproductive healthcare delivery and comanagement for adolescent and young adult WWE. Providers identified many barriers and facilitators that might serve as the basis for interventions to improve care.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: March 2020Source: Epilepsy &Behavior, Volume 104, Part AAuthor(s): Delphine Coste-Zeitoun, Mathieu Kuchenbuch, Daniela Pennaroli, Clémence Castaignède, Sylvia Napuri, Christine Satre, Jean-Luc Schaff, Sylvie Sukno, Marie Hélias, Nathalie de Grissac-Moriez, Georges Delattolas, Dominique Olive, Christine Bulteau, Guy Zeitoun, Anna KaminskaAbstractIntroductionThe reason why some children and adolescent with epilepsy (CAWE) still challenge the “inclusive” educative policy needs to be explored.Methods/patientsWe conducted a transversal study in French medical, social, and e...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionsDG-0.5g and DG-1g treatments exerted neuroprotective effects on I/R injury by activating p38 MAPK-mediated p90RSK/p-Bad-induced anti-apoptotic-Cytc/caspase-3-related and p90RSK/CREB/BDNF survival signaling in the hippocampus 7 d after transient GCI.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 25 January 2020Source: The Journal of Prosthetic DentistryAuthor(s): Javier Montero, Luis A. Leiva, Inmaculada Martín-Quintero, Rocío Barrios-RodríguezAbstractStatement of problemThere is a need to quantitatively differentiate between impaired and normal mastication by using straightforward and reliable methods because currently available methods are expensive, complex, and time-consuming.PurposeThe purpose of this clinical study was to assess the reliability, validity, and clinical utility of a new Web-based software program designed to calculate masticatory performa...
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
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