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Condition: Cerebral Palsy

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Total 550 results found since Jan 2013.

The Upper Extremity Flexion Synergy Is Minimally Expressed in Young Individuals With Unilateral Cerebral Palsy Following an Early Brain Injury
This study uses kinematics of a ballistic reaching task to evaluate the expression of the flexion synergy in individuals with pediatric hemiplegia (PH) ages six to seventeen years. Fifteen individuals with brain injuries before birth (n = 8) and around full-term (n = 7) and nine age-matched controls with no known neurological impairment completed a set of reaches in an admittance controlled robotic device. Descending drive, and the possible expression of the upper extremity flexion synergy, was modulated by increasing shoulder abduction loading. Individuals with early-onset PH achieved lower peak velocities when reaching w...
Source: Frontiers in Human Neuroscience - October 16, 2020 Category: Neuroscience Source Type: research

A comparative evaluation of telehealth and direct assessment when screening for spasticity in residents of two long-term care facilities.
CONCLUSION: Telehealth may provide a useful, efficient method of identifying residents of long-term care facilities that likely need referral for spasticity evaluation. PMID: 33040604 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - October 11, 2020 Category: Rehabilitation Authors: Harper KA, Butler EC, Hacker ML, Naik A, Eoff BR, Phibbs FT, Isaacs DA, Gallion SJ, Thomas EP, Scott JL, Ploucher S, Meystedt JC, McLeod ME, Charles PD Tags: Clin Rehabil Source Type: research

Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish
AbstractHypoxia, the major cause of ischemic injury, leads to debilitating disease in infants via birth asphyxia and cerebral palsy, whereas in adults via heart attack and stroke. A widespread, natural protective phenomenon termed ‘hypoxic preconditioning’ (PH) occurs when prior exposures to hypoxia eventually result in robust hypoxia resistance. Accordingly, we have developed and optimized a novel model of hypoxic preconditioning in adult zebrafish to mimic the tolerance of mini stroke(s) in human, which appears to prote ct against the severe damage inflicted by a major stroke event. Here, we observed a remarkable dif...
Source: Molecular Neurobiology - October 7, 2020 Category: Neurology Source Type: research

About 14% of cerebral palsy cases may be tied to brain wiring genes
(NIH/National Institute of Neurological Disorders and Stroke) In an article published in Nature Genetics, NIH funded researchers confirm that about 14% of all cases of cerebral palsy, a disabling brain disorder for which there are no cures, may be linked to a patient's genes and suggest that many of those genes control how brain circuits become wired during early development. The results led to recommended changes in the treatment of at least three patients, highlighting the importance of understanding the role genes play in the disorder.
Source: EurekAlert! - Biology - September 28, 2020 Category: Biology Source Type: news

Motor outcome after perinatal stroke and early prediction of unilateral spastic cerebral palsy.
CONCLUSION: Using GMA and HAI can enable prediction of USCP before the age of 5 months in infants with perinatal stroke. Nevertheless, GMA must be interpreted with caution in this particular population. The HAI was found to be a very accurate screening tool for early detection of asymmetry and prediction of USCP. PMID: 32988734 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - September 20, 2020 Category: Neurology Authors: Pascal A, Govaert P, Ortibus E, Naulaers G, Lars A, Fjørtoft T, Oostra A, Zecic A, Cools F, Cloet E, Casaer A, Cornette L, Laroche S, Samijn B, Van den Broeck C Tags: Eur J Paediatr Neurol Source Type: research

Neuroimaging perspectives of perinatal arterial ischemic stroke
Perinatal stroke is second only to adult stroke in the overall stroke incidence. It is a major contributor to long term neurologic morbidity which include cognitive dysfunction, cerebral palsy and seizures. Risk factors of stroke in the perinatal period differs from those in children and tend to be multi-factorial. Differences in territorial predilection, response to injury and stroke evolution exist when compared to childhood and adult stroke, and also amongst differing gestation age groups in the perinatal period (i.e.
Source: Pediatric Neurology - August 20, 2020 Category: Neurology Authors: Asthik Biswas, Kshitij Mankad, Manohar Shroff, Prasad Hanagandi, Pradeep Krishnan Tags: Review Article Source Type: research

Animal models of disuse-induced bone loss: study protocol for a systematic review
DiscussionThis systematic review will provide an overview of available animal models of disuse-induced bone loss and discuss the different methods used to quantify and analyze the bone loss. Since bone loss caused by disuse is a hallmark of various diseases from different medical specialties, this overview will be of great benefit for all researchers planning to conduct disuse animal studies in the future.Systematic review registrationPROSPEROCRD42020157452.
Source: Systematic Reviews - August 15, 2020 Category: International Medicine & Public Health Source Type: research

Blog: When you ’re the wrong sort of ‘vulnerable’
I’ve been a local government worker and a UNISON member for 15 years. I have cerebral palsy and arthritis, which means I sometimes struggle to walk and to communicate. I had a stroke five years ago and I’m more susceptible to infection. If I got COVID-19, I dread to think what might happen. But the government don’t seem to care about my individual circumstances. Instead, they have divided disabled people into two new groups – extremely vulnerable people and vulnerable people.  Only extremely vulnerable people were told to shield. Apparently, I’m just plain old vulnerable. I’m not extremely vulnerable, accordin...
Source: UNISON Health care news - August 10, 2020 Category: UK Health Authors: Martin Cullen Tags: Article Covid-19 disabled members Source Type: news

Robotic assessment of rapid motor decision making in children with perinatal stroke
Activities of daily living frequently require children to make rapid decisions and execute desired motor actions while inhibiting unwanted actions. Children with hemiparetic cerebral palsy due to perinatal str...
Source: Journal of NeuroEngineering and Rehabilitation - July 14, 2020 Category: Rehabilitation Authors: Rachel L. Hawe, Andrea M. Kuczynski, Adam Kirton and Sean P. Dukelow Tags: Research Source Type: research

IJERPH, Vol. 17, Pages 4133: The Effectiveness of Virtual Reality Exercise on Individual ’s Physiological, Psychological and Rehabilitative Outcomes: A Systematic Review
Conclusion: The findings suggest that VR exercise has the potential to exert a positive impact on individual’s physiological, psychological, and rehabilitative outcomes compared with traditional exercise. However, the quality, quantity, and sample size of existing studies are far from ideal. Therefore, more rigorous studies are needed to confirm the observed positive effects.
Source: International Journal of Environmental Research and Public Health - June 9, 2020 Category: Environmental Health Authors: Jiali Qian Daniel J. McDonough Zan Gao Tags: Review Source Type: research

Sensors, Vol. 20, Pages 3236: A Mobile Application for Smart Computer-Aided Self-Administered Testing of Cognition, Speech, and Motor Impairment
We present a model for digital neural impairment screening and self-assessment, which can evaluate cognitive and motor deficits for patients with symptoms of central nervous system (CNS) disorders, such as mild cognitive impairment (MCI), Parkinson’s disease (PD), Huntington’s disease (HD), or dementia. The data was collected with an Android mobile application that can track cognitive, hand tremor, energy expenditure, and speech features of subjects. We extracted 238 features as the model inputs using 16 tasks, 12 of them were based on a self-administered cognitive testing (SAGE) methodology and...
Source: Sensors - June 5, 2020 Category: Biotechnology Authors: Andrius Lauraitis Rytis Maskeli ūnas Robertas Dama ševičius Tomas Krilavi čius Tags: Article Source Type: research

RECO Flow Restoration Device Versus Solitaire FR With the Intention for Thrombectomy Study (REDIRECT): a prospective randomized controlled trial.
CONCLUSIONS: The RECO stent retriever is effective and safe as a mechanical thrombectomy device for AIS due to LVO.Clinical trial registration no.: NCT01983644 (clinicaltrials.gov). PMID: 32502991 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - June 4, 2020 Category: Neurosurgery Authors: Cao J, Lin H, Lin M, Ke K, Zhang Y, Zhang Y, Zheng W, Chen X, Wang W, Zhang M, Xuan J, Peng Y, REDIRECT Trial Investigators Tags: J Neurosurg Source Type: research

Is the Blood Oxygenation Level-Dependent fMRI Response to Motor Tasks Altered in Children After Neonatal Stroke?
Functional MRI is increasingly being used in the assessment of brain activation and connectivity following stroke. Many of these studies rely on the Blood Oxygenation Level Dependent (BOLD) contrast. However, the stability, as well as the accuracy of the BOLD response to motor task in the ipsilesional hemisphere, remains ambiguous. In this work, the BOLD signal acquired from both healthy and affected hemispheres was analyzed in 7-year-old children who sustained a Neonatal Arterial Ischemic Stroke (NAIS). Accordingly, a repetitive motor task of the contralesional and the ipsilesional hands was performed by 33 patients with ...
Source: Frontiers in Human Neuroscience - April 28, 2020 Category: Neuroscience Source Type: research

Sensors, Vol. 20, Pages 2114: DataSpoon: Validation of an Instrumented Spoon for Assessment of Self-Feeding
on Friedman Clinically feasible assessment of self-feeding is important for adults and children with motor impairments such as stroke or cerebral palsy. However, no validated assessment tool for self-feeding kinematics exists. This work presents an initial validation of an instrumented spoon (DataSpoon) developed as an evaluation tool for self-feeding kinematics. Ten young, healthy adults (three male; age 27.2 ± 6.6 years) used DataSpoon at three movement speeds (slow, comfortable, fast) and with three different grips: “natural”, power and rotated power grip. Movement kinemati...
Source: Sensors - April 8, 2020 Category: Biotechnology Authors: Tal Krasovsky Patrice L. Weiss Oren Zuckerman Avihay Bar Tal Keren-Capelovitch Jason Friedman Tags: Article Source Type: research

What Are Some Risk Factors for Cerebral Palsy?
Discussion The term, cerebral palsy, or CP has gone through many iterations with the first description in 1861 by W.J. Little who described it as “The condition of spastic rigidity of the limbs of newborn children.” The most recent definition is from Rosenbaun et al. in 2007 which states it is “a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cog...
Source: PediatricEducation.org - March 9, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news