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Condition: Non-alcoholic Fatty Liver Diseases (NAFLD)

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NAFLD Not Associated With Risk of Cardiovascular Disease NAFLD Not Associated With Risk of Cardiovascular Disease
Non-alcoholic fatty liver disease (NAFLD) is not associated with an increased risk of acute myocardial infarction (AMI) or stroke, according to a new cohort study in nearly 18 million Europeans.Reuters Health Information
Source: Medscape Medical News Headlines - October 27, 2019 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Causal relationships between obesity and the leading causes of death in women and men
by Jenny C. Censin, Sanne A. E. Peters, Jonas Bovijn, Teresa Ferreira, Sara L. Pulit, Reedik M ägi, Anubha Mahajan, Michael V. Holmes, Cecilia M. Lindgren Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains unclear whether there are similar causal effects of obesity traits on other non-communicable diseases. Also, it is largely unexplored whether there are any sex-specific differences in the causal effects of obe sity traits on cardiometabolic diseases and other leading causes of death. We constructed sex-specific genetic risk scores (GRS) for three obesity traits; body mass index (BM...
Source: PLoS Genetics - October 23, 2019 Category: Genetics & Stem Cells Authors: Jenny C. Censin Source Type: research

Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke
There is an increasing appreciation of the cardiovascular implications of nonalcoholic fatty liver disease with advanced fibrosis (NAFLD-fibrosis). However, data regarding stroke risk are limited. We sought to investigate whether NAFLD-fibrosis is associated with stroke in addition to heart disease.
Source: Journal of the Neurological Sciences - October 12, 2019 Category: Neurology Authors: Neal S. Parikh, Lisa B. VanWagner, Mitchell S.V. Elkind, Jose Gutierrez Source Type: research

Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults
Source: BMJ - October 8, 2019 Category: General Medicine Source Type: research

Brain involvement in non-alcoholic fatty liver disease (NAFLD): A systematic review
Non-alcoholic fatty liver disease (NAFLD) is associated with high cardiovascular morbidity and mortality which usually is considered to be related to cardiac involvement, while scarce attention is addressed to brain damage. Viceversa NAFLD is associated with asymptomatic brain lesions, alterations in cerebral perfusion and activity, cognitive impairment and brain aging and with increased risk and severity of both ischemic and haemorrhagic stroke. Besides known metabolic risk factors, NAFLD is characterized by a pro inflammatory state, which contributes to atherosclerosis and microglia activation, endothelial dysfunction, p...
Source: Digestive and Liver Disease - June 5, 2019 Category: Gastroenterology Authors: Rosa Lombardi, Silvia Fargion, Anna Ludovica Fracanzani Tags: Liver, Pancreas and Biliary Tract Source Type: research

Study: Skipping Breakfast Tied To Higher Risk Of Heart-Related Death
(CNN) — Whether you eat breakfast might be linked with your risk of dying early from cardiovascular disease, according to a new study. Skipping breakfast was significantly associated with an increased risk of cardiovascular-related death, especially stroke-related death, in the study published in the Journal of the American College of Cardiology on Monday. After a person’s age, sex, race, socioeconomic status, diet, lifestyle, body mass index and disease status were taken into account, the study found that those who never had breakfast had a 87% higher risk of cardiovascular mortality compared with people who h...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 22, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Heart Disease Source Type: news

Exercise as a Prescription for Patients with Various Diseases
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - April 20, 2019 Category: Sports Medicine Source Type: research

Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

The Discovery and Development of Liraglutide and Semaglutide
We describe one such approach, albumin binding, and explain how it was applied in the development of the human GLP-1 analog liraglutide once daily and, subsequently, semaglutide once weekly. The pharmacology of these two long-acting GLP-1 analogs, in terms of improving glycemic control, reducing body weight and decreasing cardiovascular (CV) risk, is also reviewed, together with some novel biology. In addition, we describe the importance of accurate target (GLP-1 receptor) tissue expression analysis. Now an established class of agents, GLP-1-based therapies represent a significant advance in the treatment of T2D. All curr...
Source: Frontiers in Endocrinology - April 11, 2019 Category: Endocrinology Source Type: research

Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage.
CONCLUSION:: Serum levels of LDL was a protective factor. NAFLD did not increase the unfavorable outcome of ICH patients in our study. PMID: 30922067 [PubMed - as supplied by publisher]
Source: Cell Transplantation - March 28, 2019 Category: Cytology Authors: Tu S, Zhao R, Fang H, Wang L, Shao A, Sheng J Tags: Cell Transplant Source Type: research

Polycystic ovary syndrome: a reproductive and metabolic web of risk, comorbidities, and disease
Polycystic ovary syndrome (PCOS) has been described as the most common endocrine disorder affecting reproductive age women. PCOS is often associated with metabolic dysfunction, obesity, glucose intolerance with hyperinsulinemia, lipid abnormalities. and hypertension. Women with PCOS also suffer higher rates of cardiovascular (CV) disease, peripheral vascular disease, stroke, diabetes, sleep apnea, non-alcoholic fatty liver disease, and breast and uterine cancer. However, rather than a strict cause and effect relationship, many have argued that these conditions are independent or related to a specific feature such as obesit...
Source: Fertility and Sterility - March 1, 2019 Category: Reproduction Medicine Authors: G. Wright Bates Tags: Reflections Source Type: research

Subterminal hydroxyeicosatetraenoic acids: Crucial lipid mediators in normal physiology and disease states
In conclusion, elucidation of different roles of subterminal HETEs in normal and disease states leads to identification of novel therapeutic targets and development of new therapeutic modalities in different disease states.
Source: Chemico Biological Interactions - December 11, 2018 Category: Biochemistry Source Type: research

Subterminal hydroxyeicosatetraenoic acids: Crucial lipid mediators in normal physiology and disease states.
In conclusion, elucidation of different roles of subterminal HETEs in normal and disease states leads to identification of novel therapeutic targets and development of new therapeutic modalities in different disease states. PMID: 30543782 [PubMed - as supplied by publisher]
Source: Chemico-Biological Interactions - December 10, 2018 Category: Molecular Biology Authors: Shoieb SM, El-Sherbeni AA, El-Kadi AOS Tags: Chem Biol Interact Source Type: research

Association of non-alcoholic fatty liver disease with cardiovascular disease and subclinical atherosclerosis.
Authors: Sao R, Aronow WS Abstract Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFL...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research